Arthur M. Edelman PhD

Arthur Edelman

Arthur M. Edelman
PhD

Associate Professor

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cell Cycle; Cell growth, differentiation and development; Gene Expression; Molecular and Cellular Biology; Molecular Basis of Disease; Oncology; Signal Transduction; Transcription and Translation

Contact Information
955 Main Street
Room 3224
Buffalo, New York 14203
Phone: (716) 829-3491
Fax: (716) 829-2801
aedelman@buffalo.edu



Professional Summary:

Protein phosphorylation is an essential mechanism by which intercellular signals regulate specific intracellular events. Protein kinases, the enzymes catalyzing protein phosphorylation reactions, represent a major superfamily of genes, collectively representing 2% of the protein coding potential of the human genome. Current projects in Dr. Edelman‘s lab are devoted to the role of protein kinases in prostate and ovarian cancer. These projects utilize a wide range of techniques and involve, collaboration with investigators at Roswell Park Cancer Institute to develop protein kinase-targeted therapies for both types of cancer.

Education and Training:

  • PhD, Neuro- and Biobehavioral- Sciences, Stanford University (1978)
  • BA, Psychology, University of California at Berkeley (1968)

Employment:

  • Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1994-present)
  • Adjunct Assistant Professor, Biological Sciences, State University of New York at Buffalo (1989–1995)
  • Clinical Assistant Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–1994)
  • Assistant Professor, Pharmacology & Therapeutics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1985–1992)

Research Expertise:

  • Mechanisms of cancer initiation and progression: signaling pathway analysis, gene regulation, quantitative PCR, protein chemistry, immunocytochemistry, cell cycle analysis, gene cloning and expression

Grants and Sponsored Research:

  • September 2016–August 2018
    Targeting Akt Activation to Prevent Platinum Resistance in Ovarian Cancer
    Department of Defense
    Role: Principal Investigator
    $398,750
  • July 2015–June 2016
    Overcoming Resistance to Carboplatin Chemotherapy in Ovarian Cancer Cells by Inhibition of CaMKK2 (Pre-doctoral Fellowship)
    Mark Diamond Research Fund, SUNY Buffalo
    Role: Contributor
    $2,483
  • September 2004–November 2007
    Identification of In Vivo Targets of Protein Kinases
    NIH
    Role: Principal Investigator
    $381,514
  • January 2007–January 2007
    Individual Development Grant
    UUP
    Role: Co-Investigator
    $500
  • January 2006–December 2006
    PI Incentive Program
    OVPR
    Role: Principal Investigator
    $4,412
  • September 2001–February 2006
    Signal Transduction of Doublecortin Kinases
    National Science Foundation
    Role: Principal Investigator
    $359,995
  • March 2003–February 2004
    Identification of In vivo Targets of Protein Kinases by RNA Interference and Mass Spectrometry
    IRCAF
    Role: Principal Investigator
    $38,000
  • January 1994–December 2001
    Regulation of Calmodulin-Dependent Protein Kinases
    NIH
    Role: Principal Investigator
    $1,054,239
  • September 1993–January 1994
    Regulation of calmodulin-dependent protein kinases
    Burroughs Wellcome Fund
    Role: Principal Investigator
    $11,532
  • February 1988–January 1994
    Myosin Phosphorylation in the Nervous System
    NIH
    Role: Principal Investigator
    $428,104
  • September 1993–December 1993
    Myosin phosphorylation in the nervous system
    NIH
    Role: Principal Investigator
    $7,942
  • July 1993–September 1993
    Regulation of calmodulin-dependent protein kinases
    BRSG/NIH
    Role: Principal Investigator
    $9,882
  • February 1988–January 1989
    Myosin phosphorylation in the nervous system
    Research Development Fund-SUNY
    Role: Principal Investigator
    $6,980
  • May 1987–October 1988
    Myosin phosphorylation in the nervous system
    NSF
    Role: Principal Investigator
    $20,000
  • May 1987–June 1988
    Myosin phosphorylation in the nervous system
    Research Development Fund-SUNY
    Role: Principal Investigator
    $3,000
  • June 1986–June 1987
    Myosin phosphorylation in the nervous system
    BRSG/NIH
    Role: Principal Investigator
    $7,870
  • June 2001
    Protein Kinase Regulation
    University at Buffalo Foundation, Inc.
    Role: Principal Investigator
    $559,174
See all (7 more)

Journal Articles:

  • Gocher AM, Azabdaftari G, Euscher LM, Dai S, Karacosta LG, Franke TF, Edelman AM. (2017) Akt activation by Ca2+/calmodulin-dependent Kinase Kinase-2 in Ovarian Cancer Cells. Journal of Biological Chemistry (Aug), 292(34): 14204-14188.
  • Karacosta LG, Foster BA, Azabdaftari G, Feliciano DM, Edelman AM. (2012) A Regulatory Feedback Loop Between Ca2+/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) and the Androgen Receptor in Prostate Cancer Progression. J Biol Chem (Jul), 287: 24832-24843.
  • Hawley, S.A., Pan, D.A., Mustard, K.J. Ross, L. Bain, J., Edelman, A.M., Frenguelli, B.G. and Hardie, D. G. (2005) Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism (Jul), 2(1): 9-19.
  • Srivastava T., Fortin D., Nygaard S., Kaech S., Sonenberg N., Edelman AM, Soderling T.R. (2012) Regulation of Neuronal mRNA Translation by CaM-kinase I Phosphorylation of eIF4GII. J Neurosci (Apr), 32: 5620-5630.
  • Karacosta LG, Kuroski LA, Hofmann WA, Azabdaftari G, Mastri M, Gocher AM, Dai S, Hoste AJ, Edelman AM. (2016) Nucleoporin 62 and Ca(2+) /calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells. Prostate (Feb), 76(3): 294-306.
  • Karacosta LG, Kuroski LK, Hofmann WA, Azabdaftari G, Mastri M, Gocher AG, Dai S, Hoste A.J., Edelman AM. (2016) Nucleoporin 62 and Ca2+/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells. The Prostate (Feb), 76(3): 294-306.
  • Edelman AM, Kim WY, Higgins D, Goldstein EG, Oberdoerster M, Sigurdson W. (2005) Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. J Biol Chem (Mar), 280(9): 8531-8543.
  • Shang L, Kwon YG, Nandy S, Lawrence DS, Edelman AM. (2003) Catalytic and regulatory domains of doublecortin kinase-1. Biochemistry (Feb), 42(7): 2185-2194.
  • Edelman AM, Takio K, Blumenthal DK, Hansen RS, Walsh KA, Titani K, Krebs EG. (1985) Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase. J Biol Chem (Sep), 260(20): 11275-11285.
  • Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, Selbert MA, Edelman AM, Fremeau RT, Means AR. (1998) Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J Biol Chem (Nov), 273(48): 31880-31889.
  • White RR, Kwon YG, Taing M, Lawrence DS, Edelman AM. (1998) Definition of optimal substrate recognition motifs of Ca2+-calmodulin-dependent protein kinases IV and II reveals shared and distinctive features. J Biol Chem (Feb), 273(6): 3166-3172.
  • Abbott, M.J., Edelman A.M., Turcotte, L.P. (2009) CaMKK is an upstream signal of AMP-activated protein kinase in the regulation of substrate metabolism in contracting skeletal muscle. Am. J. Physiol. (Dec), 297: R1724-R1732.
  • Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. (1995) 5‘-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem (Nov), 270(45): 27186-27191.
  • Polak KA, Edelman AM, Wasley JW, Cohan CS. (1991) A novel calmodulin antagonist, CGS 9343B, modulates calcium-dependent changes in neurite outgrowth and growth cone movements. J Neurosci (Feb), 11(2): 534-542.
  • Lee JC, Edelman AM. (1994) A protein activator of Ca(2+)-calmodulin-dependent protein kinase Ia. J Biol Chem (Jan), 269(3): 2158-2164.
  • Lee JC, Kwon YG, Lawrence DS, Edelman AM. (1994) A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia. Proc Natl Acad Sci U S A (Jul), 91(14): 6413-6417.
  • Kennelly PJ, Colburn JC, Lorenzen J, Edelman AM, Stull JT, Krebs EG. (1991) Activation mechanism of rabbit skeletal muscle myosin light chain kinase. 5‘-p-fluorosulfonylbenzoyl adenosine as a probe of the MgATP-binding site of the calmodulin-bound and calmodulin-free enzyme. FEBS Lett (Jul), 286(1-2): 217-220.
  • Aletta JM, Selbert MA, Nairn AC, Edelman AM. (1996) Activation of a calcium-calmodulin-dependent protein kinase I cascade in PC12 cells. J Biol Chem (Aug), 271(34): 20930-20934.
  • Lee JC, Edelman AM. (1995) Activation of Ca(2+)-calmodulin-dependent protein kinase Ia is due to direct phosphorylation by its activator. Biochem Biophys Res Commun (May), 210(2): 631-637.
  • Rabin RA, Edelman AM, Wagner JA. (1992) Activation of protein kinase A is necessary but not sufficient for ethanol-induced desensitization of cyclic AMP production. J Pharmacol Exp Ther (Jul), 262(1): 257-262.
  • Takio K, Blumenthal DK, Edelman AM, Walsh KA, Krebs EG, Titani K. (1985) Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase. Biochemistry (Oct), 24(22): 6028-6037.
  • Raese JD, Edelman AM, Makk G, Bruckwick EA, Lovenberg W, Barchas JD. (1979) Brain striatal tyrosine hydroxylase: activation of the enzyme by cyclic AMP-independent phosphorylation. Commun Psychopharmacol (Jan), 3(5): 295-301.
  • DeRemer MF, Saeli RJ, Edelman AM. (1992) Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain I. Identification, purification, and structural comparisons. J Biol Chem (Jul), 267(19): 13460-13465.
  • DeRemer MF, Saeli RJ, Brautigan DL, Edelman AM. (1992) Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation. J Biol Chem (Jul), 267(19): 13466-13471.
  • Gallis B, Edelman AM, Casnellie JE, Krebs EG. (1983) Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle. J Biol Chem (Nov), 258(21): 13089-13093.
  • Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR. (1995) Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. EMBO J (Aug), 14(15): 3679-3686.
  • Blumenthal DK, Takio K, Edelman AM, Charbonneau H, Titani K, Walsh KA, Krebs EG. (1985) Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. Proc Natl Acad Sci U S A (May), 82(10): 3187-3191.
  • Edelman AM, Raese JD, Lazar MA, Barchas JD. (1978) In vitro phosphorylation of a purified preparation of bovine corpus striatal tyrosine hydroxylase. Commun Psychopharmacol (Jan), 2(6): 461-465.
  • Kennelly PJ, Starovasnik MA, Edelman AM, Krebs EG. (1990) Modulation of the stability of rabbit skeletal muscle myosin light chain kinase through the calmodulin-binding domain. J Biol Chem (Jan), 265(3): 1742-1749.
  • Edelman AM, Mitchelhill KI, Selbert MA, Anderson KA, Hook SS, Stapleton D, Goldstein EG, Means AR, Kemp BE. (1996) Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence. J Biol Chem (May), 271(18): 10806-10810.
  • Edelman AM, Higgins DM, Bowman CL, Haber SN, Rabin RA, Cho-Lee J. (1992) Myosin light chain kinase is expressed in neurons and glia: immunoblotting and immunocytochemical studies. Brain Res Mol Brain Res (Jan), 14: 27-34.
  • Selbert MA, Anderson KA, Huang QH, Goldstein EG, Means AR, Edelman AM. (1995) Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. J Biol Chem (Jul), 270(29): 17616-17621.
  • Edelman AM, Krebs EG. (1982) Phosphorylation of skeletal muscle myosin light chain kinase by the catalytic subunit of cAMP-dependent protein kinase. FEBS Lett (Feb), 138(2): 293-298.
  • Edelman AM, Lin WH, Osterhout DJ, Bennett MK, Kennedy MB, Krebs EG. (1990) Phosphorylation of smooth muscle myosin by type II Ca2+/calmodulin-dependent protein kinase. Mol Cell Biochem (Sep), 97(1): 87-98.
  • Qin, H., Raught, B., Sonenberg, N., Goldstein E.G. and Edelman, A.M. (2003) Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca2+/calmodulin-dependent protein kinase I. J. Biol. Chem. (Sep).
  • Andreasen TJ, Keller CH, LaPorte DC, Edelman AM, Storm DR. (1981) Preparation of azidocalmodulin: a photoaffinity label for calmodulin-binding proteins. Proc Natl Acad Sci U S A (May), 78(5): 2782-2785.
  • Edelman AM, Blumenthal DK, Krebs EG. (1987) Protein serine/threonine kinases. Annu Rev Biochem (Jan), 56: 567-613.
  • Olwin BB, Edelman AM, Krebs EG, Storm DR. (1984) Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates. J Biol Chem (Sep), 259(17): 10949-10955.
  • Kennelly PJ, Edelman AM, Blumenthal DK, Krebs EG. (1987) Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain. J Biol Chem (Sep), 262(25): 11958-11963.
  • Feliciano, D.M., Edelman A.M. (2009) Repression of Ca2 /Calmodulin-dependent protein kinase IV signaling accelerates retinoic Acid-induced differentiation of human neuroblastoma cells. J Biol Chem (Sep), 284: 26466-26481.
  • Dale S, Wilson WA, Edelman AM, Hardie DG. (1995) Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I. FEBS Lett (Mar), 361(2-3): 191-195.
  • Edelman AM, Hunter DD, Hendrickson AE, Krebs EG. (1985) Subcellular distribution of calcium- and calmodulin-dependent myosin light chain phosphorylating activity in rat cerebral cortex. J Neurosci (Oct), 5(10): 2609-2617.
  • Blumenthal DK, Charbonneau H, Edelman AM, Hinds TR, Rosenberg GB, Storm DR, Vincenzi FF, Beavo JA, Krebs EG. (1988) Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes. Biochem Biophys Res Commun (Oct), 156(2): 860-865.
  • Edelman AM, Raese JD, Lazar MA, Barchas JD. (1981) Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase. J Pharmacol Exp Ther (Mar), 216(3): 647-653.
See all (34 more)

Books and Book Chapters:

  • Edelman AM Berger PA Renson JF. (1977) Neuroregulators and Psychiatric Disorders. In: 5-Hydroxytryptamine: basic and clinical perspectives. Oxford University Press, 177-187.
  • Raese, J.D., Edelman AM, Lazar, M.A., Barchas, J.D. (1977) Structure and Function of Monoamine Enzymes. In: Bovine striatal tyrosine hydroxylase: Multiple forms and evidence for phosphorylation by cyclic AMP-dependent protein kinase. Marcel Dekker, 383-400.
  • Arthur Edelman, Angus C. Nairn. (1995) The Protein Kinase Factsbook. In: Calcium-Calmodulin-Dependent Protein Kinase I. , 128-130.
  • Peter J. Kennelly, Arthur Edelman. (1994) In: General Introduction to Protein Serine-Threonine Kinases. , 65-74.
  • Elliott, G.R., Edelman AM, Renson, J.F., Berger, P.A. (1977) Psychopharmacology from Theory to Practice. In: Indoleamines and other neuroregulators. Oxford University Press
  • Kennelly, P.J., Takio, K., Blumenthal, D.K., Edelman, A.M., Glaccum, M.B., Klevit, R.E., Roush, C.L., Scott, J.D., Titani, K., Walsh, K.A. and Krebs, E.G. (1987) Calcium Binding Proteins in Health and Disease. In: Organization of myosin light chain kinase from rabbit skeletal muscle. Academic Press, 494-504.
  • Krebs, E.G., Blumenthal DK, Edelman AM, Hales, C.N. (1985) Mechanisms of Receptor Regulation. In: Role of cyclic AMP-dependent protein kinase in the regulation of cellular processes. Plenum Press, 159-195.
  • Raese, J.D, Edelman AM, Lazar, M.A., Barchas, J.D. (1978) Catecholamines:Basic and Clinical Frontiers. In: Tyrosine hydroxylase from brain: Phosphorylation of the enzyme by cyclic AMP-dependent protein kinase. Pergamon Press, 46-48.

Professional Memberships:

  • American Association for Cancer Research (2011–present)
  • Society for Neuroscience (2006–present)
  • American Society for Pharmacology and Experimental Therapeutics (1993–present)
  • American Association for the Advancement of Science (1987–present)
  • American Society for Biochemistry and Molecular Biology (1987–present)

Presentations:

  • "CaMKK2 - A Signaling Hub with Links to Prostate, and Ovarian, Cancer" Seminar Series; Roswell Park Cancer Institute; Genitourinary (2016)
  • "Prostate Cancer – An Unlikely Protein Kinase Connection" Seminar Series; Indiana University School of Medicine; Department of Biochemistry and Molecular Biology (2012)
  • "CaMKK2 regulates cellular proliferation and androgen receptor activity during prostate cancer progression" AACR Advances in Prostate Cancer Research; AACR; Special Meeting (2012)
  • "CaM Kinase Cascades - Roles in Cancer Cells" Seminar Series; State University of New York at Buffalo; Department of Pharmacology and Toxicology (2009)
  • "Localization of Doublecortin Kinase-2 in adult rat brain" Annual Meeting of the Society for Neuroscience; Society for Neuroscience (2006)
  • "Calcium Regulation of Protein Kinases" Seminar Series; Northeastern Ohio University College of Medicine; Department of Biochemisty (2005)
  • "Doublecortin Kinase-2, a novel chimeric kinase related to both doublecortin (the gene mutated in X-lissencephaly/double cortex syndrome) and to CaM kinases" ASBMB satellite of the International Congress of Biochemistry; ASBMB; Protein Phosphorylation and Molecular Recognition (2001)
  • "Phosphorylation screening identifies potential physiological substrates of CaM kinase I." ASBMB satellite of the International Congress of Biochemistry (2001)
  • "Protein Kinases" Seminar Series; State University of New York at Buffalo; Department of Biochemistry (1999)
  • "Comparison of the substrate specificities of Ca2+-calmodulin-dependent protein kinases I, II and IV" ASBMB Satellite of the International Congress of Biochemistry; ASBMB; Cellular Regulation by Protein Phosphorylation-Forty Years of Progress (1997)
  • "CaM Kinase Kinases" Seminar Series; SUNY at Buffalo; Department of Biochemistry (1996)
  • "Activation of Calmodulin-dependent protein kinase I" Ninth International Conference on Second Messengers and Protein Phosphoproteins; ; Minisymposium on CaM kinases (1995)
  • "Phosphorylation and Activation of CaM Kinases I and IV" Ninth International Symposium on Calcium-binding Proteins and Calcium Function in Health and Disease (1995)
  • "Calmodulin-dependent Protein Kinases" Seminar Series; SUNY at Buffalo; Center for Advanced Molecular Biology and Immunology (1995)
  • "Calmodulin regulated protein Phosphorylation" Seminar Series; SUNY at Buffalo; Department of Biochemical Pharmacology (1995)
  • "Calcium Regulation of Protein Kinases" Seminar Series; SUNY at Buffalo; Department of Pharmacology and Therapeutics (1993)
  • "Calcium Regulation of Protein Kinases" Seminar Series; SUNY at Buffalo; Department of Biochemistry (1993)
  • "Calmodulin-dependent Protein Kinases" Seminar Series; SUNY at Buffalo; Department of Anatomical Sciences (1993)
  • "Calmodulin-regulation of Protein Phosphorylation" Seminar Series; Ohio State University College of Medicine; Department of Pharmacology (1993)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series; University of Health Sciences-The Chicago Medical School; Department of Pharmacology and Molecular Biology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series; Baylor College of Medicine; Department of Pharmacology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series; SUNY at Buffalo; Department of Biochemical Pharmacology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series; University of Rochester; Department of Pharmacology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series; SUNY at Buffalo; Department of Pharmacology and Therapeutics (1991)
  • "Mechanism of Activation of Myosin Light Chain Kinase" Seminar Series; Brown University; Section of Neurobiology (1988)
  • "Characterization of Myosin Light Chain Kinase" Seminar Series; SUNY at Buffalo; Department of Biochemical Pharmacology (1986)
  • "Characterization of Myosin Light Chain Kinase" Seminar Series; SUNY at Buffalo; Department of Biochemistry (1985)
  • "Characterization of Myosin Light Chain Kinase" Seminar Series; SUNY at Buffalo; Department of Anatomical Sciences (1985)
  • "Phosphorylation of Tyrosine Hydroxylase" Gordon Research Conference; Gordon Research Conferences; Cyclic Nucleotides (1977)
See all (19 more)

Service Activities:

  • Prostate Cancer UK; Prostate Cancer UK;; Ad Hoc Reviewer (2012)
  • Department of Defense; Prostate Cancer Research Program LCTA Award Review Panel;; Panel Member (2011)
  • Department of Defense; Prostate Cancer Research Program, Pre-proposal Peer Review Panel;; Panel Member (2010–2012)
  • Department of Defense PCRP; Prostate Cancer Peer Review Panel;; Panel Member (2009)
  • Departmental Awards Committee; Chair (2009–present)
  • Departmental Graduate Programs Subcommittee; Member (2009–present)
  • Graduate Affairs Committee; Member (2009–present)
  • UB2020 Scholars Fund Life Sciences Review Panel; Member (2007)
  • Molecular Recognition in Bio. Systems/Bioinf. Central Recruitment Committee; Member (2006–present)
  • Radiation Safety Committee; Member (2005–2006)
  • Ad Hoc Adjudication Committee; Member (2004)
  • Department of Pharmacology Faculty Search Committee; Member (2004)
  • Pew Scholars Program Nomination Committee; Member (2004)
  • IGPBS Admissions Committee; Alternate Member (2004)
  • Israel Science Foundation; Israel Science Foundation;; External Reviewer (2003)
  • NIH; NIDDK, Program Project Site Visit;; Panel Member (2001)
  • Proposition Exam; Chair (2000–2001)
  • NIH; Biochemistry Study Section;; Ad Hoc Reviewer (1999)
  • Apppointment, Promotions,Tenure & Privileges; Member (1999–2001)
  • Research Promotions; Member (1998–2001)
  • Center for Advanced Molecular Biology and Immunology; Co-Chair (1998–2000)
  • IFR; Member (1998)
  • Journal of Biological Chemistry; Editorial Board Member (1997–2003)
  • NIH; Physiological Chemistry Study Section;; Ad Hoc Reviewer (1996)
  • Distinguished Scientist Lecture Series; Chair (1995–2002)
  • IGPBS Admissions Committee; Member (1995–1998)
  • NIH; Physiological Chemistry Study Section;; Ad Hoc Reviewer (1994)
  • Department of Pharmacology Seminar Series; Coordinator (1993–1996)
  • Department of Energy; Division of Energy Resources;; External Reviewer (1992)
  • Department of Pharmacology Faculty Search Committee; Member (1989–1990)
  • Faculty Council; Member (1988–1990)
  • Graduate Education Policies in Biomedical Science; Member (1988–1990)
  • National Science Foundation; NSF-Signal Transduction/Cell Regulation;; External Reviewer (1987–2005)
  • Endocrinology and Reproduction Research Branch Site Vist , NICHD; Site visit panel member;; Panel Member (1987)
  • Department of Pharmacology Admissions Committee; Member (1986–1990)
  • Department of Pharmacology Seminar Series; Coordinator (1986–1989)

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Contact Information

955 Main Street
Room 3224
Buffalo, New York 14203
Phone: (716) 829-3491
Fax: (716) 829-2801
aedelman@buffalo.edu