Fumito Ito MD, PhD
Fumito Ito
MD, PhD
Associate Professor of Surgery / Associate Professor of Oncology - Dept. of Surgery / Surgical Oncology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Gene therapy; Immunology; Stem Cells; Surgery
Education and Training:
- Center for iPS Cell Research and Application (2011)
- Fellowship, Roswell Park Cancer Institute (2010)
- Residency, University of Wisconsin (2008)
- Residency, University at Washington (2005)
- PhD, Shiga University (2004)
- Fellowship, University of Michigan (2003)
- Residency, Shiga University and Affiliated Hospital (1999)
- MD, Shiga University (1995)
- Shiga University (1991)
Employment:
- Associate Professor, Surgery, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2017-present)
- Associate Professor of Oncology, Roswell Park Cancer Institute Jacobs School of Medicine & Biomedical Sciences (2017-present)
- Member, Center for Immunotherapy, Roswell Park Cancer Institute Jacobs School of Medicine & Biomedical Sciences (2015-present)
- Assistant Professor of Oncology, Surgery, Roswell Park Cancer Institute (2015–2017)
- Assistant Professor of Surgery, Surgery, University of Michigan (2011–2015)
- Surgeon, Surgery, Veterans Affairs Hospital (2011–2015)
- Attending Physician, Kyoto Miniren Chuo Hospital (2010–2011)
- Clinical Lecturer, University at Buffalo (2009–2010)
Awards and Honors:
- Cancer Research Institute Technology Impact Award (2019)
- Best Clinical Poster Award: Celebration of Scholarship, Jacob School of Medicine and Biomedical Sciences (2019)
- STL Cure Sarcoma Research Award (2017)
- Trainee Abstract Award (Mentee): American Association of Immunologists (2015)
- Outstanding Poster Award (Mentee) 26th Annual Research Conference University of Michigan (2015)
- Young Investigator Award: Melanoma Research Alliance (2015)
- Turcotte Enrichment Award: Central Surgical Association Foundation (2014)
- American College of Surgeons Faculty Research Fellowship Award (2014)
- New Investigator Award: Society of Thermal Medicine (2010)
- Basic Research Award 1st Place: Western New York Chapter of the American College of Surgeons (2009)
- Clinical Research Award 1st Place: Western New York Chapter of the American College of Surgeons (2009)
- Travel Award: Cancer and Leukemia Group B (2008)
- Scholarship: Japan-North America Medical Exchange Foundation (2000)
- Scholarship: Japan-North America Medical Exchange Foundation (1998)
Research Expertise:
- General Surgery
- Stem Cell and Developmental Biology
- Surgical Oncology
- Tumor Immunology and Cancer Immunotherapy
Grants and Sponsored Research:
- September 2019–August 2021
Cancer Research Institute Technology Impact Award
Cancer Research Institute
Role: Co-Principal Investigator
$200,000 - August 2015–July 2020
NIH/NCI K08 Mentored Clinical Scientist Research Career Development Award
NIH/NCI
Role: Principal Investigator
$810,000 - January 2019–December 2019
Roswell Park Alliance Foundation Grant
Roswell Park Alliance Foundation
Role: Principal Investigator
$100,000 - March 2018–February 2019
Roswell Park Alliance Foundation Grant
Roswell Park Alliance Foundation
Role: Principal Investigator
$127,500 - July 2017–June 2018
Sarcoma Foundation of America Award
Sarcoma Foundation of America
Role: Principal Investigator
$50,000 - May 2015–April 2018
Melanoma Research Alliance Young Investigator Award
Melanoma Research Alliance
Role: Principal Investigator
$225,000 - July 2014–June 2016
American College of Surgeons Faculty Research Fellowships
American College of Surgeons Faculty Research Fellowships
Role: Principal Investigator
$80,000 - July 2014–June 2015
Central Surgical Association Foundation Award
Central Surgical Association Foundation
Role: Principal Investigator
$10,000
Journal Articles:
- Ito F, Ku AW., Bucsek MJ., Muhitch J., Vardam-Kaur T., Kim M., Fisher DT., Camoriano M., Khoury T, Skitzki J, Gollnick SO., Evans SS. (2015) Immune Adjuvant Activity of Pre-resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer. Plos One (Jan), 23(10).
- Saito H., Okita K., Fusaki N., Sabel MS, Chang AE, Ito F. (2016) Adoptive transfer of CD8 T cells generated from induced pluripotent stem cells triggers regressions of large tumors along with immunological memory. Cancer Research (Jan), 76(12): 3473-3483.
- Saito H., Okita K., Fusaki N., Sabel MS, Chang AE, Ito F. (2016) Reprogramming of Melanoma Tumor-infiltrating Lymphocytes to Induced Pluripotent Stem Cells. Stem Cells International (Jan), 11.
- Ito F, Camoriano M., Mukund S., Evans SS., Kane I, Skitzki J. (2011) Water: A simple solution for tumor spillage. Annals of Surgical Oncology (Jan), 18(8): 2347-2363.
- Oba T, Long MD, Keler T, Marsh HC, Minderman H, Abrams SI, Liu S, Ito F. (2020) Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s. Nat Commun (Oct), 11(1): 5415-5415.
- Oba T, Hoki T, Yamauchi T, Keler T, Marsh HC, Cao X, Ito F. (2020) A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. J Immunol (Oct), 205(7): 1867-1877.
- Yamauchi T, Hoki T, Oba T, Saito H, Attwood K, Sabel MS, Chang AE, Odunsi K, Ito F. (2020) CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. JCI Insight (Jan), 5(8).
- Ito F, Vardam TD, Appenheimer MM, Eng KH, Gollnick SO, Muhitch JB, Evans SS. (2019) In situ thermal ablation augments antitumor efficacy of adoptive T cell therapy. Int J Hyperthermia (Nov), 36(sup1): 22-36.
- Patel SJ, Yamauchi T, Ito F. (2019) Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy. Surg Oncol Clin N Am (Jan), 28(3): 489-504.
- Hoki T, Katsuta E, Yan L, Takabe K, Ito F. (2019) Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma. J Surg Res (Jan), 234: 343-352.
- Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP. (2018) Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System. Cell Rep (Jan), 22(12): 3175-3190.
Professional Memberships:
- Society for Immunotherapy of Cancer (SITC) (2019–present)
- Association for Academic Surgery (AAS); Member (2017–present)
- International Society for Stem Cell Research (ISSCR); Member #49134 (2016–present)
- American Association of Immunologists (AAI); Member #00233537 (2014–present)
- Central Surgical Association (CSA); Member (2012–present)
- American Society of Clinical Oncology (ASCO) (2011–present)
- Society of Thermal Medicine (STM); Member #6562 (2009–present)
- The Society of Surgical Oncology (SSO); Member #101936 (2008–present)
- American Association for Cancer Research (AACR); Member #80425 (2003–present)
- American College of Surgeons (ACS); Member # 003085895 (2003–present)
- Japan Surgical Society; Member #457483 (1995–present)
- Japanese Society of Gastroenterological Surgey; Member #G0246840 (1995–present)
Presentations:
- "Pluripotent stem cells as a source of adoptive T-cell therapy for Melanoma." Melanoma Disease Site Research Group Retreat (2016)
- "Reprogramming Technology to Build The Team for Cancer Immunotherapy" Dept. of Microbiology & Immunology Seminar Series. (2016)
- "Regeneration of antigen-specific T cells from pluripotent stem cells for immunotherapy." Roswell Park Cancer Institute Science Retreat. (2016)
- "Adoptive transfer of induced pluripotent stem cell-derived regenerated T cells mediates effective regression of large tumors and establishes imunological memory." Annual Meeting of the American Association of Immunologists (2016)
- "Cancer Immunotherapy with induced pluripotent stem cell-derived regenerated antigen-specific CD8+ T cells." Immuno-Oncology Young Investigator's Forum (2016)
- "Adoptive T cell therapy using rejuvenated antigen-specific T cells from induced pluripotent stem cells." Annual Meeting of the American Association of Immunologists (2015)
- "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." Annual Meeting of the Society of American Association for Cancer Research (2015)
- "Generation of rejuvenated murine antigen-specific T cells by reprogramming to pluripotency and redifferentiation." Annual Meeting of the Society of American Association for Cancer Research (2015)
- "Adoptive cell therapy with rejuvenated induced pluripotent stem cell-derived antigen-specific T cells." Annual Meeting of the Immuno-Hematology Symposium (2015)
- "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." Moses Gunn 26th Annual Research Conference (2014)
- "Generation of induced pluripotent sem cells from tumor-infiltrating lymphocytes." 67th Annual Meeting of the Society of Surgical Oncology (2014)
- "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." 12th Annual Pathology Research Symposium (2014)
- "Enhancing the antitumor effects of adoptive cell transfer immunotherapy using preconditioning thermal ablation." Annual Meeting of the American Association of Immunologists (2014)
- "Overcoming hurdles to efective immunotherapy using radiofrequency ablation." 13th Annual Meeting of the Buffalo Conference on Immunology (2014)
- "Overcoming hurdles to effective immunotherapy using radiofrequency ablation." 13th Annual Meeting of the Translational Research Cancer Center Consortium (2014)
- "Radiofrequency ablation amplifies the efficacy of adoptive T cell transfer therapy in the generation of antitumor immunity." 31st Annual Meeting of the Society for Thermal Medicine (2014)
- "Synergistic Antitumor Activity of Thermal Ablation and Adoptive T Cell Transfer Cancer Immunotherapy." American College of Cryosurgery Annual Meeting (2014)
- "Preconditioning regimens overcome obstacles to CCL21-dependent T cell trafficking in tumor-draining lymph nodes." 2nd Annual Midwest Melanoma Partnership Meeting (2013)
- "Reprogramming exhausted tumor-infiltrating lymphocytes by Sendai viral vectors." 8th Annual Meeting New York Stem Cell Foundation (2013)
- "Overcoming obstacles to naive T lymphocyte trafficking in tumor-bearing mice." 12th Annual Buffalo Conference on Immunology (2012)
- "Overcoming obstacles to naive T lymphocyte trafficking in tumor-bearing mice." 15th Annual Upstate New York Immunology Conference (2012)
- "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 15th Annual Translational Research Cancer Centers Consortium (2012)
- "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." University of Toronto, Department of Medical Biophysics (2012)
- "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." Roswell Park Cancer Institute Scientific Trainee Research Symposium; ; SUNY Geneseo (2012)
- "Radio-frequency ablation augments antitumor activity of adoptive immunotherapy." 64th Annual Meeting of the Society of Surgical Oncology (2011)
- "Systemic thermal therapy overcomes obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 28th Annual Meeting Society Thermal Medicine (2011)
- "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." 63rd Annual Meeting of the Society of Surgical Oncology (2010)
- "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." 63rd Annual Meeting of the Society of Surgical Oncology (2010)
- "Peritoneal lavage with distilled water is tumoricidal: science or legend?" 63rd Annual Meeting of the Society of Surgical Oncology (2010)
- "Synergistic antitumor activity of radio-frequency ablation and adoptive immunotherapy." Annual Meeting of the Society for Thermal Medicine (2010)
- "Thermal stress overcomes impediments to naive T lymphocytes trafficking across high endothelial venules in tumor-draining lymph nodes." Annual Meeting of the Society for Thermal Medicine Meeting. (2010)
- "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." Western New York Chapter of the American College of Surgeons (2009)
- "Peritoneal lavage with distilled water is tumoricidal" Western New York Chapter of the American College of Surgeons (2009)
- "Peritoneal lavage with distilled water is tumoricidal" Western New York Chapter of the American College of Surgeons (2009)
- "Systemic thermal therapy overcomes obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 9th Annual Buffalo Conference on Immunology (2009)
- "Hilar cholangiocarcinoma: outcome over 21 years at a tertiary referral center." 60th Annual Meeting of the Society of Surgical Oncology (2007)
- "The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid homone testing." Annual Meeting of the Wisconsin Surgical Society (2006)
- "The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing." American Association of Endocrine Surgeons (2006)
- "Anti-CD 137 antibody administration polarizes T cells activated by tumor-lysate pulsed dendritic cells via NK cells." American Association for Cancer Research (2004)
- "Anti-CD137 antibody administration enhances the efficacy of dendritic cell-based tumor vaccines." American Association of Immunologist (2003)
- "Radiotherapy potentiates the antitumor efficacy of intratumoral dendritic cell administration in a murine model." American Association of Immunologist (2003)
- "Antitumor reactivity of anti-CD3/anti-CD28 bead activated lymphoid cells: implications for cell therapy." American Society of Hematology (2002)
- "Adoptive immunotherapy of murine tumor MCA205 using tumor-reactive T cells generated through 4-1BB and CD28 co-Stimulation." American Association for Cancer Research (2002)
- "Generation of tumor-specific effector T cells from tumor-bearing hosts by anti-CD3/CD28 bead activation." American Association for Cancer Research (2002)
Service Activities:
- Nature Communications; Ad Hoc Reviewer (2019–present)
- STEM CELLS Translational Medicine; Ad Hoc Reviewer (2018–present)
- Department of Defense (DOD) and Congressionally -Directed Medical Research Program’s (CDMRP); DOD Lung Cancer Research Program (LCRP);; Grant Reviewer (2017)
- American Association for the Advancement of Science; State of Regenerative Medicine Research Fund;; Grant Reviewer (2016)
- Postdoctoral Fellow Mentor Toshifumi Hoki, M.D., Ph.D (2016–present)
- IRB member Roswell Park Cancer Institute Scientific Review Committee of the RPCI Institutional Review Board (IRB); Member (2016–present)
- Roswell Park Tumor Immunology & Immunotherapy Program RPCI-CCSG; Member (2015–present)
- Ann Arbor Veterans Affairs Hospital Cancer Committee; Committee Member (2011–2015)
- Comprehensive Cancer Center University of Michigan Medical School University of Michigan Comprehensive Cancer Center; Member (2011–2015)