Julian L. Ambrus, Jr. MD
Julian L. Ambrus, Jr.
MD
Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Autoimmune Conditions; Autoimmunity; Genetics; Immunology; Immunology; Metabolic Disorders; Rheumatology
Professional Summary:
My research revolves around IL-14 and its role in immunological memory. Studies delve into 3 areas - vaccination, autoimmunity and lymphoid malignancies. The majority of my current work involves studies examining early events in Sjogren‘s syndrome. We have identified new autoantibodies that occur early in the course of the disease. We are examining mediators involved in the early injury to the salivary and lacrimal glands. We are studying events that result in the transition from the autoimmune disease to lymphoma.
Education and Training:
- MD, Medicine, Jefferson Medical College (1979)
- BA, Molecular Biophysics and Biochemistry, Yale University (1975)
Employment:
- Professor of Medicine, Medicine (2015-present)
- Director, Systemic Autoimmune Disease Research Center of WNY (1998-present)
- Associate Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996-present)
- Practicing Physician, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996–2019)
- Associate Physician, Barnes Hospital (1992–1996)
- Associate Professor of Pathology, Pathology, WUSM Washington University School of Medicine (1992–1996)
- Assistant Attending, Jewish Hospital of St. Louis (1989–1996)
- Associate Professor, Medicine, Division of Rheumatology Washington University School of Medicine (1989–1996)
- Assistant Attending Physician, Barnes Hospital (1989–1992)
- Medical Fellow, NIH-National Institute of Allergy and Infectious Diseases (1982–1985)
- Chief Resident, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1981–1982)
- Medical Resident, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1980–1982)
- Medical Intern, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1979–1980)
Awards and Honors:
- Visionary Innovator Award (2013)
- Laureate Award American College of Physicians (2010)
- PHS Letter of Commendation (1989)
- Dr. Norman Chassin Award for Outstanding Intern in Internal Medicine (1980)
- Senior Biology Division (1970)
Research Expertise:
- Immunology: Study of immunological memory in autoimmune diseaese, cancer and vaccine biology
Grants and Sponsored Research:
- January 2017–December 2022
Novel Role for the P2Y2 Receptor in the Autoimmune Disease Sjögren’s Syndrome
NIDCR
Role: Co-Investigator - January 2018–December 2020
Investigation of anti-LTa in Sjögren’s syndrome in IL14aTG mice
Genentech
Role: Co-Principal Investigator - January 2018–December 2020
Cytokines in Early Sjogren's Syyndrome
Amgen
Role: Co-Principal Investigator - October 2012–September 2014
Role of Interleukin 14 in Sjogren's disease
PHS/NIDCR
Role: Principal Investigator
$435,875 - July 2012–September 2013
Evaluation of Autoantibodies in Sjogren's Syndrome at Various Stages of the Disease
CAT
Role: Principal Investigator
$125,784 - September 2001–July 2006
Community Based Research on Autoimmune Disease and Asthma
National Institute of Environmental Health Sciences
Role: Co-Investigator
$1,607,795 - January 1996–December 2000
Analysis of IL-14 production by a Burkitt lymphoma cell line
Troupe Foundation
Role: Principal Investigator
$100,000 - January 1997–December 1998
Evaluation of immunologic tolerance in solid organ transplantation
Role: Co-Principal Investigator
$20,000 - January 1993–December 1996
Structural analysis of HMW-BCGF
NIH
Role: Co-Investigator
$284,452 - January 1991–December 1993
Role of eicosanoids in normal and SLE B cell function
GD Searle and Company
Role: Co-Investigator
$161,500 - January 1991–December 1993
Characterization of a unique protein in common variable immunodeficiency sera
March of Dimes Birth Defects Foundation
Role: Co-Investigator
$50,000 - January 1992
Regulation of intracellular calcium during the induction of human B cell proliferation
Arthritis Foundation - Eastern Missouri Chapter
Role: Principal Investigator
$30,000
Patents:
- Method of Diagnosing Sjogren's syndrome Three novel autoatibodies to identify patients with Sjogren's syndrome: anti-salivary gland protein 1, anti-carbonic anhydrase 6 and anti-parotid secretory protein (2014)
- IL-14alpha RNA inhibitors IL-14alpha RNA inhibitors and antibodies to IL14alpha for treatment of autoimmune disease and malignancy (2007)
- DNP-RNA to silence c-Myc DNP-RNA that can be used in vivo to block the transcription and translation of c-MyC (2005)
- Method to remove viruses from blood Dialysis cartridge to remove blood borne viruses (1999)
- HIV chemokines Chemokine produced by HIV (1999)
Journal Articles:
- Jacob A, He J, Peck A, Jamil A, Bunya V, Alexander JJ, Ambrus JL. (2025) Metabolic changes during evolution of Sjögren's in both an animal model and human patients. Heliyon (Jan), 11(1): e41082. doi:10.1016/j.heliyon.2024.e41082
- Hashemi MH, Ambrus JL, Shukla AA, Zhu D, Ying GS, Asbell PA, . (2024) Association of Systemic Markers of Inflammation with Signs and Symptoms of Dry Eye Disease and Sjogren's Syndrome in the Dry Eye Assessment and Management (DREAM©) Study. Current eye research (Jun), 49(6): 574-581.
- Nascimento Da Conceicao V, Sun Y, Chai X, Ambrus JL, Mishra BB, Singh BB. (2023) Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren's syndrome-prone mouse models. Journal of translational autoimmunity (Dec), 7: 100210. doi:10.1016/j.jtauto.2023.100210
- Peck AB, Ambrus JL. (2023) Marginal Zone B (MZB) Cells: Comparison of the Initial Identification of Immune Activity Leading to Dacryoadenitis and Sialadenitis in Experimental Sjögren's Syndrome. International journal of molecular sciences (Jul), 24(15). doi:10.3390/ijms241512209
- Sun Y, Nascimento Da Conceicao V, Chauhan A, Sukumaran P, Chauhan P, Ambrus JL, Vissink A, Kroese FGM, Muniswamy M, Mishra BB, Singh BB. (2023) Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling. Clinical and translational medicine (Apr), 13(4): e1228. doi:10.1002/ctm2.1228
- He J, Chen J, Miao M, Zhang R, Cheng G, Wang Y, Feng R, Huang B, Luan H, Jia Y, Jin Y, Zhang X, Shao M, Wang Y, Zhang X, Li J, Zhao X, Wang H, Liu T, Xiao X, Zhang X, Su Y, Mu R, Ye H, Li R, Liu X, Liu Y, Li C, Liu H, Hu F, Guo J, Liu W, Zhang WB, Jacob A, Ambrus JL, Ding C, Yu D, Sun X, Li Z. (2022) Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial. JAMA network open (Nov), 5(11): e2241451. doi:10.1001/jamanetworkopen.2022.41451
- Peck AB, Ambrus JL. (2022) A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren's Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mouse. International journal of molecular sciences (Oct), 23(19). doi:10.3390/ijms231911709
- Peck AB, Nguyen CQ, Ambrus JL. (2022) A MZB Cell Activation Profile Present in the Lacrimal Glands of Sjögren's Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mice Defined by Global RNA Transcriptomic Analyses. International journal of molecular sciences (May), 23(11). doi:10.3390/ijms23116106
- Peck AB, Nguyen CQ, Ambrus JL. (2021) Upregulated Chemokine and Rho-GTPase Genes Define Immune Cell Emigration into Salivary Glands of Sjögren's Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mice. International journal of molecular sciences (Jul), 22(13). doi:10.3390/ijms22137176
- Harris HK, Nakayama T, Lai J, Zhao B, Argyrou N, Gubbels CS, Soucy A, Genetti CA, Suslovitch V, Rodan LH, Tiller GE, Lesca G, Gripp KW, Asadollahi R, Hamosh A, Applegate CD, Turnpenny PD, Simon MEH, Volker-Touw CML, Gassen KLIV, Binsbergen EV, Pfundt R, Gardeitchik T, Vries BBA, Immken LL, Buchanan C, Willing M, Toler TL, Fassi E, Baker L, Vansenne F, Wang X, Ambrus JL, Fannemel M, Posey JE, Agolini E, Novelli A, Rauch A, Boonsawat P, Fagerberg CR, Larsen MJ, Kibaek M, Labalme A, Poisson A, Payne KK, Walsh LE, Aldinger KA, Balciuniene J, Skraban C, Gray C, Murrell J, Bupp CP, Pascolini G, Grammatico P, Broly M, Küry S, Nizon M, Rasool IG, Zahoor MY, Kraus C, Reis A, Iqbal M, Uguen K, Audebert-Bellanger S, Ferec C, Redon S, Baker J, Wu Y, Zampino G, Syrbe S, Brosse I, Jamra RA, Dobyns WB, Cohen LL, Blomhoff A, Mignot C, Keren B, Courtin T, Agrawal PB, Beggs AH, Yu TW. (2021) Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior. Genetics in medicine : official journal of the American College of Medical Genetics (Jun), 23(6): 1028-1040. doi:10.1038/s41436-021-01114-z
- Peck AB, Nguyen CQ, Ambrus J. (2021) Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren's Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease. International journal of molecular sciences (Feb), 22(4). doi:10.3390/ijms22041919
- Aranez V, Ambrus J. (2020) Immunologic Adverse Effects of Biologics for the Treatment of Atopy. Clinical reviews in allergy & immunology (Oct), 59(2): 220-230.
- Singh BB, Ohm J, Quenum Zanbede FO, Chauhan P, Kroese FGM, Vissink A, Ambrus JL, Mishra BB. (2020) Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition. Autoimmunity (Aug), 53(5): 270-282. doi:10.1080/08916934.2020.1768376
- Bax K, Isackson PJ, Moore M, Ambrus JL. (2020) Carnitine Palmitoyl Transferase Deficiency in a University Immunology Practice. Current rheumatology reports (Feb), 22(3): 8.
- He J, Zhang R, Shao M, Zhao X, Miao M, Chen J, Liu J, Zhang X, Zhang X, Jin Y, Wang Y, Zhang S, Zhu L, Jacob A, Jia R, You X, Li X, Li C, Zhou Y, Yang Y, Ye H, Liu Y, Su Y, Shen N, Alexander J, Guo J, Ambrus J, Lin X, Yu D, Sun X, Li Z. (2020) Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial. Annals of the rheumatic diseases (Jan), 79(1): 141-149. doi:10.1136/annrheumdis-2019-215396
- Vivino FB, Bunya VY, Massaro-Giordano G, Johr CR, Giattino SL, Schorpion A, Shafer B, Peck A, Sivils K, Rasmussen A, Chiorini JA, He J, Ambrus JL. (2019) Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment. Clinical immunology (Orlando, Fla.) (Jun), 203: 81-121.
- Witas R, Peck AB, Ambrus JL, Nguyen CQ. (2019) Sjogren's Syndrome and TAM Receptors: A Possible Contribution to Disease Onset. Journal of immunology research (Jan), 2019: 4813795. doi:10.1155/2019/4813795
- Woods LT, Camden JM, Khalafalla MG, Petris MJ, Erb L, Ambrus JL, Weisman GA, Ambrus, Jr. JL. (2018) P2Y2R Deletion Ameliorates Sialadenitis in IL-14α-transgenic Mice. Oral Dis (Jan).
- Zhang RJ, Zhang X, Chen J, Shao M, Yang Y, Balaubramaniam B, Sun XL, Ambrus JL, He J, Li ZG, Ambrus, Jr. JL. (2018) Serum soluble CD25 as a risk factor of renal impairment in systemic lupus erythematosus - a prospective cohort study. Lupus (Jan)9612033187-9612033187.
- Beckman KA, Luchs J, Milner MS, Ambrus JL, Ambrus, Jr. JL. (2017) The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren's Syndrome Diagnosis. Adv Ther (Apr), 34(4): 799-812.
- Everett S, Vishwanath S, Cavero V, Shen L, Suresh L, Malyavantham K, Lincoff-Cohen N, Ambrus JL, Ambrus, Jr. JL. (2017) Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes. BMC Ophthalmol (Mar), 17(1): 20-20.
- De Langhe E, Bossuyt X, Shen L, Malyavantham K, Ambrus JL, Suresh L, Ambrus, Jr. JL. (2017) Evaluation of Autoantibodies in Patients with Primary and Secondary Sjogren's Syndrome. Open Rheumatol J (Jan), 11: 10-15.
- Ambrus JL, Suresh L, Peck A, Ambrus, Jr. JL. (2016) Multiple Roles for B-Lymphocytes in Sjogren's Syndrome. J Clin Med (Oct), 5(10).
- Shen L, Gao C, Suresh L, Xian Z, Song N, Chaves LD, Yu M, Ambrus JL, Ambrus, Jr. JL. (2016) Central role for marginal zone B cells in an animal model of Sjogren's syndrome. Clin Immunol (Jul), 168: 30-36.
- Kim-Lee C, Suresh L, Ambrus JL, Ambrus, Jr. JL. (2015) Gastrointestinal disease in Sjogren's syndrome: related to food hypersensitivities. Springerplus (Dec), 4: 766-766.
- Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I, Ambrus, Jr. JL. (2015) IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep (Sep), 5: 13953-13953.
- Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I, Ambrus, Jr. JL. (2015) IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep (Sep), 5: 13953-13953.
- Shi G, Ambrus JL, Ye S, Shen L, Ambrus, Jr. JL. (2015) Inflammatory Joint Diseases. Biomed Res Int (May), 2015: 973510-973510.
- Suresh L, Malyavantham K, Shen L, Ambrus JL, Ambrus, Jr. JL. (2015) Investigation of novel autoantibodies in Sjogren's syndrome utilizing Sera from the Sjogren's international collaborative clinical alliance cohort. BMC Ophthalmol (Apr), 15: 38-38.
- Gupta S, Zivadinov R, Ramasamy D, Ambrus JL, Ambrus, Jr. JL. (2014) Reversible cerebral vasoconstriction syndrome (RCVS) in antiphospholipid antibody syndrome (APLA): the role of centrally acting vasodilators. Case series and review of literature. Clin Rheumatol (Dec), 33(12): 1829-1833.
- Shen L, Kapsogeorgou EK, Yu M, Suresh L, Malyavantham K, Tzioufas AG, Ambrus JL, Ambrus, Jr. JL. (2014) Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome. Clin Immunol (Nov), 155(1): 42-46.
- Vishwanath S, Shen L, Suresh L, Ambrus JL, Ambrus, Jr. JL. (2014) Anti-salivary gland protein 1 antibodies in two patients with Sjogren's syndrome: two case reports. J Med Case Rep (May), 8: 145-145.
- Vishwanath S, Everett S, Shen L, Malyavantham K, Suresh L, Ambrus JL, Ambrus, Jr. JL. (2014) Xerophthalmia of Sjogren's Syndrome Diagnosed with Anti-Salivary Gland Protein 1 Antibodies. Case Rep Ophthalmol (May), 5(2): 186-189.
- Relan M, Vishwanath S, Shen L, Ambrus JL, Ambrus, Jr. JL. (2014) Update on the use of biologics in lupus. Curr Pharm Biotechnol (Jan), 15(6): 516-520.
- Vishwanath S, Relan M, Shen L, Ambrus JL, Ambrus, Jr. JL. (2014) Update on the use of biologics in vasculitides. Curr Pharm Biotechnol (Jan), 15(6): 558-562.
- Xuan J, Shen L, Zhang C, Ambrus JL, Ambrus, Jr. JL. (2014) Biologics in systemic sclerosis. Curr Pharm Biotechnol (Jan), 15(6): 549-557.
- Xuan J, Shen L, Malyavantham K, Pankewycz O, Ambrus JL, Suresh L, Ambrus, Jr. JL. (2013) Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome. BMC Oral Health (Oct), 13: 51-51.
- Al Ustwani O, Ford LA, Sait SJ, Block AM, Barcos M, Vigil CE, Griffiths EA, Thompson JE, Wang ES, Ambrus J, Wetzler M. (2013) Myelodysplastic syndromes and autoimmune diseases--case series and review of literature. Leukemia research (Aug), 37(8): 894-9. doi:10.1016/j.leukres.2013.04.007
- Shen L, Suresh L, Malyavantham K, Kowal P, Xuan J, Lindemann MJ, Ambrus JL, Ambrus, Jr. JL. (2013) Different Stages of Primary Sjogren's Syndrome Involving Lymphotoxin and Type 1 IFN. J Immunol (Jul), 191(2): 608-613.
- Zivadinov R, Shucard JL, Hussein S, Durfee J, Cox JL, Bergsland N, Dwyer MG, Benedict RH, Ambrus J, Shucard DW. (2013) Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement. Lupus (Jun), 22(7): 675-83.
- Shen L, Suresh L, Lindemann M, Xuan J, Kowal P, Malyavantham K, Ambrus JL, Ambrus, Jr. JL. (2012) Novel autoantibodies in Sjogren's syndrome. Clin Immunol (Dec), 145(3): 251-255.
- Zivadinov R, Ramanathan M, Ambrus J, Hussein S, Ramasamy DP, Dwyer MG, Bergsland N, Minagar A, Weinstock-Guttman B. (2012) Anti-phospholipid antibodies are associated with response to interferon-beta1a treatment in MS: results from a 3-year longitudinal study. Neurological research (Oct), 34(8): 761-9.
- Pankewycz O, Ambrus J, Shen L, Xuan J, Li H, Wu J, Guo LW, Feng L, Laftavi MR, Ambrus, Jr. JL. (2012) Inhibiting Wipf2 downregulation by transgenic expression of its 3' mRNA-untranslated region improves cytotoxicity and vaccination response. Eur J Immunol (Sep), 42(9): 2409-2418.
- Abdullah M, Vishwanath S, Elbalkhi A, Ambrus JL, Ambrus, Jr. JL. (2012) Mitochondrial myopathy presenting as fibromyalgia: a case report. J Med Case Rep (Feb), 6: 55-55.
- Vishwanath S, Abdullah M, Elbalkhi A, Ambrus JL, Ambrus, Jr. JL. (2011) Metabolic myopathy presenting with polyarteritis nodosa: a case report. J Med Case Rep (Jun), 5: 262-262.
- Al Ustwani O, Francis J, Wallace PK, Ambrus J, Wetzler M, Ambrus, Jr. JL. (2011) Treating myelodysplastic syndrome improves an accompanying autoimmune disease along with a reduction in regulatory T-cells. Leuk Res (May), 35(5): 35-36.
- Shen L, Suresh L, Wu J, Xuan J, Li H, Zhang C, Pankewycz O, Ambrus JL. (2010) A role for lymphotoxin in primary Sjogren's disease. J Immunol (Nov), 185(10): 6355-6363.
- Vega F, Davuluri Y, Cho-Vega JH, Singh RR, Ma S, Wang RY, Multani AS, Drakos E, Pham LV, Lee YC, Shen L, Ambrus J, Medeiros LJ, Ford RJ, Ambrus JL. (2010) Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and dissemination. J Cell Mol Med (Jun), 14(6B): 1532-1545.
- Stosic M, Ambrus J, Garg N, Weinstock-Guttman B, Ramanathan M, Kalman B, Minagar A, Munschauer FE, Galey TM, Hussein S, Bakshi R, Zivadinov R. (2010) MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis. Journal of neurology (Jan), 257(1): 63-71.
- Shen L, Suresh L, Li H, Zhang C, Kumar V, Pankewycz O, Ambrus JL, Ambrus, Jr. JL. (2009) IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans. Clin Immunol (Mar), 130(3): 304-312.
- Shen L, Suresh L, Li H, Zhang C, Kumar V, Pankewycz O, Ambrus JL. (2009) IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans. Clin Immunol (Mar), 130(3): 304-312.
- Leca N, Laftavi M, Shen L, Matteson K, Ambrus J, Pankewycz O, Ambrus JL. (2008) Regulation of human interleukin 14 transcription in vitro and in vivo after renal transplantation. Transplantation (Jul), 86(2): 336-341.
- Garg N, Zivadinov R, Ramanathan M, Vasiliu I, Locke J, Watts K, Lema J, Rajeswary J, Munschauer FE, Ambrus J, Weinstock-Guttman B. (2007) Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients. Journal of neuroimmunology (Jul), 187(1-2): 159-65.
- Ford RJ, Shen L, Lin-Lee YC, Pham LV, Multani A, Zhou HJ, Tamayo AT, Zhang C, Hawthorn L, Cowell JK, Ambrus JL. (2007) Development of a murine model for blastoid variant mantle-cell lymphoma. Blood (Jun), 109(11): 4899-4906.
- Shucard JL, Gaines JJ, Ambrus J, Shucard DW, Ambrus JL. (2007) C-reactive protein and cognitive deficits in systemic lupus erythematosus. Cogn Behav Neurol (Mar), 20(1): 31-37.
- Shucard JL, Gaines JJ, Ambrus J, Shucard DW, Ambrus, Jr. JL. (2007) C-reactive protein and cognitive deficits in systemic lupus erythematosus. Cogn Behav Neurol (Mar), 20(1): 31-37.
- Ludwig LB, Ambrus JL, Krawczyk KA, Sharma S, Brooks S, Hsiao CB, Schwartz SA. (2006) Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products. Retrovirology (Nov), 3: 80-80.
- Chadha K, Weinstock-Guttman B, Zivadinov R, Bhasi K, Muhitch J, Feichter J, Tamaño-Blanco M, Abdelrahman N, Ambrus J, Munschauer F, Ramanathan M. (2006) Interferon inhibitory activity in patients with multiple sclerosis. Archives of neurology (Nov), 63(11): 1579-84.
- Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL. (2006) Development of autoimmunity in IL-14alpha-transgenic mice. J Immunol (Oct), 177(8): 5676-5686.
- Ambrus JL, Chadha KC, Islam A, Akhter S, Ambrus JL, Ambrus, Jr. JL. (2006) Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents. Exp Biol Med (Maywood) (Sep), 231(8): 1283-1286.
- Carone DA, Benedict RH, Zivadinov R, Singh B, Ambrus JL. (2006) Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder. J Neuroimaging (Apr), 16(2): 163-166.
- Shen L, Zhang C, Ambrus JL, Wang JH. (2005) Silencing of human c-myc oncogene expression by poly-DNP-RNA. Oligonucleotides (Jan), 15(1): 23-35.
- Ambrus JL Sr, Dembinski W, Chadha K, Ambrus J, Chadha KC. (2004) Resistance to interferons. Discov Med (Oct), 4(23): 310-314.
- Ambrus JL Sr, Dembinski W, Chadha K, Ambrus J, Chadha KC. (2004) Resistance to interferons. Discov Med (Oct), 4(23): 310-314.
- Ambrus JL Sr, Dembinski W, Chadha K, Ambrus J, Chadha KC. (2004) Resistance to interferons. Discov Med (Oct), 4(23): 310-314.
- Ambrus JL Sr, Dembinski W, Chadha K, Ambrus J, Chadha KC. (2004) Resistance to interferons. Discov Med (Oct), 4(23): 310-314.
- Ambrus JL Sr, Dembinski W, Chadha K, Ambrus J, Chadha KC. (2004) Resistance to interferons. Discov Med (Oct), 4(23): 310-314.
- Ambrus JL Sr, Dembinski W, Chadha K, Ambrus J, Chadha KC. (2004) Resistance to interferons. Discov Med (Oct), 4(23): 310-314.
- Ambrus JL, Ambrus JL, Ambrus, Jr. JL. (2004) Nutrition and acquired immunodeficiency syndrome. Exp Biol Med (Maywood) (Oct), 229(9): 865-865.
- Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL. (2004) Interferons and interferon inhibitory activity in disease and therapy. Exp Biol Med (Maywood) (Apr), 229(4): 285-290.
- Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL. (2004) Interferons and interferon inhibitory activity in disease and therapy. Exp Biol Med (Maywood) (Apr), 229(4): 285-290.
- Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL. (2004) Interferons and interferon inhibitory activity in disease and therapy. Exp Biol Med (Maywood) (Apr), 229(4): 285-290.
- Ambrus JL, Ambrus JL, Bardos TJ, Dembinski W, Chadha KC, Ambrus, Jr. JL. (2004) New approaches to the treatment of AIDS with special reference to overcoming interferon resistance. J Med (Jan), 35(1-6): 201-209.
- Shucard JL, Parrish J, Shucard DW, McCabe DC, Benedict RH, Ambrus J. (2004) Working memory and processing speed deficits in systemic lupus erythematosus as measured by the paced auditory serial addition test. J Int Neuropsychol Soc (Jan), 10(1): 35-45.
- Ambrus JL, Dembinski W, Ambrus JL, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. (2003) Free interferon-alpha/beta receptors in the circulation of patients with adenocarcinoma. Cancer (Dec), 98(12): 2730-2733.
- Ambrus JL, Dembinski W, Ambrus JL, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. (2003) Free interferon-alpha/beta receptors in the circulation of patients with adenocarcinoma. Cancer (Dec), 98(12): 2730-2733.
- Tullis RH, Duffin RP, Zech M, Ambrus JL. (2003) Affinity hemodialysis for antiviral therapy. II. Removal of HIV-1 viral proteins from cell culture supernatants and whole blood. Blood Purif (Jan), 21(1): 58-63.
- Tullis RH, Duffin RP, Zech M, Ambrus JL. (2002) Affinity hemodialysis for antiviral therapy. I. Removal of HIV-1 from cell culture supernatants, plasma, and blood. Ther Apher (Jun), 6(3): 213-220.
- Ambruss CM, Karakousis CP, Stadler A, Stadler I, Ambrus JL, Anthone S, Ambrus JL, Ambrus, Jr. JL. (2002) Reducing toxicity of cisplatin in cancer chemotherapy by extracorporeal removal of excess cisplatin. J Med (Jan), 33(1-4): 119-127.
- Tullis RH, Ambrus JA, Joyce JA, Ambrus, Jr. JL. (2001) HIV affinity hemodialysis as a treatment for AIDS. Am Clin Lab (Oct), 20(9): 22-23.
- Kandeel AA, Zeid M, Helm T, Lillie MA, Donahue E, Ambrus JL. (2001) Evaluation of chronic urticaria in patients with Hashimoto thyroiditis. J Clin Immunol (Sep), 21(5): 335-347.
- Ambrus CM, Anthone S, Stadler A, Cameron MS, Wells K, Stadler I, Ambrus JL. (2001) Treatment of lead poisoning with an immobilized chelator comparison with conventional therapy. Res Commun Mol Pathol Pharmacol (Jan), 110(3-4): 253-263.
- Kandeel A, Ramesh S, Chen Y, Celik C, Jenis E, Ambrus JL. (2000) Microscopic polyangiitis in a pediatric patient. Arch Fam Med (Nov), 9(10): 1189-1192.
- Ambrus CM, Lajos TZ, Stadler I, Stadler A, Alfano J, Tulumello JA, Ambrus JL. (1999) Myocardial release of non-transferrin-bound iron during cardio-pulmonary bypass surgery. J Med (Jan), 30(3-4): 157-167.
- Ambrus CM, Stadler I, Toumbis CA, Stadler A, Anthone S, Anthone R, DeAlarcon P, Deshpande G, Conway J, Vladutiu AO, Ambrus JL. (1999) Removal of non-transferrin-bound iron from blood with iron overload using a device with immobilized desferrioxamine. J Med (Jan), 30(3-4): 211-224.
- Ambrus JL, Sridhar NR. (1997) Immunologic aspects of renal disease. JAMA (Dec), 278(22): 1938-1945.
- Ambrus JL, Ambrus JL, Chadha S, Novick D, Rubinstein M, Gopalakrishnan B, Bernstein Z, Priore RL, Chadha KC. (1997) Mechanism(S) of interferon inhibitory activity in blood from patients with AIDS and patients with lupus erythematosus with vasculitis. Res Commun Mol Pathol Pharmacol (Jun), 96(3): 255-265.
- Ambrus JL, Ambrus JL, Chadha S, Novick D, Rubinstein M, Gopalakrishnan B, Bernstein Z, Priore RL, Chadha KC. (1997) Mechanism(S) of interferon inhibitory activity in blood from patients with AIDS and patients with lupus erythematosus with vasculitis. Res Commun Mol Pathol Pharmacol (Jun), 96(3): 255-265.
- Ambrus JULIAN, Contractor V, Joseph A, Long J, Blumenthal D. (1995) A Potential Role for PGE and IL-14 (HMW-BCGF) in B-Cell Hyperactivity of Patients with Systemic Lupus Erythematosus. Am J Ther (Dec), 2(12): 933-942.
- Ford R, Tamayo A, Martin B, Niu K, Claypool K, Cabanillas F, Ambrus J. (1995) Identification of B-cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas. Blood (Jul), 86(1): 283-293.
- Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ. (1993) Identification of a cDNA for a human high-molecular-weight B-cell growth factor. Proc Natl Acad Sci U S A (Jul), 90(13): 6330-6334.
- Levy E, Ambrus J, Kahl L, Molina H, Tung K, Holers VM. (1992) T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE). Clin Exp Immunol (Nov), 90(2): 235-244.
- Ford RJ, Tamayo A, Ambrus JL. (1992) The role of growth factors in human lymphomas. Curr Top Microbiol Immunol (Jan), 182: 341-347.
- Ambrus JL, Haneiwich S, Chesky L, McFarland P, Engler RJ. (1991) Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen). J Allergy Clin Immunol (Nov), 88(5): 775-783.
- Aszalos A, Chadha KC, Stadler I, Ambrus JL, Ambrus JL, Ambrus, Jr. JL. (1991) Effect of an interferon inhibitor on the antiproliferative signal of interferon-alpha. Biochem Med Metab Biol (Oct), 46(2): 267-270.
- Ambrus JL, Haneiwich S, Chesky L, McFarland P, Peters MG, Engler RJ. (1991) Abnormal response to a human B cell growth factor in patients with common variable immunodeficiency (CVI). J Allergy Clin Immunol (Jun), 87(6): 1138-1149.
- Young KR, Ambrus JL, Malbran A, Fauci AS, Tenner AJ. (1991) Complement subcomponent C1q stimulates Ig production by human B lymphocytes. J Immunol (May), 146(10): 3356-3364.
- Ambrus JL, Chesky L, McFarland P, Young KR, Mostowski H, August A, Chused TM. (1991) Induction of proliferation by high molecular weight B cell growth factor or low molecular weight B cell growth factor is associated with increases in intracellular calcium in different subpopulations of human B lymphocytes. Cell Immunol (May), 134(2): 314-324.
- Ambrus JL, Chesky L, Chused T, Young KR, McFarland P, August A, Brown EJ. (1991) Intracellular signaling events associated with the induction of proliferation of normal human B lymphocytes by two different antigenically related human B cell growth factors (high molecular weight B cell growth factor (HMW-BCGF) and the complement facto. J Biol Chem (Feb), 266(6): 3702-3708.
- Chadha KC, Ambrus JL, Stadler I, Ambrus JL. (1991) Interferon inhibitor in the blood of patients with systemic lupus erythematosus. J Biol Regul Homeost Agents (Jan), 5(1): 1-9.
- Chadha KC, Ambrus JL, Stadler I, Ambrus JL. (1991) Interferon inhibitor in the blood of patients with systemic lupus erythematosus. J Biol Regul Homeost Agents (Jan), 5(1): 1-9.
- Ambrus JL, Chesky L, Stephany D, McFarland P, Mostowski H, Fauci AS. (1990) Functional studies examining the subpopulation of human B lymphocytes responding to high molecular weight B cell growth factor. J Immunol (Dec), 145(12): 3949-3955.
- Goldstein H, Koerholz D, Chesky L, Fan XD, Ambrus JL. (1990) Divergent activities of protein kinases in IL-6-induced differentiation of a human B cell line. J Immunol (Aug), 145(3): 952-961.
- Ambrus JL, Peters MG, Fauci AS, Brown EJ. (1990) The Ba fragment of complement factor B inhibits human B lymphocyte proliferation. J Immunol (Mar), 144(5): 1549-1553.
- Begley CG, Burton JD, Tsudo M, Brownstein BH, Ambrus JL, Waldmann TA. (1990) Human B lymphocytes express the p75 component of the interleukin 2 receptor. Leuk Res (Jan), 14(3): 263-271.
- Uckun FM, Fauci AS, Chandan-Langlie M, Myers DE, Ambrus JL. (1989) Detection and characterization of human high molecular weight B cell growth factor receptors on leukemic B cells in chronic lymphocytic leukemia. J Clin Invest (Nov), 84(5): 1595-1608.
- Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF, Meijer S, van der Giessen M, van der Hem GK, The TH. (1989) Association between active Wegener's granulomatosis and anticytoplasmic antibodies. Arch Intern Med (Nov), 149(11): 2461-2465.
- Uckun FM, Myers DE, Fauci AS, Chandan-Langlie M, Ambrus JL. (1989) Leukemic B-cell precursors constitutively express functional receptors for human interleukin-1. Blood (Aug), 74(2): 761-776.
- Lewis RA, Rankin JA, Allison AC, Ambrus JL. (1989) Regulated generation of leukotrienes in mononuclear cells. Adv Prostaglandin Thromboxane Leukot Res (Jan), 19: 495-498.
- Peters MG, Ambrus JL, Fauci AS, Brown EJ. (1988) The Bb fragment of complement factor B acts as a B cell growth factor. J Exp Med (Oct), 168(4): 1225-1235.
- Ambrus JL, Jurgensen CH, Brown EJ, McFarland P, Fauci AS. (1988) Identification of a receptor for high molecular weight human B cell growth factor. J Immunol (Aug), 141(3): 861-869.
- Ambrus JL, Jurgensen CH, Witzel NL, Lewis RA, Butler JL, Fauci AS. (1988) Leukotriene C4 produced by a human T-T hybridoma suppresses Ig production by human lymphocytes. J Immunol (Apr), 140(7): 2382-2388.
- Uckun FM, Jaszcz W, Ambrus JL, Fauci AS, Gajl-Peczalska K, Song CW, Wick MR, Myers DE, Waddick K, Ledbetter JA. (1988) Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins. Blood (Jan), 71(1): 13-29.
- Nakagawa T, Nakagawa N, Ambrus JL, Fauci AS. (1988) Differential effects of interleukin 2 vs B cell growth factor on human B cells. J Immunol (Jan), 140(2): 465-469.
- Uckun FM, Fauci AS, Heerema NA, Song CW, Mehta SR, Gajl-Peczalska K, Chandan M, Ambrus JL. (1987) B-cell growth factor receptor expression and B-cell growth factor response of leukemic B cell precursors and B lineage lymphoid progenitor cells. Blood (Oct), 70(4): 1020-1034.
- Goldstein H, Ambrus JL, Grove JH, Margolick JB, Fauci AS. (1987) Functional and biochemical characterization of B-cell differentiation factor (BCDF) produced by an HTLV-I-transformed human T-cell clone and demonstration of specific binding of the factor to a BCDF responsive cell line. Cell Immunol (Sep), 108(2): 343-355.
- Osur SL, Lillie MA, Chen PB, Ambrus JL, Wilson ME. (1987) Elevation of serum IgG levels and normalization of T4/T8 ratio after hepatitis in a patient with common variable hypogammaglobulinemia. J Allergy Clin Immunol (Jun), 79(6): 969-975.
- Ambrus CM, Anthone S, Horvath C, Kalghatgi K, Lele AS, Eapen G, Ambrus JL, Ryan AJ, Li P. (1987) Extracorporeal enzyme reactors for depletion of phenylalanine in phenylketonuria. Ann Intern Med (Apr), 106(4): 531-537.
- Nakagawa N, Nakagawa T, Volkman DJ, Ambrus JL, Fauci AS. (1987) The role of interleukin 2 in inducing Ig production in a pokeweed mitogen-stimulated mononuclear cell system. J Immunol (Feb), 138(3): 795-801.
- Ambrus JL, Jurgensen CH, Bowen DL, Tomita S, Nakagawa T, Nakagawa N, Goldstein H, Witzel NL, Mostowski HS, Fauci AS. (1987) The activation, proliferation, and differentiation of human B lymphocytes. Adv Exp Med Biol (Jan), 213: 163-175.
- Peters M, Ambrus JL, Zheleznyak A, Walling D, Hoofnagle JH. (1986) Effect of interferon-alpha on immunoglobulin synthesis by human B cells. J Immunol (Nov), 137(10): 3153-3157.
- Jurgensen CH, Ambrus JL, Fauci AS. (1986) Production of B cell growth factor by normal human B cells. J Immunol (Jun), 136(12): 4542-4547.
- Bowen DL, Ambrus JL, Fauci AS. (1986) Identification and characterization of a B cell activation factor (BCAF) produced by a human T cell line. J Immunol (Mar), 136(6): 2158-2163.
- Margolick JB, Ambrus JL, Volkman DJ, Fauci AS. (1986) Human T4+ lymphocytes produce a phagocytosis-inducing factor (PIF) distinct from interferon-alpha and interferon-gamma. J Immunol (Jan), 136(2): 546-554.
- Ambrus JL, Jurgensen CH, Brown EJ, Fauci AS. (1985) Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor. J Exp Med (Oct), 162(4): 1319-1335.
- Tomita S, Ambrus JL, Volkman DJ, Longo DL, Mitsuya H, Reitz MS, Fauci AS. (1985) Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation. J Exp Med (Jul), 162(1): 393-398.
- Goldstein H, Volkman DJ, Ambrus JL, Fauci AS. (1985) Characterization of a T4+/Leu-8+ T cell clone that directly helps B cell Ig production by secreting B cell differentiation factor. J Immunol (Jul), 135(1): 339-343.
- Ambrus JL, Fauci AS. (1985) Human B lymphoma cell line producing B cell growth factor. J Clin Invest (Feb), 75(2): 732-739.
- Butler JL, Ambrus JL, Fauci AS. (1984) Characterization of monoclonal B cell growth factor (BCGF) produced by a human T-T hybridoma. J Immunol (Jul), 133(1): 251-255.
- Ambrus JL, Fauci AS. (1984) Diffuse histiocytic lymphoma in a patient treated with cyclophosphamide for Wegener's granulomatosis. Am J Med (Apr), 76(4): 745-747.
- Kehrl JH, Muraguchi A, Falkoff RJ, Ambrus JL, Butler JL, Fauci AS. (1984) Activation and immunoregulation of human B lymphocytes. Uremia Invest (Jan), 8(3-4): 157-166.
- Bielat KL, Halpern J, Simich JP, Huben RP, Ambrus JL. (1900) A morphological analysis of an in vitro model of cytotoxic antitumor activity. Cancer Detect Prev (Jan), 12(1-6): 1-7.
- Halpern J, Joy JV, Bielat KL, Ambrus JL. (1900) Human peripheral blood mononuclear cells (PBM's) cultured in serum free medium (II): Lymphocyte-macrophage interaction and related morphological changes. J Med (Jan), 16(4): 461-482.
- Halpern J, Islam A, Simich JP, Piver MS, Ambrus JL, Bielat KL. (1900) Tumor-infiltrating lymphocytes: in vitro characterization of morphological and phenotypical changes. Cancer Detect Prev (Jan), 13(1): 1-7.
- Halpern JN, Bielat KL, Simich JP, Ambrus JL. (1900) Ultrastructural descriptions of interactions between tumor-infiltrating lymphocytes and tumor cells in an in vitro model of culture in serum-free medium. Cancer Detect Prev (Jan), 13(3-4): 213-223.
- Sayyid SH, Bielat KL, Mahafzah MM, Ambrus JL. (1900) Ultrastructural study of a murine model for Chediak Higashi syndrome. J Med (Jan), 22(6): 339-354.
Abstracts:
- Matteson K, Laftavi M, Case S, Leca N, Stephan RN, Shanahan T, Ambrus JL, Pankewycz O. (2003) Does IL-14 Play a Significant Role in Maintaining High Panel Reactive Antibody (PRA) In High PRA Patients?. The South Pacific Organ Procurement Society, (Jan)
Professional Memberships:
- American Association of Immunologists
- American Federation for Clinical Research
- Buffalo Academy of Medicine; President
- Buffalo Allergy Society
- Federation of American Societies for Experimental Biology
Presentations:
- "Mutations in Metabolic Genes in a Cohort of Patients with Sjogren's DIsease" CORA conference on Autoimmunity (2025)
- "Lessons Learned from the IL14a Transgenic Mouse" Salivary Gland Gordon Conference; NIDCR; Immunology (2015)
- "Atypical Hemolytic Uremic Syndrome" Rheumatology Grand Rounds; Mount Sinai School of Medicine; Rheumatology (2013)
- "Innate Immunity in Sjogren's Syndrome" CORA; CORA; Autoimmunity (2013)
- "Role of Lymphotoxin and Interferon in Sjogren's Syndrome" Gordon Conference Salivary Gland biology; Federation of Biology; Sjogren's (2013)
- "Early Events in Sjogren's Syndrome" American College of Rheumatology; American College of Rheumatology; Sjogren's (2012)
Service Activities:
- NIH; U1 Review Panel; Review U1 grants;; Grant Reviewer (2013–present)
- NIDCR; MOSS-A; Review various RO1 and R21 grants;; Grant Reviewer (2010–present)
- NIDCR; Special Emphasis Panel; Review R21 and R01 grants;; Grant Reviewer (2009–present)
- NIH; Special Emphasis Panel; Review various RO1 and R21 grants;; Grant Reviewer (2009–present)
- NIAMS; Special Emphasis Panel; Review various RO1, RO3 and R21 grants;; Grant Reviewer (2000–present)
- Committee on Appointment and Promotions to Clinical Ranks; Member (2000–present)
- Medical Records Committee; Member (1997–1999)
- Faculty Council; Member (1996–2000)
- Hospital Computer Committee; Member (1996–2000)