Suzanne G. Laychock PhD

Suzanne Laychock

Suzanne G. Laychock
PhD

Professor and Senior Associate Dean For Faculty Affairs & Facilities

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Apoptosis and cell death; Endocrinology; Gene Expression; Molecular and Cellular Biology; Regulation of metabolism; Signal Transduction

Contact Information
Jacobs School of Medicine and Biomedical Sciences
room 6155
955 Main Street
Buffalo, New York 14203-1121
Phone: (716) 829-2808
Fax: (716) 829-2437
laychock@buffalo.edu



Professional Summary:

Suzanne Laychock, PhD, is senior associate dean for faculty affairs and facilities, and professor of pharmacology and toxicology. She is responsible for overseeing faculty development, space management, and undergraduate biomedical education programs.

Dr. Laychock earned a bachelor’s degree in biology from Brooklyn College, a master’s degree in biology for the City University of New York and a doctorate in pharmacology from the Medical College of Virginia.

An accomplished scientist, Dr. Laychock’s research focuses on endocrine pharmacology with an emphasis on signal transduction mechanisms involved in insulin secretion and models of diabetes mellitus.

The author of numerous journal articles, she has served as associate editor of the research journal LIPIDS, and on the editorial boards of Diabetes and the Journal of Pharmacology and Experimental Therapeutics. She is the recipient of research grants from, among others, the Juvenile Diabetes Research Foundation, the National Institutes of Health, and the American Diabetes Association.

Dr. Laychock is Council Member and has chaired the Women in Pharmacology Committee of the American Society for Pharmacology and Experimental Therapeutics. She has served the university as a member and chair of the President’s Review Board, and as co-director of the Institute for Research and Education on Women and Gender.

Education and Training:

  • PhD, Pharmacology, Medical College of Virginia (1976)
  • MA, Biology, City University of New York (1973)
  • BS, Biology, Brooklyn College (1971)

Employment:

  • (2010-present)
  • Associate Dean of Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2010-present)
  • Facilities Planning Officer, SUNY at Buffalo School of Medicine (2002-present)
  • Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1989-present)
  • Senior Associate Dean for Research and Biomedical Education, SUNY at Buffalo School of Medicine and Biomedical Sciences (2002–2010)
  • Director of Institute for Research and Education on Women and Gender, Institute for Research & Education on Women & Gender, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001–2002)
  • Professor and Associate Chair, Pharmacology and Toxicology, Pharmacology & Toxicology, & Center for Advanced Molecular Biology & Immunology Jacobs School of Medicine & Biomedical Sciences (1995–2002)
  • Professor and Associate Chair, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1995–2002)
  • Affiliate Professor, Pharmacology & Toxicology, Medical College of Virginia (1990–1995)
  • Associate Professor, Medical College of Virginia Medical College of Virginia (1985–1989)
  • Assistant Professor, Pharmacology & Toxicology, Medical College of Virginia (1978–1985)
See all (1 more)

Awards and Honors:

  • Dean's Award (2010)
  • Stockton-Kimball Award (2007)
  • Sustained Achievement Award (2002)
  • Distinguished Alumnus Award, School of Basic Health Sciences (1990)
  • Virginia Commonwealth University Alumni STAR Award (1990)
  • Outstanding Young Research Investigator of the American Diabetes Associatio (1989)
  • Outstanding Young Research Investigator of the American Diabetes Association (1989)
  • Sandra Tate Russell Memorial Award ($1200) (1989)
  • Outstanding Faculty Member in Dept. of Pharmacology (1983)
  • NIH Postdoctoral Research Fellowship (NHLBI) (1977)
  • National Merit Scholarship (1967)
  • New York State Regents Scholarship (1967)

Research Expertise:

  • gene regulation: mRNA analysis, RT-PCR
  • metabolism: glycolysis, glucose oxidation
  • secretion: insulin secretion
  • signal transduction: second messenger analysis,cyclic AMP,prostaglandins,calcium,lipids,phospholipids,cyclic GMP, inositol trisphosphate

Grants and Sponsored Research:

  • September 2009–August 2012
    Scalable Expansion and Directed Differentiation of Human Embryonic Stem Cells to Pancreatic Progeny
    NYS Department of Health
    Role: Co-Principal Investigator
    $179,246
  • January 2006–December 2007
    Growth Factors and Angiogenesis in Pancreatic Islet Transplantation.
    Juvenile Diabetes Research Foundation International
    Role: Principal Investigator
    $125,000
  • August 2004–July 2006
    Regulated Insulin Secretion from Tissue Engineered Skin for Type-1 Diabetes
    NIH
    Role: Co-Principal Investigator
    $75,000
  • August 2002–July 2005
    EDG Receptor and Sphingosine-1-Phosphate EFfects in Pancreatic Islets
    Juvenile Diabetes Research Foundation
    Role: Principal Investigator
    $370,197
  • July 1979–June 2002
    Putative Mediators of Insulin Secretion
    NIH
    Role: Principal Investigator
    $289,746
  • July 1998–June 2001
    Regulation of Expression of Receptors for Inositol Trisphosphate and Ryanodine in Pancreatic Islets
    American Diabetes Association
    Role: Principal Investigator
    $150,000
  • September 1996–April 1998
    Diet-induced hyperinsulinemia and beta cell function
    National Institute of Diabetes and Digestive and Kidney Diseases
    Role: Co-Principal Investigator
    $160,000

Journal Articles:

See all (92 more)

Books and Book Chapters:

  • Laychock SG. (2003) In: Insulin Receptor Signaling.
  • Laychock SG. (2004) In: The Pancreas and Pancreatic Hormones.
  • Patel, M.S., Srinivasan, M., Laychock, S.G. (2005) The Impact of Maternal Nutrition on the Offspring. In: Nutrient Induced Maternal Hyperinsulinemia and Metabolic Programming in the Progeny. Karger, 137-152.

Abstracts:

  • Tian, J., Lei, P., Laychock, S.G., Andreadis, S.T. (2007) Regulated secretion of insulin from genetically modified skin cells for treatment of diabetes. (Jan)
  • Tian, J., Lei, P., Laychock, S.G., Andreadis, S.T. (2007) Regulated secretion of insulin from genetically modified skin cells for treatment of diabetes. (Jan)
  • Laychock, S.G., Sessanna, S.M. (2006) Sphingosine 1-phosphate modulates apoptosis in cytokine challenged pancreatic islet β-cells. (Jan) A347
  • Laychock, S.G., Sessanna, S.M., Tian, Y., and Mastrandrea, L.D. (2003) Sphingosine-1-phosphate signaling and beta-cell survival. (Jan) A187
  • You, H. and Laychock, S.G. (2008) Atrial natriuretic peptide (ANP) and islet beta-cell growth. ExBio Annual Meeting/ASPET. (Mar)Poster
  • Mastrandrea L, Laychock SG. (2004) Characterization of sphingosine-1 phosphate phosphohydrolase activity in INS-1 Cells. American Diabetes Association Annual Meeting. (Jan)Poster
  • Mastrandrea LD, Sessanna SM, Tian Y, Laychock SG. (2003) EDG Receptor and Sphingosine 1-Phosphate Signaling in Rat Islets and INS-1 Cells. International Diabetes Association Annual Meeting - European Association Study of Diabetes. Paris, (Aug)Poster
  • Mastrandrea, L.D., Sessanna, S., Tian, Y. and Laychock, S.G. (2003) EDG receptor and sphingosine-1-phosphate signaling in rat islets and INS-1 cells. (Jan)
  • Laychock SG, Sessanna SM, Lin M-H. (2005) Effects of sphingosine-1-phosphate (S1P) on cytokine-induced apoptosis in pancreatic islets and INS-1 cells. American Diabetes Association 65th Annual Meeting Diabetes vol 54. (Jan)
  • Tian J, Lei P, Laychock SG, Andreadis ST. (2006) Regulated secretion of insulin from genetically modified skin cells for treatment of diabetes. (May) S30, (77)Poster
  • Mastrandrea LD, Laychock SG, Sessanna SM. (2006) Sphingosine Kinase in Pancreatic Islets is Activated by Glucose and Glucose Analogues. American Diabetes Association. (Jun)Poster
  • Laychock, S.G., Sessanna, S.M. (2006) Sphingosine 1-phosphate modulates apoptosis in cytokine challenged pancreatic islet ß-cells. (Jan)Poster
  • Laychock SG, Sessanna SM, Tian Y, Mastrandrea LD. (2003) Sphingosine 1-Phosphate Signaling and Beta-Cell Survival. Annual Meeting of the American Diabetes Association. (Jun)Poster
  • Mastrandrea LD, Laychock SG. (2005) Sphingosine Kinase 2 is the Predominant Enzyme in Rat Pancreatic Islets and INS-1 Cells and is Activated by Cytokines. ExBio/ASPET. (Apr)Poster
  • Laychock SG, Sessanna SM, Mastrandrea LD. (2007) Sphingosine Kinase Expression and Activity in Rat Pancreatic Islets. American Diabetes Association Annual Meeting. (Jun)Poster
  • You, H. and Laychock, S.G. (2008) Atrial natriuretic peptide (ANP) and islet beta-cell growth. (Jan)
  • Patel, MS, Srinivasan, M, Laychock SG. (2004) Nutrient-induced maternal hyperinsulinemia and metabolic programming in the progeny. (Jan) 137-147
See all (7 more)

Presentations:

  • "EDG receptors, sphingosine-1-phosphate and apoptosis" European Association for the Study of Diabetes Annual Meeting; European Association for the Study of Diabetes (2003)
  • "Sphingosine-1-phosphate and beta-cell survival" International Diabetes Federation Congress; International Diabetes Federation; Beta Cell Biology (2003)
  • "Sphingosine 1-Phosphate: Signaling Inside and Out" Research Symposium on Islet Biology; American Diabetes Association and European Association for the Study of Diabetes; islet biology (2002)
  • "Juggling Life and Career Goals" ASPET; ; Women in Pharmacology Forum (1998)
  • "Eicosanoids and Insulin Release" 13th International Diabetes Federation Congress (1988)
  • "The Biochemistry of Cell Activation as Related to the Putative Actions of Flavonoids" Symposium - Plant Flavonoids in Biology & Medicine (1985)
  • "Regulation of Insulin Secretion" European Association for the Study of Diabetes; ; Annual Meeting (1984)
  • "Prostaglandins and Pancreatic Islets" Summer Conference on Secretion; FASEB (1983)

Service Activities:

  • education committee; Chair (2017–2020)
  • Councilor - ASPET Elected to serve as Council member of the American Society of Pharmacology and Experimental Therapeutics; Councilor (2008–2011)
  • NIH; Cellular Aspects of Diabetes and Obesity;; Ad Hoc Reviewer (2007)
  • NIH; Cellular Aspects of Diabetes and Obesity (CADO);; Ad Hoc Reviewer (2006)
  • Diabetes Action Research and Education Foundation; Diabetes Action Research and Education Foundation;; External Reviewer (2006–2009)
  • NIH; Site Visit Team;; Panel Member (2003)
  • Endocrine curriculum design committee; Chair new curriculum design committee (2000–2002)
  • NIH; Special Emphasis Panel, Program Project Site Visit; NIDDK;; Panel Member (2000)
  • PRB; member & Chair (1998–2001)
  • NIH; Metabolism Study Section;; Panel Member (1994–1998)
  • NIH; Program Project Study Section; NIDDK;; Ad Hoc Reviewer (1994)
  • NIH; Metabolism Study Section;; Ad Hoc Reviewer (1993–1994)
  • NIH; Ad Hoc Study Section, Diabetes Interdisciplinary Research Program;; Ad Hoc Reviewer (1991)
  • NIH; Ad hoc Special Study Section Diabetes;; Chair (1985)
  • NIH; Ad hoc Special Study Section, Diabetes;; Ad Hoc Reviewer (1984)

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Contact Information

Jacobs School of Medicine and Biomedical Sciences
room 6155
955 Main Street
Buffalo, New York 14203-1121
Phone: (716) 829-2808
Fax: (716) 829-2437
laychock@buffalo.edu