Lin Liu MD, PhD
Lin Liu
MD, PhD
Clinical Assistant Professor
Department of Pathology and Anatomical Sciences
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Surgical Pathology
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDProfessional Summary:
I am interested in all aspects in general surgical pathology with major focus on medical renal and genitourinary pathology. I also have special interest in immunology and molecular pathology. Due to my previous long years research training, I would like to continue the endeavor in research directed to address clinical related questions and disease mechanisms.
Education and Training:
- Fellowship, Surgical Pathology, Pennsylvania Hospital, Penn Medicine (2015)
- Residency, Pathology, Univeristy of Pittsburgh Medical Center (2012)
- Immunology, University of Pittsburgh (2008)
- Immunology, Yale University School of Medicine (2003)
- PhD, Biochemistry and Biophysics, Univeristy of Pennsylvania (1999)
- Internal Medicine, China-Japan Friendship Hospital (1994)
- MD, Beijing Medical University (Peking University Health Science Center) (1992)
Awards and Honors:
- NIH Training Grant (2005)
- NIH Training Grant (2003)
- Howard Hughes Institute fellowship (2001)
- Full scholarship from University of Pennsylvania Gratuate Biological Studies (1999)
Journal Articles:
- Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL. (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (Feb), 19(2): 1202-1209.
- Gregory PD, Schmid A, Zavari M, Liu L, Berger SL, Hörz W,. (1998) Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast. Mol Cell (Mar), 1(4): 495-505.
- Liu L*, Wang L*, Berger SL (*these authors contributed equally to this work). (1998) Critical residues for histone acetylation by GCN5, functioning in ADA and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev (Mar), 12(5): 640-653.
- Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL. (1998) Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku/DNA-PK complex. Mol Cell Biol (Mar), 18(3): 1349-1358.
- Liu L, Shen RY, Kapatos G, Chiodo LA, Shen R. (1994) Dopamine neuron membrane physiology: characterization of the transient outward current (IA) and demonstration of a common signal transduction pathway for IA and IK. Synapse (Aug), 17(4): 230-240.
- Huang XF, Jiang WT, Liu L, Song FC, Zhu X, Shi GL, Ding SM, Ke HM, Wang W, O'Donnell JM, Zhang HT, Luo HB, Wan YQ, Song GQ, Xu Y, O‘Donnell JM. (2018) A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling. CNS Neurosci Ther (May).
- Liu L, Zheng J, Huang XF, Zhu X, Ding SM, Ke HM, O'Donnell JM, Zhang HT, Song GQ, Xu Y, O‘Donnell JM. (2018) The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor. CNS Neurosci Ther (Apr).
- Wang L, Xiaokaiti Y, Wang G, Xu X, Chen L, Huang X, Liu L, Pan J, Hu S, Chen Z, Xu Y. (2017) Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways. Sci Rep (Sep), 7(1): 12044-12044.
- Wei L, Chintala S, Ciamporcero E, Ramakrishnan S, Elbanna M, Wang J, Hu Q, Glenn ST, Murakami M, Liu L, Gomez EC, Sun Y, Conroy J, Miles KM, Malathi K, Ramaiah S, Anbarasu A, Woloszynska-Read A, Johnson CS, Conroy J, Liu S, Morrison CD, Pili R. (2016) Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts. Oncotarget (Nov), 7(47): 76374-76389.
- Chowdhry VK, Liu L, Goldberg S, Adams JA, De Amorim Bernstein K, Liebsch NJ, Niemierko A, Chen YL, DeLaney TF. (2016) Thoracolumbar spinal cord tolerance to high dose conformal proton-photon radiation therapy. Radiother Oncol (Apr), 119(1): 35-39.
- Eaton BR, Chowdhry V, Weaver K, Liu L, Ebb D, MacDonald SM, Tarbell NJ, Yock TI. (2015) Use of proton therapy for re-irradiation in pediatric intracranial ependymoma. Radiother Oncol (Aug), 116(2): 301-308.
- Esmailpour T, Riazifar H, Liu L, Donkervoort S, Huang VH, Madaan S, Shoucri BM, Busch A, Wu J, Towbin A, Chadwick RB, Sequeira A, Vawter MP, Sun G, Johnston JJ, Biesecker LG, Kawaguchi R, Sun H, Kimonis V, Huang T. (2014) A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome. J Med Genet (Mar), 51(3): 185-196.
- Guo P, Wang X, Liu L, Belinsky MG, Kruh GD, Gallo JM. (2007) Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal (Apr), 43(5): 1789-1795.
- Cao ZA, Bass KE, Balasubramanian S, Liu L, Schultz B, Verner E, Dai Y, Molina RA, Davis JR, Misialek S, Sendzik M, Orr CJ, Leung L, Callan O, Young P, Dalrymple SA, Buggy JJ. (2006) CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. Mol Cancer Ther (Jul), 5(7): 1693-1701.
- Buggy JJ, Cao ZA, Bass KE, Verner E, Balasubramanian S, Liu L, Schultz BE, Young PR, Dalrymple SA. (2006) CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther (May), 5(5): 1309-1317.
- N. Barlev, Liu L, NH. Chehab, T. Halazonetis, S.L. Berger. (2001) Acetylation of p53 at 320 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell (Jan), 8(6): 1243-1254.
- Liu L. (2005) Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. J Exp Med. (Nov), 21(10): 1341-1347.
- Ju S, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang X, Lu B. (2009) Gadd45b and Gadd45g are important for anti-tumor immune responses. Eur J Immunol (Nov), 39(11): 3010-3018.
- Gonzalez-Garcia I, Zhao, Y, Ju, S, Gu, Q, Liu L, Kolls, JK, Lu, B. (2006) IL-17 signaling-independent central nervous system autoimmunity is negatively regulated by TGF-beta. J Immunol. (Mar), 1(182): 2665-2671.
- Lu B, Chen L, Liu L, Zhu Y, Wu C, Jing J, Zhang X. (2011) USCAP 2012 poster) Lu B, Chen L, Liu L, Zhu Y, Wu C, Jiang J, Zhang X. T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract. Immunol Res. (Aug), 50(2-3): 269-275.
- Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B. (2010) T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol. (Sep), 15(185): 3174-3183.
Abstracts:
- Liu L, Randhawa P. (2012) The Banff Schema for Renal Allograft Pathology: Revisiting Scoring Paradigms for Inflammation and Tubulit. (Jan)