Kenneth L. Seldeen PhD
Kenneth L. Seldeen
PhD
Research Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Bioinformatics; Gene Expression; Geriatric Medicine; Metabolism; Molecular and Cellular Biology; Molecular genetics; Nutrition; Protein Folding; Protein Function and Structure; RNA; Stem Cells; Vitamins and Trace Nutrients
Professional Summary:
Dr. Kenneth Seldeen holds a doctorate in biochemistry and molecular biology from the University of Miami and is currently an assistant professor in the field of gerontology at the University at Buffalo and the VA Western New York Healthcare System. Presently, he is initiating a double-blind randomized controlled trial to evaluate the benefits of nicotinamide riboside supplementation to enhance functional capacity in older Veterans (NCT04691986). His specific research interests include the identification of possible lifestyle strategies for successful aging, including shorter exercise regimens that can fit into busy schedules and/or nutritional supplementation to boost or maintain functional capacity (e.g., vitamin D and nicotinamide riboside). Dr. Seldeen's expertise is in muscle biology and the use of animal behavioral tests that mirror human clinical measurements – including the use of an animal model of frailty assessment based upon the Fried et al frailty phenotype. He supports such strategies as a means to optimize and accelerate the translation of novel therapeutics. In particular, his work has translated pre-clinical animal models of high intensity interval training to implementation in clinical trials involving Veteran populations. Future goals of this research are to identify underlying predictors of HIIT response (i.e., miRNA biomarkers) as well as the development of HIIT@home protocols to expand community level engagement.
Education and Training:
- PhD, Biochemistry and Molecular Biology, University of Miami (2009)
- BS, Biology, California Lutheran University (1999)
Employment:
- Research Assistant Professor, Medicine, Division of Geriatrics and Palliative Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2016-present)
- Lecturer and Postdoctoral Associate, Medicine, University at Buffalo (2013–2015)
- Postdoctoral Associate, Geriatric Medicine, University of Miami (2011–2013)
- Postdoctoral Associate, Biochemistry, University of Miami (2009–2011)
- Database Programmer, Impartner (Formally Treehouse Interactive) (2000–2004)
Awards and Honors:
- Best Poster award, 1st Annual Jacobs School Celebration of Scholarship (2019)
- "Rising Star" Designee, NIA/AGS U13 Bench to Bedside Conference Series (2019)
- Best Poster Award and Winner of the Big Blue Cocktail Glass Award, UB Department of Medicine Research Day (2018)
- Best Poster Award, UB Department of Medicine Research Day (2016)
- Honorable Mention, UB Postdoctoral Poster competition (2015)
- 2nd Prize Award - Department of Medicine Research Day (2015)
- 1st prize award - UB Postdoc Poster Competition (2014)
- Honorable Mention, Young investigator basic science presentation (2013)
- 2011 Post-doctoral Travel Award, Nathan Shock Conference on Aging (2011)
Research Centers:
- Clinical and Translational Research Center (CTRC)
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
Grants and Sponsored Research:
- October 2022–September 2026
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
VA RR&D
Role: Co-Investigator
$1,200,000 - July 2021–June 2025
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
VA Rehabilitation Research and Development
Role: Principal Investigator
$1,199,995 - July 2020–June 2025
Restoring the Regenerative Capacity of the Aged Muscle
NIH
Role: Co-Investigator
$1,676,402 - October 2018–September 2023
Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis
NIH NIDCR
Role: Co-Investigator
$1,250,000
Journal Articles:
- Colón-Emeric C, Whitson HE, Berry SD, Fielding RA, Houston DK, Kiel DP, Rosen CJ, Seldeen KL, Volpi E, White JP, Troen BR. (2020) AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders. J Am Geriatr Soc (Jan), 68(1): 31-38.
- Seldeen KL, Redae YZ, Thiyagarajan R, Berman RN, Leiker MM, Troen BR. (2019) High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools. Mech Ageing Dev (Apr), 180: 49-62.
- Pang M, RodrÃguez-Gonzalez M, Hernandez M, Recinos CC, Seldeen KL, Troen BR. (2019) AP-1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors. J Cell Biochem (Feb).
- Seldeen KL, Redae YZ, Thiyagarajan R, Berman RN, Leiker MM, Troen BR. (2019) Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice. J Vis Exp (Feb)(144).
- Kirkwood KL, Zhang L, Thiyagarajan R, Seldeen KL, Troen BR. (2018) Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility. Immunol Invest (Nov), 47(8): 844-854.
- Sharikova AV, Quaye E, Park JY, Maloney MC, Desta H, Thiyagarajan R, Seldeen KL, Parikh NU, Sandhu P, Khmaladze A, Troen BR, Schwartz SA, Mahajan SD. (2018) Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. J Neuroimmune Pharmacol (Sep), 13(3): 396-411.
- Alexander JJ, Sankaran JS, Seldeen KL, Thiyagarajan R, Jacob A, Quigg RJ, Troen BR, Judex S. (2018) Absence of Complement Factor H Alters Bone Architecture and Dynamics. Immunobiology (Aug).
- Seldeen KL, Pang M, Leiker MM, Bard JE, RodrÃguez-Gonzalez M, Hernandez M, Sheridan Z, Nowak N, Troen BR. (2018) Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice. Aging (Albany NY) (Jun), 10(6): 1338-1355.
- Seldeen KL, Lasky G, Leiker MM, Pang M, Personius KE, Troen BR. (2018) High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice. J Gerontol A Biol Sci Med Sci (Mar), 73(4): 429-437.
- Seldeen KL, Halley PG, Volmar CH, RodrÃguez MA, Hernandez M, Pang M, Carlsson SK, Suva LJ, Wahlestedt C, Troen BR, Brothers SP. (2018) Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density. Neuropeptides (Feb), 67: 45-55.
- Seldeen KL, Pang M, RodrÃguez-Gonzalez M, Hernandez M, Sheridan Z, Yu P, Troen BR. (2017) A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?. Nutr Metab (Lond) (Mar), 14: 26-26.
- Yu P, Li Q, Liu Y, Zhang J, Seldeen K, Pang M, Seldeen KL. (2015) Pro-angiogenic efficacy of transplanting endothelial progenitor cells for treating hindlimb ischemia in hyperglycemic rabbits. J Diabetes Complications (Jan), 29(1): 13-19.
- Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, Deegan BJ, McDonald CB, Seldeen KL, Kurouski D, Faridi MH, Shareef MM, Gupta V, Lednev IK, Farooq A. (2013) Heat-induced fibrillation of BclXL apoptotic repressor. Biophys Chem (Sep), 179: 12-25.
- Mikles DC, Bhat V, Schuchardt BJ, Deegan BJ, Seldeen KL, McDonald CB, Farooq A. (2013) pH modulates the binding of early growth response protein 1 transcription factor to DNA. FEBS J (Aug), 280(15): 3669-3684.
- McDonald CB, Bhat V, Kurouski D, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK, Farooq A. (2013) Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor. Biophys Chem (May), 175-1: 54-62.
- McDonald CB, El Hokayem J, Zafar N, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A. (2013) Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner. J Mol Recognit (Feb), 26(2): 92-103.
- Bhat V, Kurouski D, Olenick MB, McDonald CB, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK, Farooq A. (2012) Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor. Arch Biochem Biophys (Dec), 528(1): 32-44.
- McDonald CB, Buffa L, Bar-Mag T, Salah Z, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Malhotra A, Sudol M, Aqeilan RI, Nawaz Z, Farooq A. (2012) Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors. J Mol Biol (Sep), 422(1): 58-74.
- McDonald CB, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A. (2012) Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner. FEBS J (Jun), 279(12): 2156-2173.
- McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A. (2012) Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner. Biochemistry (Mar), 51(10): 2122-2135.
- Bhat V, McDonald CB, Mikles DC, Deegan BJ, Seldeen KL, Bates ML, Farooq A. (2012) Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor. J Mol Biol (Feb), 416(1): 57-77.
- McDonald CB, McIntosh SK, Mikles DC, Bhat V, Deegan BJ, Seldeen KL, Saeed AM, Buffa L, Sudol M, Nawaz Z, Farooq A. (2011) Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. Biochemistry (Nov), 50(44): 9616-9627.
- Deegan BJ, Bona AM, Bhat V, Mikles DC, McDonald CB, Seldeen KL, Farooq A. (2011) Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor a-DNA interactions. J Mol Recognit (Nov), 24(6): 1007-1017.
- McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A. (2011) Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms. J Mol Recognit (Jul), 24(4): 585-596.
- Seldeen KL, Deegan BJ, Bhat V, Mikles DC, McDonald CB, Farooq A. (2011) Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA. FEBS J (Jun), 278(12): 2090-2104.
- Deegan BJ, Bhat V, Seldeen KL, McDonald CB, Farooq A. (2011) Genetic variations within the ERE motif modulate plasticity and energetics of binding of DNA to the ERa nuclear receptor. Arch Biochem Biophys (Mar), 507(2): 262-270.
- Jones KL, Zhang L, Seldeen KL, Gong F. (2010) Detection of bulky DNA lesions: DDB2 at the interface of chromatin and DNA repair in eukaryotes. IUBMB Life (Nov), 62(11): 803-811.
- Deegan BJ, Seldeen KL, McDonald CB, Bhat V, Farooq A. (2010) Binding of the ERalpha nuclear receptor to DNA is coupled to proton uptake. Biochemistry (Jul), 49(29): 5978-5988.
- Seldeen KL, McDonald CB, Deegan BJ, Bhat V, Farooq A. (2010) Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA. Biochem Biophys Res Commun (Apr), 394(4): 1030-1035.
- McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A. (2010) Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control. Arch Biochem Biophys (Feb), 494(2): 216-225.
- Al-Ali H, Rieger ME, Seldeen KL, Harris TK, Farooq A, Briegel KJ. (2010) Biophysical characterization reveals structural disorder in the developmental transcriptional regulator LBH. Biochem Biophys Res Commun (Jan), 391(1): 1104-1109.
- Seldeen KL, McDonald CB, Deegan BJ, Bhat V, Farooq A. (2009) DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif. Biochemistry (Dec), 48(51): 12213-12222.
- McDonald CB, Seldeen KL, Deegan BJ, Farooq A. (2009) SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner. Biochemistry (May), 48(19): 4074-4085.
- Seldeen KL, McDonald CB, Deegan BJ, Farooq A. (2009) Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimeric transcription factor. Biochemistry (Mar), 48(9): 1975-1983.
- Seldeen KL, McDonald CB, Deegan BJ, Farooq A. (2008) Evidence that the bZIP domains of the Jun transcription factor bind to DNA as monomers prior to folding and homodimerization. Arch Biochem Biophys (Dec), 480(2): 75-84.
- McDonald CB, Seldeen KL, Deegan BJ, Farooq A. (2008) Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1. Arch Biochem Biophys (Nov), 479(1): 52-62.
- Seldeen KL, McDonald CB, Deegan BJ, Farooq A. (2008) Thermodynamic analysis of the heterodimerization of leucine zippers of Jun and Fos transcription factors. Biochem Biophys Res Commun (Oct), 375(4): 634-638.
- McDonald CB, Seldeen KL, Deegan BJ, Lewis MS, Farooq A. (2008) Grb2 adaptor undergoes conformational change upon dimerization. Arch Biochem Biophys (Jul), 475(1): 25-35.
- Seldeen KL, McDonald CB, Deegan BJ, Farooq A. (2008) Coupling of folding and DNA-binding in the bZIP domains of Jun-Fos heterodimeric transcription factor. Arch Biochem Biophys (May), 473(1): 48-60.
- Khan SJ, Yanez G, Seldeen K, Wang H, Lindsay SM, Fletcher TM, Seldeen KL. (2007) Interactions of TRF2 with model telomeric ends. Biochem Biophys Res Commun (Nov), 363(1): 44-50.
Presentations:
- "Mouse models: what they mean for human frailty" AGS19 Annual Scientific Meeting; American Geriatric Society; U13 Conference Recap (2019)
- "Pharmacologic interventions for osteoporosis/frailty/sarcopenia" U13 Bench-to-Bedside Conference Series; National Institutes of Health (NIH) / American Geriatric Society (AGS); Osteoporosis and Soft Tissue (Muscle/Fat) Disorders (2019)
- "Enhancing Healthspan with Nicotinamide Riboside" UB GEM Research Day; UB Genome, Environment, and Microbiome (GEM) Research; Research Talks (2018)
- "Enhancing Healthspan with Nicotinamide Riboside" UB Center for Successful Aging; University at Buffalo Center for Successful Aging; Aging (2018)
- "High and Low Response to High Intensity Interval Training Correlates with Distinct Muscle miRNA‑mRNA profiles" International Conference on Frailty and Sarcopenia Research - Miami; ICFSR; Musculoskeletal aging (2018)
- "Keys to successful aging: Enhancing healthspan with vitamin D and high intensity interval training" Roswell Park Cancer Institute Genetics Seminar Series; Roswell Park Cancer Institute; Cancer (2017)
- "Understanding physical performance within an animal model of vitamin D insufficiency" Weekly Seminar Series - University at Buffalo, Department of Nephrology; University at Buffalo; Nephrology (2017)
- "Why do we age and how do we stop it?" UB CTRC Seminar Series; University at Buffalo; CTRC (2017)
- "Understanding physical performance within an animal model of vitamin D insufficiency" Invited Speaker - Western University of Canada; Western University of Canada; Geriatrics (2016)
- "HIIT exercise improves performance and reduces frailty in aged mice" International Conference on Frailty and Sarcopenia Research - Philadelphia; ICSFR; Oral Communications (2016)
- "Combatting frailty in old mice: Is HIITing them the answer?" Weekly Seminar Series - University at Buffalo, Department of Physical Therapy; University at Buffalo, Department of Physical Therapy (2015)
- "Working Smarter not Harder with High Intensity Interval Training" Department of Medicine Research Day; University at Buffalo, Department of Medicine; Basic Research (2015)
- "Impacts of Vitamin D on exercise and physical performance during aging" Weekly Seminar Series - MIAMI Geriatric Research, Education and Clinical Center (GRECC); Miami GRECC, VA Miami healthcare service and University of Miamii; MIAMI Geriatric Research, Education and Clinical Center (GRECC) (2015)
- "Physical Performance in an Animal Model of Vitamin D Insufficiency" Gerontological Society of American Annual Meeting; GSA; Body Composition (2013)
Service Activities:
- SUNY Senator (alternate) (2021–present)
- VA Institutional Animal Care and Use Committee (IACUC) Chair; Chair (2020–present)