Bruce R. Troen, MD, is professor and chief of the Division of Geriatrics and Palliative Medicine in the Department of Medicine, a physician-investigator with the Western New York VA Healthcare System, and Chief of Geriatric Services at Erie County Medical Center. Dr. Troen is a thought leader in aging-related geroscience and molecular biology and regional leader in geriatric care. He founded and directs the Center of Excellence for Alzheimer's Disease of Western New York and the Center for Successful Aging at the University at Buffalo.
Dr. Troen is a physician-scientist formally trained in geriatrics and molecular biology, a Fellow of the American Geriatrics Society, and has been a VA physician-investigator for more than 30 years. He was recently Co-Chair of the NIA/AGS conference on Osteoporosis and Soft Tissue (Muscle and Fat) Disorders and was honored in 2020 to receive a University at Buffalo Exceptional Scholar – Sustained Achievement Award.
Dr. Troen has several major foci of research: frailty, longevity/aging mechanisms, and osteoporosis, all of which result in great morbidity in older adults. He and his team have been elucidating what interventions can enhance physical performance, mobility, and cognition, particularly in those who are frail. Their study on high intensity interval training was profiled in the New York Times. Dr. Troen is the Principal Investigator or Co-Investigator on biomedical translational grants from the NIH, VA, NY State Department of Health, and the State University of New York.
Education and Training:
Fellowship, Geriatrics, University of Michigan School of Medicine (1990)
Fellowship, Molecular Biology, Laboratory of Molecular Biology, NCI, NIH (1988)
UB Exceptional Scholar Sustained Achievement Award (2020)
Senior Leadership Award, Amherst Senior Citizens Foundation (2018)
American Geriatrics Society Fellow (2015)
Best Paper Award, Biology of Aging - American Geriatrics Society (2002)
Bristol Myers Award for Excellence in Oncology Research (1991)
Research Expertise:
Biology of Aging
Frailty
Geriatrics & Gerontology
Osteoporosis
Vitamin D
Research Centers:
Clinical and Translational Research Center (CTRC)
UB 2020 Strategic Strengths:
Health and Wellness Across the Lifespan
Grants and Sponsored Research:
October 2022–September 2026 High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans Veterans Affairs - RR&D Role: Principal Investigator $1,199,721
October 2021–September 2025 Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans Veterans Affairs - RR&D Role: Co-Investigator $1,199,783
May 2019–April 2024 Enhancing Geroscience Faculty Development and Scholarship in Order to Minimize Frailty and Maximize Healthspan NIH / National Institute of Aging Role: Principal Investigator $750,000
October 2018–September 2023 Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis NIH NIDCR Role: Co-Investigator $1,250,000
July 2019–June 2023 High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging Veterans Affairs Role: Principal Investigator $645,000
January 2019–January 2023 Translational Models to Study Frailty Indian Trail Foundation Role: Principal Investigator $200,000
September 2020–August 2022 The impacts of vitamin D status and HIIT on physical performance and frailty during aging NIA / NIH Role: Principal Investigator $491,000
January 2021–July 2022 Home-based Dual-Task Exercise for Older Adults with Mild Cognitive Impairment UB Clinical Translational Scientific Institute Role: Co-Principal Investigator $37,995
October 2020–June 2022 Promoting Interdisciplinary Approaches to Geroscience Research SUNY Research Seed Grant Program Role: Principal Investigator $40,000
March 2016–May 2022 Center of Excellence for Alzheimer’s Disease State of New York, Department of Health Role: Principal Investigator $2,800,000
May 2019–April 2021 Community-Based Participatory Research for Reducing Medication Harm among Retirees Retirement Research Foundation Role: Co-Investigator $200,000
October 2018–September 2020 Enhancing functional capacity in older adults with short session high intensity interval training Veterans Affairs Role: Principal Investigator $200,000
September 2018–June 2020 Alzheimer’s and related dementias Care improvement Through Data Science Education (ACT-DSE): Custom training for Research National Institutes of Health Role: Co-Investigator $270,000
September 2019–September 2019 Keyence BZ-X800E All-in-One Fluorescence Microscope – ORD Shared Equipment Program Veterans Affairs Role: Principal Investigator $301,070
June 2018–June 2019 Collaborative Drug Safety Management with Frail Elders & Caregivers for Successful Aging University at Buffalo, Innovative Micro-Programs Accelerating Collaboration in Themes (IMPACT) Role: Co-Investigator $35,000
April 2017–March 2018 Exosomal biomarkers as predictors of sarcopenia and frailty in WHI participants University at Buffalo Clinical Translational Scientific Institute Role: Principal Investigator $49,350
November 2015–October 2017 Integrated Therapies to Reduce Threats to Function among Older Patients Managing Cerebrovascular Disease CTSA / NIH Role: Contributor $200,000
August 2015–August 2015 Extracellular Flux Analyzer, ORD Shared Equipment Program Veterans Affairs Role: Principal Investigator $175,024
April 2011–March 2015 Differential impact of resveratorol and resveratrol mimetics upon aging bone Department of Veterans Affairs Role: Principal Investigator $618,780
January 2013–December 2014 Physical performance in an animal model of vitamin D insufficiency Dep;artment of Veterans Affairs Role: Principal Investigator $200,000
November 2010–October 2012 An animal model to study molecular determinants and modulators of aging and age related diseases Indian TRail Foundation Role: Principal Investigator $190,000
Nichols HM, Dababnah S, Troen B, Vezzoli J, Mahajan R, Mazefsky CA. (2020) Racial Disparities in a Sample of Inpatient Youth with ASD. Autism research : official journal of the International Society for Autism Research (Apr), 13(4): 532-538.
Sharikova AV, Quaye E*, Aalinkeel R, Park JY, Maloney MC, Desta H, Thiyagarajan R, Seldeen K, Khmaladze A, Troen B, Schwartz SA and Mahajan SD. (2018) Methamphetamine-induced mitochondrial toxicity is a major determinant of microglial apoptosis. J Neuroimmune Pharmacol (Sep), 13(3): 396-411.
Duque G and Troen BR, Editors. (2022) Osteosarcopenia. Elsevier, London, UK.
Duque G, Fatima M and Zanker J, and Troen BR. (2022) Osteoporosis. In: Osteoporosis. In "Hazzard's Principles of Geriatric Medicine and Gerontology" – 8th edition. McGraw-Hill, New York
Seldeen KL, MacDonald BA, Troen BR. (2022) Frailty: The end of the osteosarcopenia continuum?. In: Frailty: The end of the osteosarcopenia continuum?. In “Osteosarcopenia” (Duque G and Troen BR, Eds.). Elsevier, London, UK, 239-253.
Duque G and Troen BR. (2006) Geriatric Nutrition: The Health Professional’s Handbook. In: Skeletal Aging. Jones and Bartlett, 325-343.
Professional Memberships:
American Society for Bone and Mineral Researh (1996–present)
Gerontological Society of America (1992–present)
American Federation for Aging Research (1991–present)
American Geriatrics Society; Program committee. Chair for the 2010 annual meeting and Vice Chair for the 2009 annual meeting. (1991–present)
Presentations:
"Scientific Communication & Presentation Tips" University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (2022)
"Falls and Their Prevention: A Geriatrics Imperative" University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (2022)
"Approach to the Geriatric Patient: Healthspan & Frailty" Clinical Practice of Medicine II, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (2022)
"Dementia: What You Need To Know" Alzheimer’s Association of Western New York, Buffalo, New York (2021)
"Innovating for Successful Aging" Aging Innovation Challenge, Blackstone LaunchPad, University at Buffalo, Buffalo, NY (2021)
"Healthspan, Frailty, and Cognition–Bedside to Benchtop (and Back?)" Grand Rounds, Medical University of South Carolina, Institute For Healthy Aging and Population Health (2021)
"Approach to the Geriatric Patient - Age Friendly Health System Initiative" City Wide Grand Rounds, Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (2021)
"Promoting Healthy Aging - HIIT: High Intensity Interval Training" Mini-Medical School, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (2021)
"Vitamin D: Skeletal Health and Beyond (Does it Really Matter)?" Geriatric Medicine Grand Rounds, University of Rochester Medical Center, Rochester, NY (2020)
"Vascular Dementia" Alzheimer’s Association of Western New York (2020)
"Frailty and Healthspan: Benchtop to Bedside (and Back?)" Australian Institute for Musculoskeletal Science, Melbourne, Australia (2020)
"Hallmarks of Aging in Muscle, Bone, and Soft Tissue" American Geriatrics Society Annual Scientific Meeting, Portland, OR (2019)
"Clinical phenotypes and targeting" AGS/NIA U13 Bench-to-Bedside Conference - Osteoporosis and Soft Tissue (Muscle/Fat) Disorders, Bethesda, MD (2019)
"Osteoporosis and Soft Tissue (Muscle/Fat) Disorders" AGS/NIA U13 Bench-to-Bedside Conference - Osteoporosis and Soft Tissue (Muscle/Fat) Disorders, Bethesda, MD (2019)
"Why UB, Buffalo, WNY, and the USA Need Aging Innovation" UB Health Sciences and Medical Emeritus Faculty Luncheon, Canterbury Woods, East Amherst, NY (2019)
"Osteoporosis: Falls and Fractures" UB Department of Medicine City Wide Grand Rounds; Jacobs School of Medicine and Biomedical Sciences (2017)
"Endocrinology of Aging" Jacobs School of Medicine and Biomedical Sciences; Jacobs School of Medicine and Biomedical Sciences (2017)
"Falls and Their Prevention: A Geriatrics and Pharmacological Imperative" Public Health Live, NY State Department of Health; University at Albany School of Public Health and the New York Department of Health (2016)
"Healthspan and Frailty: Bedside to Benchtop (and Back?)" Geriatrics Division Grand Rounds, St. Louis University Medical School; St. Louis University School of Medicine; Department of Medicine (2016)
"Healthspan and Frailty: Bones, Muscles, and Aging?" Grand Rounds, Department of Medicine, Western University; Western University (2016)
"Osteoporosis: Thinking Beyond Bone" American Geriatrics Society Annual Scientific Meeting; American Geriatrics Society; Plenary Symposium: That Was The Year That Will Be (2016)
"Falls and Their Prevention: A Geriatrics Imperative" Grand Rounds, Buffalo Psychiatric Center; Buffalo Psychiatric Center (2015)
"Healthspan and Frailty: Bones, Muscles, and Aging?" Grand Rounds, University of Maryland; University of Maryland; Department of Epidemiology and Public Health (2015)
"Frailty and musculoskeletal system: From bench to bedside" International Conference on Frailty & Sarcopenia Research; ; Plenary Symposium: Frailty, Falls, and Fractures: Common Pathophysiology and Therapeutic Approach (2015)
"Healthspan and Frailty: Bedside to Benchtop (and Back)?" City-Wide Grand Rounds Department of Medicine; University At Buffalo; Professor & Chief, Geriatrics & Palliative Medicine (2013)
"Vitamin D: Beyond Skeletal Health - Implications for Frailty" Interprofessional Geriatrics Symposium (2012)
"Multidisciplinary Strategies for Preventing and Managing Osteoporosis in Frail High Risk Elderly in Long Term Care" Gerontological Society of America Annual Meeting; Gerontological Society of America (2011)
"Science of Aging Bone & Medical Management" Gerontological Society of American Annual Meeting; Gerontological Society of American (2011)
"Bone Biology During Aging: Impact on the Development of Osteoporosis and Subsequent Treatment Strategies - Understanding the RANK-RANKL-OPG Pathway & its Importance in Bone Matabolism" American Geriatrics Society Annual Meeting; American Geriatrics Society (2011)
"New Advances in Osteoporosis Therapy in the Very Old, Frail, and Institutionalized Elderly: Reduction in Fractures and Improved Quality of Life" American Geriatrics Society Annual Meeting; American Geriatrics Society (2011)
"Vitamin D: Skeletal Heath and Beyond (A Stealthy Epidemic)" American Geriatrics Society Annual Meeting; American Geriatrics Society (2011)
"Osteoporosis: State of the Art Clinical Updates" American Geriatrics Society Annualk Meeting; American Geriatrics Society (2010)
"Prolongevity Compounds and Aging Bone" Dept. of Medicine Research Conference; University of Texas health ScienceCenter at San Antonio (2010)
"Why Do We Grow Old: Perspectives on the Biology of Aging" American Federation for Aging Research; American Federation for Aging Research (2010)
"Vitamin D and Osteoporosis" VISN8 Ambulatory Care Forum (2009)
"Frailty Syndrome: Assessment, Correlates, and Approach" Division of Aging Grand Rounds; University of Sydney; Nepean Clinical School (2009)
"Osteoporosis in the Nursing HOme: What is the Best Approach?" Consensus Conference ont eh Treatment of Osteoporosis in Long Term Care; Univeristy of Sydney; Nepean Clinical School (2009)