Core Facilities

Molecular Interactions

Mark Sutton, PhD, helps maintain the Molecular Interactions facility, which has instrumentation for acquiring high quality kinetic, affinity and thermodynamic data.

Our facility offers powerful analytical instrumentation used to study macromolecular interactions.

We have instrumentation ideal for acquiring high quality kinetic, affinity and thermodynamic data for biomolecular interactions.

Our facility enables you to achieve direct, label-free measurement of binding affinity and thermodynamics of biomolecules in a single experiment.

Surface plasmon resonance (SPR) is an optical technique for measuring macromolecular interactions in real time. It does not require modification of binding partners, and it provides detailed information about on- and off-rates, as well as stoichiometry.

Isothermal titration calorimetry (ITC) — a technique used in quantitative studies of a wide variety of biomolecular interactions — requires no modification of binding partners, either with fluorescent tags or through immobilization. It measures the affinity of binding partners in their native states, including ligand binding to live cells or to ligand binding sites incorporated into synthetic vesicles or particles.


  • Reichert SR7000DC System Processing Unit surface plasmon resonance based technology for studying biomolecular interactions in real time
  • MicroCal Isothermal Calorimeter quantifies heat released or absorbed in the equilibrium binding of ligand to macromolecule, or the interaction between two macromolecules


Reichert SPR
955 Main Street
Rooms 3130 and 3135
Buffalo, NY 14203

MicroCal ITC
955 Main Street
Rooms 3130
Buffalo, NY 14203

Contact Information

Reichert SPR

Sutton, Mark

Mark Sutton, PhD


955 Main Street, Room 4217 Buffalo, NY 14203

Phone: (716) 829-3581; Fax: (716) 829-2725


MicroCal ITC

Kosman, Daniel

Daniel Kosman, PhD

SUNY Distinguished Professor

653 Biomedical Education Building, 140 Farber Hall (mailing address) Buffalo, NY 14214

Phone: (716) 829-2842; Fax: (716) 829-2661