The Health Sciences Collaborative Core Facilities (HSCCF) provide multipurpose services to the biomedical research community at the University at Buffalo.

This figure is from Ira Blader’s lab; it shows the 3D arrangement of proteins and membranes of Toxoplasma gondii parasites undergoing replication. This image was acquired on the Leica SP8 STED super-resolution confocal microscope.

Panels A through C compare the three-dimensional locations of 3 different components of the parasite (IMC3, ISP1 and a-myc) to the location of the FBOX01 protein.  The volume rendered image shows that FBOX01 protein is an initiation site for these other components. F-box proteins are known to control cell cycle and membrane trafficking and thus are important in the replication of this parasite which is the cause of the disease, toxoplasmosis.