Anthony L. Auerbach PhD
Anthony L. Auerbach
PhD
Professor
Department of Physiology and Biophysics
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Biophysical Modeling; Chemistry - Inorganic and Physical Chemistry; Drug Discovery; Electrophysiology; Ion channel kinetics and structure; Membrane Biophysics; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Neuroscience; Protein Engineering; Protein Function and Structure
Professional Summary:
Synapses are the primary points of communication between cells of the nervous system. Our laboratory is interested in synaptic receptors and ion channels. We study the molecular events that constitute agonist binding, channel activation and receptor desensitization. Our research bridges physiology pharmacology, biochemistry and structural biology, and our experimental approaches include electrophysiology, computational chemistry (MD simulations) and molecular biology. We seek to to understand the molecular operation of receptors and other allosteric membrane proteins in the context of their physiological roles.
CONTACT INFORMATION: auerbach.anthony@gmail.com (716) 510-0793
Education and Training:
- PhD, Neuroscience, University of Oregon (1978)
- BS, Biochemistry, University of California at Santa Barbara (1972)
Employment:
- Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998-present)
- Associate Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–1998)
- Assistant Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1987–1992)
- Research Assistant Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1983–1987)
- Post Doctoral Fellow, Biophysical Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1981–1983)
- Post Doctoral Fellow, Neurobiology, Institute of Neurobiology San Juan, PR Institute of Neurobiology (1978–1981)
Awards and Honors:
- Chancellor's Award for Excellence in Scholarship and Creative Activities (2012)
- Javits Award (2006-2014) (2006)
- SUNY Chancellor's Award for Research (2003)
- Chair, NIH Study Section BSCT (2003)
- SUNY Research Achievement Award (2002)
- Javits Award (1999-2006) (1999)
Research Expertise:
- biophysics: receptors and ion channels
Grants and Sponsored Research:
- June 2009–May 2014
Engineering a Transmitter Binding Site
NIH
Role: Principal Investigator - April 1986–March 2014
Multiple Activity Patterns of Acetylcholine Receptors
NIH
Role: Principal Investigator - September 2017
Desensitization of Nicotinic Acetylcholine Receptors
NIH
Role: Principal Investigator
$1,500,000
Journal Articles:
- Auerbach, Anthony. (2021) Agonists to ions: Efficiency suggests ‘zipper’ mechanism for nicotinic receptor activation. BioRxiv (Dec), 2021.12.18.473297 doi:doi: https://doi.org/10.1101/2021.12.18.473297
- Indurthi D.C., Auerbach A. (2021) Agonist efficiency from concentration-response curves: Structural implications and applications. Biophysical Journal (May), 120(9): 1800-1813. doi:10.1016/j.bpj.2021.02.034
- Auerbach A. (2020) Pathways for nicotinic receptor desensitization. The Journal of general physiology (Oct), 152(10). doi:10.1085/jgp.202012639
- Szigeti K, Ihnatovych I, Birkaya B, Chen Z, Ouf A, Indurthi DC, Bard JE, Kann J, Adams A, Chaves L, Sule N, Reisch JS, Pavlik V, Benedict RHB, Auerbach A, Wilding G. (2020) CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease. EBioMedicine (Sep), 59: 102892. doi:10.1016/j.ebiom.2020.102892
- Nayak TK, Vij R, Bruhova I, Shandilya J, Auerbach A. (2019) Efficiency measures the conversion of agonist binding energy into receptor conformational change. The Journal of general physiology (Apr), 151(4): 465-477. doi:10.1085/jgp.201812215
- Tripathy S, Zheng W, Auerbach A. (2019) A single molecular distance predicts agonist binding energy in nicotinic receptors. The Journal of general physiology (Apr), 151(4): 452-464. doi:10.1085/jgp.201812212
- Ihnatovych I, Nayak TK, Ouf A, Sule N, Birkaya B, Chaves L, Auerbach A, Szigeti K. (2019) iPSC model of CHRFAM7A effect on a7 nicotinic acetylcholine receptor function in the human context. Translational psychiatry (Feb), 9(1): 59. doi:10.1038/s41398-019-0375-z
- Nayak TK, Auerbach A. (2017) Cyclic activation of endplate acetylcholine receptors. Proceedings of the National Academy of Sciences of the United States of America (Nov), 114(45): 11914-11919. doi:10.1073/pnas.1711228114
- Bruhova I, Auerbach A. (2017) Molecular recognition at cholinergic synapses: acetylcholine versus choline. The Journal of physiology (Feb), 595(4): 1253-1261. doi:10.1113/JP273291
- Gupta S, Chakraborty S, Vij R, Auerbach A. (2017) A mechanism for acetylcholine receptor gating based on structure, coupling, phi, and flip. The Journal of general physiology (Jan), 149(1): 85-103. doi:10.1085/jgp.201611673
- Nayak TK, Chakraborty S, Zheng W, Auerbach A. (2016) Structural correlates of affinity in fetal versus adult endplate nicotinic receptors. Nature communications (Apr), 7: 11352. doi:10.1038/ncomms11352
- Auerbach A. (2016) Dose-Response Analysis When There Is a Correlation between Affinity and Efficacy. Molecular pharmacology (Feb), 89(2): 297-302. doi:10.1124/mol.115.102509
- Vij R, Purohit P, Auerbach A. (2015) Modal affinities of endplate acetylcholine receptors caused by loop C mutations. The Journal of general physiology (Nov), 146(5): 375-86. doi:10.1085/jgp.201511503
- Auerbach A. (2015) Activation of endplate nicotinic acetylcholine receptors by agonists. Biochemical pharmacology (Oct), 97(4): 601-608. doi:10.1016/j.bcp.2015.06.024
- Auerbach A. (2015) Agonist activation of a nicotinic acetylcholine receptor. Neuropharmacology (Sep), 96(Pt B): 150-6. doi:10.1016/j.neuropharm.2014.10.004
- Purohit P, Chakraborty S, Auerbach A. (2015) Function of the M1 p-helix in endplate receptor activation and desensitization. The Journal of physiology (Jul), 593(13): 2851-66. doi:10.1113/JP270223
- Nayak TK, Bruhova I, Chakraborty S, Gupta S, Zheng W, Auerbach A. (2014) Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors. Proceedings of the National Academy of Sciences of the United States of America (Dec), 111(49): 17660-5. doi:10.1073/pnas.1414378111
- Purohit P, Bruhova I, Gupta S, Auerbach A. (2014) Catch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutations. Biophysical journal (Jul), 107(1): 88-99. doi:10.1016/j.bpj.2014.04.057
- Nayak TK, Auerbach A, Auerbach AL. (2013) Asymmetric transmitter binding sites of fetal muscle acetylcholine receptors shape their synaptic response. Proc Natl Acad Sci U S A (Aug), 110(33): 13654-13659.
- Auerbach A, Auerbach AL. (2013) The energy and work of a ligand-gated ion channel. J Mol Biol (May), 425(9): 1461-1475.
- Gupta S, Purohit P, Auerbach A, Auerbach AL. (2013) Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor. J Biol Chem (May), 288(18): 12667-12679.
- Purohit P, Auerbach A, Auerbach AL. (2013) Loop C and the mechanism of acetylcholine receptor-channel gating. J Gen Physiol (Apr), 141(4): 467-478.
- Gupta S, Purohit P, Auerbach A, Auerbach AL. (2013) Function of interfacial prolines at the transmitter binding sites of the neuromuscular acetylcholine receptor. J Biol Chem (Mar).
- Bruhova I, Gregg T, Auerbach A,. (2013) Energy for wild-type acetylcholine receptor channel gating from different choline derivatives. Biophys J (Feb), 104(3): 565-574.
- Jadey S, Purohit P, Auerbach A, Auerbach AL. (2013) Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue aG153. J Gen Physiol (Jan), 141(1): 95-104.
- Purohit P, Gupta S, Jadey S, Auerbach A. (2013) Functional anatomy of an allosteric protein. Nature communications (Jan), 4: 2984. doi:10.1038/ncomms3984
- Jadey S, Auerbach A, Auerbach AL. (2012) An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors. J Gen Physiol (Jul), 140(1): 17-28.
- Purohit P, Bruhova I, Auerbach A, Auerbach AL. (2012) Sources of energy for gating by neurotransmitters in acetylcholine receptor channels. Proc Natl Acad Sci U S A (Jun), 109(24): 9384-9389.
- Nayak TK, Purohit PG, Auerbach A, Auerbach AL. (2012) The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel. J Gen Physiol (May), 139(5): 349-358.
- Jha A, Gupta S, Zucker SN, Auerbach A, Auerbach AL. (2012) The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels. J Physiol (Jan), 590(Pt 1): 119-129.
- Auerbach A, Auerbach AL. (2012) Thinking in cycles: MWC is a good model for acetylcholine receptor-channels. J Physiol (Jan), 590(Pt 1): 93-98.
- Jadey SV, Purohit P, Bruhova I, Gregg TM, Auerbach A, Auerbach AL. (2011) Design and control of acetylcholine receptor conformational change. Proc Natl Acad Sci U S A (Mar), 108(11): 4328-4333.
- Purohit P, Auerbach A, Auerbach AL. (2011) Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site. Mol Pharmacol (Mar), 79(3): 351-359.
- Gupta S, Auerbach A, Auerbach AL. (2011) Mapping heat exchange in an allosteric protein. Biophys J (Feb), 100(4): 904-911.
- Gupta S, Auerbach A, Auerbach AL. (2011) Temperature dependence of acetylcholine receptor channels activated by different agonists. Biophys J (Feb), 100(4): 895-903.
- Zheng W, Auerbach A, Auerbach AL. (2011) Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model. PLoS Comput Biol (Jan), 7(1): 1001046-1001046.
- Bruhova I, Auerbach A, Auerbach AL. (2010) Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating. J Biol Chem (Dec), 285(50): 38898-38904.
- Cadugan DJ, Auerbach A, Auerbach AL. (2010) Linking the acetylcholine receptor-channel agonist-binding sites with the gate. Biophys J (Aug), 99(3): 798-807.
- Jha A, Auerbach A. (2010) Acetylcholine receptor channels activated by a single agonist molecule. Biophysical journal (May), 98(9): 1840-6. doi:10.1016/j.bpj.2010.01.025
- Purohit P, Auerbach A. (2010) Energetics of gating at the apo-acetylcholine receptor transmitter binding site. The Journal of general physiology (Apr), 135(4): 321-31. doi:10.1085/jgp.200910384
- Auerbach A, Auerbach AL. (2010) The gating isomerization of neuromuscular acetylcholine receptors. J Physiol (Feb), 588(Pt 4): 573-586.
- Jha A, Purohit P, Auerbach A. (2009) Energy and structure of the M2 helix in acetylcholine receptor-channel gating. Biophysical journal (May), 96(10): 4075-84. doi:10.1016/j.bpj.2009.02.030
- Bafna PA, Jha A, Auerbach A, Auerbach AL. (2009) Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels. J Biol Chem (Mar), 284(13): 8582-8588.
- Purohit P, Auerbach A, Auerbach AL. (2009) Unliganded gating of acetylcholine receptor channels. Proc Natl Acad Sci U S A (Jan), 106(1): 115-120.
- Pollak E, Auerbach A, Talkner P, Auerbach AL. (2008) Observations on rate theory for rugged energy landscapes. Biophys J (Nov), 95(9): 4258-4265.
- Bafna PA, Purohit PG, Auerbach A. (2008) Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap. PloS one (Jun), 3(6): e2515. doi:10.1371/journal.pone.0002515
- Jha A, Cadugan DJ, Purohit P, Auerbach A. (2007) Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. The Journal of general physiology (Dec), 130(6): 547-58. doi:10.1085/jgp.200709856
- Purohit P, Auerbach A, Auerbach AL. (2007) Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker. J Gen Physiol (Dec), 130(6): 559-568.
- Auerbach A, Auerbach AL. (2007) How to turn the reaction coordinate into time. J Gen Physiol (Dec), 130(6): 543-546.
- Purohit P, Auerbach A, Auerbach AL. (2007) Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain. J Gen Physiol (Dec), 130(6): 569-579.
- Cadugan DJ, Auerbach A, Auerbach AL. (2007) Conformational dynamics of the alphaM3 transmembrane helix during acetylcholine receptor channel gating. Biophys J (Aug), 93(3): 859-865.
- Purohit P, Mitra A, Auerbach A, Auerbach AL. (2007) A stepwise mechanism for acetylcholine receptor channel gating. Nature (Apr), 446(7138): 930-933.
- Lema GM, Auerbach A, Auerbach AL. (2006) Modes and models of GABA(A) receptor gating. J Physiol (Apr), 572(Pt 1): 183-200.
- Zhou Y, Pearson JE, Auerbach A, Auerbach AL. (2005) Phi-value analysis of a linear, sequential reaction mechanism: theory and application to ion channel gating. Biophys J (Dec), 89(6): 3680-3685.
- Mitra A, Tascione R, Auerbach A, Licht S. (2005) Plasticity of acetylcholine receptor gating motions via rate-energy relationships. Biophysical journal (Nov), 89(5): 3071-8. doi:10.1529/biophysj.105.068783
- Mitra A, Cymes GD, Auerbach A, Auerbach AL. (2005) Dynamics of the acetylcholine receptor pore at the gating transition state. Proc Natl Acad Sci U S A (Oct), 102(42): 15069-15074.
- Auerbach A, Zhou Y, Auerbach AL. (2005) Gating reaction mechanisms for NMDA receptor channels. J Neurosci (Aug), 25(35): 7914-7923.
- Auerbach A, Auerbach AL. (2005) Gating of acetylcholine receptor channels: brownian motion across a broad transition state. Proc Natl Acad Sci U S A (Feb), 102(5): 1408-1412.
- Chakrapani S, Auerbach A. (2005) A speed limit for conformational change of an allosteric membrane protein. Proceedings of the National Academy of Sciences of the United States of America (Jan), 102(1): 87-92. doi:10.1073/pnas.0406777102
- Mitra A, Bailey TD, Auerbach AL. (2004) Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating. Structure (Camb) (Oct), 12(10): 1909-1918.
- Popescu G, Robert A, Howe JR, Auerbach A. (2004) Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature (Aug), 430(7001): 790-3.
- Popescu G, Auerbach A. (2004) The NMDA receptor gating machine: lessons from single channels. Neuroscientist (Jun), 10(3): 192-198.
- Chakrapani S, Bailey TD, Auerbach A. (2004) Gating dynamics of the acetylcholine receptor extracellular domain. The Journal of general physiology (Apr), 123(4): 341-56. doi:10.1085/jgp.200309004
- Chakrapani S, Bailey TD, Auerbach A. (2003) The role of loop 5 in acetylcholine receptor channel gating. The Journal of general physiology (Nov), 122(5): 521-39. doi:10.1085/jgp.200308885
- Auerbach A. (2003) Life at the top: the transition state of AChR gating. Science's STKE : signal transduction knowledge environment (Jun), 2003(188): re11.
- Popescu G, Auerbach A. (2003) Modal gating of NMDA receptors and the shape of their synaptic response. Nature neuroscience (May), 6(5): 476-83.
- Popescu G, Auerbach A. (2003) Modal gating of NMDA receptors and the shape of their synaptic response. Nature Neuroscience (Apr).
- Elenes S, Auerbach A. (2002) Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. The Journal of physiology (Jun), 541(Pt 2): 367-83. doi:10.1113/jphysiol.2001.016022
- Elenes S, Auerbach A. (2002) Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. J Physiol (Jun), 541(Pt 2): 367-383.
- Cymes GD, Grosman C, Auerbach A. (2002) Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry (Apr), 41(17): 5548-5555.
- Cymes GD, Grosman C, Auerbach A. (2002) Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry (Apr), 41(17): 5548-55.
- Auerbach A, Auerbach AL. (2002) Acetylcholine receptors, between closed and open. Novartis Found Symp (Jan), 245: 223-234.
- Grosman C, Auerbach A. (2001) The dissociation of acetylcholine from open nicotinic receptor channels. Proc Natl Acad Sci U S A (Nov), 98(24): 14102-14107.
- Zhu Y, Auerbach A. (2001) Na(+) occupancy and Mg(2+) block of the n-methyl-d-aspartate receptor channel. J Gen Physiol (Mar), 117(3): 275-286.
- Zhu Y, Auerbach A. (2001) K(+) occupancy of the N-methyl-d-aspartate receptor channel probed by Mg(2+) block. J Gen Physiol (Mar), 117(3): 287-298.
- Qin F, Auerbach A, Sachs F. (2000) A direct optimization approach to hidden Markov modeling for single channel kinetics. Biophys J (Oct), 79(4): 1915-1927.
- Qin F, Auerbach A, Sachs F. (2000) Hidden Markov modeling for single channel kinetics with filtering and correlated noise. Biophys J (Oct), 79(4): 1928-1944.
- Grosman C, Salamone FN, Sine SM, Auerbach A. (2000) The extracellular linker of muscle acetylcholine receptor channels is a gating control element. J Gen Physiol (Sep), 116(3): 327-340.
- Grosman C, Auerbach A. (2000) Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants. J Gen Physiol (May), 115(5): 621-635.
- Grosman C, Auerbach A. (2000) Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist. J Gen Physiol (May), 115(5): 637-651.
- Grosman C, Zhou M, Auerbach A. (2000) Mapping the conformational wave of acetylcholine receptor channel gating. Nature (Feb), 403(6771): 773-776.
- Akk G, Auerbach A. (1999) Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists. Br J Pharmacol (Dec), 128(7): 1467-1476.
- Zhou M, Engel AG, Auerbach A. (1999) Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. Proc Natl Acad Sci U S A (Aug), 96(18): 10466-10471.
- Salamone FN, Zhou M, Auerbach A. (1999) A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. J Physiol (Apr), 516 (: 315-330.
- Akk G, Zhou M, Auerbach A. (1999) A mutational analysis of the acetylcholine receptor channel transmitter binding site. Biophys J (Jan), 76(1 Pt): 207-218.
- Auerbach A, Akk G. (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. J Gen Physiol (Aug), 112(2): 181-197.
- Chen J, Auerbach A. (1998) A distinct contribution of the delta subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segment. Biophys J (Jul), 75(1): 218-225.
- Premkumar LS, Auerbach A. (1997) Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns. J Gen Physiol (Nov), 110(5): 485-502.
- Wang HL, Auerbach A, Bren N, Ohno K, Engel AG, Sine SM. (1997) Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation. J Gen Physiol (Jun), 109(6): 757-766.
- Qin F, Auerbach A, Sachs F. (1997) Maximum likelihood estimation of aggregated Markov processes. Proc R Soc Lond B Biol Sci (Mar), 264(1380): 375-383.
- Qin F, Auerbach A. (1997) (Feb), 109(2): 181-189.
- Akk G, Sine S, Auerbach A. (1996) Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. J Physiol (Oct), 496 (: 185-196.
- Auerbach A, Sigurdson W, Chen J, Akk G. (1996) Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors. J Physiol (Jul), 494 (: 155-170.
- Akk G, Auerbach A. (1996) Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophys J (Jun), 70(6): 2652-2658.
- Premkumar LS, Auerbach A. (1996) Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel. Neuron (Apr), 16(4): 869-880.
- Qin F, Auerbach A, Sachs F. (1996) Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys J (Jan), 70(1): 264-280.
- Chen J, Zhang Y, Akk G, Sine S, Auerbach A. (1995) Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophys J (Sep), 69(3): 849-859.
- Zhang Y, Auerbach A. (1995) Kinetic properties of NMDA receptors in embryonic Xenopus spinal neurons. J Neurophysiol (Jul), 74(1): 153-161.
- Gao J, Chou LW, Auerbach A. (1993) The nature of cation-pi binding: interactions between tetramethylammonium ion and benzene in aqueous solution. Biophys J (Jul), 65(1): 43-47.
- Auerbach A. (1993) A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating. J Physiol (Feb), 461: 339-378.
- Auerbach A. (1991) Single-channel dose-response studies in single, cell-attached patches. Biophys J (Sep), 60(3): 660-670.
- Davidson RM, Tatakis DW, Auerbach AL. (1990) Multiple forms of mechanosensitive ion channels in osteoblast-like cells. Pflugers Arch (Aug), 416(6): 646-651.
- Auerbach A, Lingle CJ. (1987) Activation of the primary kinetic modes of large- and small-conductance cholinergic ion channels in Xenopus myocytes. J Physiol (Dec), 393: 437-466.
- Auerbach A, Lingle CJ. (1986) Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes. J Physiol (Sep), 378: 119-140.
- Auerbach A, Sachs F. (1984) Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts. Biophys J (Jan), 45(1): 187-198.
- Auerbach A, del Castillo J, Specht PC, Titmus M. (1983) Correlation of agonist structure with acetylcholine receptor kinetics: studies on the frog end-plate and on chick embryo muscle. J Physiol (Oct), 343: 551-568.
- Lingle C, Auerbach A. (1983) Comparison of excitatory currents activated by different transmitters on crustacean muscle. I. Acetylcholine-activated channels. J Gen Physiol (Apr), 81(4): 547-569.
- Auerbach A, Sachs F. (1983) Flickering of a nicotinic ion channel to a subconductance state. Biophys J (Apr), 42(1): 1-10.
- Lingle C, Auerbach A. (1983) Comparison of excitatory currents activated by different transmitters on crustacean muscle. II. Glutamate-activated currents and comparison with acetylcholine currents present on the same muscle. J Gen Physiol (Apr), 81(4): 571-588.
- Auerbach A, Barker DL. (1981) [(3)H]Choline uptake and metabolism in nonsynaptic regions of a crustacean sensory nerve. J Neurochem (May), 36(5): 1648-1658.
- Sachs F, Auerbach A. (1900) Single-channel electrophysiology: use of the patch clamp. Methods Enzymol (Jan), 103: 147-176.
- Auerbach A, Sachs F, Neil J, McGarrigle R. (1900) Temperature measurement and control of small volumes: applications for single channel recording. Methods Enzymol (Jan), 124: 190-206.
- Kumari, Monika Khatoon, Nadira Sharma, Rachita Adusumilli, Sushanth Auerbach, Anthony Kashyap, Hemant K Nayak, Tapan. (1900) Hydrophobic gating of the acetylcholine receptor channel pore. Proceeding of the National Academy of Sciences (USA) (Jan)
- Auerbach A. (1900) Acetylcholine receptors, between closed and open. Novartis Found Symp (Jan), 245: 223-234.
- del Castillo J, Specht P, Auerbach A. (1900) Automatic control of potential and agonist-induced current across the endplate membrane by drug electrophoresis. J Neurosci Res (Jan), 8(1): 35-48.
- Auerbach A, Sachs F. (1900) Patch clamp studies of single ionic channels. Annu Rev Biophys Bioeng (Jan), 13: 269-302.
- Anthony Auerbach. (1900) Agonists to ions: Efficiency suggests ‘zipper’ mechanism for nicotinic receptor activation. BioRxiv (Jan)
Professional Memberships:
- Society for Neuroscience
- Biophysical Society
Presentations:
- "Lectures on agonist efficiency" YouTube presentation (2022)
- "Agonist Efficiency" Departmental Seminar; Bioelectricity; University of Texas (2021)
- "Agonist Efficiency" Departmental Seminar; Physiology; University Washington (2021)
- "Agonist Efficiency and a Zipper Mechanism for Receptor Conformational Change" Departmental Seminar; Theoretical and Computational Biophysics Seminar Series; University of Illinois, Urbana Champaign (2021)
- "Agonist Efficiency: Zipping up the AChR" Symposium: Structural Dynamics of Ion Channels and Receptors (2021)
- "Acetylcholine Receptors" Departmental Seminar; Temple University (2019)
- "Acetylcholine Receptors" Ion Channel Biophysics Conference; Telluride (2019)
- "Acetylcholine Receptors" LGIC Conference (2019)
- "Acetylcholine Receptors" Seminar; GlaxoSmithKline (2019)
- "Acetylcholine Receptors" Departmental Seminar; Univ. Pennsylvania (2019)
- "Acetylcholine Receptors" Department Seminar; Columbia University (2019)
- "Acetylcholine Receptors" Departmental Seminar; University of Texas (2019)
- "Acetylcholine Receptors" Departmental Seminar; Univ College of London (2019)
- "Acetylcholine Receptors" Departmental Seminar; Univ. Wisconsin (2019)
- "Acetylcholine Receptors" Departmental Seminar; University at Buffalo (2019)
- "Acetylcholine Receptors" Departmental Seminar; Department of Physics; University at Buffalo (2018)
- "Acetylcholine Receptors" Departmental Seminar; Univ. Pittsburgh (2018)
- "Acetylcholine Receptors" Departmental Seminar; Yale Univ. (2017)
- "Acetylcholine Receptors" Departmental seminar; Chemistry; Duquene Univ. (2015)
- "Acetylcholine Receptors" Biophysical Society Membrane Biophysics Symposium (2015)
- "Acetylcholine Receptors" Ionotropic Glutamate Receptors Retreat; University at Albany (2015)
- "Acetylcholine Receptors" iGluR annual meeting; Univ Miami (2014)
- "Acetylcholine Receptors" Departmental University; Dept. Physiology; Case Western Reserve Univ. (2014)
- "Acetylcholine Receptors" Symposium on Allosteric Interactions and Biological Regulation; Pasteur Institute (2013)
- "Acetylcholine Receptors" Membrane Protein Structural Dynamics Symposium; Chicago, IL (2012)
- "Acetylcholine Receptors" Departmental Seminar; Chemistry; University at Buffalo (2012)
- "Acetylcholine Receptors" Departmental Seminar; Physiology and Biophysics; Cornell Weill (2012)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; Einstein Medical College (2012)
- "Ion Channels Molecular Machines" Telluride Workshops (2011)
- "Nicotinic Receptors" Wellcome Trust Meeting; Pharmacology; Univ. College London (2011)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; Univ. Miami (2010)
- "Acetylcholine Receptors" Departmental Seminar; Pasteur Institute (2010)
- "Acetylcholine Receptors" Computational Biology and Molecular Biophysics; Washington University (2010)
- "Acetylcholine Receptors" University at Buffalo Neuroscience (2010)
- "Acetylcholine Receptors" Single Molecules of Physiology IUPS Symposium; Kyoto, Japan (2009)
- "Acetylcholine Receptors" Society for Neuroscience Symposium; Ligand Gated Ion Channels (2009)
- "Acetylcholine Receptors" Biochemistry and Molecular Biology; Kyung Hee University (2009)
- "Acetylcholine Receptors" J. Physiology Symposium; Cys-loop ligand gated ion channels (2009)
- "Acetylcholine Receptors" Seminar; Hauptmann-Woodward Institute (2009)
- "Acetylcholine Receptors" Departmental Seminar; Molecular and Computational Biology; Univ. Southern California (2008)
- "Acetylcholine Receptors" Chair; Biophysical Society Symposium; Allosteric Proteins (2008)
- "Acetylcholine Receptors" XIII International Symposium on Cholinergic Mechanisms (2008)
- "Acetylcholine Receptors" American Chemical Society National Meeting; Symposium Speaker (2007)
- "Acetylcholine Receptors" Departmental Distinguished Speaker Series; University California at Davis (2007)
- "Acetylcholine Receptors" Departmental Seminar; Chemical Engineering; University at Buffalo (2007)
- "Acetylcholine Receptors" Roswell Park Cancer Institute; Molecular Genetics (2007)
- "Acetylcholine Receptors" Keystone Conference; Ion Channel Biophysics; invited speaker (2007)
- "Acetylcholine Receptors" Departmental Seminar; Physics; University of Maine (2007)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Yale University (2007)
- "Acetylcholine Receptors" Departmental Seminar; Physics; University at Buffalo (2007)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Univ California San Diego (2006)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacy; Univ California San Francisco (2006)
- "Acetylcholine Receptors" Departmental Seminar; Neurobiology; Univ California Berkley (2006)
- "Acetylcholine Receptors" Departmental Seminar; Biophysics; Cornell University (2006)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Emory University (2006)
- "Acetylcholine Receptors" Departmental Seminar; Chemistry; Brandeis University (2006)
- "Acetylcholine Receptors" Gordon Research Conference; Invited Speaker (2006)
- "Acetylcholine Receptors" University of Puerto Rico del Castillo Symposium (2005)
- "Acetylcholine Receptors" International Conference on Basic and Systemic Mechanisms of Anesthesia (2005)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; Cornell University (2005)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; Univ Wisconsin (2005)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Boston University (2004)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Univ Miami (2004)
- "Acetylcholine Receptors" Chair; FASEB Membrane Biophysics (2004)
- "Acetylcholine Receptors" Departmental Seminar; Molecular and Cellular Physiology; Stanford University (2003)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; Univ Pennsylvania (2003)
- "Acetylcholine Receptors" Seminar; Neuroscience; NIH (2003)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; Univ Alabama (2002)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; Univ Virginia (2002)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; Woods Hole (2002)
- "Acetylcholine Receptors" Departmental Seminar; Cell Molecular Physiology; University Chicago (2002)
- "Acetylcholine Receptors" IUPAC Symposium on Bioorganic Reaction Mechanisms; Cornell University Medical Center (2002)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; Brown University (2002)
- "Acetylcholine Receptors and Neuromuscular Junction: From Atoms to Synapse" Biophysical Society Symposium; Chair (2002)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Cornell University Medical Center (2001)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; SUNY Downstate (2001)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology/Phys; UMDNJ (2001)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; Baylor University (2001)
- "Acetylcholine Receptors" Departmental Seminar; Walter and Eliza Hall Institute of Medical Research (2001)
- "Acetylcholine Receptors" Departmental Seminar; Structural Biology; Univ. California San Francisco (2001)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; Univ. California Santa Barbara (2001)
- "Acetylcholine Receptors" Departmental Seminar; Center for Research on Occupational and Environmental Toxicology; Oregon Health and Science University (2001)
- "Acetylcholine Receptors" Departmental Seminar; Neurobiology; Harvard Univ. (2001)
- "Biological Physics of Ion Transport" 4th International Conference on Biological Physics (2001)
- "Bridging the Gap Between Structural and Molecular Biology" American Microscopy Society Annual Meeting (2001)
- "Ion Channels - From Atomic Resolution to Functional Genomics" Novartis Symposium; London (2001)
- "Ligand Binding and Molecular Recognition" Gordon Research Conference (2001)
- "Acetylcholine Receptors" Ontario and WNY Ion Channel Interest Group Conference (2000)
- "Acetylcholine Receptors" Departmental Seminar; Phamacology; Southern Illinois University (2000)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; CalTech (2000)
- "Acetylcholine Receptors" Departmental Seminar; Anesthesiology; Univ. California Los Angeles (2000)
- "Acetylcholine Receptors" Departmental Seminar; Anesthesiology; Washington Univ. (2000)
- "Acetylcholine Receptors" Departmental Seminar; Chemistry; Marquette University (2000)
- "Acetylcholine Receptors" Departmental Seminar; Neurobiology; Salk Institute (2000)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Univ. California San Diego (2000)
- "Acetylcholine Receptors" Departmental Seminar; Physiology and Biophysics; SUNY Stony Brook (2000)
- "Acetylcholine Receptors" Departmental Seminar; Neurology; University of Oxford (2000)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; University College London (2000)
- "Acetylcholine Receptors" Departmental Seminar; Molecular Biology; University of Cambridge (2000)
- "Acetylcholine Receptors" Departmental Seminar; Biology; University of Maryland (2000)
- "Ion Channels" Gordon Research Conference (2000)
- "Acetylcholine Receptors" Departmental Seminar; Center for Molecular Recognition; Columbia University (1999)
- "Acetylcholine Receptors" Departmental Seminar; Physiology and Biophysics; Univ. Washington (1999)
- "Acetylcholine Receptors" Departmental Seminar; Neurobiology, Pharmacology and Physiology; Univ. Chicago (1999)
- "Acetylcholine Receptors" Departmental Seminar; Neuroscience; Albert Einstein College of Medicine (1999)
- "Acetylcholine Receptors" Departmental Seminar; Physiology and Biophysics; University of Miami (1998)
- "Acetylcholine Receptors" Departmental Seminar; Biophysics; Johns Hopkins (1998)
- "Acetylcholine Receptors" Departmental Seminar; Molecular Biophysics and Physiology; Rush Univ. (1998)
- "Membrane Proteins" Symposium on Membrane Proteins; Hauptmann-Woodward Institute (1998)
- "Acetylcholine Receptors" Departmental Seminar; Physiology; University of Massachusetts (1997)
- "Acetylcholine Receptors" Departmental Seminar; Pharmacology; Cornell University (1997)
- "Channel Analysis Techniques" Biophysical Society Symposium (1996)
- "Ion Channels" Gordon Research Conference (1996)
- "Acetylcholine Receptors" Departmental Seminar; Physiology and Biophysics; Mayo Foundation (1995)
- "Molecular Biophysics of Ion Channels" Tanaguchi Symposium; Nagoya, Japan (1994)
Service Activities:
- NIH; MDCN-3; biophysics of ion channels, synapses, and transporters;; Chair (2003–2005)