James D. Reynolds MD

James Reynolds

James D. Reynolds
MD

Jerald and Ester Bovino Professor & Chairman

Department of Ophthalmology

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Ophthalmology; Pathophysiology; Pediatric Ophthalmology; Retina; Vision science

Contact Information
Ross Eye Institute
1176 Main Street
Buffalo, New York 14209
Phone: 716-881-7900
Fax: 716-887-2990
jreynold@buffalo.edu
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Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Overview Research Publications Activities Latest News

Professional Summary:

Dr. Reynolds has various research interests in pediatric ophthalmology, but his main niche is retinopathy of prematurity. ROP is a disease of the developing immature retinal vasculature, modulated by hyperoxia/hypoxia micro environments in the retina, which can lead to neovascularization, scarring, and potential blindness. Dr. Reynolds is a recognized expert in the field and is the author of many peer reviewed articles and several invited review chapters. His NIH funding has been nearly continuous while at U.B. while participating in several multi-center clinical trials in ROP as center P.I. and project director.

Dr. Reynolds was the center P.I. at U.B. for the first large treatment trial for ROP, CRYO-ROP. This trial established the first known effective treatment for this high socioeconomic impact disease. As center P.I. he participated in the group collaborative publications as well as co authoring many individually by-lined papers (Ref. 22, 23, 24, 25, 26, 28, 29, 31, 32, 37, 40, 42). His successful and productive work as a center P.I. on this trial led to the funding for the LIGHT-ROP multi-center trial for which he served as project director and lead P.I. This trial definitively answered a long debated hypothesis in ROP i.e. that ambient light was not a causal factor in ROP (Ref. 38, 41, 45, 47). Dr. Reynolds was again selected as a center P.I. for the next large multi-center ROP trial, ET-ROP, which just reported its primary results demonstrating that earlier laser treatment for this disease was effective.

Although all multi-center clinical trials are cooperative agreements at the NIH and thus are funded as UO1s rather than RO1s, Dr. Reynolds was an integral participant in all the ROP trials from the mid-eighties to the present, leading one, and actively co-authoring many of the studies?publications as noted in the bibliography. The future of Dr. Reynolds?ROP research will undoubtedly involve more funded multi-center trials. However, a basic science collaboration into the pathophysiology of ROP in an animal model is planned, investigating the renin-angiotension connection.

Education and Training:
  • Fellowship, Pediatric Ophthalmology, University of Pittsburgh (1982)
  • Ophthalmology, SUNY/Buffalo (1981)
  • MD, SUNY/Buffalo (1978)
  • BA, Biology, SUNY/Buffalo (1974)

Employment:
  • Professor and Chair, Ophthalmology, State University of New York at Buffalo (1998-present)
  • Associate Professor, Ophthalmology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1988–1998)
  • Associate Professor, Ophthalmology, University of Arkansas for Medical Sciences (1987–1988)
  • Assistant Professor, Ophthalmology, University of Arkansas for Medical Sciences (1983–1987)

Awards and Honors:
  • Named to Business First 2008 Healthcare 50 (2008)
  • Vision of Light Award for Distinguished Service (1996)
  • WNY Top Doctors. Spree Magazine
  • America‘s Top Doctors

Research Centers:
  • Ira G. Ross Eye Institute Research Center

Grants and Sponsored Research:
  • January 2015–January 2021
    Novartis RAINBOW Trial
    Novartis
    Role: Contributor
  • January 2009–January 2016
    Research to Prevent Blindness Unrestricted Grant
    Research to Prevent Blindness
    Role: Principal Investigator
    $860,000
  • January 2013–January 2015
    G-ROP NIH Multicenter Trial
    NIH
    Role: Co-Investigator
  • September 2000–June 2006
    Women‘s Health Initiative - Sight Exam (WHI-SE)
    University of California-Wyeth Ayerst Pharmaceutical Co.
    Role: Co-Investigator
    $194,330
  • June 2000–September 2004
    Early Treatment for Retinopathy of Prematurity (ETROP)
    NIH
    Role: Co-Principal Investigator
    $147,454
  • April 1995–April 1999
    Multicenter Trial of Cryotherapy for Retinopathy of Prematurity
    NIH
    Role: Co-Principal Investigator
    $280,155
  • April 1995–April 1999
    LIGHT-ROP Multicenter Trial
    NIH
    Role: Principal Investigator
    $1,657,754
  • June 1993–May 1996
    CRYO-ROP Phase III - Randomized Infants
    NIH
    Role: Co-Principal Investigator
    $25,926
  • January 1991–December 1991
    Feasibility and Outcome of Goggle Light Reduction in Low Birth Weight Premature Infants
    Women and Children‘s Health Research Foundation
    Role: Principal Investigator
    $14,000
  • January 1990–December 1990
    Fetal Ocular Blood Flow and Retinal Anti-oxidant Physiology Under Hyperbaric Conditions
    American Legion Auxiliary - State President’s Project
    Role: Co-Investigator
    $9,000

Journal Articles:

See all (42 more)

Books and Book Chapters:

  • James D Reynolds MD, Andrew L Reynolds MD. (2019) UpToDate. In: Overview of glaucoma in infants and children. UpToDate Inc
  • James D Reynolds MD, Andrew L Reynolds MD. (2019) UpToDate. In: Primary infantile glaucoma. UpToDate Inc
  • Reynolds JD. (2011) Retinopathy of Prematurity. Springer-Verlag Berline Heidelberg.
  • Reynolds JD. (2005) Harley‘s Pediatric Ophthalmology. In: Retinopathy of Prematurity. Lippincott Williams & Wilkins, 67-83.
  • James Reynolds. (1996) In: Retinopathy of Prematurity. , 149-159.
  • James Reynolds. (1995) In: Pediatric Glaucoma. , 393-408.

Professional Memberships:
  • Association for Research in Vision and Ophthalmology (1983–present)
  • American Academy of Ophthalmology (1983–present)
  • American Association of Pediatric Ophthalmology and Strabismus (1983–present)
  • American Ophthalmological Society
  • Buffalo Ophthalmologic Society
  • Erie County Medical Society
  • New York State Medical Society

Presentations:
  • "“Beyond the ICROP Classification, The Search for Consistency." Al Biglan Annual Lecture; University of Pittsburgh Medical Center (2017)
  • "“Beyond the International Classification: A Search for Consistency”. “Anti-VEGF Treatment for ROP: Which Patients? What Drug? What Dose? What Worries?" SUNY Downstate Medical Center 45th Annual Ophthalmology Alumni Meeting; SUNY Downstate Medical Center Ophthalmology Alumni (2017)
  • "Beyond the ICROP Classification, The Search for Consistency" Annual Buffalo Ophthalmology Symposium (2017)
  • "“Visual Literacy: The Art of Science or the Science of Art”" Visual Literacy and Perception in the Contemporary World; Ontario College of Art and Design University (2017)
  • "“The Eye in Childhood”" Association of Technical Personnel in Ophthalmology (ATPO) 14th Annual Buffalo Conference; Association of Technical Personnel in Ophthalmology (ATPO) (2016)
  • "“Update on ROP”" ; University of Michigan, Kellogg Eye Center (2016)
  • "“Acute onset esotropia”" 3rd World Congress of Paediatric Ophthalmology and Strabismus; Paediatric Ophthalmology and Strabismus (2015)
  • "Anti-VEGF treatment of ROP: which drug and why?" 3rd World Congress of Paediatric Ophthalmology and Strabismus; Paediatric Ophthalmology and Strabismus (2015)
  • "Update on ROP" Knights Templar Foundation Lecture at Emory University; Knights Templar Foundation (2014)
  • "Insights in ROP" AACO Annual Meeting 2013; Richard G. Scobee Memorial Lecture (2013)
  • "VEGF – Inhibitors and ROP" Grand Rounds. SUNY/Downstate; SUNY/Downstate (2013)
  • "ROP-Consensus, Questions, and Possible Solutions: A Model for Cooperative Interactions Across the SEI" 4th Annual SEI Meeting; SUNY Eye Institute (2012)
  • "Bevacizumab and ROP" Edward S. Harkness Eye Institute Grand Rounds and Seminar Series; Edward S. Harkness Eye Institute (2012)
  • "Tips for the Medical Expert" AAPOS Annual Meeting 2012; AAPOS (2012)
  • "What Every Pediatrician Should Know" Children’s Mercy Hospitals & Clinics; Children’s Mercy Hospitals & Clinics (2012)
  • "Bevacizumab and ROP" Combined American Academy of Ophthalmology Annual Meeting and American Association of Certified Orthoptists; American Academy of Ophthalmology Annual Meeting (2011)
  • "Bevacizumab and ROP" American Academy of Ophthalmology Annual Meeting; American Academy of Ophthalmology and American Associaton of Certified Orthoptists (2011)
  • "Examiner Consistency and its Implications for ROP Screening" Hot Topics in ROP Meeting (2010)
  • "Refractive Error as a Clue to Diagnosis of Ocular and Systemic Disease" American Academy of Ophthalmology Annual Meeting (2010)
  • "Retinopathy of Prematurity" American Academy of Family Physicians FP Audio Program (2010)
  • "ROP: A Cautionary Tale. What we know and what we think we know." American Academy of Ophthalmology Annual Meeting; American Academy of Ophthalmology (2009)
  • "The Treatment of ROP" American Academy of Ophthalmology Annual Meeting (2009)
  • "Wright Mini-Tenotomy to Treat Diplopia Associated with Small ANgle Strabismus" American Ophthalmological Society Annual Meeting (2009)
  • "ROP and Oxygen: Changing NICU Practices?" Pediatric Subspecialty Day, American Academy of Ophthalmology Annual Meeting (2008)
  • "Understanding, Preventing, and Treating Diabetic Retinopathy" University at Buffalo Mini Med School (2008)
  • "Exotropia: The Reality Workshop Part I" American Association of Certified Orthoptists National Meeting (2007)
  • "New Insights into Retinopathy of Prematurity" Annual Buffalo Ophthalmology Conference (2005)
  • "New Insights into Retinopathy of Prematurity" The 50th Annual Ophthalmology Conference, University of Rochester (2005)
  • "Update on ROP" American Association of Certified Orthoptists National Meeting; American Association of Certified Orthoptists (2003)
  • "Incidence of Serverity of Retinopathy of Prematurity in Vietnam, a Developing Middle Income Country" Annual Buffalo Ophthalmology Symposium; University at Buffalo (2003)
  • "Nursery Lighting and its Impact on the Premature Infant" 61st Annual Perinatal and Developmental Medicine Symposium; Mead Johnson Corporation (2002)
  • "Current Research in Retinopathy of Prematurity" Association of Technical Personnel in Ophthalmology Annual Meeting (2002)
  • "Advances in Pediatric Glaucoma" Association of Technical Personnel in Ophthalmology Annual Meeting; Association of Technical Personnel in Ophthalmology (2001)
  • "Bevacizumab and ROP" American Academy of Ophthalmology Annual Meeting; American Academy of Ophthalmology and American Association of Certified Orthoptists (2001)
  • "Light Reduction on Retinopathy of Prematurity" Johns Hopkins University Annual Meeting; Johns Hopkins University (2001)
  • "1)Metabolic & Physiologic Bsis of Visual Development. 2) ROP: Light and Vision. 3) The NICU: Prematurity & Light. 4) Design and Lighting." University of South Florida College of Medicine; University of South Florida College of Medicine (2000)
  • "The Pre-Term Retina" Department of Physiology Seminar Series, SUNY/Buffalo (2000)
  • "1) Screeing for Retinopathy of Prematurity. 2) Atypical Strabismus-Tumor or Benign. 3) Superior Oblique Palsy. 4) Potpourri Pediatric Pearls." 50th Annual Post-Graduate Review Course: Ophthalmology SUNY Health Science Center, Syracuse (1999)
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Contact Information

Ross Eye Institute
1176 Main Street
Buffalo, New York 14209
Phone: 716-881-7900
Fax: 716-887-2990
jreynold@buffalo.edu
View map

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD
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