Jun-Xu Li MD, PhD
Jun-Xu Li
MD, PhD
Associate Professor
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Behavioral pharmacology; Drug abuse; Neurobiology
Professional Summary:
I have two primary research interests. First, I use pharmacological approaches to seek novel therapeutics for pain. Pain is an agonizing symptom and disease that affects millions of people. Analgesics like opioids (e.g., OxyContin) are powerful for treating many pain conditions. However, opioids are not efficacious for some pain (e.g., neuropathic pain) and prolonged use of opioids has many side effects, including tolerance and dependence. My research has found that drugs acting on imidazoline I2 receptors may produce analgesic effects that are devoid of opioid-like side effects. I am continuing this line of research to further delineate the pharmacological properties of these drugs--how they work, how effective and safe they are, and how long the beneficial effects last--as a novel class of analgesics.
Second, I am interested in pharmacotherapy of stimulant abuse. Stimulants represent a large family of abused drugs, including traditional drugs of abuse such as cocaine and methamphetamine (“meth”) and valuable pharmacotherapies such as Adderall and Ritalin. Stimulant abuse and addiction remain challenging problems that lack FDA-approved pharmacotherapies. We use powerful behavioral pharmacological approaches, in animal models that are predictive of human stimulant abuse conditions, to study novel drug targets and evaluate potential pharmacotherapeutic treatments.
One unifying theme of the ongoing research in my laboratory is the application of receptor theory to the guidance and interpretation of the drug interactions in behaving animals. The long-term goal of my laboratory is to develop new analgesics for pain control and pharmacotherapeutics for stimulant addiction.
Education and Training:
- Postdoctoral Fellow, Behavioral Pharmacology, University of Texas Health Science Center at San Antonio (2008)
- PhD, Pharmacology, Peking University (2005)
- MD, Medicine, Binzhou Medical University (2000)
Employment:
- Assistant Professor, University at Buffalo (2010–2016)
- Instructor, Pharmacology, University of Texas Health Science Center at San Antonio, Graduate School of Biomedical Sciences (2008–2010)
Awards and Honors:
- CPDD Joseph Cochin Young Investigator Award (2016)
- UB Exceptional Scholar-Young Investigator Award (2014)
- Maharaj Ticku Memorial Travel Fellowship (2012)
- ASPET Young Scientist Travel Award (2009)
- ASPET Best Paper Award (2009)
- CPDD Early Career Investigator Award (2007)
- ASPET Young Scientist Travel Award (2007)
Research Expertise:
- Behavioral Pharmacology: We use various behavioral pharmacological procedures to understand how drugs work at the behavioral level. Procedures used include drug discrimination, schedule-controlled responding, drug self-administration, delay discounting, place conditioning, locomotor activity and various acute and chronic pain tests.
- Pain and Addiction: We are interested in understanding the neurobiological crosstalk between pain and addiction. To reach this goal, we are developing novel behaivoral procedures to simultaneously measure pain affect and addiction-related behaviors.
- Quantitative Pharmacological Analysis: The precise understanding of the interactions between drugs from the same or different classes requires quantitative analysis methods. These analytical strategies help to ascertain the behavioral effects of drugs in an quantitative manner.
Grants and Sponsored Research:
- February 2016–January 2021
Allosteric modulation of the CB1 receptor
National Institute on Drug Abuse
Role: Co-Investigator
$301,136 - March 2013–November 2018
Imidazoline I2 receptors as targets for the treatment of pain
National Institute on Drug Abuse
Role: Principal Investigator
$1,624,680 - July 2016–June 2018
TAAR 1 modulation of addiction-related effects of nicotine
NIDA/NIH
Role: Principal Investigator
$479,199 - June 2013–May 2015
Behavioral effects of methamphetamine & imidazoline I2 receptor ligands
National Institute on Drug Abuse
Role: Principal Investigator
$463,845 - January 2010–January 2015
Delay discounting: effects of drug dependence and withdrawal.
NIDA/NIH
Role: Co-Investigator - January 2010–January 2015
Discriminative stimulus effects of opioid withdrawal.
NIDA/NIH
Role: Co-Investigator
Journal Articles:
- Thorn DA, Siemian JN, Zhang Y, Li JX, Li J. Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain: interactions with oxycodone. Psychopharmacology (Berl). 2015.
- Jing L, Zhang Y, Li JX. Effects of the trace amine associated receptor 1 agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats. Intl J Neuropsychopharmacol. 2014.
- Thorn DA, Jing L, Qiu Y, Gancarz-Kausch AM, Galuska CM, Dietz DM, Zhang Y and Li JX. Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Effects of Cocaine in Rats. Neuropsychopharmacology. 2014.
- Li JX, Thorn DA, Qiu Y, Peng BW, Zhang Y.. Anti-hyperalgesic effects of imidazoline I2 receptor ligands in rat models of inflammatory and neuropathic pain. Br J Pharmacol. 2013.
- Thorn DA, An XF, Zhang Y, Pigini M, Li JX. Characterization of the hypothermic effects of imidazoline I(2) receptor agonists in rats. Br J Pharmacol. 2012.
- Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, Xie C, Zhang Z, Yao H. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Mol Psychiatry. 2018.
- Xue Z, Siemian JN, Zhu Q, Blough BE, Li JX, Li J. Further pharmacological comparison of D-methamphetamine and L-methamphetamine in rats: abuse-related behavioral and physiological indices. Behav Pharmacol. 2018.
- Liu JF, Li JX, Li J. Drug addiction: a curable mental disorder? Acta Pharmacol Sin. 2018.
- Siemian JN, Shang L, Seaman RW, Zhu Q, Zhang Y, Li JX, Li J. Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats. Behav Pharmacol. 2018.
- Jiang B, Wang H, Wang JL, Wang YJ, Zhu Q, Wang CN, Song L, Gao TT, Wang Y, Zhu WZ, Meng GL, Wu F, Huang C, Ling Y, Zhang W, Li JX, Li J. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biol Psychiatry. 2018.
- Liu JF, Tian J, Li JX, Li J. Modulating reconsolidation and extinction to regulate drug reward memory. Eur J Neurosci. 2018.
- Werner CT, Viswanathan R, Martin JA, Gobira PH, Mitra S, Thomas SA, Wang ZJ, Liu JF, Stewart AF, Neve RL, Li JX, Gancarz AM, Dietz DM, Li J. E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking. Biol Psychiatry. 2018.
- Luo HB, Shang N, Xie WZ, Wen DJ, Qu M, Huang S, Fan SS, Chen W, Mou NQ, Liu XY, Chen Q, Xie FF, Li JX, Li J. Trillium tschonoskii maxim extract attenuates abnormal Tau phosphorylation. Neural Regen Res. 2018; 13(5).
- Liu JF, Li JX, Li J. TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg. Front Pharmacol. 2018; 9.
- Siemian JN, Jia S, Liu JF, Zhang Y, Li JX, Li J. Neuroanatomical characterization of imidazoline I2receptor agonist-induced antinociception. Eur J Neurosci. 2018.
- Liu JF, Seaman R, Siemian JN, Bhimani R, Johnson B, Zhang Y, Zhu Q, Hoener MC, Park J, Dietz DM, Li JX, Li J. Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects. Neuropsychopharmacology. 2018.
- Siemian JN, Wang K, Zhang Y, Li JX, Li J. Mechanisms of imidazoline I2receptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission. Br J Pharmacol. 2018.
- Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX, Li J. The imidazoline I2receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochem Pharmacol. 2018.
- Bernosky-Smith KA, Qiu YY, Feja M, Lee YB, Loughlin B, Li JX, Bass CE, Li J. Ventral tegmental area D2 receptor knockdown enhances choice impulsivity in a delay-discounting task in rats. Behav Brain Res. 2018; 341.
- Xue Z, Siemian JN, Johnson BN, Zhang Y, Li JX, Li J. Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397. Neuropharmacology. 2017.
- Nguyen T, German N, Decker AM, Langston TL, Gamage TF, Farquhar CE, Li JX, Wiley JL, Thomas BF, Zhang Y, Li J. Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution. J Med Chem. 2017.
- Siemian JN, Qiu Y, Zhang Y, Li JX, Li J. Role of intracellular Ca(2+) signaling in the antinociceptive and discriminative stimulus effects of the imidazoline I2 receptor agonist 2-BFI in rats. Psychopharmacology (Berl). 2017.
- Siemian JN, Zhang Y, Li JX, Li J. Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats. Behav Pharmacol. 2017.
- Nguyen T, Decker AM, Langston TL, Mathews KM, Siemian JN, Li JX, Harris DL, Runyon SP, Zhang Y, Li J. Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists. ACS Chem Neurosci. 2017.
- Siemian JN, Xue Z, Blough BE, Li JX, Li J. Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats. Psychopharmacology (Berl). 2017.
- Witkin JM, Cerne R, Wakulchik M, S J, Gleason SD, Jones TM, Li G, Arnold LA, Li JX, Schkeryantz JM, Methuku KR, Cook JM, Poe MM, Li J. Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors. Pharmacol Biochem Behav. 2017.
- Thorn DA, Zhang Y, Li JX. Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I2 receptor agonist phenyzoline in adult male rats. Psychopharmacology (Berl). 2017.
- Li JX. Imidazoline I2 receptors: An update. Pharmacol Ther. 2017.
- Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. Antinociceptive effects of a novel α2/α3-subtype selective GABAA receptor positive allosteric modulator. ACS Chem Neurosci. 2017.
- Liu JF, Siemian JN, Seaman R, Zhang Y, Li JX. Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior. J Neurosci. 2017; 37(4).
- He M, Min JW, Kong WL, He XH, Li JX, Peng BW. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016; 115.
- Perrey DA, Li JX, Zhang Y.. Modified synthesis of NOP receptor antagonist SB612111. Synthesis. 2016; 48.
- Li JX. Buprenorphine analogue BU08028 is one step closer to the Holy Grail of opioid research. Proc Natl Acad Sci U S A. 2016.
- Wang ZJ, Martin JA, Mueller LE, Caccamise A, Werner CT, Neve RL, Gancarz AM, Li JX, Dietz DM. BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior. Biol Psychiatry. 2016.
- Thorn DA, Li J, Qiu Y, Li JX. Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats. Behav Pharmacol. 2016.
- Siemian JN, Obeng S, Zhang Y, Zhang Y, Li JX. Antinociceptive interactions between the imidazoline I2 receptor agonist 2-BFI and opioids in rats: role of efficacy at the μ opioid receptor. J Pharmacol Exp Ther. 2016.
- Zhu Q, Sun Y, Mao L, Liu C, Jiang B, Zhang W, Li JX. Antinociceptive effects of sinomenine in a rat model of postoperative pain. Br J Pharmacol. 2016.
- Qin WJ, Wang YT, Li PM, Wang XX, Li JX, Noori HR, Bernardi RE, Liang JH, Zhang XL. Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. Psychopharmacology (Berl). 2016.
- Thorn DA, Zhang Y, Li JX, Li J. Effects of the imidazoline I2 receptor agonist 2-BFI on the development of tolerance and behavioral/physical dependence to morphine in rats. Br J Pharmacol. 2016.
- Zhu Q, Mao LN, Liu CP, Sun YH, Jiang B, Zhang W, Li JX. Antinociceptive effects of vitexin in a mouse model of postoperative pain. Sci Rep. 2016; 6.
- Liu JF, Thorn DA, Zhang Y, Li JX. Effects of Trace Amine-associated Receptor 1 Agonists on the Expression, Reconsolidation, and Extinction of Cocaine Reward Memory. Int J Neuropsychopharmacol. 2016.
- Thorn DA, Qiu Y, Jia S, Zhang Y, Li JX. Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats. Behav Pharmacol. 2015.
- Siemian JN, Li J, Zhang Y, Li JX. Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding. Psychopharmacology (Berl). 2015.
- Grandy DK, Miller GM, Li JX. “TAARgeting Addiction”—The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. Drug Alcohol Depend. 2015.
- Perrey DA, Decker AM, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y, Li J. The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Bioorg Med Chem. 2015.
- Jing L, Li JX, Li J. Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction. Eur J Pharmacol. 2015; 761.
- Nguyen T, German N, Decker AM, Li JX, Wiley JL, Thomas BF, Kenakin TP, Zhang Y, Li J. Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. Bioorg Med Chem. 2015; 23(9).
- Perrey DA, German NA, Decker AM, Thorn D, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y. The Effect of 1-Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin-1 Receptor. ACS Chem Neurosci. 2015.
- Qiu Y, Zhang Y, Li JX. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. Eur J Pharmacol. 2015.
- Zhu Q, Sun Y, Zhu J, Fang T, Zhang W, Li JX, Li J. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci Rep. 2014; 4.
- Qiu Y, He XH, Zhang Y, Li JX, Li J. Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats. Sci Rep. 2014; 4.
- Jing L, Qiu Y, Zhang Y, Li JX. Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Drug Alcohol Depend. 2014.
- Ding Y, Qiu Y, Jing L, Thorn DA, Zhang Y, Li JX.. Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats. Pharmacol Res Perspect. 2014.
- Li YL, Liu Q, Gong Q, Li JX, Wei SP, Wang YT, Liang H, Zhang M, Jing L, Yong Z, Lawrence AJ, Liang JH, Li J. Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats. Acta Pharmacol Sin. 2014.
- Zhu Q, Sun Y, Yun X, Ou Y, Zhang W, Li JX, Li J. Antinociceptive effects of curcumin in a rat model of postoperative pain. Sci Rep. 2014; 4.
- Zhang C, Flowers E, Li JX, Wang Q, Sun W, Li J. Loudness Perception Affected by High Doses of Salicylate-a Behavioral Model of Hyperacusis. Behav Brain Res. 2014.
- Li JX. Pain and depression comorbidity: a preclinical perspective. Behav Brain Res. 2014.
- Li JX. Trace Amines and Cocaine Abuse. ACS Chem Neurosci. 2014.
- Qiu Y, Thorn DA, Zhang Y, He X, Li JX, Li J. Behavioral effects of the imidazoline I2 receptor ligand BU99006 in rats. Behav Pharmacol. 2014.
- Thorn DA, Zhang C, Zhang Y, Li JX, Li J. The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats. Neurosci Lett. 2014.
- Jing L, Zhang M, Li JX, Huang P, Liu Q, Li YL, Liang H, Liang JH, Li J. Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice. Neurosci Lett. 2013.
- Wei-Lin Kong,Jia-Wei Min,Yuan-Lin Liu,Jun-Xu Li, Xiao-Hua He, Bi-Wen Peng. Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice. Epilepsy & Behavior. 2013.
- Min J, Peng B, He X, Zhang Y,Li JX. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. Eur J Pharmacol. 2013.
- Perrey DA, German NA, Gilmour BP, Li JX, Harris DL, Thomas BF, Zhang Y, Li J. Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor. J Med Chem. 2013.
- Li JX. The application of conditioning paradigms in the measurement of pain. Eur J Pharmacol. 2013.
- Li JX, Thorn DA, Jin C. The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. Eur J Pharmacol. 2012.
- Li JX, Koek W, France CP. Interactions between ?9-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys. Behav Pharmacol. 2012.
- Li JX, Shah AP, Patel SK, Rice KC, France CP. Modification of the behavioral effects of morphine in rats by serotonin (5-HT)(1A) and 5-HT (2A) receptor agonists: antinociception, drug discrimination, and locomotor activity. Psychopharmacology (Berl). 2012.
- Maguire DR, Li JX, France CP. Impulsivity and drugs of abuse: a juice-reinforced operant procedure for determining within-session delay discounting functions in rhesus monkeys. J Pharmacol Toxicol Methods. 2012.
- Maguire DR, Li JX, Koek W, France CP. Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys. Psychopharmacology (Berl). 2012.
- Zhang M, Jing L, Liu Q, Wen RT, Li JX, Li YL, Gong Q, Liang JH. Tramadol induces conditioned place preference in rats: interactions with morphine and buprenorphine. Neurosci Lett. 2012.
- An XF, Zhang Y, Winter JC, Li JX. Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats. Pharmacol Biochem Behav. 2012; 101(3).
- Thorn DA, Winter JC, Li JX. Agmatine attenuates methamphetamine-induced conditioned place preference in rats. Eur J Pharmacol. 2012; 680(1-3).
- Liu Q, Zhang M, Qin WJ, Wang YT, Li YL, Jing L, Li JX, Lawrence AJ, Liang JH. Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats. Brain Res. 2012.
- Li JX, Zhang Y. Emerging drug targets for pain treatment. Eur J Pharmacol. 2012.
- Sampson C, Zhang Y, Bello FD, Li JX. Effects of imidazoline I2 receptor ligands on acute nociception in rats. Neuroreport. 2012; 23(2).
- Li JX, Ju S, Baladi MG, Koek W, France CP. Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction. Behav Pharmacol. 2011; 22(8).
- Li JX, Zhang Y, Winter JC. Morphine-induced antinociception in the rat: Supra-additive interactions with imidazoline I(2) receptor ligands. Eur J Pharmacol. 2011; 669(1-3).
- Thorn DA, Zhang Y, Peng BW, Winter JC, Li JX. Effects of imidazoline I(2) receptor ligands on morphine- and tramadol-induced antinociception in rats. Eur J Pharmacol. 2011; 670(2-3).
- Liu Q, Qin W, Zhang M, Wang Y, Li J, Li JX, Liang J. Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats. Neural Regen Res. 2011; 6(28).
- Li JX, Zhang Y. Imidazoline I(2) receptors: Target for new analgesics? Eur J Pharmacol. 2011; 658(2-3).
- Peng BW, Justice JA, Zhang K, Li JX, He XH, Sanchez RM. Gabapentin promotes inhibition by enhancing hyperpolarization-activated cation currents and spontaneous firing in hippocampal CA1 interneurons. Neurosci Lett. 2011; 494(1).
- Li JX, Koek W, Rice KC, France CP. Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. Neuropsychopharmacology. 2011; 36(5).
- Li JX, Crocker C, Koek W, Rice KC, France CP. Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies. Psychopharmacology (Berl). 2011; 213(2-3).
- Li X, Li JX, France CP.. Interactions between morphine, scopolamine and nicotine: schedule-controlled responding in rats. Pharmacol Biochem Behav. 2010; 96(1).
- Li JX, Koek W, Rice KC, France CP. Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys. J Pharmacol Exp Ther. 2010; 333(1).
- Becker GL, Gerak LR, Li JX, Koek W, France CP.. Precipitated and conditioned withdrawal in morphine-treated rats. Psychopharmacology (Berl). 2010; 209(1).
- Li X, Li JX, Zhu X, Cui R, Jiao J. Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats. Behav Brain Res. 2010; 206(2).
- Li JX, Unzeitig A, Javors MA, Rice KC, Koek W, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats. J Pharmacol Exp Ther. 2009; 331(2).
- France CP, Li JX, Owens WA, Koek W, Toney GM, Daws LC. Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats. Int J Neuropsychopharmacol. 2009; 12(6).
- Li JX, Koek W, France CP. Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats. Eur J Pharmacol. 2009; 613(1-3).
- McMahon LR, Li JX, Carroll FI, France CP. Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys. Psychopharmacology (Berl). 2009; 203(2).
- Li JX, Rice KC, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses. J Pharmacol Exp Ther. 2009; 328(3).
- May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, Young R, Li JX, Rice KC, France CP. Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. Pharmacol Biochem Behav. 2009; 91(3).
- Li JX, McMahon LR, Gerak LR, Becker GL, France CP. Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception. Psychopharmacology (Berl). 2008; 199(2).
- Li JX, France CP. Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats. Behav Pharmacol. 2008; 19(4).
- Li JX, Rice KC, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys. J Pharmacol Exp Ther. 2008; 324(2).
- Li JX, McMahon LR, France CP. Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys. Psychopharmacology (Berl). 2008; 195(4).
- Li JX, Rice KC, France CP. Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. Behav Pharmacol. 2007; 18(4).
- Li JX, Becker GL, Traynor JR, Gong ZH, France CP. Thienorphine: receptor binding and behavioral effects in rhesus monkeys. J Pharmacol Exp Ther. 2007; 321(1).
- Li JX, Han R, Deng YP, Chen SQ, Liang JH. Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. Behav Brain Res. 2005; 161(1).
- Li JX, Zhao WL, Liang JH. Effects of carbamazepine on morphine-induced behavioral sensitization in mice. Brain Res. 2004; 1019(1-2).
- Li JX, Zhang Q, Liang JH. Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behav Brain Res. 2004; 152(2).
- Liang JH, Li JX, Wang XH, Chen B, Lu Y, Zhang P, Han R, Ye XF. L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta Pharmacol Sin. 2004; 25(5).
- Zhang Q, Li JX, Zheng JW, Liu RK, Liang JH. L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice. Eur J Pharmacol. 2003; 467(1-3).
Books and Book Chapters:
- Li JX, Gerak LR, France CP. Drug discrimination studies in rhesus monkeys: drug dependence and withdrawal. In: RA Glennon, R Young. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies. New York: John Wiley & Sons Inc; 2010..
Professional Memberships:
- International Association for the Study of Pain (2010–present)
- Behavioral Pharmacology Society (2009–present)
- Sigma Xi (2008–present)
- American Society for Pharmacology and Experimental Therapeutics (2007–present)
- The College on Problems of Drug Dependence (2007–present)
Presentations:
- "Interactions between serotonin (5-HT) receptor agonists and opioids in rhesus monkeys: effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) on i.v. heroin self-administration." CPDD 73th annual meeting (2011)
- "5-HT and opioid drug interactions in rats and monkeys: drug discrimination." European Behavioural Pharmacology Society 13th biennial meeting (2010)
- "Delta9-tetrahydrocannabinol decreases the heroin self-administration behavior in rhesus monkeys." International Study Group Investigating Drugs as Reinforcers annual meeting (2010)
- "Effects of contingent and noncontingent THC treatment on heroin self administration in rhesus monkeys." CPDD 72th annual meeting (2010)
- "Differential modification of the antinociceptive and discriminative stimulus effects of morphine by 5-HT1A and 5-HT2A receptor agonists in rhesus monkeys" CPDD 71th annual meeting (2009)
- "Discriminative stimulus effects of DOM in rhesus monkeys: interactions between 5-HT1A and 5-HT2A receptor agonists" Experimental Biology 2009 annual meeting (2009)
- "Interactions between serotonin ligands: rat¡Ùmonkey." 2009 Behavioral Pharmacology Society meeting (2009)
- "Food restriction and streptozotocin decrease sensitivity of rats to hypothermic effects of direct- and indirect-acting serotonin receptor agonists." American College of Neuropsychopharmacology 2008 annual meeting (2008)
- "Interactions between direct- and indirect-acting 5-HT2 receptor agonists and the discriminative stimulus effects of morphine in rhesus monkeys: perceptual masking?" CPDD 70th annual meeting (2008)
- "Apparent pA2 analysis of 5-HT2A receptor antagonists in rhesus monkeys discriminating DOM" Experimental Biology 2008 annual meeting (2008)
- "Is there behavioral evidence for constitutive activity at 5-HT2A receptors?" Texas Research Society on Alcoholism 2008 annual meeting (2008)
- "Comparison of the discriminative stimulus effects of DOM, MDL100907 and ketanserin in rats: inverse agonism?" CPDD 69th annual meeting (2007)
- "Behavioral effects of dipropyltryptamine (DPT) in rats: role of 5-HT1A and 5-HT2A receptors" Experimental Biology 2007 annual meeting (2007)
- "Interaction between ¦¤9-THC, DOM, quipazine and the discriminative stimulus effects of morphine in rhesus monkeys: perceptual masking?" Society for Neuroscience 36th annual meeting (2006)
- "Behavioral effects of thienorphine in rhesus monkeys." CPDD 68th annual meeting (2006)