M. Laura Feltri MD
M. Laura Feltri
MD
SUNY Distinguished Professor, Professor of Biochemistry and Neurology. Acting Director, Institute for Myelin and Glia Exploration
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cytoskeleton and cell motility; Inherited Metabolic Disorders; Lysosomal Storage Diseases; Molecular and Cellular Biology; Molecular Basis of Disease; Molecular genetics; Myelin Diseases; Neurobiology; Neurology; Neuroscience; Signal Transduction; Transgenic organisms
Professional Summary:
My laboratory seeks to understand the molecular basis of myelination and myelin diseases. Myelin is a multi-lamellar sheath that invests large axons and permits rapid conduction of nerve signals. Failure in myelin synthesis and myelin breakdown cause several important neurological diseases, including multiple sclerosis, leukodystrophies and peripheral dysmyelinating neuropathies.
In some of these diseases, genetic mutations cause defects in cytoskeletal, adhesion and signaling molecules. I work with a team of undergraduate and graduate students, postdoctoral fellows, technicians, senior scientists and many international collaborators to discover how these molecules normally coordinate cell-cell and cell-extracellular matrix interactions to generate the cytoarchitecture of myelinated axons. We use a variety of approaches, including generation of mice carrying genetic abnormalities, cultures of myelinating glia and neurons, imaging, biochemistry and morphology to understand the role of these molecules in normal and pathological development. By comparing normal myelination to the abnormalities occurring in human diseases, we aim to identify molecular mechanisms that pharmacological intervention might correct.
For example, we described how the protein dystroglycan associates with different proteins, some of which impact human neuropathies, depending on a proteolitic cleavage that can be regulated to improve the disease. Similarly, we found that molecules such as integrins and RhoGTPAses are required for glia to extend large processes that will become myelin around axons. In certain neuromuscular disorders, defective signaling pathways that converge on these molecules cause failure to produce or mantain an healthy myelin Finally, in collaborations with scientists and clinicians in the Hunter J. Kelly Research Institute, we are generating transgenic forms of GalC, an enzyme deficient in Krabbe leukodystrophy, to investigate which cells requires the enzyme. Investigating how GalC is handled may help find a cure for this devastating disease.
Education and Training:
- Neuroscience, Thomas Jefferson University (1992)
- Residency, Neurology, University of Milano, Italy (1992)
- Medicine and Surgery, University of Milano, Italy (1988)
- MD, Medicine and Surgery, University of Milano, Italy (1988)
Employment:
- Professor, Hunter James Kelly Research Institute & Biochemistry, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011-present)
- Head of Neuro Glia Unit, Division of Cell Biology & Genetics, San Raffaele Scientific Institute Medicine (2006-present)
- Adjunct Associate Professor, Neurology, University of Pennsylvania School of Medicine (2002-present)
- Assistant Professor, San Raffaele Scientific Institute, DIBIT (1995–2004)
- Assistant Professor, Neurology, San Raffaele Scientific Institute, Neurology (1992–1995)
- Post Doctoral Fellow, Neurology, Thomas Jefferson University Medicine (1989–1992)
- Resident, Neurology, University of Milano, Italy (1988–1992)
Awards and Honors:
- Chair, Cellular and molecular biology of Glia Study Session (2021)
- President Elect (2021)
- SUNY Distinguished Professor (2020)
- State University of New York (SUNY) Chancellor award for Excellence in Scholarship & Creative Activities (2019)
- Exceptional Scholar – Sustained Achievement Award (2016)
- Distinguished Postdoc Mentor Award (2013)
- AAAS Fellow
Research Centers:
- Center of Excellence in Bioinformatics and Life Sciences
- Hunter J. Kelly Research Institute (Hunter's Hope Foundation)
UB 2020 Strategic Strengths:
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- January 2020–December 2025
Laminin receptors and signals in Schwann cells
NIH-NINDS
Role: Principal Investigator
$1,899,599 - November 2020–November 2024
4. NIH/NINDS 1 R01 NS 112327 (PI Shin, Feltri co-I) 12/01/2020-11/30/2024. Selective galactosylceramidase ablation to study the pathogenesis of Krabbe leukodystrophy. Total cost 125000$
NINDS-NIH
Role: Co-Investigator
$1,494,341 - November 2021–October 2024
Innovative model systems to study and boost innate immunity in Krabbe Disease. time in zebrafish.
the legacy of angels foundation
Role: Co-Investigator
$527,623 - November 2021–October 2024
Innovative model systems to study and boost innate immunity in Krabbe Disease
Th Legacy of Angels Foundation
Role: Principal Investigator
$527,623 - July 2008–March 2024
Laminin receptors and signals in schwann cells
NIH-NINDS
Role: Principal Investigator
$1,284,790 - February 2019–January 2024
The peripheral nervous system: a window over Krabbe disease
NIH-NINDS
Role: Principal Investigator
$2,074,062 - November 2021–October 2023
Support for the infrastructure of Krabbe disease and myelin research at the University at Buffalo
The Legacy of Angel Foundation
Role: Principal Investigator
$381,168 - May 2023–May 2023
. Support for the infrastructure of Krabbe disease and myelin research at the University at Buffalo
the legacy of angels foundation
Role: Principal Investigator - January 2021–November 2022
Improving proteasome function to treat Charcot Marie Tooth 1
Charcot Marie Tooth Association
Role: Co-Principal Investigator
$125,556 - May 2021–February 2022
P38MAPK gamma as a target to promote demyelination in Multiple Sclerosis and other demyelinating diseases
Empire Development Corporation
Role: Principal Investigator
$120,000 - January 2019–November 2021
Mechanisms of axonal degeneration in late onset CMT1B neuropathies: molecular pathways and therapeutic approaches
Charcot-Marie-Tooth Association
Role: Co-Investigator - December 2016–November 2021
The prohibitin family and their function in myelination and axonal health
NIH-NINDS
Role: Principal Investigator
$1,704,880 - May 2019–October 2021
GALC Pharmacological Chaperone Drugs for Krabbe Disease
NIH-NICHD
Role: Co-Investigator
$273,044 - July 2018–June 2021
Novel Stress-Activated Inhibitor of Myelination
US Army Medical Research Acquisition Activity (DOD)
Role: Principal Investigator
$956,123 - July 2003–March 2019
Laminin receptors and signals in Schwann cells
NIH-NINDS
Role: Principal Investigator
$1,729,962 - January 2014–September 2017
CHARACTERIZATION OF A NOVEL INHIBITOR OF MYELINATION: MAPK12/P38MAPKgamma.
National Multiple Sclerosis Society
Role: Principal Investigator
$648 - September 2012–August 2014
Subcellular domains of myelinating-glia: capturing axonal contact
NIH
Role: Principal Investigator
$435,875 - April 2013–April 2014
Modulation of neuroinflammation repairs the brain after traumatic injury by remyelination.
SUNY RF
Role: Principal Investigator
$8,000 - October 2011–December 2013
Modulating neuregulin−1 signals to treat hereditary demyelinating neuropathies
Telethon Italia
Role: Principal Investigator
$289,410 - April 2008–March 2012
Neuron-glia interactions in nerve development and disease.
European Community, FP7
Role: Principal Investigator
$368,920 - January 2008–January 2011
Laminins and their receptors in hereditary neuropathies.
Telethon, Italia
Role: Principal Investigator
$585,400
Journal Articles:
- Feltri ML, Poitelon Y. (2018) HIPPO Stampede in Nerve Sheath Tumors. Cancer Cell (Feb), 33(2): 160-161.
- Ghidinelli M, Poitelon Y, Shin YK, Ameroso D, Williamson C, Ferri C, Pellegatta M, Espino K, Mogha A, Monk K, Podini P, Taveggia C, Nave KA, Wrabetz L, Park HT, Feltri ML. (2017) Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination. PLoS Biol (Jun), 15(6).
- Colombelli C, Palmisano M, Eshed-Eisenbach Y, Zambroni D, Pavoni E, Ferri C, Saccucci S, Nicole S, Soininen R, McKee KK, Yurchenco PD, Peles E, Wrabetz L, Feltri ML. (2015) Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol (Feb), 208(3): 313-329.
- Welser-Alves JV, Boroujerdi A, Tigges U, Wrabetz L, Feltri ML, Milner R. (2013) Endothelial ß4 Integrin Is Predominantly Expressed in Arterioles, Where It Promotes Vascular Remodeling in the Hypoxic Brain. Arterioscler Thromb Vasc Biol (Mar), 33(5): 943-953.
- Patzk� A, Bai Y, Saporta MA, Katona I, Wu X, Vizzuso D, Feltri ML, Wang S, Dillon LM, Kamholz J, Kirschner D, Sarkar FH, Wrabetz L, Shy ME. (2012) Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice. Brain (Dec), 135(Pt 12): 3551-3566.
- La Marca R, Cerri F, Horiuchi K, Bachi A, Feltri ML, Wrabetz L, Blobel CP, Quattrini A, Salzer JL, Taveggia C. (2011) TACE (ADAM17) inhibits Schwann cell myelination. Nat Neurosci (Jul), 14(7): 857-865.
- Avila RL, D‘Antonio M, Bachi A, Inouye H, Feltri ML, Wrabetz L, Kirschner DA. (2010) P0 (protein zero) mutation S34C underlies instability of internodal myelin in S63C mice. J Biol Chem (Dec), 285(53): 42001-42012.
- Yun B, Anderegg A, Menichella D, Wrabetz L, Feltri ML, Awatramani R. (2010) MicroRNA-deficient Schwann cells display congenital hypomyelination. J Neurosci (Jun), 30(22): 7722-7728.
- Woodhoo A, Alonso MB, Droggiti A, Turmaine M, D‘Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P, Shen J, Guillemot F, Radtke F, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR. (2009) Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (Jul), 12(7): 839-847.
- Share Neuron-specific ablation of the Krabbe disease gene galactosylceramidase in mice results in neurodegeneration. Kreher C, Favret J, Weinstock NI, Maulik M, Hong X, Gelb MH, Wrabetz L, Feltri ML, Shin D. (2023) 3 Neuron-specific ablation of the Krabbe disease gene galactosylceramidase in mice results in neurodegeneration. plos biology 2022 (May) doi:10.1371/journal.pbio.3001661
- Park HJ, Tsai E, Huang D, Weaver M, Frick L, Alcantara A, Moran JJ, Patzig J, Melendez-Vasquez CV, Crabtree GR, Feltri ML, Svaren J, Casaccia P. (2023) 6 Cite Share ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve. e science (May) doi:PMID: 35434551 PMCID: PMC9010646 DOI: 10.1016/j.isci.2022.104132
- VerPlank JJS, Gawron J, Silvestri NJ, Feltri ML, Wrabetz L, Goldberg AL. (2023) 12 Cite Share Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy. brain 2022 (May) doi:doi: 10.1093/brain/awab249.
- (2023) 1 Cite Share Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits. (May)
- Jenica Acheta 1 , Jiayue Hong 1 , Haley Jeanette 1 , Simrandeep Brar 1 , Anish Yalamanchili 1 , M Laura Feltri 2 , M Chiara Manzini 3 , Sophie Belin 1 , Yannick Poitelon 1. (2022) 4 Cite Share Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System. (May) doi:PMID: 35592111 PMCID: PMC9113218 DOI: 10.3389/fnmol.2022.881571
- Catlin JP, Marziali LN, Rein B, Yan Z, Feltri ML, Schaner Tooley CE. (2021) Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development. Cell death & disease (Oct), 12(11): 1014. doi:10.1038/s41419-021-04316-0
- Feltri ML, Weinstock NI, Favret J, Dhimal N, Wrabetz L, Shin D. (2021) Mechanisms of demyelination and neurodegeneration in globoid cell leukodystrophy. Glia (Oct), 69(10): 2309-2331. doi:10.1002/glia.24008
- Bianchi-Smiraglia A, Wolff DW, Marston DJ, Deng Z, Han Z, Moparthy S, Wombacher RM, Mussell AL, Shen S, Chen J, Yun DH, O. (2021) Regulation of local GTP availability controls RAC1 activity and cell invasion. Nature communications (Oct), 12(1): 6091.
- Della-Flora Nunes G, Wilson ER, Hurley E, He B, O. (2021) Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination. eLife (Sep), 10. doi:10.7554/eLife.66278
- VerPlank JJS, Gawron J, Silvestri NJ, Feltri ML, Wrabetz L, Goldberg AL. (2021) Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy. Brain : a journal of neurology (Aug).
- Wilson ER, Della-Flora Nunes G, Weaver MR, Frick LR, Feltri ML. (2021) Schwann cell interactions during the development of the peripheral nervous system. Developmental neurobiology (Jul), 81(5): 464-489. doi:10.1002/dneu.22744
- Della-Flora Nunes G, Wilson ER, Marziali LN, Hurley E, Silvestri N, He B, O. (2021) Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nature communications (Jun), 12(1): 3285. doi:10.1038/s41467-021-23552-8
- Reed CB, Feltri ML, Wilson ER. (2021) Peripheral glia diversity. Journal of anatomy (Jun).
- Pellegatta M, Berti C, Hurley E, Palmisano M, de Curtis I, Feltri ML, Frick LR. (2021) Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination. Neuroscience letters (May), 753: 135868.
- Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ, D. (2021) Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy. The Journal of neuroscience : the official journal of the Society for Neuroscience (May), 41(20): 4536-4548. doi:10.1523/JNEUROSCI.2384-20.2021
- ellegatta M, Berti C, Hurley E, Palmisano M, de Curtis I, Feltri ML, Frick LR. (2021) 17 Cite Share Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination. eurosci Lett. (May)
- Jeanette H, Marziali LN, Bhatia U, Hellman A, Herron J, Kopec AM, Feltri ML, Poitelon Y, Belin S. (2021) YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration. Glia (Apr), 69(4): 1061-1074. doi:10.1002/glia.23949
- Feltri ML, Weaver MR, Belin S, Poitelon Y. (2021) The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases. Journal of the peripheral nervous system : JPNS (Mar), 26(1): 4-16. doi:10.1111/jns.12431
- Saraswat D, Welliver RR, Ravichandar R, Tripathi A, Polanco JJ, Broome J, Hurley E, Dutta R, Feltri ML, Sim FJ. (2021) Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience (Mar), 41(10): 2245-2263. doi:10.1523/JNEUROSCI.0580-20.2021
- Catignas KK, Frick LR, Pellegatta M, Hurley E, Kolb Z, Addabbo K, McCarty JH, Hynes RO, van der Flier A, Poitelon Y, Wrabetz L, Feltri ML. (2021) aV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia (Jan), 69(1): 91-108. doi:10.1002/glia.23886
- Weinstock NI, Kreher C, Favret J, Nguyen D, Bongarzone ER, Wrabetz L, Feltri ML, Shin D. (2020) Brainstem development requires galactosylceramidase and is critical for pathogenesis in a model of Krabbe disease. Nature communications (Oct), 11(1): 5356. doi:10.1038/s41467-020-19179-w
- Scapin C, Ferri C, Pettinato E, Bianchi F, Del Carro U, Feltri ML, Kaufman RJ, Wrabetz L, D. (2020) Phosphorylation of eIF2a Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR. The Journal of neuroscience : the official journal of the Society for Neuroscience (Oct), 40(42): 8174-8187. doi:10.1523/JNEUROSCI.0957-20.2020
- Reed CB, Frick LR, Weaver A, Sidoli M, Schlant E, Feltri ML, Wrabetz L. (2020) Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience (Aug), 40(32): 6165-6176. doi:10.1523/JNEUROSCI.0951-20.2020
- N.I. Weinstock*, D. Shin*, N. Dhimal, X. Hong, E. E. Irons, N. Silvestri, C.B. Reed, D. Nguyen, O. Sampson, Y.C. Cheng, J.T.Y. Lau, E. Bongarzone, J. Kofler, M. Escolar, M. Gelb, L. Wrabetz, M.L. Feltri. (2020) Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction. Neuron (Jul), 107(1): 65-81.
- Walker MR, Amante JJ, Li J, Liu H, Zhu LJ, Feltri ML, Goel HL, Mercurio AM. (2020) Alveolar progenitor cells in the mammary gland are dependent on the ß4 integrin. Developmental biology (Jan), 457(1): 13-19. doi:10.1016/j.ydbio.2019.10.001
- Favret JM, Weinstock NI, Feltri ML, Shin D. (2020) Pre-clinical Mouse Models of Neurodegenerative Lysosomal Storage Diseases. Frontiers in molecular biosciences (Jan), 7: 57. doi:10.3389/fmolb.2020.00057
- Ahmed M, Marziali LN, Arenas E, Feltri ML, Ffrench-Constant C. (2019) Laminin a2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development. Development (Cambridge, England) (Aug), 146(16). doi:10.1242/dev.172668
- Volpi VG, Ferri C, Fregno I, Del Carro U, Bianchi F, Scapin C, Pettinato E, Solda T, Feltri ML, Molinari M, Wrabetz L, D. (2019) Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice. PLoS genetics (Apr), 15(4): e1008069. doi:10.1371/journal.pgen.1008069
- Scapin C, Ferri C, Pettinato E, Zambroni D, Bianchi F, Del Carro U, Belin S, Caruso D, Mitro N, Pellegatta M, Taveggia C, Schwab MH, Nave KA, Feltri ML, Wrabetz L, D. (2019) Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model. Human molecular genetics (Mar), 28(6): 992-1006. doi:10.1093/hmg/ddy411
- Belin S, Ornaghi F, Shackleford G, Wang J, Scapin C, Lopez-Anido C, Silvestri N, Robertson N, Williamson C, Ishii A, Taveggia C, Svaren J, Bansal R, Schwab MH, Nave K, Fratta P, D'Antonio M, Poitelon Y, Feltri ML, Wrabetz L, Feltri M. (2019) Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy. Hum Mol Genet (Jan).
- Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O‘Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ. (2018) Muscarinic receptor M3R signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells. J Neurosci (Jun).
- Florio F, Ferri C, Scapin C, Feltri ML, Wrabetz L, D‘Antonio M. (2018) Sustained Expression of Negative Regulators of Myelination Protects Schwann Cells from Dysmyelination in a Charcot-Marie-Tooth 1B Mouse Model. J Neurosci (May), 38(18): 4275-4287.
- Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML, Feltri M. (2018) A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies. J Neurochem (May), 145(3): 245-257.
- Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D‘Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR, Feltri M. (2018) GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. J Exp Med (Mar), 215(3): 941-961.
- VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L, Feltri M. (2018) Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia (Feb), 66(2): 379-395.
- Poitelon Y, Feltri ML, Feltri M. (2018) The Pseudopod System for Axon-Glia Interactions: Stimulation and Isolation of Schwann Cell Protrusions that Form in Response to Axonal Membranes. Methods Mol Biol (Jan), 1739: 233-253.
- VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L. (2017) Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia (Oct), 66(2): 379-395.
- Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA. (2017) Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution. Nat Methods (Sep), 14(10): 1003-1009.
- Della-Flora Nunes G, Mueller L, Silvestri N, Patel MS, Wrabetz L, Feltri ML, Poitelon Y. (2017) Acetyl-CoA production from pyruvate is not necessary for preservation of myelin. Glia (Jun), 65(10): 1626-1639.
- Poitelon Y, Nunes GD, Feltri ML. (2017) Myelinating cells can feel disturbances in the force. Oncotarget (Jan), 8(4): 5680-5681.
- Sidoli M, Musner N, Silvestri N, Ungaro D, D‘Antonio M, Cavener DR, Feltri ML, Wrabetz L. (2016) Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse. J Neurosci (Nov), 36(44): 11350-11361.
- Weinstock NI, Wrabetz L, Feltri ML, Shin D. (2016) Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease. J Neurosci Res (Nov), 94(11): 1094-1107.
- Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML. (2016) YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nat Neurosci (Jul), 19(7): 879-887.
- Lopez-Anido C, Poitelon Y, Gopinath C, Moran JJ, Ma KH, Law WD, Antonellis A, Feltri ML, Svaren J. (2016) Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development. Hum Mol Genet (Jul), 25(14): 3055-3069.
- Feltri ML, Poitelon Y, Previtali SC, Feltri M. (2016) How Schwann Cells Sort Axons: New Concepts. Neuroscientist (Jun), 22(3): 252-265.
- Noseda R, Guerrero-Valero M, Alberizzi V, Previtali SC, Sherman DL, Palmisano M, Huganir RL, Nave KA, Cuenda A, Feltri ML, Brophy PJ, Bolino A, Feltri M. (2016) Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold. PLoS Biol (Apr), 14(4): 1002440-1002440.
- Musner N, Sidoli M, Zambroni D, Del Carro U, Ungaro D, DeAntonio M, Feltri ML, Wrabetz L, Feltri M. (2016) Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy. ASN Neuro (Mar), 8(2).
- Shin D, Feltri ML, Wrabetz L. (2016) Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity. J Neurosci (Feb), 36(6): 1858-1870.
- Li J, Sun H, Feltri ML, Mercurio AM, Feltri M. (2015) Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol (Nov), 407(2): 313-320.
- Poitelon Y, Bogni S, Matafora V, Della-Flora Nunes G, Hurley E, Ghidinelli M, Katzenellenbogen BS, Taveggia C, Silvestri N, Bachi A, Sannino A, Wrabetz L, Feltri ML, Feltri M. (2015) Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nat Commun (Sep), 6: 8303-8303.
- Monk KR, Feltri ML, Taveggia C, Feltri M. (2015) New insights on schwann cell development. Glia (Apr), 63(8): 1376-1393.
- Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Scheberg T, Piao X, Monk KR, Feltri M. (2015) The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron (Feb), 85(4): 755-769.
- Feltri ML, Poitelon Y, Previtali SC, Feltri M. (2015) How Schwann Cells Sort Axons: New Concepts. Neuroscientist (Feb), 22(3): 252-265.
- Chen P, Cescon M, Zuccolotto G, Nobbio L, Colombelli C, Filaferro M, Vitale G, Feltri ML, Bonaldo P, Feltri M. (2015) Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization. Acta Neuropathol (Jan), 129(1): 97-113.
- Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD, Feltri M. (2015) Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin. Glia (Jan), 63(1): 66-77.
- Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U, Feltri M. (2014) The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease. Brain (Mar), 137(Pt 3): 668-682.
- Heller BA, Ghidinelli M, Voelkl J, Einheber S, Smith R, Grund E, Morahan G, Chandler D, Kalaydjieva L, Giancotti F, King RH, Fejes-Toth AN, Fejes-Toth G, Feltri ML, Lang F, Salzer JL, Feltri M. (2014) Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol (Mar), 204(7): 1219-1236.
- Porrello E, Rivellini C, Dina G, Triolo D, Del Carro U, Ungaro D, Panattoni M, Feltri ML, Wrabetz L, Pardi R, Quattrini A, Previtali SC, Feltri M. (2014) Jab1 regulates Schwann cell proliferation and axonal sorting through p27. J Exp Med (Jan), 211(1): 29-43.
- Pellegatta M, De Arcangelis A, D‘Urso A, Nodari A, Zambroni D, Ghidinelli M, Matafora V, Williamson C, Georges-Labouesse E, Kreidberg J, Mayer U, McKee KK, Yurchenco PD, Quattrini A, Wrabetz L, Feltri ML, Feltri M. (2013) a6ß1 and a7ß1 integrins are required in Schwann cells to sort axons. J Neurosci (Nov), 33(46): 17995-18007.
- Feltri M. (2013) DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination. J Neurosci (Sep), 33(38): 15295-15305.
- Noseda R, Belin S, Piguet F, Vaccari I, Scarlino S, Brambilla P, Martinelli Boneschi F, Feltri ML, Wrabetz L, Quattrini A, Feinstein E, Huganir RL, Bolino A. (2013) DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience (Sep), 33(38): 15295-305. doi:10.1523/JNEUROSCI.2408-13.2013
- Walko G, Wögenstein KL, Winter L, Fischer I, Feltri ML, Wiche G. (2013) Stabilization of the dystroglycan complex in Cajal bands of myelinating Schwann cells through plectin-mediated anchorage to vimentin filaments. Glia (Aug), 61(8): 1274-87.
- Feltri M. (2013) Stabilization of the dystroglycan complex in Cajal bands of myelinating Schwann cells through plectin-mediated anchorage to vimentin filaments. Glia (Aug), 61(8): 1274-1287.
- D‘Antonio M, Musner N, Scapin C, Ungaro D, Del Carro U, Ron D, Feltri ML, Wrabetz L, Feltri M. (2013) Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. J Exp Med (Apr), 210(4): 821-838.
- Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM, Feltri M. (2013) Schwann Cell LRP1 Regulates Remak Bundle Ultrastructure and Axonal Interactions to Prevent Neuropathic Pain. J Neurosci (Mar), 33(13): 5590-5602.
- Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB. (2013) Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells. Brain (Feb), 136(Pt 2): 549-563.
- Wang L, Pytel P, Feltri ML, Wrabetz L, Roos RP. (2012) Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice. Neurobiology of disease (Oct), 48(1): 52-7.
- Mac Saporta, B Shy, A Patzko, Y Bai, M Pennuto, C Ferri, E Tinelli, P Saveri, D Kirschner, M Crowther, C Southwood, K Wu, A. Gow, ML Feltri, L Wrabetz, ME. Shy. (2012) MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth. Brain (Jul), 135(Pt 7): 2032-2047.
- Saporta MA, Shy BR, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E, Saveri P, Kirschner D, Crowther M, Southwood C, Wu X, Gow A, Feltri ML, Wrabetz L, Shy ME, Feltri M. (2012) MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B. Brain (Jul), 135(Pt 7): 2032-2047.
- Bangratz M, Sarrazin N, Devaux J, Zambroni D, Echaniz-Laguna A, Ren� F, Bo�rio D, Davoine CS, Fontaine B, Feltri ML, Benoit E, Nicole S. (2012) A Mouse Model of Schwartz-Jampel Syndrome Reveals Myelinating Schwann Cell Dysfunction with Persistent Axonal Depolarization in Vitro and Distal Peripheral Nerve Hyperexcitability When Perlecan Is Lacking. Am J Pathol (Mar), 180(5): 2040-2055.
- Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML, Nourshargh S. (2012) Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. FASEB J (Mar), 26(3): 1064-1076.
- Lijun Wang; Peter Pytel; M. Laura Feltri; Lawrence Wrabetz; Raymond P. Roos. (2012) Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice. Neurobiology of Disease (Jan), 48(1): 52-57.
- Berti C, Bartesaghi L, Ghidinelli M, Zambroni D, Figlia G, Chen ZL, Quattrini A, Wrabetz L, Feltri ML. (2011) Non-redundant function of dystroglycan and ß1 integrins in radial sorting of axons. Development (Sep), 138(18): 4025-4037.
- Court FA, Zambroni D, Pavoni E, Colombelli C, Baragli C, Figlia G, Sorokin L, Ching W, Salzer JL, Wrabetz L, Feltri ML. (2011) MMP2-9 cleavage of dystroglycan alters the size and molecular composition of Schwann cell domains. J Neurosci (Aug), 31(34): 12208-12217.
- Fratta P, Saveri P, Zambroni D, Ferri C, Tinelli E, Messing A, D‘Antonio M, Feltri ML, Wrabetz L. (2011) P0S63del impedes the arrival of wild-type P0 glycoprotein to myelin in CMT1B mice. Hum Mol Genet (Jun), 20(11): 2081-2090.
- Park HT, Feltri ML, Feltri M. (2011) Rac1 GTPase controls myelination and demyelination. Bioarchitecture (May), 1(3): 110-113.
- Jin F, Dong B, Georgiou J, Jiang Q, Zhang J, Bharioke A, Qiu F, Lommel S, Feltri ML, Wrabetz L, Roder JC, Eyer J, Chen X, Peterson AC, Siminovitch KA. (2011) N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination. Development (Apr), 138(7): 1329-1337.
- Carlson KB, Singh P, Feaster MM, Ramnarain A, Pavlides C, Chen ZL, Yu WM, Feltri ML, Strickland S. (2011) Mesenchymal stem cells facilitate axon sorting, myelination, and functional recovery in paralyzed mice deficient in Schwann cell-derived laminin. Glia (Feb), 59(2): 267-277.
- Jung J, Cai W, Lee HK, Pellegatta M, Shin YK, Jang SY, Suh DJ, Wrabetz L, Feltri ML, Park HT. (2011) Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration. J Neurosci (Feb), 31(6): 2009-2015.
- Dacci P, Dina G, Cerri F, Previtali SC, Lopez ID, Lauria G, Feltri ML, Bolino A, Comi G, Wrabetz L, Quattrini A. (2010) Foot pad skin biopsy in mouse models of hereditary neuropathy. Glia (Dec), 58(16): 2005-2016.
- Taveggia C, Feltri ML, Wrabetz L. (2010) Signals to promote myelin formation and repair. Nat Rev Neurol (May), 6(5): 276-287.
- Verheijen MH, Camargo N, Verdier V, Nadra K, de Preux Charles AS, Médard JJ, Luoma A, Crowther M, Inouye H, Shimano H, Chen S, Brouwers JF, Helms JB, Feltri ML, Wrabetz L, Kirschner D, Chrast R, Smit AB. (2009) SCAP is required for timely and proper myelin membrane synthesis. Proc Natl Acad Sci U S A (Dec), 106(50): 21383-21388.
- Bradford BM, Tuzi NL, Feltri ML, McCorquodale C, Cancellotti E, Manson JC. (2009) Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion. J Neurosci (Dec), 29(49): 15445-15454.
- D‘Antonio M, Feltri ML, Wrabetz L. (2009) Myelin under stress. J Neurosci Res (Nov), 87(15): 3241-3249.
- Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW. (2009) Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A (Mar), 106(11): 4465-4470.
- Court FA, Hewitt JE, Davies K, Patton BL, Uncini A, Wrabetz L, Feltri ML, Feltri M. (2009) A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments. J Neurosci (Mar), 29(12): 3908-3919.
- Feltri ML, Suter U, Relvas JB. (2008) The function of RhoGTPases in axon ensheathment and myelination. Glia (Nov), 56(14): 1508-1517.
- Nodari A, Previtali SC, Dati G, Occhi S, Court FA, Colombelli C, Zambroni D, Dina G, Del Carro U, Campbell KP, Quattrini A, Wrabetz L, Feltri ML, Feltri M. (2008) Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci (Jun), 28(26): 6714-6719.
- Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R, Jessen KR. (2008) c-Jun is a negative regulator of myelination. J Cell Biol (May), 181(4): 625-637.
- Pennuto M, Tinelli E, Malaguti M, Del Carro U, DeAntonio M, Ron D, Quattrini A, Feltri ML, Wrabetz L. (2008) Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron (Feb), 57(3): 393-405.
- Nodari A, Zambroni D, Quattrini A, Court FA, DeUrso A, Recchia A, Tybulewicz VL, Wrabetz L, Feltri ML, Feltri M. (2007) Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination. J Cell Biol (Jun), 177(6): 1063-1075.
- Court FA, Wrabetz L, Feltri ML. (2006) Basal lamina: Schwann cells wrap to the rhythm of space-time. Curr Opin Neurobiol (Oct), 16(5): 501-507.
- DeAntonio M, Droggiti A, Feltri ML, Roes J, Wrabetz L, Mirsky R, Jessen KR. (2006) TGFbeta type II receptor signaling controls Schwann cell death and proliferation in developing nerves. J Neurosci (Aug), 26(33): 8417-8427.
- Wrabetz L, DeAntonio M, Pennuto M, Dati G, Tinelli E, Fratta P, Previtali S, Imperiale D, Zielasek J, Toyka K, Avila RL, Kirschner DA, Messing A, Feltri ML, Quattrini A. (2006) Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice. J Neurosci (Feb), 26(8): 2358-2368.
- Berti C, Nodari A, Wrabetz L, Feltri ML. (2006) Role of integrins in peripheral nerves and hereditary neuropathies. Neuromolecular Med (Jan), 8(1-2): 191-204.
- Avila RL, Inouye H, Baek RC, Yin X, Trapp BD, Feltri ML, Wrabetz L, Kirschner DA. (2005) Structure and stability of internodal myelin in mouse models of hereditary neuropathy. J Neuropathol Exp Neurol (Nov), 64(11): 976-990.
- Occhi S, Zambroni D, Del Carro U, Amadio S, Sirkowski EE, Scherer SS, Campbell KP, Moore SA, Chen ZL, Strickland S, Di Muzio A, Uncini A, Wrabetz L, Feltri M. (2005) Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier. J Neurosci (Oct), 25(41): 9418-9427.
- Colognato H, ffrench-Constant C, Feltri ML. (2005) Human diseases reveal novel roles for neural laminins. Trends Neurosci (Sep), 28(9): 480-486.
- Bolis A, Coviello S, Bussini S, Dina G, Pardini C, Previtali SC, Malaguti M, Morana P, Del Carro U, Feltri ML, Quattrini A, Wrabetz L, Bolino A. (2005) Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-Tooth type 4B1 neuropathy with myelin outfoldings. J Neurosci (Sep), 25(37): 8567-8577.
- Feltri ML, Wrabetz L. (2005) Laminins and their receptors in Schwann cells and hereditary neuropathies. J Peripher Nerv Syst (Jun), 10(2): 128-143.
- Yu WM, Feltri ML, Wrabetz L, Strickland S, Chen ZL. (2005) Schwann cell-specific ablation of laminin gamma1 causes apoptosis and prevents proliferation. J Neurosci (May), 25(18): 4463-4472.
- W Yu, ML Feltri, L .Wrabetz, S. Strickland, and Z. Chen. (2005) Schwann Cell-Specific Ablation of Laminin g1 Causes Apoptosis and Prevents Proliferation. J Neuroscience (Jan), 25(18): 4463-4472.
- R.L. Avila, B.A. Inouye, R.C. Baek, B.A. Xinghua Yin, B.D. Trapp, M.L. Feltri, L. Wrabetz and D.A. Kirschner. (2005) Myelin Membrane Packing and Stability in Transgenic Mouse Models of Dysmyelinating Diseases. Journal of Neuropathology and Experimental Neurology (Jan), 64: 976-990.
- Bolino A, Bolis A, Previtali SC, Dina G, Bussini S, Dati G, Amadio S, Del Carro U, Mruk DD, Feltri ML, Cheng CY, Quattrini A, Wrabetz L. (2004) Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis. J Cell Biol (Nov), 167(4): 711-721.
- Taveggia C, Pizzagalli A, Fagiani E, Messing A, Feltri ML, Wrabetz L. (2004) Characterization of a Schwann cell enhancer in the myelin basic protein gene. J Neurochem (Nov), 91(4): 813-824.
- Yin X, Kidd GJ, Pioro EP, McDonough J, Dutta R, Feltri ML, Wrabetz L, Messing A, Wyatt RM, Balice-Gordon RJ, Trapp BD. (2004) Dysmyelinated lower motor neurons retract and regenerate dysfunctional synaptic terminals. J Neurosci (Apr), 24(15): 3890-3898.
- Previtali SC, Nodari A, Taveggia C, Pardini C, Dina G, Villa A, Wrabetz L, Quattrini A, Feltri ML. (2003) Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci (Jul), 23(13): 5520-5530.
- Previtali SC, Zerega B, Sherman DL, Brophy PJ, Dina G, King RH, Salih MM, Feltri L, Quattrini A, Ravazzolo R, Wrabetz L, Monaco AP, Bolino A, Feltri ML. (2003) Myotubularin-related 2 protein phosphatase and neurofilament light chain protein, both mutated in CMT neuropathies, interact in peripheral nerve. Hum Mol Genet (Jul), 12(14): 1713-1723.
- Previtali SC, Dina G, Nodari A, Fasolini M, Wrabetz L, Mayer U, Feltri ML, Quattrini A. (2003) Schwann cells synthesize alpha7beta1 integrin which is dispensable for peripheral nerve development and myelination. Mol Cell Neurosci (Jun), 23(2): 210-218.
- Saito F, Moore SA, Barresi R, Henry MD, Messing A, Ross-Barta SE, Cohn RD, Williamson RA, Sluka KA, Sherman DL, Brophy PJ, Schmelzer JD, Low PA, Wrabetz L, Feltri ML, Campbell KP. (2003) Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron (Jun), 38(5): 747-758.
- Bolino A, Marigo V, Ferrera F, Loader J, Romio L, Leoni A, Di Duca M, Cinti R, Cecchi C, Feltri ML, Wrabetz L, Ravazzolo R, Monaco AP. (2002) Molecular characterization and expression analysis of Mtmr2, mouse homologue of MTMR2, the Myotubularin-related 2 gene, mutated in CMT4B. Gene (Jan), 283(1-2): 17-26.
- Feltri ML, Graus Porta D, Previtali SC, Nodari A, Migliavacca B, Cassetti A, Littlewood-Evans A, Reichardt LF, Messing A, Quattrini A, Mueller U, Wrabetz L. (2002) Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J Cell Biol (Jan), 156(1): 199-209.
- Previtali SC, Feltri ML, Archelos JJ, Quattrini A, Wrabetz L, Hartung H. (2001) Role of integrins in the peripheral nervous system. Prog Neurobiol (May), 64(1): 35-49.
- Quattrini A, Lorenzetti I, Sciorati C, Corbo M, Previtali SC, Feltri ML, Canal N, Wrabetz L, Nemni R, Clementi E. (2001) Human IgM anti-GM1 autoantibodies modulate intracellular calcium homeostasis in neuroblastoma cells. J Neuroimmunol (Mar), 114(1-2): 213-219.
- Wrabetz L and Feltri ML. (2001) Do Schwann Cells Stop, DR(o)P2 and Roll?. Neuron (Jan), 30: 642-644.
- Previtali SC, Quattrini A, Fasolini M, Panzeri MC, Villa A, Filbin MT, Li W, Chiu SY, Messing A, Wrabetz L, Feltri M. (2000) Epitope-tagged P(0) glycoprotein causes Charcot-Marie-Tooth-like neuropathy in transgenic mice. J Cell Biol (Nov), 151(5): 1035-1046.
- Yin X, Kidd GJ, Wrabetz L, Feltri ML, Messing A, Trapp BD. (2000) Schwann cell myelination requires timely and precise targeting of P(0) protein. J Cell Biol (Mar), 148(5): 1009-1020.
- Wrabetz L, Feltri ML, Quattrini A, Imperiale D, Previtali S, D‘Antonio M, Martini R, Yin X, Trapp BD, Zhou L, Chiu SY, Messing A. (2000) P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J Cell Biol (Mar), 148(5): 1021-1034.
- Previtali SC, Quattrini A, Fasolini M, Panzeri MC, Villa A, Filbin MT, Li W, Chiu S-Y, Messing A, Wrabetz L, and Feltri ML. (2000) Epitope-tagged P0 glycoprotein causes Charcot-Marie-Tooth-like neuropathy in transgenic mice. J Cell Bio (Jan), 151(5): 1035-1046.
- Quattrini A, Feltri ML, Previtali S, Fasolini M, Messing A, Wrabetz L. (1999) Peripheral nerve dysmyelination due to P0 glycoprotein overexpression is dose-dependent. Ann N Y Acad Sci (Sep), 883: 294-301.
- Feltri ML, D‘Antonio M, Previtali S, Fasolini M, Messing A, Wrabetz L. (1999) P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells. Ann N Y Acad Sci (Sep), 883: 116-123.
- Feltri ML, D‘antonio M, Quattrini A, Numerato R, Arona M, Previtali S, Chiu SY, Messing A, Wrabetz L. (1999) A novel P0 glycoprotein transgene activates expression of lacZ in myelin-forming Schwann cells. Eur J Neurosci (May), 11(5): 1577-1586.
- Previtali SC, Quattrini A, Pardini CL, Nemni R, Feltri ML, Boncinelli E, Canal N, Wrabetz L. (1999) Laminin receptor alpha6beta4 integrin is highly expressed in ENU-induced glioma in rat. Glia (Mar), 26(1): 55-63.
- Taveggia C, Pizzagalli A, Feltri ML, Grinspan JB, Kamholz J, Wrabetz L. (1998) MEBA derepresses the proximal myelin basic protein promoter in oligodendrocytes. J Biol Chem (Oct), 273(42): 27741-27748.
- Wrabetz L, Taveggia C, Feltri ML, Quattrini A, Awatramani R, Scherer SS, Messing A, Kamholz J. (1998) A minimal human MBP promoter-lacZ transgene is appropriately regulated in developing brain and after optic enucleation, but not in shiverer mutant mice. J Neurobiol (Jan), 34(1): 10-26.
- Ferraresi S, Lorenzetti I, Nemni R, Kamholz J, Feltri M, Wrabetz L. (1997) Toward a transgenic mouse model of remyelination. Mult Scler (Apr), 3(2): 80-83.
- Feltri M, Arona M, Scherer SS, Wrabetz L. (1997) Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve. Gene (Feb), 186(2): 299-304.
- Feltri ML, Arona M, Scherer SS, and Wrabetz L. (1997) Cloning and sequence of the cDNA encoding the beta4 integrin subunit in rat peripheral nerve. Gene (Jan), 186(2): 299-304.
- Quattrini A, Previtali S, Feltri M, Canal N, Nemni R, Wrabetz L. (1996) Beta 4 integrin and other Schwann cell markers in axonal neuropathy. Glia (Aug), 17(4): 294-306.
- Wrabetz L, Feltri M, Kim H, Daston M, Kamholz J, Scherer SS, Ratner N. (1995) Regulation of neurofibromin expression in rat sciatic nerve and cultured Schwann cells. Glia (Sep), 15(1): 22-32.
- Scherer SS, Xu YT, Roling D, Wrabetz L, Feltri M, Kamholz J. (1994) Expression of growth-associated protein-43 kD in Schwann cells is regulated by axon-Schwann cell interactions and cAMP. J Neurosci Res (Aug), 38(5): 575-589.
- Feltri ML, Scherer SS, Nemni R, Kamholz J, Vogelbacker H, Scott MO, Canal N, Quaranta V, Wrabetz L. (1994) Beta 4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent. Development (May), 120(5): 1287-1301.
- Wrabetz L, Shumas S, Grinspan J, Feltri M, Bozyczko D, McMorris FA, Pleasure D, Kamholz J. (1993) Analysis of the human MBP promoter in primary cultures of oligodendrocytes: positive and negative cis-acting elements in the proximal MBP promoter mediate oligodendrocyte-specific expression of MBP. J Neurosci Res (Nov), 36(4): 455-471.
- Feltri M, Scherer SS, Wrabetz L, Kamholz J, Shy ME. (1992) Mitogen-expanded Schwann cells retain the capacity to myelinate regenerating axons after transplantation into rat sciatic nerve. Proc Natl Acad Sci U S A (Sep), 89(18): 8827-8831.
- Nemni R, Feltri ML, Fazio R, Quattrini A, Lorenzetti I, Corbo M, Canal N. (1990) Axonal neuropathy with monoclonal IgG kappa that binds to a neurofilament protein. Ann Neurol (Sep), 28(3): 361-364.
- Welser-Alves JV, Boroujerdi A, Feltri ML, Milner R. (1900) ß4 integrin is not essential for localization of hemidesmosome proteins plectin and CD151 in cerebral vessels. Brain circulation (Jan), 2(4): 189-196. doi:10.4103/2394-8108.195285
Books and Book Chapters:
- Steven Scherer, M. Laura Feltri & Lawrence Wrabetz. (1900) Neuro Glia. In: Genetics mutations affecting myelin formation. Oxford University Press
Professional Memberships:
- President Elect; Peripheral Nerve Society (2021–2023)
- Chair , Cellular and Molecular Biology of Glia NINDS Study session (2019–2021)
- Member of the CBMG NINDS-NIH Study Session (2015–2021)
- Member of the National Multiple Sclerosis Society Study Session (2012–2015)
- Scientific Advisory Board Member of the Charcot-Marie-Tooth Association (2009–2018)
Presentations:
- "strietin connect rac1 to the hippo patwhay and are essential for peripheral myelinatiom" gordon research conference on glia (2023)
- "Striatins in Peripheral Nerve Development Invited Plenary Speaker" Argentinian Society for Neuroscience (2021)
- "Richard Bunge Plenary Lecture: Signals to Schwann cells during myelination and peripheral Neuropathies" Peripheral Nerve Society Annual Meeting (2021)
- "Invited speaker" Krabbe Research and Translational Consortium (2021)
- "UNIVERSITY OF CONNECTICUT: Novel components of the Hippo pathway and their role in peripheral nerve myelination" Department series, NEUROSCIENCE (2021)
- "“Schwann cell myelination: riding on a Hippo from the basal lamina to the nucleus and back”" Max Plank Institute invited Speaker series (virtual) (2020)
- Myelin Gordon Conference (2018)
- "Chemical and Mechanical Signals Govern Schwann Cell Development and Myelination" Plenary Lecture Euroglia Meeting (2017)
- "The Role of Prohibitins in Myelination and Axonal Health" Pittsburgh Institute of Neurodegeneration Lecture (2017)
- Euroglia Meeting (2017)
- "Ensheathment and Support of Neurons" Cold Spring Harbor Meeting (2016)
- "Adhesive and Mechanical Signals that Control Schwann Cell-Axon Interactions" Helen Wilshire Walsh Lecture at the Miami Project to Cure Paralysis (2016)
- "Extracellular Signals in Demyelinating Diseases" PFIZER Neuroscience Series (2016)
- "Essential Role for Prohibitions in Myelination Revealed by Proteomic Analysis of Early Axo-Glial Interactions" International Society for Neurochemistry/American Society for Neurochemistry biannual meeting (2015)
- "Pseudopods and Prohibitins: New Methods and Molecules in Peripheral Myelination" (2015)
- "Spatial Mapping of Polarized Axo-Glial Interactions Reveals New Molecules Involved in Myelination" XII European Meeting on Glial Cells in Health and Disease (2015)
- Peripheral Nerve Society Meeting (2015)
- "International Graduate Training Course in Peripheral Nervous System Development and Disease" (2014)
- ; Adelson Medical Research Foundation (2014)
- "Signaling from the Extracellular Matrix in Myelination" (2013)
- "First Contact Between Neurons and Schwann Cells" Great Lakes Glia Meeting (2013)
- "Peripheral Demyelination" Muscle Study Group Meeting (2013)
- "Laminin Receptors in Peripheral Neuropathies" (2013)
- "The Many Faces of Dystroglycan in Peripheral Nerve Development" (2013)
- "Regulation of myelination and re-myelination symposium" International Society for Neurochemistry/American Society for Neurochemistry biannual meeting (2013)
- "Signaling by p38 MAPK in Myelination" ; Cleveland Clinic (2013)
- "UB2020 Molecular Recognition in Biological Systems and Bioinformatics Minisymposium" Molecular Basis of Neurodegenerative Disorders; University at Buffalo (2012)
- "Glia in Health and Disease" Cold Spring Harbor Meeting (2012)
- "Discussion Leader, “Cell Biology of Myelin” session" Myelin Gordon conference; Gordon Research Conference (2012)
- "Laminin receptors and signals in Schwann cell development" Center for Neuroscience Research at Children’s National Medical Center seminar series; Institute for Neuroscience at the George Washington University (2012)
- "Cytoskeletal Proteins in Myelinating Glia" American Society for Neurochemistry Meeting; American Society for Neurochemistry (2012)
- "Cell-cell and cell-matrix interactions in morphogenesis of peripheral nerves" PhD Invited Series; New York University (2011)
- "alpha6 beta1 and alpha7beta1 are the integrins required for axonal sorting of axons by Schwann cells" ISN/ASN Myelin Satellite; International Society for Neurochemistry/American Society for Neurochemistry (2011)
- "Mouse models of developmental neuropathies" ESNM meeting on preclinical models of Charcot-Marie-Tooth; European Neuromuscular Center (2011)
- "Matrix and receptors in myelination" Fondation Le Treilles; Fondation Le Treilles (2010)
- "Regulation of dystroglycan by metalloproteinases in nerve development and pathology" Roswell Park Cancer Institute seminar series; Roswell Park Cancer Institute (2010)
- "Laminins in peripheral nerve development" Basal Lamina Consortium; Vanderbilt University (2010)
- "Laminin signals in myelination" Paris Lecture Series; Hopital La Salpétriere (2010)
- "Laminin receptors and signals in nerve development" Paris Lecture Series; Pierre & Marie Curie University (2010)
- "Laminin signals in myelination and demyelinating neuropathies" ISF-Legacy Heritage Fund Inaugural Meeting On New Approaches To Neurodegenerative Diseases; Israel Science Foundation (2010)
- "Laminin receptors and proteinases in congenital muscular dystrophy and Charcot-Marie-Tooth disease" MRC Centre for Neuromuscular Diseases; The National Hospital for Neurology and Neurosurgery (2009)
- "Laminin receptors and signals in myelination" University of Marseille seminar series; University of Marseille (2009)
- "Non-redundant function of dystroglycan and beta1 integrins in radial sorting of axons Myelin Development, Function and Related Diseases." Ninth Biennial Satellite Meeting of the ISN on Myelin Biology; International Society for Neurochemistry/American Society for Neurochemistry (2009)
- "Laminin receptors and signals in nerve development and disease" The Children Hospital of Philadelphia, Developmental Biology Program for Pediatric Disorders Seminars Series (2008)
- "Dystroglycan Complex in Schwann cells" Myelin Gordon Research Conference (2008)
- "Extracellular Matrix in Peripheral nervous system development and myelination" Erasmus Lectures on Genetics (2008)
- "Genetic models of complex neuropathies" Meeting Gruppo Italiano Sistema Nervoso Periferico; Italian Peripheral Nerve Society (2008)
- "Dystroglycan in the architecture of internodes and nodes of Ranvier in the peripheral nervous system" Lecture Series; University of Marseille (2008)
- "Extracellular matrix in Schwann cell-axon interactions and myelination." Finland Lecture Series; University of Oulu (2008)
- Lecture Series; University of Koln (2007)
- "Common regulatory mechanisms in hemopoiesis and neurogenesis" EMBO Workshop (2007)
- Euroglia Meeting; ; ECM in myelination session, organizer and speaker (2007)
- ESN Meeting; Federation of Europeans Neurological Society (FENS); Symposium on Hereditary Neuropathies (2007)
- "Invited speaker: Schwann cell development" Karolinska Institute, Stockholm, Sweden. Nobel Mini-Symposium “The Dark Side of The Brain: Myelinating Glia in the Central and Peripheral Nervous System”,
Service Activities:
- E-life, Plos Biology , J. of Neuroscience, Nature Communication; Ad hoce reviewer (2021)
- Journal of the peripheral nervous system; Editorial board member (2021)
- UB - SUNY distinguished professorship and chancellor award committee; Member of the committee (2021)
- Peripheral Nerve Society (international); President-Elect (2021)
- ; Ad Hoc member F35 neurodegeneration Study section (2021)
- JSMBS Dean and VP of Health Sciences; Member of the search committee (2021)
- Charcot-Marie-Tooth 4B3 research Foundation; Member of the scientific advisory Board (2021)
- GLIA; Editorial Board member (2019–2021)
- Krabbe Connect Association; Scientific Advisory Board Member (2019–2021)
- ; Chair (2019–2021)
- Journal of Experimental Neurology; Editorial Board member (2018–2021)
- ; Faculty Council Steering Committee for Admission policies to the Medical School, University at Buffalo School of Medicine and Biomedical Sciences. (2016–2021)
- CMBG;; Panel Member (2015–2021)
- Muscular Dystrophy Association USA; Muscular Dystrophy Association USA;; Panel Member (2012–present)
- National Multiple Sclerosis Society; (2012–2018)
- Charcot Marie Tooth association (USA); Scientific Advisory Board member (2011–present)
- European Leukodystrophy Association (ELA); European Leukodystrophy Association (ELA);; Grant Reviewer (2010–present)
- Italian Multiple Sclerosis Foundation (FISM); Italian Multiple Sclerosis Foundation (FISM);; Grant Reviewer (2010–present)
- The French National Research Agency (ANR); The French National Research Agency (ANR);; Grant Reviewer (2009–present)
- Charcot Marie Tooth Association;; Panel Member (2009–present)
- French Muscular Dystrophy Association; French Muscular Dystrophy Association;; Grant Reviewer (2008–present)
- Charcot Marie Tooth Association; Charcot Marie Tooth Association;; Grant Reviewer (2007–2008)
- UK Multiple Sclerosis Society; UK Multiple Sclerosis Society;; Grant Reviewer (2007)
- Medical Research Council UK (MRC); Medical Research Council UK (MRC);; Grant Reviewer (2007)
- University of Antwerp Research Counsel; University of Antwerp Research Counsel;; Grant Reviewer (2006)
- Shota Rustaveli National Science Foundation;; Grant Reviewer
- Great Britain Multiple Sclerosis Society;; Grant Reviewer
- Austrian Science Foundation;; Grant Reviewer
- MRC;; Grant Reviewer
- INSERM-CNRS;; Grant Reviewer
- Genethon;; Grant Reviewer
- AFM;; Grant Reviewer
- ELA foundation;; Grant Reviewer
- Charcot-Marie-Tooth Association;; Grant Reviewer
- Muscular Dystrophy Association;; Grant Reviewer
- Fondazione Italiana Sclerosi Multipla (FISM);; Grant Reviewer
- Search Committee, Faculty position Assistant/Associate Professor, Hunter James Kelly Research Institute; Member