Satrajit Sinha PhD

Satrajit Sinha

Satrajit Sinha
PhD

Professor

Department of Biochemistry

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Gene Expression; Genomics and proteomics; Molecular and Cellular Biology

Contact Information
955 Main Street
Buffalo, New York 14203
Phone: (716) 881-7994
ssinha2@buffalo.edu



Professional Summary:

My laboratory is interested in understanding the transcriptional control mechanisms that dictate epithelial cell development, differentiation and cancer. Specifically, we seek to understand the functional role of a p53-family member, p63 and Ets family of proteins in epithelial cells such as those of the skin, mammary glands and salivary glands. Towards this end, we have generated transgenic mice in which the normal expression pattern of these crucial factors is altered by both gain-of-function (Tet-inducible transgenic system) and loss-of-function (knockout) experiments. Our broad objectives are to elucidate the molecular mechanism by which transcription factors such as p63 and Ets proteins regulate their target genes and how such regulation of specific pathways dictate cell fate, development and differentiation. We utilize broad biochemical and genetic approaches, mouse and human cell culture systems and state of the art genome-wide interrogation techniques to answer questions about differentiation of progenitor/stem populations and to examine molecular consequences of altered expression of transcription factors. These studies will not only help better understand the normal physiological processes but also lead to novel mechanistic insights into the pathophysiology of wide range of disease including cancer.

Education and Training:

  • PhD, Biochemistry, University of Texas Health Science Center Houston (1995)
  • Calcutta Medical College (1989)

Employment:

  • Director of Graduate Studies, Biochemistry
  • Professor (2019-present)
  • Associate Professor (Tenured), Biochemistry, State University of New York at Buffalo (2007–2011)
  • Assistant Professor, Biochemistry, State University of New York at Buffalo (2001–2007)

Awards and Honors:

  • Young Investigator Award, SUNY at Buffalo (2005)
  • Postdoctoral Fellowship. NRSA Award (1998)
  • John P. McGovern Student Award, GSBS Univ. of Texas Health Science Center (1995)
  • Outstanding Accomplishments Award, University of Texas (1994)
  • 1st Prize Univ. of Texas M.D. Anderson Grad. Student Symposium (1994)

Research Expertise:

  • Molecular Biology

Grants and Sponsored Research:

  • March 2018–February 2024
    Genomic and functional investigations of the transcriptional regulatory network of salivary gland morphogenesis and stem cell fate choices in defined genetic models
    NIDCR
    Role: Co-Principal Investigator
  • March 2018–December 2022
    Genomic and epigenomic investigations of the transcriptional regulatory network of skin keratinocytes in defined genetic models
    NIAMS
    Role: Principal Investigator

Journal Articles:

See all (70 more)

Professional Memberships:

  • Open Dermatology Journal; Editorial Board Member (2008–2009)

Service Activities:

  • Journal of Investigative Dermatology Cell Death and Disease Frontiers in Cancer (2021)
  • ZRG1 F10-B-K20, NIH; Member (2021)
  • ICER, NIH; Member (2021)
  • ZRG1 MOSS-B-82, MOSS; Member (2021)
  • JSMBS Faculty Promotion Committee (2018–2021)
  • ; Director of Graduate Studies (2018–present)
  • NIH Study Section; NIAMS; P30 Skin Diseases Research Core Center;; Ad Hoc Reviewer (2011–2012)
  • NIH Study Section; DEV 2;; Ad Hoc Reviewer (2011–2012)
  • NIH Study Section; Special Emphasis Panel MOSS-D 12; Panel Member ZRG1;; Panel Member (2011–2012)
  • NIH Study Section; NIGMS (NIH Loan Repayment application);; Ad Hoc Reviewer (2009–2010)
  • NIH Study Section; NIAMS (Recovery Act Limited Competition for NIH;; Ad Hoc Reviewer (2009–2010)
  • NIH Study Section; NIAMS; Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure Grand Opportunities;; Ad Hoc Reviewer (2009–2010)
  • NIH; NIAMS P30 Skin Diseases Research Core Center;; Ad Hoc Reviewer (2008–2009)
  • NIH; NIAMS CORT P50 Special Emphasis Panel;; Ad Hoc Reviewer (2006–2007)
  • NIH; Center for Scientific Review;; Ad Hoc Reviewer (2005–2006)

School News:

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Contact Information

955 Main Street
Buffalo, New York 14203
Phone: (716) 881-7994
ssinha2@buffalo.edu