Barbara Rita Alevriadou PhD
Barbara Rita Alevriadou
PhD
SUNY Empire Innovation Professor in Biomedical Engineering
Department of Biomedical Engineering
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cardiopulmonary physiology; Cardiovascular Disease; Metabolism; Molecular and Cellular Biology; Molecular Basis of Disease; Research Lab; Signal Transduction; Vascular Medicine
Professional Summary:
Dr. Alevriadou received her BS in Chemical Engineering from the Aristotle University, Thessaloniki, Greece, in 1986 and her PhD in Chemical Engineering (Bioengineering & Biosciences Institute) from Rice University, Houston, TX in 1992. Following postdoctoral training in the Department of Molecular & Experimental Medicine at Scripps Research Institute, La Jolla, CA, she joined the BME Department at Johns Hopkins University, Baltimore, MD, as Assistant Professor. In 2003, she joined the BME Center (Department, since 2008) and Davis Heart & Lung Research Institute of The Ohio State University as Associate Professor of BME and Internal Medicine, Cardiovascular Medicine. In 2019, she joined the BME Department at the University at Buffalo - The State University of New York as SUNY Empire Innovation Professor. Her research on vascular mechanobiology and oxidative stress is/has been supported by the National Institutes of Health (NIH) and the American Heart Association (AHA). Dr. Alevriadou is a member of the Biomedical Engineering Society (BMES) (elected member on the Board of Directors, 2014-2017), Society for Redox Biology & Medicine (SfRBM), North American Vascular Biology Organization (NAVBO), and AHA. She regularly reviews for federal/local funding agencies (NIH, NSF, AHA) and biomedical and cardiovascular journals, and is an Editorial Board member of the American Journal of Physiology-Cell Physiology (2002-present).
Education and Training:
- The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA (1993)
- Rice University, Houston, TX (1992)
- Rice University, Houston, TX (1989)
- Aristotle University, Thessaloniki, Greece (1986)
Employment:
- Adjunct Professor, Chemical and Biological Engineering, University at Buffalo - The State University of New York, Buffalo, NY (2021-present)
- SUNY Empire Innovation Professor in Biomedical Engineering, Department of Biomedical Engineering, University at Buffalo - The State University of New York, Buffalo, NY (2019-present)
- Affiliate Faculty, Davis Heart and Lung Research Institute and the Center for Regenerative Medicine & Cell-Based Therapies, The Ohio State University Wexner Medical Center, Columbus, OH (2003–2019)
- Associate Professor of Biomedical Engineering, Departments of Biomedical Engineering and Internal Medicine (Cardiovascular Medicine), The Ohio State University, Columbus, OH (2003–2019)
- Affiliate Faculty in Chemical and Biomolecular Engineering, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD (1993–2003)
- Assistant Professor of Biomedical Engineering, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD (1993–2003)
Awards and Honors:
- Chair, Mitochondrial Biology Symposium (2021)
- Empire Innovation Professor and PRODiG Awardee (2019)
- Associate Editor of the American Journal of Physiology – Cell Physiology (2019)
- American Physiological Society (APS) STAR Reviewer (2016)
- Certificate of Recognition for dedication and volunteerism, Society for Redox Biology and Medicine (2016)
- Board of Directors, Biomedical Engineering Society (2014)
- Chair, The Ohio State University College of Engineering Committee on the Responsible Conduct of Research (2013)
- Nominee for the WM Keck Foundation Research Award, The Ohio State University (2011)
- Co-Chair, Cardiovascular Track, BMES 2009 Annual Meeting (2009)
- Director's Executive Cabinet, Davis Heart & Lung Research Institute, The Ohio State University (2008)
- Editorial Board, The American Journal of Physiology - Cell Physiology (2002)
- Graduate Fellowship, Robert A. Welch Foundation, Rice University (1992)
Research Expertise:
- MOLECULAR BASIS OF CARDIOVASCULAR DISEASE: Understanding the role of hemodynamics and chemical agonists in regulating the endothelial phenotype and initiating atherosclerosis/coronary artery disease and other cardiovascular diseases/conditions (cardiac ischemia/reperfusion injury, heart failure, diabetes, etc.)
- VASCULAR ENDOTHELIAL (DYS)FUNCTION: Assessing the cell's calcium and reactive oxygen species (including nitric oxide) signaling, mitochondrial function and metabolism, gene expression/protein synthesis, inflammation, and propensity for apoptosis
- VASCULAR MECHANOBIOLOGY / MECHANOTRANSDUCTION: Effects of hemodynamic forces (e.g., shear stress, pressure) and/or oxygen tension on the vascular endothelium; Signal transduction due to changes in the cell‘s mechanochemical environment
Research Centers:
- Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- August 2018–June 2022
Control of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for Atherosclerosis. Alevriadou BR (PI), Madesh M (co-PI). Agency: NIH/NHLBI. Type: R01 HL142673. Total cost: $1.82 million
Role: Principal Investigator - January 2016–June 2018
Redox Regulation of Autophagy in Postischemic Vascular Endothelial Cells. Alevriadou BR (PI), Zweier JL (co-I). Agency: AHA. Type: Grant-In-Aid. Total cost: $154,000
Role: Principal Investigator - June 2011–May 2013
Emerging Functions of Mitochondrial Fission in Postischemic Endothelial Cells. Alevriadou BR (PI), Matzavinos A (co-I). Agency: NIH/NHLBI. Type: R21 HL106392. Total cost: $423,000
Role: Principal Investigator - January 2008–December 2009
Mechanoregulation of Endothelial Mitochondrial Function. Alevriadou BR (PI), Chen Y-R (co-I), Szeto HH (co-I). Agency: NIH/NHLBI. Type: R21 HL091417. Total cost: $410,000
Role: Principal Investigator - December 2001–February 2006
Reperfusion-Induced Endothelial Cell Dysfunction. Alevriadou BR (PI), Irani K (co-I). Agency: NIH/NHLBI. Type: R01 HL067027. Total cost: $1.25 million
Role: Principal Investigator
Journal Articles:
- Alevriadou BR, Patel A, Noble M, Ghosh S, Gohil VM, Stathopulos PB, Madesh M, Alevriadou B. (2021) Molecular nature and physiological role of the mitochondrial calcium uniporter channel. Am J Physiol Cell Physiol (Apr), 320(4): 465-482.
- Mentkowski KI, Euscher LM, Patel A, Alevriadou BR, Lang JK, Alevriadou B. (2020) Monocyte recruitment and fate specification after myocardial infarction. Am J Physiol Cell Physiol (Nov), 319(5): 797-806.
- Moshkforoush A, Ashenagar B, Tsoukias NM, Alevriadou BR. (2019) Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics. Sci Rep (Nov), 9(1): 17072-17072.
- McKee C, Tumin D, Alevriadou BR, Nicol KK, Yates AR, Hayes D, Tobias JD. (2018) Age-Dependent Association Between Pre-transplant Blood Transfusion and Outcomes of Pediatric Heart Transplantation. Pediatr Cardiol (Apr), 39(4): 743-748.
- Alevriadou BR, Shanmughapriya S, Patel A, Stathopulos PB, Madesh M. (2017) Mitochondrial Ca2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces. J R Soc Interface (Dec), 14(137).
- Scheitlin CG, Julian JA, Shanmughapriya S, Madesh M, Tsoukias NM, Alevriadou BR. (2016) Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress. Am J Physiol Cell Physiol (Mar), 310(6): 479-490.
- Scheitlin CG, Nair DM, Crestanello JA, Zweier JL, Alevriadou BR. (2014) Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective. Cell Mol Bioeng (Dec), 7(4): 483-496.
- Wootton DM, Alevriadou BR. (2012) The shear stress of busting blood clots. N Engl J Med (Oct), 367(14): 1361-1363.
- Giedt RJ, Pfeiffer DR, Matzavinos A, Kao CY, Alevriadou BR. (2012) Mitochondrial dynamics and motility inside living vascular endothelial cells: role of bioenergetics. Ann Biomed Eng (Sep), 40(9): 1903-1916.
- Giedt RJ, Yang C, Zweier JL, Matzavinos A, Alevriadou BR. (2012) Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species. Free Radic Biol Med (Jan), 52(2): 348-356.
- Chen J, Chen CL, Alevriadou BR, Zweier JL, Chen YR. (2011) Excess no predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical. Biochim Biophys Acta (May), 1807(5): 491-502.
- Lyczkowski RW, Alevriadou BR, Horner M, Panchal CB, Shroff SG. (2009) Application of multiphase computational fluid dynamics to analyze monocyte adhesion. Ann Biomed Eng (Aug), 37(8): 1516-1533.
- Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR. (2009) Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther (Apr), 329(1): 94-101.
- Jones CI, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR. (2008) Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite. Am J Physiol Cell Physiol (Jul), 295(1): 180-191.
- Jones CI, Zhu H, Martin SF, Han Z, Li Y, Alevriadou BR. (2007) Regulation of antioxidants and phase 2 enzymes by shear-induced reactive oxygen species in endothelial cells. Ann Biomed Eng (May), 35(5): 683-693.
- Han Z, Chen YR, Jones CI, Meenakshisundaram G, Zweier JL, Alevriadou BR. (2007) Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells. Am J Physiol Cell Physiol (Mar), 292(3): 1103-1112.
- Martin SF, Chatterjee S, Parinandi N, Alevriadou BR. (2005) Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells. Vascul Pharmacol (Sep), 43(3): 148-156.
- Haun JB, Baldwin WM, Alevriadou BR. (2005) Clearance of complement by human vascular endothelial cells: effects of hypoxia/reoxygenation and IL-1beta activation. Transpl Int (Apr), 18(4): 475-482.
- Vijayan KV, Huang TC, Liu Y, Bernardo A, Dong JF, Goldschmidt-Clermont PJ, Alevriadou BR, Bray PF. (2003) Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3. FEBS Lett (Apr), 540(1-3): 41-46.
- Ng CK, Deshpande SS, Irani K, Alevriadou BR. (2002) Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1. Am J Physiol Cell Physiol (Jul), 283(1): 93-102.
- Wootton DM, Popel AS, Alevriadou BR. (2002) An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator. Biotechnol Bioeng (Feb), 77(4): 405-419.
- Yeh LH, Kinsey AM, Chatterjee S, Alevriadou BR. (2001) Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression. J Vasc Res (Nov), 38(6): 551-559.
- Huang TC, Jordan RE, Hantgan RR, Alevriadou BR. (2001) Differential effects of c7E3 Fab on thrombus formation and rt-PA-Mediated thrombolysis under flow conditions. Thromb Res (Jun), 102(5): 411-425.
- Hinds MT, Park YJ, Jones SA, Giddens DP, Alevriadou BR. (2001) Local hemodynamics affect monocytic cell adhesion to a three-dimensional flow model coated with E-selectin. J Biomech (Jan), 34(1): 95-103.
- Yeh LH, Park YJ, Hansalia RJ, Ahmed IS, Deshpande SS, Goldschmidt-Clermont PJ, Irani K, Alevriadou BR. (1999) Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS. Am J Physiol (Jan), 276(4): 838-847.
- Graham DA, Huang TC, Keyt BA, Alevriadou BR. (1998) Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow. Ann Biomed Eng (Jul), 26(4): 712-724.
- Huang TC, Graham DA, Nelson LD, Alevriadou BR. (1998) Fibrinolytic agents inhibit platelet adhesion onto collagen type I-coated surfaces at high blood flow conditions. Blood Coagul Fibrinolysis (Apr), 9(3): 213-226.
- Alevriadou BR, Moake JL, Turner NA, Ruggeri ZM, Folie BJ, Phillips MD, Schreiber AB, Hrinda ME, McIntire LV. (1993) Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood (Mar), 81(5): 1263-1276.
- Alevriadou BR, Eskin SG, McIntire LV, Schilling WP. (1993) Effect of shear stress on 86Rb+ efflux from calf pulmonary artery endothelial cells. Ann Biomed Eng (Jan), 21(1): 1-7.
- Alevriadou BR, McIntire LV, Lasslo A. (1992) Inhibition of platelet adhesion and thrombus formation on a collagen-coated surface by novel carbamoylpiperidine antiplatelet agents. Biochim Biophys Acta (Nov), 1137(3): 279-286.
Professional Memberships:
- American Physiological Society (APS) (Member, Cell and Molecular Physiology Section); Member (2020–present)
- American Heart Association (AHA) (Member, Council on Basic Cardiovascular Sciences) (2010–present)
- Society for Redox Biology and Medicine (SFRBM) (Women in Science Mentoring Committee, 2005-present) (1995–present)
- North American Vascular Biology Organization (NAVBO) (Founding Member) (1994–present)
- Biomedical Engineering Society (BMES) (Board of Directors 2014-17; Student Affairs and Diversity Committees 2014-18; International Affairs Committee 2018-present) (1994–present)