Cardiopulmonary physiology; Cardiovascular Disease; Metabolism; Molecular and Cellular Biology; Molecular Basis of Disease; Research Lab; Signal Transduction; Vascular Medicine
Dr. Alevriadou received her BS in Chemical Engineering from the Aristotle University, Thessaloniki, Greece, in 1986 and her PhD in Chemical Engineering (Bioengineering & Biosciences Institute) from Rice University, Houston, TX in 1992. Following postdoctoral training in the Department of Molecular & Experimental Medicine at Scripps Research Institute, La Jolla, CA, she joined the BME Department at Johns Hopkins University, Baltimore, MD, as Assistant Professor. In 2003, she joined the BME Center (Department, since 2008) and Davis Heart & Lung Research Institute of The Ohio State University as Associate Professor of BME and Internal Medicine, Cardiovascular Medicine. In 2019, she joined the BME Department at the University at Buffalo - The State University of New York as SUNY Empire Innovation Professor. Her research on vascular mechanobiology and oxidative stress is/has been supported by the National Institutes of Health (NIH) and the American Heart Association (AHA). Dr. Alevriadou is a member of the Biomedical Engineering Society (BMES) (elected member on the Board of Directors, 2014-2017), Society for Redox Biology & Medicine (SfRBM), North American Vascular Biology Organization (NAVBO), and AHA. She regularly reviews for federal/local funding agencies (NIH, NSF, AHA) and biomedical and cardiovascular journals, and is an Editorial Board member of the American Journal of Physiology-Cell Physiology (2002-present).
Education and Training:
The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA (1993)
Rice University, Houston, TX (1992)
Rice University, Houston, TX (1989)
Aristotle University, Thessaloniki, Greece (1986)
Employment:
Adjunct Professor, Chemical and Biological Engineering, University at Buffalo - The State University of New York, Buffalo, NY (2021-present)
SUNY Empire Innovation Professor in Biomedical Engineering, Department of Biomedical Engineering, University at Buffalo - The State University of New York, Buffalo, NY (2019-present)
Affiliate Faculty, Davis Heart and Lung Research Institute and the Center for Regenerative Medicine & Cell-Based Therapies, The Ohio State University Wexner Medical Center, Columbus, OH (2003–2019)
Associate Professor of Biomedical Engineering, Departments of Biomedical Engineering and Internal Medicine (Cardiovascular Medicine), The Ohio State University, Columbus, OH (2003–2019)
Affiliate Faculty in Chemical and Biomolecular Engineering, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD (1993–2003)
Assistant Professor of Biomedical Engineering, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD (1993–2003)
Awards and Honors:
Chair, Mitochondrial Biology Symposium (2021)
Empire Innovation Professor and PRODiG Awardee (2019)
Associate Editor of the American Journal of Physiology – Cell Physiology (2019)
American Physiological Society (APS) STAR Reviewer (2016)
Certificate of Recognition for dedication and volunteerism, Society for Redox Biology and Medicine (2016)
Board of Directors, Biomedical Engineering Society (2014)
Chair, The Ohio State University College of Engineering Committee on the Responsible Conduct of Research (2013)
Nominee for the WM Keck Foundation Research Award, The Ohio State University (2011)
Director's Executive Cabinet, Davis Heart & Lung Research Institute, The Ohio State University (2008)
Editorial Board, The American Journal of Physiology - Cell Physiology (2002)
Graduate Fellowship, Robert A. Welch Foundation, Rice University (1992)
Research Expertise:
MOLECULAR BASIS OF CARDIOVASCULAR DISEASE: Understanding the role of hemodynamics and chemical agonists in regulating the endothelial phenotype and initiating atherosclerosis/coronary artery disease and other cardiovascular diseases/conditions (cardiac ischemia/reperfusion injury, heart failure, diabetes, etc.)
VASCULAR ENDOTHELIAL (DYS)FUNCTION: Assessing the cell's calcium and reactive oxygen species (including nitric oxide) signaling, mitochondrial function and metabolism, gene expression/protein synthesis, inflammation, and propensity for apoptosis
VASCULAR MECHANOBIOLOGY / MECHANOTRANSDUCTION: Effects of hemodynamic forces (e.g., shear stress, pressure) and/or oxygen tension on the vascular endothelium; Signal transduction due to changes in the cell‘s mechanochemical environment
Research Centers:
Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
Health and Wellness Across the Lifespan
Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
August 2018–June 2022 Control of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for Atherosclerosis. Alevriadou BR (PI), Madesh M (co-PI). Agency: NIH/NHLBI. Type: R01 HL142673. Total cost: $1.82 million Role: Principal Investigator
January 2016–June 2018 Redox Regulation of Autophagy in Postischemic Vascular Endothelial Cells. Alevriadou BR (PI), Zweier JL (co-I). Agency: AHA. Type: Grant-In-Aid. Total cost: $154,000 Role: Principal Investigator
June 2011–May 2013 Emerging Functions of Mitochondrial Fission in Postischemic Endothelial Cells. Alevriadou BR (PI), Matzavinos A (co-I). Agency: NIH/NHLBI. Type: R21 HL106392. Total cost: $423,000 Role: Principal Investigator
January 2008–December 2009 Mechanoregulation of Endothelial Mitochondrial Function. Alevriadou BR (PI), Chen Y-R (co-I), Szeto HH (co-I). Agency: NIH/NHLBI. Type: R21 HL091417. Total cost: $410,000 Role: Principal Investigator
December 2001–February 2006 Reperfusion-Induced Endothelial Cell Dysfunction. Alevriadou BR (PI), Irani K (co-I). Agency: NIH/NHLBI. Type: R01 HL067027. Total cost: $1.25 million Role: Principal Investigator
American Physiological Society (APS) (Member, Cell and Molecular Physiology Section); Member (2020–present)
American Heart Association (AHA) (Member, Council on Basic Cardiovascular Sciences) (2010–present)
Society for Redox Biology and Medicine (SFRBM) (Women in Science Mentoring Committee, 2005-present) (1995–present)
North American Vascular Biology Organization (NAVBO) (Founding Member) (1994–present)
Biomedical Engineering Society (BMES) (Board of Directors 2014-17; Student Affairs and Diversity Committees 2014-18; International Affairs Committee 2018-present) (1994–present)