Kedar Aras Ph.D.

Kedar Aras

Kedar Aras
Ph.D.

Assistant Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Arrhythmias; Bioinformatics; Biomedical Engineering; Cardiac Electrophysiology - Clinical; Cardiovascular Disease; Circadian Rhythm/Chronobiology; Metabolic Syndrome; Obesity; Sex Differences

Contact Information
Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences
955 Main Street, Room 4126
Buffalo, New York 14203
aras@buffalo.edu



Professional Summary:

THE PROBLEM
Thanks to major advances in medicine and biomedical innovations there had been a steady decline in cardiovascular deaths over the last century. However, over the last decade, heart disease has regained its status as the leading cause of death in the US, which has coincided with the growing epidemic of obesity, a complex and multifactorial disease interconnected with metabolic syndrome (high blood pressure, insulin resistance, and high cholesterol).
Obesity poses a significant health care burden with rising morbidity and mortality associated with increased risk of heart failure and/or sudden cardiac death linked to cardiac arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF). While obesity is an established cardiovascular risk factor, there exists a seemingly counterintuitive phenomenon called the “obesity paradox” associated with survival advantage in the obese patients as compared with normal weight individuals in multiple settings of heart failure, acute coronary syndrome, among others.
The pathological mechanisms by which cardiac obesity could result in the development of cardiac arrhythmias and heart failure, while also under certain conditions potentially provide cardioprotection is not well understood.

THE APPROACH
My lab focuses on investigating the role of both intrinsic (e.g., autonomic dysfunction) and extrinsic factors (e.g., cardiac adiposity) in promoting cardiac arrhythmias and heart failure. We take a unique approach to investigating acute and chronic effects of cardiac obesity on arrhythmogenesis by combining small and large animal model studies with donor human hearts, which provides an optimal balance between basic research and direct clinical impact.
Using spatiotemporal multi pronged (integrated omics, functional and structural imaging) and multi scale (molecule to whole heart) approach, my lab will seek to characterize the role of obesity and metabolic syndrome in promoting arrhythmias and heart failure as well as develop and validate novel diagnostic tools and strategies for effective therapy of obesity mediated cardiac conduction and rhythm disorders.

Education and Training:

  • PhD, Biomedical Engineering, University of Utah (2015)
  • MS, Computer Science and Engineering, University of Notre Dame (2006)
  • BS, Computer Science and Engineering Technology, Andrews University (2000)

Employment:

  • Assistant Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2022-present)
  • Postdoctoral Research Fellow, Biomedical Engineering, George Washington University (2015–2022)
  • Research & Development Engineer, Whirlpool Corporation (2000–2007)

Awards and Honors:

  • National Institutes of Health (NIH) Pathway to Independence Award (K99/R00) (2020)
  • Jos Willems Young Investigator Award, International Society for Computerized Electrocardiology (2014)

Research Expertise:

  • Adipose Biology
  • Bioelectronics
  • Bioinformatics
  • Cardiac Electrophysiology

Research Centers:

  • Center for Research in Cardiovascular Medicine
  • Center of Excellence in Bioinformatics and Life Sciences
  • Clinical and Translational Research Center (CTRC)

UB 2020 Strategic Strengths:

  • Health and Wellness Across the Lifespan
  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • May 2020–April 2023
    Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human hearts
    NIH/NHLBI
    Role: Principal Investigator
    $198,272

Journal Articles:

See all (13 more)

Professional Memberships:

  • American Heart Association (2015–present)
  • Heart Rhythm Society (2015–present)

Service Activities:

  • American Journal of Physiology - Heart and Circulatory Physiology; Ad hoc Manuscript Reviewer
  • Heart Rhythm Journal; Ad hoc Manuscript Reviewer
  • Nature Scientific Reports; Ad hoc Manuscript Reviewer
  • Circulation Arrhythmia and Electrophysiology; Ad hoc Manuscript Reviewer
  • International Journal of Biochemistry and Cell Biology; Ad hoc Manuscript Reviewer
  • Frontiers in Cardiovascular Medicine; Ad hoc Manuscript Reviewer
  • Cardiovascular Engineering and Technology; Ad hoc Manuscript Reviewer
  • Journal of Electrocardiology; Ad hoc Manuscript Reviewer

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Contact Information

Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences
955 Main Street, Room 4126
Buffalo, New York 14203
aras@buffalo.edu