Brahm H. Segal MD
Brahm H. Segal
MD
Professor of Medicine
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Immunology; Infectious Disease; Oncology
Professional Summary:
I care for hospitalized patients and outpatients at Roswell Park Comprehensive Cancer Center, where I am head of Infectious Diseases. My area of clinical expertise relates to infections in patients with cancer and stem cell transplant recipients, and I have served on several national panels that establish guidelines for preventing, diagnosing, and managing infections in these patients. I also have a specific interest in patients with primary phagocytic disorders (e.g., chronic granulomatous disease).
Roswell Park is the site of my clinical teaching. At Roswell Park, I serve asChair of the Dept. of Internal Medicine and Chief of Infectious Diseases. I teach medical students in lecture settings and in small group sessions in their first and second years, including courses in lung pathophysiology and microbiology-immunology. I mentor residents in their clinical training and in research. I also teach fellows in all aspects of their training and mentor those who perform their research projects in my lab. I have mentored a large number of trainees in lab research, including high school and college students on summer rotations, medical students, doctoral students, and post-doctoral fellows.
Our lab research has focused on innate immune responses to infection and injury. Over the past several years, we have extended our interest in innate responses to the cancer microenvironment with the overall goals of understanding mechanisms that drive tumor progression and developing novel prognostic biomarkers and therapeutic approaches. We find that the immune pathways that mediate antimicrobial host defense can also promote metastasis and impair anti-tumor immunity. Our most recent work points to neutrophils acquiring a suppressor function within the tumor microenvironment that results in suppression of T cell proliferation and activation required for anti-tumor immunity. We identified mechanisms driving this neutrophil suppressor phenotype, including complement signaling, that are potential targets for therapeutic modulation to enhance anti-tumor immunotherapy.
Education and Training:
- Infectious Diseases, National Institute of Allergy and Infectious Diseases (1999)
- Medicine, Tufts New England Medical Center (1995)
- MD, Albert Einstein College of Medicine (1992)
- BS, Biology, McGill University (1988)
Employment:
- Chair, Internal Medicine, Roswell Park Comprehensive Cancer Center (2018-present)
- Chief, Division of Infectious Diseases, Roswell Park Comprehensive Cancer Center
- Professor, Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
- Professor, Internal Medicine and Immunology, Roswell Park Comprehensive Cancer Center (2001-present)
Awards and Honors:
- Award for Outstanding Contribution (2024)
- UB Exceptional Scholars - Sustained Achievement (2016)
- Fellow, Infectious Diseases Society of America (2007)
- Fellow, American College of Physicians (2005)
- SUNY at Buffalo Department of Medicine Award for Teaching (2001)
- Top Doctors
Research Expertise:
- Infectious diseases in patients with cancer: I am Chair of Internal Medicine and Chief of Infectious Diseases at Roswell Park Comprehensive Cancer Center. My area of clinical expertise relates to infections in patients with cancer and stem cell transplant recipients. I have served on several national panels (e.g., NCCN, IDSA, CDC) that establish guidelines for preventing, diagnosing, and managing infections in these patients. I also have a specific interest in patients with primary phagocytic disorders (e.g., chronic granulomatous disease).
- Innate Immunity: Our lab research relates to innate immune responses in the tumor microenvironment. Our long term goal is to develop novel therapeutic approaches to enhance anti-tumor immunity.
Grants and Sponsored Research:
- August 2022–August 2027
Targeting complement to enhance antitumor immunity and control malignant effusions in patients with recurrent epithelial ovarian cancer
NCI
Role: Principal Investigator
$3,310,823 - June 2015–May 2023
Novel Immunological Biomarkers in Ovarian Cancer Prognosis
NIH
Role: Principal Investigator
$3,148,229 - August 2019–May 2020
A CRISPR-based platform for testing neutrophil responses in the ovarian cancer microenvironment (3R01CA188900-05W1)
NCI
Role: Principal Investigator
$207,918 - March 2016–March 2019
The Mae Stone Goode Charitable Trust
Role: Co-Principal Investigator
$100,000 - March 2016–March 2018
Evaluation of HSCs and MSCs in ovarian cancer (PI: Dr. Thomas Cimato)
Mae Stone Trust
Role: Co-Investigator
$100,000 - March 2014–March 2016
Evaluation of effectiveness of and immune responses to bacterial preparations
Ventrus Biosciences Inc.
Role: Principal Investigator
$726,285 - February 2009–January 2016
Role of NADPH Oxidase in Regulating Inflammation
NIH
Role: Principal Investigator
$2,176,043 - February 2014–June 2015
RPCI-UPCI Ovarian Cancer SPORE Developmental Research Program (PI: Kunle Odunsi): Evaluation of novel immune biomarkers for ovarian cancer
NIH
Role: Principal Investigator
$50,000 - June 2013–June 2015
Development of Innate Immune Responses in the Tumor Microenvironment
Roswell Park Cancer Institute
Role: Co-Investigator
$100,000 - October 2012–October 2013
Development of Xenomycins as a novel class of antifungal agents
UB Center for Advanced Biomedical and Bioengineering Technology (UB CAT)
Role: Principal Investigator
$50,000 - June 2012–June 2013
Overcoming Myeloid Cell-Mediated Immunosuppression in Epithelial Ovarian Cancer
Roswell Park Cancer Institute Tumor Immunology and Immunotherapy Program
Role: Principal Investigator
$30,000 - May 2012–May 2013
Role of NADPH Oxidase in Ataxia Telangiectasia-Related Tumorigenesis
Wilmot Cancer Center / Roswell Park Cancer Institute pilot fund initiative
Role: Co-Principal Investigator
$100,000 - April 2012–April 2013
Overcoming Myeloid Cell-Mediated Immunosuppression to Enhance Vaccine Efficacy in Ovarian Cancer
Pilot & Collaborative Studies for Clinical & Translational Research, Buffalo Clinical and Translational Center.
Role: Principal Investigator
$34,000 - January 2012–January 2013
Role of Beta-glucans and Echinocandins in Shaping Innate Immune Responses to Aspergillus
Astellas
Role: Principal Investigator
$65,000 - January 2012–December 2012
Evaluation of xenomycins as novel antifungal agents
Cleveland BioLabs
Role: Principal Investigator
$55,417 - Evaluation of LAIR-1/2 and B7-H4 expression in human tumors
NextCure
Role: Principal Investigator - Regulation of Ovarian Tumor Growth in Mice by Complement and SIRPa/CD47 Pathway
Apellis Pharmaceuticals
Role: Principal Investigator
Journal Articles:
- Holling GA, Chavel CA, Sharda AP, Lieberman MM, James CM, Lightman SM, Tong JH, Qiao G, Emmons TR, Giridharan T, Hou S, Intlekofer AM, Higashi RM, Fan TWM, Lane AN, Eng KH, Segal BH, Repasky EA, Lee KP, Olejniczak SH. (2024) CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity. Cellular & molecular immunology (Mar), 21(3): 260-274. doi:10.1038/s41423-024-01124-2
- Sarkar J, Cortes Gomez E, Oba T, Chen H, Dy GK, Segal BH, Ernstoff MS, Ito F. (2023) Fluctuations in Gut Microbiome Composition During Immune Checkpoint Inhibitor Therapy. World journal of oncology (Jun), 14(3): 178-187. doi:10.14740/wjon1587
- Abdelfatah E, Long MD, Kajihara R, Oba T, Yamauchi T, Chen H, Sarkar J, Attwood K, Matsuzaki J, Segal BH, Dy GK, Ito F. (2023) Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy. Cancer research communications (Mar), 3(3): 510-520. doi:10.1158/2767-9764.CRC-22-0383
- Goretti Riça I, Joughin BA, Teke ME, Emmons TR, Griffith AM, Cahill LA, Banner-Goodspeed VM, Robson SC, Hernandez JM, Segal BH, Otterbein LE, Hauser CJ, Lederer JA, Yaffe MB. (2023) Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density neutrophils after trauma. The journal of trauma and acute care surgery (Feb), 94(2): 187-196. doi:10.1097/TA.0000000000003823
- Zsiros E, Ricciuti J, Gallo S, Argentieri D, Attwood K, Ji W, Hutson A, Visco P, Coffey D, Riebandt G, Mark J, Varghese A, Hess SM, Furlani T, Fabiano A, Hennon M, Yendamuri S, Kauffman EC, Wooten KE, Hicks WL, Young J, Takabe K, Odunsi K, Case AA, Segal BH, Johnson CS, Kuvshinoff B, Nurkin S, Paragh G, de Leon-Casasola O. (2023) Postoperative Restrictive Opioid Protocols and Durable Changes in Opioid Prescribing and Chronic Opioid Use. JAMA oncology (Feb), 9(2): 234-241. doi:10.1001/jamaoncol.2022.6278
- Mehta N, Harrington JM, Wallace MA, Wasiura JM, Burnham CD, Mullin KM, Segal BH, Almyroudis NG. (2023) Molecular epidemiology of Clostridioides difficile isolates in a non-outbreak setting at a comprehensive cancer center. Antimicrobial stewardship & healthcare epidemiology : ASHE (Jan), 3(1): e131. doi:10.1017/ash.2023.156
- Segal BH, Giridharan T, Suzuki S, Khan ANH, Zsiros E, Emmons TR, Yaffe MB, Gankema AAF, Hoogeboom M, Goetschalckx I, Matlung HL, Kuijpers TW. (2022) Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells. Immunological reviews (Dec).
- Khan ANH, Emmons TR, Magner WJ, Alqassim E, Singel KL, Ricciuti J, Eng KH, Odunsi K, Tomasi TB, Lee K, Abrams SI, Mesa C, Segal BH. (2022) VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients. Cancer immunology, immunotherapy : CII (Oct), 71(10): 2355-2369.
- Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, Li J, Turowski SG, Sexton S, Sait SJ, Singh PK, Wang J, Maitra A, Kalinski P, DePinho RA, Wang H, Liao W, Abrams SI, Segal BH, Dey P. (2022) Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer cell (Feb), 40(2): 153-167.e11. doi:10.1016/j.ccell.2022.01.003
- Santo BA, Segal BH, Tomaszewski JE, Mohammad I, Worral AM, Jain S, Visser MB, Sarder P, Visser M. (2020) Neutrophil Extracellular Traps (NETs): An unexplored territory in renal pathobiology, a pilot computational study. Proc SPIE Int Soc Opt Eng (Feb), 11320.
- Singel KL, Emmons TR, Khan ANH, Mayor PC, Shen S, Wong JT, Morrell K, Eng KH, Mark J, Bankert RB, Matsuzaki J, Koya RC, Blom AM, McLeish KR, Qu J, Ram S, Moysich KB, Abrams SI, Odunsi K, Zsiros E, Segal BH. (2019) Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment. JCI Insight (Mar), 4(5).
- Wasiura J, Segal BH, Mullin KM. (2019) Cluster of Sphingomonas paucimobilis Bacteremias Linked to Diversion of Intravenous Hydromorphone. N Engl J Med (Jan), 381(6): 584-585.
- Singel KL, Grzankowski KS, Khan ANMNH, Grimm MJ, D'Auria AC, Morrell K, Eng KH, Hylander B, Mayor PC, Emmons TR, Lénárt N, Fekete R, Környei Z, Muthukrishnan U, Gilthorpe JD, Urban CF, Itagaki K, Hauser CJ, Leifer C, Moysich KB, Odunsi K, Dénes Ã, Segal BH. (2019) Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Br J Cancer (Jan), 120(2): 207-217.
- Sharma S, Wang J, Alqassim E, Portwood S, Cortes Gomez E, Maguire O, Basse PH, Wang ES, Segal BH, Baysal BE. (2019) Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells. Genome Biol (Jan), 20(1): 37-37.
- Andermann TM, Peled JU, Ho C, Reddy P, Riches M, Storb R, Teshima T, van den Brink MRM, Alousi A, Balderman S, Chiusolo P, Clark WB, Holler E, Howard A, Kean LS, Koh AY, McCarthy PL, McCarty JM, Mohty M, Nakamura R, Rezvani K, Segal BH, Shaw BE, Shpall EJ, Sung AD, Weber D, Whangbo J, Wingard JR, Wood WA, Perales MA, Jenq RR, Bhatt AS. (2018) The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future. Biol Blood Marrow Transplant (Jan), 24(7): 1322-1340.
- Minlikeeva AN, Moysich KB, Mayor PC, Etter JL, Cannioto RA, Ness RB, Starbuck K, Edwards RP, Segal BH, Lele S, Odunsi K, Diergaarde B, Modugno F. (2018) Anthropometric characteristics and ovarian cancer risk and survival. Cancer Causes Control (Jan), 29(2): 201-212.
- Mayor PC, Eng KH, Singel KL, Abrams SI, Odunsi K, Moysich KB, Fuleihan R, Garabedian E, Lugar P, Ochs HD, Bonilla FA, Buckley RH, Sullivan KE, Ballas ZK, Cunningham-Rundles C, Segal BH. (2018) Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol (Jan), 141(3): 1028-1035.
- Ginley BG, Emmons T, Lutnick B, Urban CF, Segal BH, Sarder P. (2017) Computational detection and quantification of human and mouse neutrophil extracellular traps in flow cytometry and confocal microscopy. Sci Rep (Dec), 7(1): 17755-17755.
- Minlikeeva AN, Freudenheim JL, Cannioto RA, Eng KH, Szender JB, Mayor P, Etter JL, Cramer DW, Diergaarde B, Doherty JA, Dörk T, Edwards R, deFazio A, Friel G, Goodman MT, Hillemanns P, Høgdall E, Jensen A, Jordan SJ, Karlan BY, Kjær SK, Klapdor R, Matsuo K, Mizuno M, Nagle CM, Odunsi K, Paddock L, Rossing MA, Schildkraut JM, Schmalfeldt B, Segal BH, Starbuck K, Terry KL, Webb PM, Zsiros E, Ness RB, Modugno F, Bandera EV, Chang-Claude J, Moysich KB. (2017) History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report. Br J Cancer (Sep), 117(7): 1063-1069.
- Minlikeeva AN, Freudenheim JL, Cannioto RA, Szender JB, Eng KH, Modugno F, Ness RB, LaMonte MJ, Friel G, Segal BH, Odunsi K, Mayor P, Zsiros E, Schmalfeldt B, Klapdor R, Dӧrk T, Hillemanns P, Kelemen LE, Kӧbel M, Steed H, de Fazio A, Jordan SJ, Nagle CM, Risch HA, Rossing MA, Doherty JA, Goodman MT, Edwards R, Matsuo K, Mizuno M, Karlan BY, Kjær SK, Høgdall E, Jensen A, Schildkraut JM, Terry KL, Cramer DW, Bandera EV, Paddock LE, Kiemeney LA, Massuger LF, Kupryjanczyk J, Berchuck A, Chang-Claude J, Diergaarde B, Webb PM, Moysich KB. (2017) History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium. Cancer Causes Control (May), 28(5): 469-486.
- Szender JB, Emmons T, Belliotti S, Dickson D, Khan A, Morrell K, Khan ANMN, Singel KL, Mayor PC, Moysich KB, Odunsi K, Segal BH, Eng KH. (2017) Impact of ascites volume on clinical outcomes in ovarian cancer: A cohort study. Gynecol Oncol (Jan), 146(3): 491-497.
- Sucheston-Campbell LE, Cannioto R, Clay AI, Etter JL, Eng KH, Liu S, Battaglia S, Hu Q, Szender JB, Minlikeeva A, Joseph JM, Mayor P, Abrams SI, Segal BH, Wallace PK, Soh KT, Zsiros E, Anton-Culver H, Bandera EV, Beckmann MW, Berchuck A, Bjorge L, Bruegl A, Campbell IG, Campbell SP, Chenevix-Trench G, Cramer DW, Dansonka-Mieszkowska A, Dao F, Diergaarde B, Doerk T, Doherty JA, du Bois A, Eccles D, Engelholm SA, Fasching PA, Gayther SA, Gentry-Maharaj A, Glasspool RM, Goodman MT, Gronwald J, Harter P, Hein A, Heitz F, Hillemmanns P, Høgdall C, Høgdall EV, Huzarski T, Jensen A, Johnatty SE, Jung A, Karlan BY, Klapdor R, Kluz T, Konopka B, Kjær SK, Kupryjanczyk J, Lambrechts D, Lester J, Lubiński J, Levine DA, Lundvall L, McGuire V, McNeish IA, Menon U, Modugno F, Ness RB, Orsulic S, Paul J, Pearce CL, Pejovic T, Pharoah P, Ramus SJ, Rothstein J, Rossing MA, Rübner M, Schildkraut JM, Schmalfeldt B, Schwaab I, Siddiqui N, Sieh W, Sobiczewski P, Song H, Terry KL, Van Nieuwenhuysen E, Vanderstichele A, Vergote I, Walsh CS, Webb PM, Wentzensen N, Whittemore AS, Wu AH, Ziogas A, Odunsi K, Chang-Claude J, Goode EL, Moysich KB. (2017) No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival. Cancer Epidemiol Biomarkers Prev (Jan), 26(3): 420-424.
- Singel KL, Segal BH. (2016) Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal. Immunol Rev (Sep), 273(1): 329-343.
- Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. (2016) Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis (Aug), 63(4): 433-442.
- Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. (2016) Nicotine induces neutrophil extracellular traps. J Leukoc Biol (Jun).
- Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JH, Bennett JE. (2016) Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis (Jun).
- Cannioto RA, LaMonte MJ, Kelemen LE, Risch HA, Eng KH, Minlikeeva AN, Hong CC, Szender JB, Sucheston-Campbell L, Joseph JM, Berchuck A, Chang-Claude J, Cramer DW, DeFazio A, Diergaarde B, Dörk T, Doherty JA, Edwards RP, Fridley BL, Friel G, Goode EL, Goodman MT, Hillemanns P, Hogdall E, Hosono S, Kelley JL, Kjaer SK, Klapdor R, Matsuo K, Odunsi K, Nagle CM, Olsen CM, Paddock LE, Pearce CL, Pike MC, Rossing MA, Schmalfeldt B, Segal BH, Szamreta EA, Thompson PJ, Tseng CC, Vierkant R, Schildkraut JM, Wentzensen N, Wicklund KG, Winham SJ, Wu AH, Modugno F, Ness RB, Jensen A, Webb PM, Terry K, Bandera EV, Moysich KB. (2016) Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. Br J Cancer (Jun), 115(1): 95-101.
- Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML. (2016) Accumulation of isolevuglandin-modified protein in normal and fibrotic lung. Sci Rep (Apr), 6: 24919-24919.
- Almyroudis NG, Osawa R, Samonis G, Wetzler M, Wang ES, McCarthy PL, Segal BH. (2016) Discontinuation of Systematic Surveillance and Contact Precautions for Vancomycin-Resistant Enterococcus (VRE) and Its Impact on the Incidence of VRE faecium Bacteremia in Patients with Hematologic Malignancies. Infect Control Hosp Epidemiol (Apr), 37(4): 398-403.
- Singel KL, Segal BH. (2016) NOX2-dependent regulation of inflammation. Clin Sci (Lond) (Apr), 130(7): 479-490.
- Khan AN, Kolomeyevskaya N, Singel KL, Grimm MJ, Moysich KB, Daudi S, Grzankowski KS, Lele S, Ylagan L, Webster GA, Abrams SI, Odunsi K, Segal BH. (2015) Targeting myeloid cells in the tumor microenvironment enhances vaccine efficacy in murine epithelial ovarian cancer. Oncotarget (May), 6(13): 11310-11326.
- Kolomeyevskaya N, Eng KH, Khan AN, Grzankowski KS, Singel KL, Moysich K, Segal BH. (2015) Cytokine profiling of ascites at primary surgery identifies an interaction of tumor necrosis factor-a and interleukin-6 in predicting reduced progression-free survival in epithelial ovarian cancer. Gynecol Oncol (May).
- Itagaki K, Kaczmarek E, Lee YT, Tang IT, Isal B, Adibnia Y, Sandler N, Grimm MJ, Segal BH, Otterbein LE, Hauser CJ. (2015) Mitochondrial DNA released by trauma induces neutrophil extracellular traps. PLoS One (Mar), 10(3): 0120549-0120549.
- Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. (2014) Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis (Dec), 210(11): 1844-1854.
- Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, You T, Grimm MJ, Bohovych I, Grebogi C, Segal BH, Gow NA, Haynes K, Quinn J, Brown AJ. (2014) Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio (Jul), 5(4): 1334-1334.
- Grimm MJ, D'Auria AC, Segal BH. (2014) Assessing anti-fungal activity of isolated alveolar macrophages by confocal microscopy. J Vis Exp (Jul)(89).
- Röhm M, Grimm MJ, D'Auria AC, Almyroudis NG, Segal BH, Urban CF. (2014) NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infect Immun (May), 82(5): 1766-1777.
- Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA. (2014) Nrf2 amplifies oxidative stress via induction of Klf9. Mol Cell (Mar), 53(6): 916-928.
- Pomakova D, Segal BH. (2014) Prevention of infection in cancer patients. Cancer Treat Res (Jan), 161: 485-511.
- Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS. (2013) NF-?B inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators Inflamm (Nov), 2013: 503213-503213.
- Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS. (2013) NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators Inflamm (Nov), 2013: 503213-503213.
- Godoy HE, Khan AN, Vethanayagam RR, Grimm MJ, Singel KL, Kolomeyevskaya N, Sexton KJ, Parameswaran A, Abrams SI, Odunsi K, Segal BH. (2013) Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. PLoS One (Jul), 8(7): 69631-69631.
- Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D‘Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. (2013) Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol (Apr), 190(8): 4175-4184.
- Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS. (2013) NADPH Oxidase Limits Lipopolysaccharide-Induced Lung Inflammation and Injury in Mice through Reduction-Oxidation Regulation of NF-?B Activity. J Immunol (Mar).
- Almyroudis NG, Grimm MJ, Davidson BA, Röhm M, Urban CF, Segal BH. (2013) NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol (Mar), 4: 45-45.
- Zaynagetdinov R, Sherrill TP, Kendall PL, Segal BH, Weller KP, Tighe RM, Blackwell TS. (2013) Identification of Myeloid Cell Subsets in Murine Lungs Using Flow Cytometry. Am J Respir Cell Mol Biol (Mar).
- Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH. (2013) NADPH Oxidase and Nrf2 Regulate Gastric Aspiration-Induced Inflammation and Acute Lung Injury. J Immunol (Jan).
- Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. (2012) Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (Dec), 2(6): 1762-1773.
- Han W, Li H, Segal BH, Blackwell TS. (2012) Bioluminescence imaging of NADPH oxidase activity in different animal models. J Vis Exp (Oct)(68).
- Banik D, Khan AN, Walseng E, Segal BH, Abrams SI. (2012) Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PLoS One (Sep), 7(9): 45422-45422.
- Capitano ML, Nemeth MJ, Mace TA, Salisbury-Ruf C, Segal BH, McCarthy PL, Repasky EA. (2012) Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner. Blood (Sep), 120(13): 2600-2609.
- Segal BH, Grimm MJ, Khan AN, Han W, Blackwell TS. (2012) Regulation of innate immunity by NADPH oxidase. Free Radic Biol Med (Jul), 53(1): 72-80.
- Pizzolla A, Hultqvist M, Nilson B, Grimm MJ, Eneljung T, Jonsson IM, Verdrengh M, Kelkka T, Gjertsson I, Segal BH, Holmdahl R. (2012) Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol (May), 188(10): 5003-5011.
- Jarkowski A, Forrest A, Sweeney RP, Tan W, Segal BH, Almyroudis N, Wang ES, Wetzler M. (2012) Characterization of vancomycin pharmacokinetics in the adult acute myeloid leukemia population. J Oncol Pharm Pract (Mar), 18(1): 91-96.
- Vethanayagam RR, Almyroudis NG, Grimm MJ, Lewandowski DC, Pham CT, Blackwell TS, Petraitiene R, Petraitis V, Walsh TJ, Urban CF, Segal BH. (2011) Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One (Dec), 6(12): 28149-28149.
- Lugade AA, Vethanayagam RR, Nasirikenari M, Bogner PN, Segal BH, Thanavala Y. (2011) Nrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzae. Am J Respir Cell Mol Biol (Sep), 45(3): 557-565.
- Almyroudis NG, Lesse AJ, Hahn T, Samonis G, Hazamy PA, Wongkittiroch K, Wang ES, McCarthy PL, Wetzler M, Segal BH. (2011) Molecular epidemiology and risk factors for colonization by vancomycin-resistant enterococcus in patients with hematologic malignancies. Infect Control Hosp Epidemiol (May), 32(5): 490-496.
- Grimm MJ, Vethanayagam RR, Almyroudis NG, Lewandowski D, Rall N, Blackwell TS, Segal BH. (2011) Role of NADPH oxidase in host defense against aspergillosis. Med Mycol (Apr), 49 Su: 144-149.
- Jarkowski A, Forrest A, Sweeney RP, Tan W, Segal BH, Almyroudis N, Wang ES, Wetzler M. (2011) Characterization of vancomycin pharmacokinetics in the adult acute myeloid leukemia population. J Oncol Pharm Pract (Apr).
- Segal BH, Veys P, Malech H, Cowan MJ. (2011) Chronic granulomatous disease: lessons from a rare disorder. Biol Blood Marrow Transplant (Jan), 17(1 Sup): 123-131.
- Rahman M, Segal BH. (2011) Thematic issue: immunity, inflammation and fungal infections. Immunol Invest (Jan), 40(7-8): 670-675.
- Almyroudis NG, Segal BH. (2010) Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients. Expert Rev Anti Infect Ther (Dec), 8(12): 1451-1466.
- Sherif R, Segal BH. (2010) Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications. Curr Opin Pulm Med (May), 16(3): 242-250.
- Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. (2010) NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One (Mar), 5(3): 9631-9631.
- Nasirikenari M, Chandrasekaran EV, Matta KL, Segal BH, Bogner PN, Lugade AA, Thanavala Y, Lee JJ, Lau JT. (2010) Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation. J Leukoc Biol (Mar), 87(3): 457-466.
- Partridge-Hinckley K, Liddell GM, Almyroudis NG, Segal BH. (2009) Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients. Mycopathologia (Dec), 168(6): 329-337.
- Almyroudis NG, Fabian J, Hahn T, Segal BH, Wetzler M, McCarthy PL. (2009) Late infectious complications after cord blood stem cell transplantation. Eur J Clin Microbiol Infect Dis (Nov), 28(11): 1405-1408.
- Almyroudis NG, Segal BH. (2009) Prevention and treatment of invasive fungal diseases in neutropenic patients. Curr Opin Infect Dis (Aug), 22(4): 385-393.
- Segal BH. (2009) Aspergillosis. N Engl J Med (Apr), 360(18): 1870-1884.
- Segal BH, Romani LR. (2009) Invasive aspergillosis in chronic granulomatous disease. Med Mycol (Mar), 47 Su: 282-290.
- Segal BH, Romani L, Puccetti P. (2009) Chronic granulomatous disease. Cell Mol Life Sci (Feb), 66(4): 553-558.
- De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, Pappas PG, Maertens J, Lortholary O, Kauffman CA, Denning DW, Patterson TF, Maschmeyer G, Bille J, Dismukes WE, Herbrecht R, Hope WW, Kibbler CC, Kullberg BJ, Marr KA, Muñoz P, Odds FC, Perfect JR, Restrepo A, Ruhnke M, Segal BH, Sobel JD, Sorrell TC, Viscoli C, Wingard JR, Zaoutis T, Bennett JE. (2008) Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG). Clin Infect Dis (Jun), 46(12): 1813-1821.
- Segal BH, Freifeld AG, Baden LR, Brown AE, Casper C, Dubberke E, Gelfand M, Greene JN, Ison MG, Ito JI, Karp JE, Kaul DR, King E, Mackler E, Marcucci G, Montoya JG, Engemann AM, Rolston K, The AS. (2008) Prevention and treatment of cancer-related infections. J Natl Compr Canc Netw (Feb), 6(2): 122-174.
- Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, van Burik JA, Wingard JR, Patterson TF. (2008) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis (Feb), 46(3): 327-360.
- Romani L, Fallarino F, De Luca A, Montagnoli C, D'Angelo C, Zelante T, Vacca C, Bistoni F, Fioretti MC, Grohmann U, Segal BH, Puccetti P. (2008) Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature (Jan), 451(7175): 211-215.
- Parameswaran GI, Segal BH, Almyroudis NG, Parameswaran G. (2008) Antifungal agents in hematopoietic stem cell transplantation. Curr Pharm Des (Jan), 14(20): 2011-2021.
- Segal BH, Steinbach WJ. (2007) Combination antifungals: an update. Expert Rev Anti Infect Ther (Oct), 5(5): 883-892.
- Battiwalla M, Wu Y, Bajwa RP, Radovic M, Almyroudis NG, Segal BH, Wallace PK, Nakamura R, Padmanabhan S, Hahn T, McCarthy PL. (2007) Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Biol Blood Marrow Transplant (Jul), 13(7): 765-770.
- Parameswaran IG, Segal BH. (2007) Immunotherapy for fungal infections with special emphasis on central nervous system infections. Neurol India (Jul), 55(3): 260-266.
- Gupta S, Almyroudis NG, Battiwalla M, Bambach BJ, McCarthy PL, Proefrock AD, Ball D, Paplham P, Varma A, Kwon-Chung J, Segal BH. (2007) Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis (Jun), 9(2): 156-160.
- Brun YF, Dennis CG, Greco WR, Bernacki RJ, Pera PJ, Bushey JJ, Youn RC, White DB, Segal BH. (2007) Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm. Antimicrob Agents Chemother (May), 51(5): 1804-1812.
- Battiwalla M, Paplham P, Almyroudis NG, McCarthy A, Abdelhalim A, Elefante A, Smith P, Becker J, McCarthy PL, Segal BH. (2007) Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. Transpl Infect Dis (Mar), 9(1): 28-32.
- Segal BH, Davidson BA, Hutson AD, Russo TA, Holm BA, Mullan B, Habitzruther M, Holland SM, Knight PR. (2007) Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am J Physiol Lung Cell Mol Physiol (Mar), 292(3): 760-768.
- Segal BH, Freifeld AG. (2007) Antibacterial prophylaxis in patients with neutropenia. J Natl Compr Canc Netw (Feb), 5(2): 235-242.
- Segal BH, Almyroudis NG, Battiwalla M, Herbrecht R, Perfect JR, Walsh TJ, Wingard JR. (2007) Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts. Clin Infect Dis (Feb), 44(3): 402-409.
- Segal BH. (2007) Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. Oncologist (Jan), 12 Su: 7-13.
- Walsh TJ, Raad I, Patterson TF, Chandrasekar P, Donowitz GR, Graybill R, Greene RE, Hachem R, Hadley S, Herbrecht R, Langston A, Louie A, Ribaud P, Segal BH, Stevens DA, van Burik JA, White CS, Corcoran G, Gogate J, Krishna G, Pedicone L, Hardalo C, Perfect JR. (2007) Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis (Jan), 44(1): 2-12.
- Maertens J, Glasmacher A, Herbrecht R, Thiebaut A, Cordonnier C, Segal BH, Killar J, Taylor A, Kartsonis N, Patterson TF, Aoun M, Caillot D, Sable C. (2006) Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis. Cancer (Dec), 107(12): 2888-2897.
- Almyroudis NG, Kontoyiannis DP, Sepkowitz KA, DePauw BE, Walsh TJ, Segal BH. (2006) Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection. Clin Infect Dis (Dec), 43(11): 1449-1455.
- Nasirikenari M, Segal BH, Ostberg JR, Urbasic A, Lau JT. (2006) Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I. Blood (Nov), 108(10): 3397-3405.
- Anaissie EJ, Segal BH, Graybill JR, Arndt C, Perfect JR, Kleinberg M, Pappas P, Benjamin D, Rubin R, Aberg JA, Adderson EE, Adler-Shohet FC, Akan H, Akova M, Almyroudis NG, Alexander BD, Andes D, Arrieta A, Baddley JW, Barron MA, Belzberg H, Boucher HW, Boyce TG, Casadevall A, Chandrasekar PH, Cleary JD, Cordonnier C, Cornely OA, Cuenca-Estrella M, Daly JS, Daoura N, Denning DW, dePauw B, de Repentigny L, Dignani MC, Dismukes WE, Donnelly JP, Donowitz GR, Dupont B, Drusano G, Ellis M, Espinel-Ingroff A, Fishman JA, Fleming R, Forrest G, Ghannoum M, Goldman M, Grazziutti M, Greene JN, Greenberg RN, Gubbins PO, Hadley S, Herbrecht R, Hiemenz JW, Hope W, Hospenthal DR, Husain S, Ito JI, Jacobson RM, Johnson M, Keating MR, Kett DH, Knapp K, Kontoyiannis DP, Krcmery VC, Larsen R, Laverdiere M, Ljungman P, Lortholary O, Maertens J, Marriott D, Mattiuzzi G, McGinnis MR, Morris M, Nucci M, Odds FC, Pankey GA, Patterson T, Pfaller M, Razonable RR, Reboli AC, Rinaldi MG, Roberts GD, Rodriguez Tudela JL, Rotstein C, Ruhnke M, Schuster M, Shoham S, Sia IG, Siebel N, Silviera F, Singh N, Sobel J, Solomkin JS, Sorrell TC, Steinbach WJ, Temesgen Z, Tortorano A, Vartivarian S, VerWeij P, Viscoli C, Viviani MA, Walker RC, Wheat JL, Wiley J, Williamson P, Wingard JR, Yu VL, Zaoutis T. (2006) Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. Clin Infect Dis (Oct), 43(8): 1031-1039.
- Tao J, Segal BH, Eppolito C, Li Q, Dennis CG, Youn R, Shrikant PA. (2006) Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity. J Leukoc Biol (Sep), 80(3): 529-537.
- Bow EJ, Rotstein C, Noskin GA, Laverdiere M, Schwarer AP, Segal BH, Seymour JF, Szer J, Sanche S. (2006) A randomized, open-label, multicenter comparative study of the efficacy and safety of piperacillin-tazobactam and cefepime for the empirical treatment of febrile neutropenic episodes in patients with hematologic malignancies. Clin Infect Dis (Aug), 43(4): 447-459.
- Bhatti Z, Shaukat A, Almyroudis NG, Segal BH. (2006) Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients. Mycopathologia (Jul), 162(1): 1-15.
- Segal BH, Wang XY, Dennis CG, Youn R, Repasky EA, Manjili MH, Subjeck JR. (2006) Heat shock proteins as vaccine adjuvants in infections and cancer. Drug Discov Today (Jun), 11(11-12): 534-540.
- Segal BH, Walsh TJ. (2006) Current approaches to diagnosis and treatment of invasive aspergillosis. Am J Respir Crit Care Med (Apr), 173(7): 707-717.
- Dennis CG, Greco WR, Brun Y, Youn R, Slocum HK, Bernacki RJ, Lewis R, Wiederhold N, Holland SM, Petraitiene R, Walsh TJ, Segal BH. (2006) Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Antimicrob Agents Chemother (Feb), 50(2): 422-427.
- Segal BH, Kwon-Chung J, Walsh TJ, Klein BS, Battiwalla M, Almyroudis NG, Holland SM, Romani L. (2006) Immunotherapy for fungal infections. Clin Infect Dis (Feb), 42(4): 507-515.
- Dunford LM, Roy DM, Hahn TE, Padmanabhan S, Segal BH, Almyroudis N, McCarthy PL, Battiwalla M. (2006) Dapsone-induced methemoglobinemia after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (Feb), 12(2): 241-242.
- Reuka VI, Hahn T, Roy HN, Battiwalla M, Cooper M, Anderson B, Paplham P, Bambach BJ, Segal BH, McCarthy PL. (2005) Long-term use of oral beclometasone dipropionate for the treatment of gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant (Aug), 11(8): 587-592.
- Iyer RV, Hahn T, Roy HN, Battiwalla M, Cooper M, Anderson B, Paplham P, Brown K, Bambach B, Segal BH, McCarthy PL. (2005) Long-term use of oral beclomethasone dipropionate for the treatment of gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant (Aug), 11(8): 587-592.
- Segal BH, Barnhart LA, Anderson VL, Walsh TJ, Malech HL, Holland SM. (2005) Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clin Infect Dis (Jun), 40(11): 1684-1688.
- Almyroudis N, Holland SM, Segal BH. (2005) Invasive aspergillosis in primary immunodeficiencies. Med Mycol. (May), 43(1): S247-S259.
- Shaukat A, Bakri F, Young P, Hahn T, Ball D, Baer MR, Wetzler M, Slack JL, Loud P, Czuczman M, McCarthy PL, Walsh TJ, Segal BH. (2005) Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Mycopathologia (Feb), 159(2): 181-188.
- Cumbo TA, Segal BH. (2004) Prevention, diagnosis, and treatment of invasive fungal infections in patients with cancer and neutropenia. J Natl Compr Canc Netw (Sep), 2(5): 455-469.
- Dibo I, Pillai SK, Gold HS, Baer MR, Wetzler M, Slack JL, Hazamy PA, Ball D, Hsiao CB, McCarthy PL, Segal BH. (2004) Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient. J Clin Microbiol (Apr), 42(4): 1843-1845.
- Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW. (2004) p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J Immunol (Feb), 172(3): 1801-1808.
- van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts E, Joosten LA, van Lent PL, Coenen-de Roo CJ, Cuzzocrea S, Segal BH, Holland SM, van den Berg WB. (2003) Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am J Pathol (Oct), 163(4): 1525-1537.
- Segal BH, Ding L, Holland SM. (2003) Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice. Infect Immun (Jan), 71(1): 205-210.
- Segal BH, Bow EJ, Menichetti F. (2002) Fungal infections in nontransplant patients with hematologic malignancies. Infect Dis Clin North Am (Dec), 16(4): 935-964.
- Hahn T, Cummings KM, Michalek AM, Lipman BJ, Segal BH, McCarthy PL. (2002) Efficacy of high-efficiency particulate air filtration in preventing aspergillosis in immunocompromised patients with hematologic malignancies. Infect Control Hosp Epidemiol (Sep), 23(9): 525-531.
- Peter E, Bakri F, Ball DM, Cheney RT, Segal BH. (2002) Invasive pulmonary filamentous fungal infection in a patient receiving inhaled corticosteroid therapy. Clin Infect Dis (Sep), 35(5): 54-56.
- Segal BH, Kuhns DB, Ding L, Gallin JI, Holland SM. (2002) Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol (Mar), 71(3): 410-416.
- Koay MA, Christman JW, Segal BH, Venkatakrishnan A, Blackwell TR, Holland SM, Blackwell TS. (2001) Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infect Immun (Oct), 69(10): 5991-5996.
- Jackson SH, Miller GF, Segal BH, Mardiney M, Domachowske JB, Gallin JI, Holland SM. (2001) IFN-gamma is effective in reducing infections in the mouse model of chronic granulomatous disease (CGD). J Interferon Cytokine Res (Aug), 21(8): 567-573.
- Khushalani NI, Bakri FG, Wentling D, Brown K, Mohr A, Anderson B, Keesler C, Ball D, Bernstein ZP, Bernstein SH, Czuczman MS, Segal BH, McCarthy PL. (2001) Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review. Bone Marrow Transplant (May), 27(10): 1071-1073.
- Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG. (2001) Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. Mol Pharmacol (Apr), 59(4): 744-750.
- Segal BH, Holland SM. (2000) Primary phagocytic disorders of childhood. Pediatr Clin North Am (Dec), 47(6): 1311-1338.
- Rusyn I, Yamashina S, Segal BH, Schoonhoven R, Holland SM, Cattley RC, Swenberg JA, Thurman RG. (2000) Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Res (Sep), 60(17): 4798-4803.
- van der Veen RC, Dietlin TA, Hofman FM, Pen L, Segal BH, Holland SM. (2000) Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. J Immunol (May), 164(10): 5177-5183.
- Segal BH, Leto TL, Gallin JI, Malech HL, Holland SM. (2000) Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) (May), 79(3): 170-200.
- Segal BH, Sakamoto N, Patel M, Maemura K, Klein AS, Holland SM, Bulkley GB. (2000) Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease. Infect Immun (Apr), 68(4): 2374-2378.
- Cooper AM, Segal BH, Frank AA, Holland SM, Orme IM. (2000) Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice. Infect Immun (Mar), 68(3): 1231-1234.
- Hsich E, Segal BH, Pagano PJ, Rey FE, Paigen B, Deleonardis J, Hoyt RF, Holland SM, Finkel T. (2000) Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase. Circulation (Mar), 101(11): 1234-1236.
- Segal BH, Doherty TM, Wynn TA, Cheever AW, Sher A, Holland SM. (1999) The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs. Infect Immun (Apr), 67(4): 1659-1665.
- Segal BH, DeCarlo ES, Kwon-Chung KJ, Malech HL, Gallin JI, Holland SM. (1998) Aspergillus nidulans infection in chronic granulomatous disease. Medicine (Baltimore) (Sep), 77(5): 345-354.
- Segal BH, Walsh TJ, Liu JM, Wilson JD, Kwon-Chung KJ. (1998) Invasive infection with Fusarium chlamydosporum in a patient with aplastic anemia. J Clin Microbiol (Jun), 36(6): 1772-1776.
- Chang YC, Segal BH, Holland SM, Miller GF, Kwon-Chung KJ. (1998) Virulence of catalase-deficient aspergillus nidulans in p47(phox)-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease. J Clin Invest (May), 101(9): 1843-1850.
- Segal BH, Sneller MC. (1997) Infectious complications of immunosuppressive therapy in patients with rheumatic diseases. Rheum Dis Clin North Am (May), 23(2): 219-237.
- Segal BH, Engler HD, Little R, Wilson WH, Freifeld AG, Chanock SJ. (1997) Early foscarnet failure in herpes simplex virus infection in a patient with AIDS. AIDS (Mar), 11(4): 552-553.
- Segal BH, Factor SM. (1993) Myocardial risk factors other than human immunodeficiency virus infection may contribute to histologic cardiomyopathic changes in acquired immune deficiency syndrome. Mod Pathol (Sep), 6(5): 560-564.
Abstracts:
- Emmons TR, Giridharan T, Singel KL, Khan ANH, Ricciuti J, Howard K, Silva-Del Toro SL, Debreceni IL, Aarts CEM, Brouwer MC, Suzuki S, Kuijpers TW, Jongerius I, Allen LH, Ferreira VP, Schubart A, Sellner H, Eder J, Holland SM, Ram S, Lederer JA, Eng KH, Moysich KB, Odunsi K, Yaffe MB, Zsiros E, Segal BH. (2022) Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. (Feb), (33990375)
- Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, Li J, Turowski SG, Sexton S, Sait SJ, Singh PK, Wang J, Maitra A, Kalinski P, DePinho RA, Wang H, Liao W, Abrams SI, Segal BH, Dey P. (2022) Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. (Feb)
- Takayoshi Yamauchi, Toshifumi Hoki, Takaaki Oba, Vaibhav Jain, Hongbin Chen, Kristopher Attwood, Sebastiano Battaglia, Saby George, Gurkamal Chatta, Igor Puzanov, Carl Morrison, Kunle Odunsi, Brahm H Segal, Grace K Dy, Marc S Ernstoff, Fumito Ito. (2022) T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors. (Feb)
- Zhang N, Kim SH, Gainullina A, Erlich EC, Onufer EJ, Kim J, Czepielewski RS, Helmink BA, Dominguez JR, Saunders BT, Ding J, Williams JW, Jiang JX, Segal BH, Zinselmeyer BH, Randolph GJ, Kim KW. (2022) LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth. (Feb)
- Griffiths EA, Segal BH. (2022) Immune responses to COVID-19 vaccines in patients with cancer: Promising results and a note of caution. (Feb)
- Khan ANH, Emmons TR, Magner WJ, Alqassim E, Singel KL, Ricciuti J, Eng KH, Odunsi K, Tomasi TB, Lee K, Abrams SI, Mesa C, Segal BH. (2022) VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients. (Feb)
- Hahn T, Roy HN, Cooper M, Paplham P, Alam A, Baer MR, Bambach BJ, Chanan-Khan AA, Czuczman MS, Wetzler M, Segal BH, McCarthy PL. (2003) Oral Beclomethasone Dipropionate for Treatment of Steroid-Refractory Acute or Chronic Gastrointestinal Graft-versus-Host Disease After Blood or Marrow Transplantation (BMT). Blood, (Nov) 446b-446b
- Alam A, Varma H, Hahn T, Segal BH, Paplham P, Becker JL, Baer MR, Bambach BJ, Silva J, Slack JL, Wetzler M, McCarthy PL. (2002) Infectious Complications in Long-Term Survivors of Cord Blood Stem Cell Transplantation (CBSCT): Experience at Roswell Park Cancer Institute. Blood, (Nov)
- Paola Ghione, Juan J Gu, Kristopher Attwood, Pallawi Torka, Shipra Goel, Suchitra Sundaram, Cory Mavis, Michael Johnson, Roshneke Thomas, Kenneth McWhite, Andrea Darrall, Joseph DeMarco, Jessica Kostrewa, Alice Mohr, Leah Rivas, Mirdza Neiders, Lakshmanan Suresh, Brahm H Segal, Elizabeth A Griffiths, Vince Ramsperger, Long Shen, Francisco J Hernandez-Ilizaliturri. (1900) Impaired humoral responses to COVID-19 vaccination in patients with lymphoma receiving B-cell-directed therapies. (Jan)
Professional Memberships:
- Infectious Diseases Society of America; Member
- American Association of Immunologists (AAI); Member
- International Complement Society (ICS); Member
- American Association for Cancer Research (AACR); Member
- Service on NIH and DOD study sections (since 2015); 02/2021 NIH Transformative Research Award (TRA) Panel 10/2021 NIH III ZRG1-IDIA-D90
Presentations:
- "The unexpected contributions of local complement in ovarian cancer" American Association of Immunologists 2023 meeting: International Complement Society (ICS) Symposium Location Matters: The Evolving Roles of Cell-autonomous and Local Complement (2023)
- "Targeting neutrophils to enhance antitumor immunity" Medical Grand Rounds (2023)
- "Targeting neutrophils to enhance antitumor immunity" Immunology Bridge (2022)
- "Effective Time Management Practices for Physician Scientists" Joint Roswell Park and University of Pittsburg Retreat for T32 Immunology Fellows (2022)
- "Inflammation Injury and Immunosuppression in the Tumor Microenvironment" Dept. of Microbiology and Immunology, Syracuse University (2021)
- "Inflammation Injury and Immunosuppression in the Tumor Microenvironment" NIAID Medical Grand Rounds (2021)
- "NADPH oxidase limits inflammation and injury in aspiration-induced acute lung injury" American Thoracic Society (ATS) International Conference; American Thoracic Society (ATS) (2011)
- "Nrf2 is Protective in Neutrophil-mediated Acute Lung Injury" American Thoracic Society (ATS) International Conference; American Thoracic Society (ATS) (2011)
- "Clinical Presentation and Non-BMT Management of Patients with CGD: New Approaches" American Society of Blood and Marrow Transplantation (ASBMT),; American Society of Blood and Marrow Transplantation (ASBMT),; Chronic Granulomatous Disease (CGD): Lessons From a Rare Disorder (2011)
- "Immune System and Management of Aspergillosis" 12th Japan Mycoses Forum (2011)
- "NADPH Oxidase: a Master Regulator of Antifungal Host Defense and Inflammation" Gordon Research Conference; Gordon Research Conference (2011)
- "Immunity against Aspergillosis and Aspergillus-associated Diseases" 2nd Shanghai Oriental Respiratory Disease International Forum (2010)
- "Treatment of Aspergillosis: 2008 Guidelines of IDSA and Clinical Practice" 2nd Shanghai Oriental Respiratory Disease International Forum (2010)
- "Aspergillosis" New York State Thoracic Society Annual Scientific Assembly; New York State Thoracic Society (2010)
- "Conventional and novel risk factors for invasive aspergillosis" 20th Focus on Fungal Infections (2010)
- "Sunday Brunch with the Experts: Management of Treatment-related Infections, Thromboses, and Neuropathy" National Comprehensive Cancer Network 15th Annual Conference: Clinical Practice Guidelines & Quality Care,; NCCN (2010)
- "Aspergillosis in chronic granulomatous diseases" 4th Advances Against Aspergillosis (2010)
- "NADPH oxidase and inflammation" 4th Advances Against Aspergillosis (2010)
Service Activities:
- NCI Special Emphasis Panel in response to FOA: PAR 20-052 and PAR 20-29; Member (2022)
- Department of Defense CDMRP Ovarian Cancer Review Panel; Member (2022)
- PAR-20-072, NIAID Investigator Initiated Program Project Applications (P01); Member (2021)
- NIH Special Emphasis Panel, ZRG.1 BST-J (70) R review meeting; Member (2021)
- Innate Immunity and Inflammation; Appointed member;; Panel Member (2016–2020)
- President Review Board; Member (2014–present)
- Unqualified Promotions; Chair (2012–2014)
- Unqualified Promotions; Member (2011–2014)
- Austrian Science Fund; Austrian Science Fund;; Grant Reviewer (2011)
- Steering Committee member,NIH T35 Training grant to support summer research fellowships in infectious diseases, microbiology and immunology; Member (2011–present)
- Innate Immunity and Inflammation;; Grant Reviewer (2010)
- Agence Nationale de la Recherche, France; Integrated Mechanisms of Inflammation (Programme M12);; Grant Reviewer (2010)
- Chronic Granulomatous Disorder Research Trust; Chronic Granulomatous Disorder Research Trust;; Grant Reviewer (2010)
- Topics in Microbial Pathogens;; Grant Reviewer (2009)
- German Federal Ministry for Education and Research (BMBF); E-Rare funding initiative on transnational research consortia for rare dise;; Grant Reviewer (2009)
- Health Research Board, Ireland; Health Research Board, Ireland;; Grant Reviewer (2009)
- Institutional Review Board; Chair (2001–present)
- Infection Control; Chair (2000–present)
- Research Topic: Neutrophils in Cancer, Frontiers Immunol
- National Comprehensive Cancer Network (NCCN) guidelines on COVID-19 vaccination in patients with cancer; Co-leader