John F. Gibbs MD

John Gibbs

John F. Gibbs

Professor, Associate General Surgery Residency Program Director, Vice-Chair for Research

Department of Surgery

Jacobs School of Medicine & Biomedical Sciences

Contact Information
Buffalo General Medical Center
100 High Street
Buffalo, New York 14203

Education and Training:

  • MS, Harvard School of Public Health, Cambridge, MA (2003)
  • Rush-Presbyterian-St. Luke's Medical Center, Chicago
  • BS, University of California, San Diego
  • Fellowship, Baylor University Medical Center, Dallas
  • Fellowship, Roswell Park Cancer Institute, Buffalo
  • Fellowship, Roswell Park Cancer Institute, Department of Experimental Therapeutics
  • MD, University of California, San Diego

Journal Articles:

  • Barth MJ, Hernandez-Ilizaliturri FJ, Mavis C, Tsai PC, Gibbs JF, Deeb G, Czuczman MS. (2012) Ofatumumab demonstrates activity against rituximab-sensitive and -resistant cell lines, lymphoma xenografts and primary tumour cells from patients with B-cell lymphoma. Br J Haematol (Feb), 156(4): 490-498.
  • Yang GY, May KS, Iyer RV, Chandrasekhar R, Wilding GE, McCloskey SA, Khushalani NI, Yendamuri SS, Gibbs JF, Fakih M, Thomas CR. (2010) Renal atrophy secondary to chemoradiotherapy of abdominal malignancies. Int J Radiat Oncol Biol Phys (Oct), 78(2): 539-546.
  • May KS, Yang GY, Khushalani NI, Chandrasekhar R, Wilding GE, Flaherty L, Malhotra HK, Russo RC, Warner JC, Yap JC, Iyer RV, Nwogu CE, Yendamuri SS, Gibbs JF, Nava HR, Lamonica D, Thomas CR. (2010) Association of Technetium(99m) MAG-3 renal scintigraphy with change in creatinine clearance following chemoradiation to the abdomen in patients with gastrointestinal malignancies. J Gastrointest Oncol (Sep), 1(1): 7-15.
  • May KS, Khushalani NI, Chandrasekhar R, Wilding GE, Iyer RV, Ma WW, Flaherty L, Russo RC, Fakih M, Kuvshinoff BW, Gibbs JF, Javle MM, Yang GY, Ma W. (2010) Analysis of clinical and dosimetric factors associated with change in renal function in patients with gastrointestinal malignancies after chemoradiation to the abdomen. Int J Radiat Oncol Biol Phys (Mar), 76(4): 1193-1198.
  • Chadha MK, Lombardo J, Mashtare T, Wilding GE, Litwin A, Raczyk C, Gibbs JF, Kuvshinoff B, Javle MM, Iyer RV, Lombardo JC. (2009) High-dose octreotide acetate for management of gastroenteropancreatic neuroendocrine tumors. Anticancer Res (Oct), 29(10): 4127-4130.
  • Douglas WG, Wang Y, Gibbs JF, Tracy E, Kuvshinoff B, Huntoon K, Baumann H. (2008) Proinflammatory cytokines increase hepatocellular carcinoma cells thermotolerance: evidence of how local inflammation may negatively impact radiofrequency ablation local control rates. J Surg Res (Nov), 150(1): 118-124.
  • Ong ES, Alassas MA, Bogner PN, Bullard Dunn K, Chey WY, Gibbs JF. (2008) Total gastrectomy for gastric dysplasia in a patient with attenuated familial adenomatous polyposis syndrome. J Clin Oncol (Jul), 26(21): 3641-3642.
  • Agrawal S, Kuvshinoff BW, Khoury T, Yu J, Javle MM, LeVea C, Groth J, Coignet LJ, Gibbs JF. (2007) CD24 expression is an independent prognostic marker in cholangiocarcinoma. J Gastrointest Surg (Apr), 11(4): 445-451.
  • Foster JM, Hoshi H, Gibbs JF, Iyer R, Javle M, Chu Q, Kuvshinoff B. (2007) Gallbladder cancer: Defining the indications for primary radical resection and radical re-resection. Ann Surg Oncol (Feb), 14(2): 833-840.
  • Javle MM, Yu J, Khoury T, Chadha KS, Chadha KC, Iyer RV, Foster J, Kuvshinoff BW, Gibbs JF, Geradts J, Black JD, Brattain MG. (2006) Akt expression may predict favorable prognosis in cholangiocarcinoma. J Gastroenterol Hepatol (Nov), 21(11): 1744-1751.
  • Alrawi SJ, Carroll RE, Hill HC, Gibbs JF, Tan D, Brenner BM, Nowak NJ, Swede H, Stoler DL, Anderson GR. (2006) Genomic instability of human aberrant crypt foci measured by inter-(simple sequence repeat) PCR and array-CGH. Mutat Res (Oct), 601(1-2): 30-38.
  • Chadha KS, Khoury T, Yu J, Black JD, Gibbs JF, Kuvshinoff BW, Tan D, Brattain MG, Javle MM. (2006) Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma. Ann Surg Oncol (Jul), 13(7): 933-939.
  • Foster JM, Litwin A, Gibbs JF, Intengen M, Kuvshinoff BW. (2006) Diagnosing regenerative nodular hyperplasia, the "great masquerader" of liver tumors. J Gastrointest Surg (May), 10(5): 727-733.
  • Foster JM, Litwin, A, Intengan, M, Gibbs JF, Kuvshinoff B. (2006) Diagnosing regenerative nodular hyperplasia, the. Gastrointest Surg (Jan), 10(5): 727-733.
  • Bhagat V, Javle M, Yu J, Agrawal A, Gibbs JF, Kuvshinoff B, Nava E, Iyer R. (2006) Combined hepatocholangiocarcinoma: case-series and review of literature. Int J Gastrointest Cancer (Jan), 37(1): 27-34.
  • Alrawi S, Winston J, Tan D, Gibbs JF, Loree TR, Hicks WL, Regual N, Lor'e J Jr. (2005) Primary Adenocarcinoma of Cervical Esophagus. Case Report and Review of the Literature. Journal of Experimental and Clinical Cancer Research (Jan), 24(2): 207-212.
  • James TA, Sheldon DG, Rajput A, Kuvshinoff BW, Javle MM, Nava HR, Smith JL, Gibbs JF. (2004) Risk factors associated with earlier age of onset in familial pancreatic carcinoma. Cancer (Dec), 101(12): 2722-2726.
  • Javle MM, Tan D, Yu J, LeVea CM, Li F, Kuvshinoff BW, Gibbs JF. (2004) Nuclear survivin expression predicts poor outcome in cholangiocarcinoma. Hepatogastroenterology (Nov), 51(60): 1653-1657.
  • Chu QD, Hurd TC, Harvey S, Martinick M, Markus G, Tan D, Gibbs JF, Loree TR. (2004) Overexpression of Urinary Plasminogen Activator (uPA) Protein and mRNA in Thyroid Carcinogenesis. Diagnostic Molecular Pathology (Jan), 13(4): 241-246.
  • Varma GN, Winston JS, Hill HC, Gibbs JF, Proulx GM, McGrath BE, Javle MM. (2003) Unusual locations of involvement by malignancies: Case 3. Gastric signet ring carcinoma presenting as a diffuse thigh mass. J Clin Oncol (Sep), 21(17): 3371-3373.
  • Evans SS, Ostberg JR, O‘Leary K, Gibbs J, Repasky EA, Kraybill W. (2002) A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models. International Joournal of Hyperthermia (Jan), 18(3): 253-266.
  • Chu QD, Al-kasspooles MF, Smith JL, Nava HR, Douglass HO, Driscoll D, Gibbs JF. (2002) Is glucagonoma of the pancreas a curable disease?. Int J Pancreatol (Jan), 29(3): 155-162.
  • Gergel TJ, Proulx G, Leichman L, Nava H, Blumenson L, Khusalani N, Leichman C, Bodnar L, Gibbs J, Douglass H, Smith JL, Kuettel M. (2002) Effect of Concurrent Radiation Therapy and Chemotherapy on Pulmonary Function in Patients with Esophageal Cancer: Dose-Volume Histogram Analysis. Journal of Radiation Oncology Biology and Physics. (Jan), 8(6): 451-460.
  • Gergel TJ, Leichman L, Nava HR, Blumenson LE, Loewen GM, Gibbs JE, Khushalani NI, Leichman CG, Bodnar LM, Douglass HO, Smith JL, Kuettel MR, Proulx GM. (2002) Effect of concurrent radiation therapy and chemotherapy on pulmonary function in patients with esophageal cancer: dose-volume histogram analysis. Cancer J (Jan), 8(6): 451-460.
  • Kahlenberg MS, Kane JM, Kanter PM, Weber TK, Gibbs JF, Rodriguez-Bigas MA, Petrelli NJ. (2001) Hepatic lymphatic mapping: a pilot study for porta hepatis lymph node identification. Cancer Invest (Jan), 19(3): 256-260.
  • Gibbs JF, Huang, P., Lee R, McGrath BE, Sundquist J, McKinley, B., Driscoll, D., Kraybill WG. (2001) Malignant Fibrous Histiocytoma: An Institutional Review. Cancer Investigation (Jan), 19(1): 20-27.
  • Finley JW, Hanypsiak B, McGrath B, Kraybill W, Gibbs JF. (2001) Clear cell sarcoma: the Roswell Park experience. J Surg Oncol (Jan), 77(1): 16-20.
  • Pidhorecky I, Lee R, Proulx G, Kollmorgen DR, Jia C, Driscoll DL, Kraybill WG, Gibbs JF. (2001) Risk factors for nodal recurrence after lymphadenectomy for melanoma. Ann Surg Oncol (Jan), 8(2): 109-115.
  • Gibbs JF, Lee RJ, Driscoll DL, McGrath BE, Mindell ER, Kraybill WG. (2000) Clinical importance of late recurrence in soft-tissue sarcomas. J Surg Oncol (Feb), 73(2): 81-86.
  • Gibbs JF, Lee R, Driscoll, D., McGrath BE, Mindell, E., Kraybill WG. (2000) Clinical Importance of Late Reoccurence in Soft-Tissue Sarcomas. Journal of Surgical Oncology (Jan), 73: 81-86.
  • Kane JM, Gibbs JF, McGrath BE, Loree TR, Kraybill WG. (2000) Large, deep high-grade extremity sarcomas: when is a myocutaneous flap reconstruction necessary?. Surgical Oncology (Jan), 8(4): 205-210.
  • Beitler AL, Virgo KS, Johnson FE, Gibbs JF, Kraybill WG. (2000) Current follow-up strategies after potentially curative resection of extremity sarcomas: results of a survey of the members of the society of surgical oncology. Cancer (Jan), 88(4): 777-785.
  • Sabel MS, Gibbs JF, Cheney R, McKinley BP, Lee JS, Kraybill WG. (2000) Evolution of sentinel lymph node biopsy for melanoma at a National Cancer Institute-designated cancer center. Surgery (Jan), 128(4): 556-563.
  • Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF. (2000) Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann Surg Oncol (Jan), 7(9): 705-712.
  • Whooley BP*, Gibbs JF, Mooney BE*, McGrath BE, Kraybill WG. (2000) Primary extremity sarcoma: what is the appropriate follow-up?. Ann Surg Oncol (Jan), 7(1): 9-14.
  • Finley JW, Gibbs JF, Rodriguez LM, Letourneau R, Driscoll D, Kraybill W. (2000) Pathologic and clinical features influencing outcome of thin cutaneous melanoma: correlation with newly proposed staging system. Am Surg (Jan), 66(6): 527-531.
  • Kane JM, Gibbs JF, McGrath BE, Loree TR, Kraybill WG. (1999) Large, deep high-grade extremity sarcomas: when is a myocutaneous flap reconstruction necessary?. Surg Oncol (Dec), 8(4): 205-210.
  • Gibbs JF, Slocum HK, Cao S, Rustum YM. (1999) Image analysis for quantitation of solid tumor drug sensitivity. Int J Surg Investig (Jan), 1(2): 133-138.
  • Whooley BP, Mooney MM, Gibbs JF, Kraybill WG. (1999) Effective follow-up strategies in soft tissue sarcoma. Semin Surg Oncol (Jan), 17(1): 83-87.
  • Gibbs JF, Huang PP, Zhang PJ, Kraybill WG, Cheney R. (1999) Accuracy of pathologic techniques for the diagnosis of metastatic melanoma in sentinel lymph nodes. Ann Surg Oncol (Jan), 6(7): 699-704.
  • Anderson TM, Gibbs JF, Kollmorgen DR, Urschel JD. (1999) Paraesophageal omental hernia mimics pleural lipomatous tumor. J Cardiovasc Surg (Jan), 40(5): 757-759.
  • Barnwell JM, Arredondo MA, Kollmorgen D, Gibbs JF, Lamonica D, Carson W, Zhang P, Winston J, Edge SB. (1998) Sentinel node biopsy in breast cancer. Ann Surg Oncol (Mar), 5(2): 126-130.
  • Gibbs JF, Weber TK, Rodriguez-Bigas MA, Driscoll DL, Petrelli NJ. (1998) Intraoperative determinants of unresectability for patients with colorectal hepatic metastases. Cancer (Jan), 82(7): 1244-1249.
  • Yin MB, Guo B, Voigt W, Vanhoefer U, Gibbs JF, Skenderis BS, Frank C, Wrzosek C, Rustum YM. (1998) Novel cellular determinants for reversal of multidrug resistance in cells expressing P170-glycoprotein. Biochim Biophys Acta (Jan), 1401(3): 265-276.
  • Apffelstaedt JP, Driscoll DL, Spellman JE, Velez AF, Gibbs JF, Karakousis CP. (1996) Complications and outcome of external hemipelvectomy in the management of pelvic tumors. Ann Surg Oncol (Jan), 3(3): 304-309.
  • Schöber C, Gibbs JF, Yin MB, Slocum HK, Rustum YM. (1994) Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays. Biochem Pharmacol (Jan), 48(5): 997-1002.
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Books and Book Chapters:

  • Gibbs J, Smith JL, Douglass H. (2003) In: Surgery of Pancreatic Cancer. IN: Gastrointestinal Cancers: A companion to Sleisenger and Fordtran's Gastrointestinal and Liver Disease (eds. A.K. Rustgi, J. Crawford). , 541-547.
  • Gibbs J, Smith JL, Douglass H. (2001) In: Surgical Treatment of Pancreatic Carcinoma. IN: Gastrointestinal Cancers, (eds. A.K. Rustgi, J. Crawford).


  • Frys S, Barth MJ, Gu J, Mavis C, Gibbs JF, Czuczman MS, Hernandez-Ilizaliturri FJ. (2012) Etinostat, a Novel Histone Deacetylase (HiDAC) Inhibitor is Active in B-Cell Lymphoma Pre-Clinical Models and Enhances the Anti-Tumor Activity of Rituximab, Chemotherapy Agents and Proteasome Inhibitors. Blood, (Nov) 1649-1649
  • Barth MJ, Pendurti G, Mavis C, Czuczman NM, Gibbs JF, Deeb G, Czuczman MS, Hernandez-Ilizaliturri FJ. (2011) Activity of Rituximab and Ofatumumab Against Mantle Cell Lymphoma (MCL) in Vitro in MCL Cell Lines and Ex Vivo in Tumor Cells Derived From Patient Tumor Samples. Blood, (Nov) 4972-4972
  • Barth MJ, Hernandez-Ilizaliturri FJ, Mavis C, Tsai P, Gibbs JF, Czuczman MS. (2010) Ofatumumab, a Fully Human Monoclonal Antibody Targeting CD20, Demonstrates Activity Against and Potentiates the Anti-Tumor Activity of Chemotherapy Agents in Rituximab-Sensitive Cell Lines (RSCL), Rituximab-Resistant Cell Lines (RRCL), Lymphoma Xenograft. Blood, (Nov)
  • Barth MJ, Hernandez-Ilizaliturri FJ, Mavis C, Tsai P, Gibbs JF, Czuczman MS. (2010) Ofatumumab, a Fully Human Monoclonal Antibody Targeting CD20, Demonstrates Activity Against and Potentiates the Anti-Tumor Activity of Chemotherapy Agents In Rituximab-Sensitive Cell Lines (RSCL), Rituximab-Resistant Cell Lines (RRCL), Lymphoma Xenograft. Blood, (Nov) 3917-3917
  • Barth MJ, Hernandez-Ilizaliturri FJ, Mavis C, Tsai P, Gibbs JF, Czuczman MS. (2010) Activity of Ofatumumab (OFA), a Fully Human Monoclonal Antibody Targeting CD20, Against Rituximab (RTX)-Sensitive (RSCL) and Rituximab-Resistant Cell Lines (RRCL), In Vivo, and Primary Tumor Cells Derived from Patients with B-Cell Lymphoma. J Clin Oncol, (May) 8095-8095
  • Chu QD*, Khushalani N*, Javle MM, Douglass HO, Gibbs JF. (2003) Should adjuvant therapy be “standard of care” for patients with resected adenocarcinoma of the pancreas?. Annals of Surgical Oncology, (Jan) 539-545
  • Sarr MG, Traverso WL, Fernandez-del Castillo C, Ahrendt SA, Wilson S, Aranha GV, Evans D, Conlon K, Gillanders W, Gibbs JF, Michelassi F, Mulholland MW, Murr MM, Nealon WH, Pappas TN, Prinz RA, Shamamian P, Vickers SM, Weaver DW, Zinner MJ. (2003) The potent somatostatin analogue Vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: A prospective multicenter, double-blinded, randomized, placebo-controlled trial. Journal of the American College of Surgeons, (Jan) 556-565
  • Hoshi H, Wilkinson NW, Smith JL, Douglass H, Nava H, Gibbs J. (2003) Preoperative Endoscopic Ultrasound Staging Inaccurately Predicts Postoperative Tumor Depth for Esophageal Carcinoma. SAGES, (Jan) S271
  • Khushalani NI*, McKinley BP*, Gibbs JF, Leichman CG, Petrelli NJ. (2003) Regional chemotherapy is indicated after surgical resection of colorectal metastases to the liver: A debate. Journal of Surgical Oncology, (Jan) 65-72
  • Varma GN*, Winston JS, Hill HC*, Gibbs JF, Proulx GM, McGrath BE, Javle MM. (2003) Gastric Signet Ring Adenocarcinoma Presenting as Diffuse Mass in the Thigh. Journal of Clinical Oncology, (Jan) 3321-3373
  • Sabel MS*, Mollen K*, Smith J, Nava H, Douglass H, Gibbs JF. (2002) Esophageal resection for carcinoma in patients over 70 years of age. Annals of Surgical Oncology, (Jan) 210-214
  • Kane JM*, Finley JW*, Driscoll D, Kraybill WG, Gibbs JF. (2002) The treatment and outcome of patients with soft tissue sarcomas and synchronous metastases. Sarcoma, (Jan) 69-73
  • Chu QD*, Hill HC*, Douglass HO, Driscoll D, Smith JL, Nava HR, Gibbs JF. (2002) Predictive factors associated with long-term survival in patients with neuroendocrine tumor of the pancreas. Annals of Surgical Oncology, (Jan) 855-862
  • Al-kasspooles MF*, Hill HC*, Nava HR, Smith JL, Douglass HO, Gibbs JF. (2002) High-grade dysplasia within Barrett’s esophagus: Controversies regarding clinical opinions and approaches. Annals of Surgical Oncology, (Jan) 322-327
  • Kane JM*, Kahlenberg MS*, Kanter PM, Weber TK, Gibbs JF, Rodriguez-Bigas MA, Petrelli NJ. (2002) Intraoperative hepatic lymphatic mapping in patients with colorectal liver metastases. American Surgeon, (Jan) 745-750
  • Sabel MS*, Gibbs JF, Litwin A, McGrath B, Kraybill WG, Brooks JJ. (2001) Alveolar soft part sarcoma metastatic to small bowel mucosa causing polyposis and intusseption. Sarcoma, (Jan) 133-138
  • Wu D*, Gibbs J, Corral D, Intengan M, Brooks JJ. (2000) Massive localized lymphedema: Additional locations and association with hypothyroidism. Human Pathology, (Jan) 1162-1168
  • Proulx GM, Gibbs JF, Lee RJ, Velagapudi S, Huben R. (1999) Sarcomas of the Bladder: A case report with a review of the literature. Radiology and Oncology, (Jan) 63-68
  • Fuchshuber PR*, McGrath BE, Gibbs JF, Kraybill WG, Proulx GM, Lee, RJ. (1999) Second Malignancy after Radiotherapy for Seminoma. Radiology and Oncology, (Jan) 59-61
  • Kane III J, Gibbs J, Kraybill W. (1999) The Treatment and Outcome of Patients with Soft Tissue Sarcomas and Synchronous Metastases. Connective Tissue Oncology Society, Washington, D.C., (Jan)
  • Fuchshuber PR*, Lipman B, Kraybill WG, Gibbs JF. (1998) Ecthyma Gangrenosum Secondary to E. Coli Sepsis. Infections in Medicine, (Jan) 798-801
  • Schober C, Yin M-b, Gibbs J, Rustum Y. (1995) Heterogeneity in DNA Damage and Repair of Human Ovarian Tumor Cells Treated with Doxorubicin. Cellular Pharmacology, (Jan) 177-181
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Buffalo General Medical Center
100 High Street
Buffalo, New York 14203