James R. Olson PhD
James R. Olson
PhD
Professor
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Toxicology
Professional Summary:
Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides
• Characterization of the in vitro and in vivo metabolism and disposition of OP pesticides in animal models and humans.
• Identify new biomarkers of susceptibility to OPs by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification.
• Investigate the relationship between biomarkers of exposure, effect and susceptibility in human populations with environmental and occupational exposures to pesticides.
• Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of OPs.
Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs).
• Assessing Human Exposures to dioxins, PBDEs, and PCBs
• Characterize the metabolism and disposition of dioxins, PBDEs, and PCBs in humans.
• Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs that are ligands for the Ah receptor and mechanisms for their adverse health effects.
Education and Training:
- PhD, Pharmacology-Toxicology, Medical College of Wisconsin (1978)
- MS, Pharmacology, Medical College of Wisconsin (1976)
- BA, Chemistry, Illinois Wesleyan University (1974)
Employment:
- Director, Social and Preventive Medicine, University at Buffalo School of Health Related Professions (2010-present)
- Research Professor, Social and Preventive Medicine, University at Buffalo School of Health Related Professions (2010-present)
- Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1994-present)
- Associate Director, Toxicology Research Center, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1984-present)
- Clinical Professor, Social and Preventive Medicine, State University of New York at Buffalo School of Health Related Professions (1994–2010)
- Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1986–1994)
- Assistant Professor, Pharmacology and Toxicology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1980–1986)
Awards and Honors:
- UB Distinguished Professor (2012)
- Sustained Achievement Award (2007)
- Visionary Innovator (2005)
Research Expertise:
- Toxicology and Environmental Health: Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides • Characterization of the in vitro and in vivo metabolism and disposition of OP pesticides in animal models and humans. • Identify new biomarkers of susceptibility to OPs by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification. • Investigate the relationship between biomarkers of exposure, effect and susceptibility in human populations with environmental and occupational exposures to pesticides. • Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of OPs. Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs). • Assessing Human Exposures to dioxins, PBDEs, and PCBs • Characterize the metabolism and disposition of dioxins, PBDEs, and PCBs in humans. • Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs that are ligands for the Ah receptor and mechanisms for their adverse health effects. • Characterizing the adverse effects of dioxin on lung development and the role of the AhR pathway in the developing lung.
Grants and Sponsored Research:
- September 2016–September 2026
The Tonawanda Health Study: An Epidemiologic Study of Health Effects and Coke Oven Emissions from Tonawanda Coke
US Attorney’s Office, Department of Justice, Tonawanda Coke Corp.
Role: Co-Investigator
$7,933,256 - September 2020–June 2025
Effect of complex mixtures on oxidative stress and cognition in children
NIEHS
Role: Co-Investigator
$2,222,113 - April 2019–March 2022
JAA-F11 Anti-Thomsen-Friedenreich Antigen Targeted Imaging for Lung Cancer Differential Diagnosis
NCI Phase 1 SBIR award
Role: Co-Investigator
$300,000 - June 2016–May 2020
NIH IPA Agreement for James Olson
NCI
Role: Principal Investigator
$228,608 - March 2013–November 2019
Assessing Vulnerability of the Adolescent Brain to Organophosphorus Pesticides
Fogarty International Center and NIEHS
Role: Co-Principal Investigator
$872,699 - April 2012–March 2014
Bioactivation of PBDEs by Human Cytochrome P-450
NIEHS
Role: Co-Principal Investigator
$433,483 - February 2012–January 2014
The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos, NRSA Predoctoral Fellowship on behalf of Alice Crane, MD/PhD student
NIEHS
Role: Co-Investigator
$64,438 - June 2008–May 2013
Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity
NIEHS
Role: Co-Investigator
$777,129 - September 2007–August 2012
CYP-Specific PBPK/PD Models to Interpret Biomarkers for Organophosphate Pesticides
US EPA
Role: Principal Investigator
$749,722 - July 2009–June 2012
Assessing Vulnerability of the Adolescent Brain to Organophosphorus Pesticides
NIEHS
Role: Co-Investigator
$50,674 - May 2009–April 2012
Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity: Research Supplement to Promote Diversity in Health-Related Research on behalf ofCorie Ellison, Ph.D. Candidate, University at Buffalo, James Olson, Major Advisor
NIEHS
Role: Co-Investigator
$187,458 - September 2007–August 2010
Interpretation of Biomarkers Using Physiologically Based PharmacokineticModeling Environmental Protection Agency
EPA
Role: Principal Investigator
$749,280 - December 2006–November 2008
Dietary Isothiocyanates in Cancer Prevention: Effects on Estrogen
NCI
Role: Co-Investigator - March 2007–February 2008
Research Reagents for Human Serum Paraoxonase 1
NYSTAR Technology Transfer Incentive Program
Role: Co-Investigator - October 2003–September 2007
University-Community Consortium for Anniston Environmental Health Research
ATSDR/CDC
Role: Principal Investigator - June 2004–March 2007
Identification of functional peptide ligands for the AhR
NIEHS
Role: Principal Investigator - February 2003–December 2006
Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans
U.S. EPA
Role: Principal Investigator - April 2018
IND enabling production and preclinical safety analysis of hJAA-F11 monoclonal antibody for breast cancer therapy
NCI, Experimental Therapeutics Program (NExT)
Role: Co-Investigator
Journal Articles:
- Ismail AA, Hendy O, Abdel Rasoul G, Olson JR, Bonner MR, Rohlman DS. (2021) Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents. Toxics (Jun), 9(6). doi:10.3390/toxics9060137
- Eadeh HM, Ismail AA, Abdel Rasoul GM, Hendy OM, Olson JR, Wang K, Bonner MR, Rohlman DS. (2021) Evaluation of occupational pesticide exposure on Egyptian male adolescent cognitive and motor functioning. Environmental research (Jun), 197: 111137. doi:10.1016/j.envres.2021.111137
- VanEtten SL, Bonner MR, Ren X, Birnbaum LS, Kostyniak PJ, Wang J, Olson JR. (2021) Effect of exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) on mitochondrial DNA (mtDNA) copy number in rats. Toxicology (Apr), 454: 152744. doi:10.1016/j.tox.2021.152744
- VanEtten SL, Bonner MR, Ren X, Birnbaum LS, Kostyniak PJ, Wang J, Olson JR. (2020) Telomeres as targets for the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) in rats. Toxicology and applied pharmacology (Dec), 408: 115264.
- Pittman GS, Wang X, Campbell MR, Coulter SJ, Olson JR, Pavuk M, Birnbaum LS, Bell DA. (2020) Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II. The Science of the total environment (Nov), 742: 140424. doi:10.1016/j.scitotenv.2020.140424
- Travis SC, Aga DS, Queirolo EI, Olson JR, Daleiro M, Kordas K. (2020) Catching flame retardants and pesticides in silicone wristbands: Evidence of exposure to current and legacy pollutants in Uruguayan children. The Science of the total environment (Oct), 740: 140136.
- Rohlman DS, Davis JW, Ismail A, Abdel Rasoul GM, Hendy O, Olson JR, Bonner MR. (2020) Risk perception and behavior in Egyptian adolescent pesticide applicators: an intervention study. BMC public health (May), 20(1): 679. doi:10.1186/s12889-020-08801-7
- Pittman GS, Wang X, Campbell MR, Coulter SJ, Olson JR, Pavuk M, Birnbaum LS, Bell DA. (2020) Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey. Epigenetics (Apr), 15(4): 337-357. doi:10.1080/15592294.2019.1666654
- Anger WK, Farahat FM, Lein PJ, Lasarev MR, Olson JR, Farahat TM, Rohlman DS. (2020) Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers. Neurotoxicology (Mar), 77: 216-230. doi:10.1016/j.neuro.2020.01.012
- Butryn DM, Chi LH, Gross MS, McGarrigle B, Schecter A, Olson JR, Aga DS. (2020) Retention of polybrominated diphenyl ethers and hydroxylated metabolites in paired human serum and milk in relation to CYP2B6 genotype. Journal of hazardous materials (Mar), 386: 121904.
- Rohlman DS, Ismail A, Bonner MR, Abdel Rasoul G, Hendy O, Ortega Dickey L, Wang K, Olson JR. (2019) Occupational pesticide exposure and symptoms of attention deficit hyperactivity disorder in adolescent pesticide applicators in Egypt. Neurotoxicology (Sep), 74: 1-6. doi:10.1016/j.neuro.2019.05.002
- Ge Y, Zheng N, Chen X, Zhu J, Sun W, Olson JR, Aga DS, Hu W, Tang X, Ren X. (2019) GMDTC Chelating Agent Attenuates Cisplatin-Induced Systemic Toxicity without Affecting Antitumor Efficacy. Chemical research in toxicology (Aug), 32(8): 1572-1582.
- Yang E, Pavuk M, Sjödin A, Lewin M, Jones R, Olson J, Birnbaum L. (2018) Exposure of dioxin-like chemicals in participants of the Anniston community health survey follow-up. The Science of the total environment (Oct), 637-638: 881-891. doi:10.1016/j.scitotenv.2018.05.074
- Karacosta LG, Fisk JC, Jessee J, Tati S, Turner B, Ghazal D, Ludwig R, Johnson H, Adams J, Sajjad M, Koury S, Roy R, Olson JR, Rittenhouse-Olson K. (2018) Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. Translational oncology (Apr), 11(2): 450-466. doi:10.1016/j.tranon.2018.01.008
- Tati S, Fisk JC, Abdullah J, Karacosta L, Chrisikos T, Philbin P, Morey S, Ghazal D, Zalzala F, Jessee J, Quataert S, Koury S, Moreno D, Eng JY, Glinsky VV, Glinskii OV, Sesay M, Gebhard AW, Birthare K, Olson JR, Rittenhouse-Olson K. (2018) Corrigendum to "Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis" [Neoplasia 19.9 (2017) 716-733]. Neoplasia (New York, N.Y.) (Jan), 20(1): 118. doi:10.1016/j.neo.2017.10.001
- Callahan CL, Hamad LA, Olson JR, Ismail AA, Abdel-Rasoul G, Hendy O, Rohlman DS, Bonner MR. (2017) Longitudinal assessment of occupational determinants of chlorpyrifos exposure in adolescent pesticide workers in Egypt. International journal of hygiene and environmental health (Nov), 220(8): 1356-1362. doi:10.1016/j.ijheh.2017.09.006
- Callahan CL, Pavuk M, Birnbaum LS, Ren X, Olson JR, Bonner MR. (2017) Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey. Environment international (Nov), 108: 212-220. doi:10.1016/j.envint.2017.08.018
- Tati S, Fisk JC, Abdullah J, Karacosta L, Chrisikos T, Philbin P, Morey S, Ghazal D, Zazala F, Jessee J, Quataert S, Koury S, Moreno D, Eng JY, Glinsky VV, Glinskii OV, Sesay M, Gebhard AW, Birthare K, Olson JR, Rittenhouse-Olson K. (2017) Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis. Neoplasia (New York, N.Y.) (Sep), 19(9): 716-733. doi:10.1016/j.neo.2017.07.001
- Gao L, Mutlu E, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. (2017) DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Chemical research in toxicology (Mar), 30(3): 794-803. doi:10.1021/acs.chemrestox.6b00368
- Ismail AA, Bonner MR, Hendy O, Abdel Rasoul G, Wang K, Olson JR, Rohlman DS. (2017) Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt. PloS one (Jan), 12(2): e0172696. doi:10.1371/journal.pone.0172696
- Ismail AA, Wang K, Olson JR, Bonner MR, Hendy O, Abdel Rasoul G, Rohlman DS. (2017) The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators. Journal of toxicology and environmental health. Part A (Jan), 80(10-12): 542-555. doi:10.1080/15287394.2017.1362612
- Gross MS, Olivos HJ, Butryn DM, Olson JR, Aga DS. (2016) Analysis of hydroxylated polybrominated diphenyl ethers (OH-BDEs) by supercritical fluid chromatography/mass spectrometry. Talanta (Dec), 161: 122-129.
- Ha H, Rogerson PA, Olson JR, Han D, Bian L, Shao W. (2016) Analysis of Pollution Hazard Intensity: A Spatial Epidemiology Case Study of Soil Pb Contamination. International journal of environmental research and public health (Sep), 13(9). doi:10.3390/ijerph13090915
- Mutlu E, Gao L, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. (2016) Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague-Dawley Rats. Chemical research in toxicology (Aug), 29(8): 1335-1344. doi:10.1021/acs.chemrestox.6b00146
- Tang X, Zhu J, Zhong Z, Luo M, Li G, Gong Z, Zhang C, Fei F, Ruan X, Zhou J, Liu G, Li G, Olson J, Ren X. (2016) Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway. Toxicology and applied pharmacology (Aug), 305: 143-152. doi:10.1016/j.taap.2016.06.001
- Rohlman DS, Ismail AA, Rasoul GA, Bonner MR, Hendy O, Mara K, Wang K, Olson JR. (2016) A 10-month prospective study of organophosphorus pesticide exposure and neurobehavioral performance among adolescents in Egypt. Cortex; a journal devoted to the study of the nervous system and behavior (Jan), 74: 383-95. doi:10.1016/j.cortex.2015.09.011
- Butryn DM, Gross MS, Chi LH, Schecter A, Olson JR, Aga DS. (2015) "One-shot" analysis of polybrominated diphenyl ethers and their hydroxylated and methoxylated analogs in human breast milk and serum using gas chromatography-tandem mass spectrometry. Analytica chimica acta (Sep), 892: 140-7. doi:10.1016/j.aca.2015.08.026
- Ren X, Wu X, Sui G, Gong Z, Yawson E, Wu B, Lai G, Ruan X, Gao H, Zhou F, Su B, Olson JR, Tang X. (2015) Chronic trimethyltin chloride exposure and the development of kidney stones in rats. Journal of applied toxicology : JAT (May), 35(5): 500-7. doi:10.1002/jat.3054
- Gross MS, Butryn DM, McGarrigle BP, Aga DS, Olson JR. (2015) Primary role of cytochrome P450 2B6 in the oxidative metabolism of 2,2',4,4. Chemical research in toxicology (Apr), 28(4): 672-81.
- Ren X, Gaile DP, Gong Z, Qiu W, Ge Y, Zhang C, Huang C, Yan H, Olson JR, Kavanagh TJ, Wu H. (2015) Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress. Toxicology and applied pharmacology (Mar), 283(3): 198-209. doi:10.1016/j.taap.2015.01.014
- Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Lasarev MR, Anger WK, Rohlman DS, Olson JR. (2015) Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers. International journal of hygiene and environmental health (Mar), 218(2): 203-11. doi:10.1016/j.ijheh.2014.10.005
- Simpson S, Gross MS, Olson JR, Zurek E, Aga DS. (2015) Identification of polybrominated diphenyl ether metabolites based on calculated boiling points from COSMO-RS, experimental retention times, and mass spectral fragmentation patterns. Analytical chemistry (Feb), 87(4): 2299-305.
- Aminov Z, Haase R, Olson JR, Pavuk M, Carpenter DO, . (2014) Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama. Environment international (Dec), 73: 216-23.
- Callahan CL, Al-Batanony M, Ismail AA, Abdel-Rasoul G, Hendy O, Olson JR, Rohlman DS, Bonner MR. (2014) Chlorpyrifos exposure and respiratory health among adolescent agricultural workers. International journal of environmental research and public health (Dec), 11(12): 13117-29. doi:10.3390/ijerph111213117
- Pavuk M, Olson JR, Wattigney WA, Dutton ND, Sjödin A, Shelton C, Turner WE, Bartell SM, . (2014) Predictors of serum polychlorinated biphenyl concentrations in Anniston residents. The Science of the total environment (Oct), 496: 624-634. doi:10.1016/j.scitotenv.2014.06.113
- Jandacek RJ, Heubi JE, Buckley DD, Khoury JC, Turner WE, Sjödin A, Olson JR, Shelton C, Helms K, Bailey TD, Carter S, Tso P, Pavuk M. (2014) Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. The Journal of nutritional biochemistry (Apr), 25(4): 483-8. doi:10.1016/j.jnutbio.2014.01.002
- Pavuk M, Olson JR, Sjödin A, Wolff P, Turner WE, Shelton C, Dutton ND, Bartell S, . (2014) Serum concentrations of polychlorinated biphenyls (PCBs) in participants of the Anniston Community Health Survey. The Science of the total environment (Mar), 473-474: 286-97. doi:10.1016/j.scitotenv.2013.12.041
- Ge Y, Gong Z, Olson JR, Xu P, Buck MJ, Ren X, Buck M. (2013) Inhibition of monomethylarsonous acid (MMA(III))-induced cell malignant transformation through restoring dysregulated histone acetylation. Toxicology (Oct), 312: 30-35.
- Crane AL, Abdel Rasoul G, Ismail AA, Hendy O, Bonner MR, Lasarev MR, Al-Batanony M, Singleton ST, Khan K, Olson JR, Rohlman DS. (2013) Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers. Journal of exposure science & environmental epidemiology (Jul), 23(4): 356-62. doi:10.1038/jes.2012.113
- Feo ML, Gross MS, McGarrigle BP, Eljarrat E, Barceló D, Aga DS, Olson JR. (2013) Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6. Environmental health perspectives (Apr), 121(4): 440-6. doi:10.1289/ehp.1205446
- Dadson OA, Ellison CA, Singleton ST, Chi LH, McGarrigle BP, Lein PJ, Farahat FM, Farahat T, Olson JR. (2013) Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. Toxicology (Apr), 306: 35-9. doi:10.1016/j.tox.2013.01.023
- Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR. (2012) PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. Toxicol Appl Pharmacol (Sep).
- Crane AL, Klein K, Olson JR. (2012) Bioactivation of chlorpyrifos by CYP2B6 variants. Xenobiotica (Jul).
- Crane AL, Klein K, Zanger UM, Olson JR. (2012) Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism. Toxicology (Mar), 293(1-3): 115-122.
- Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR. (2012) Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers. J Toxicol Environ Health A (Jan), 75(4): 232-241.
- Lein PJ, Bonner MR, Farahat FM, Olson JR, Rohlman DS, Fenske RA, Lattal KM, Lasarev MR, Galvin K, Farahat TM, Anger WK. (2012) Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. Neurotoxicology (Jan).
- Ellison CA, Tian Y, Knaak JB, Kostyniak PJ, Olson JR. (2012) Human hepatic cytochrome p450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon. Drug Metab Dispos (Jan), 40(1): 1-5.
- Ellison CA, Smith JN, Lein PJ, Olson JR. (2011) Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology (Sep), 287(1-3): 137-44. doi:10.1016/j.tox.2011.06.010
- Foxenberg RJ, Ellison CA, Knaak JB, Ma C, Olson JR. (2011) Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology (Jul), 285(1-2): 57-66.
- Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, Lasarev MR, Rohlman DS, Anger WK, Lein PJ, Olson JR. (2011) Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environ Health Perspect (Jun), 119(6): 801-806.
- Yang D, Lauridsen H, Buels K, Chi LH, La Du J, Bruun DA, Olson JR, Tanguay RL, Lein PJ. (2011) Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicol Sci (May), 121(1): 146-159.
- Ovando BJ, Ellison CA, Vezina CM, Olson JR. (2010) Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands. BMC Genomics (Oct), 11: 583-583.
- Lupton SJ, McGarrigle BP, Olson JR, Wood TD, Aga DS. (2010) Analysis of hydroxylated polybrominated diphenyl ether metabolites by liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Rapid Commun Mass Spectrom (Aug), 24(15): 2227-2235.
- Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, Farahat TM, Lein PJ, Anger WK. (2010) Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology (Jun), 31(3): 297-304.
- Bloom MS, Vena JE, Olson JR, Kostyniak PJ. (2009) Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York state anglers. Int J Hyg Environ Health (Nov), 212(6): 599-611.
- Lupton SJ, McGarrigle BP, Olson JR, Wood TD, Aga DS. (2009) Human liver microsome-mediated metabolism of brominated diphenyl ethers 47, 99, and 153 and identification of their major metabolites. Chemical research in toxicology (Nov), 22(11): 1802-9.
- Kransler KM, McGarrigle BP, Swartz DD, Olson JR. (2009) Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci (Feb), 107(2): 498-511.
- Kransler KM, McGarrigle BP, Russell RJ, Olson JR. (2008) Effects of Helicobacter infection on developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats. Lab Anim (NY) (Apr), 37(4): 171-175.
- Kransler KM, Tonucci DA, McGarrigle BP, Napoli JL, Olson JR. (2007) Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat. Toxicology and applied pharmacology (Oct), 224(1): 29-38.
- McCann SE, Wactawski-Wende J, Kufel K, Olson J, Ovando B, Kadlubar SN, Davis W, Carter L, Muti P, Shields PG, Freudenheim JL. (2007) Changes in 2-hydroxyestrone and 16alpha-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Feb), 16(2): 256-62. doi:10.1158/1055-9965.EPI-06-0633
- Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR. (2007) Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos (Feb), 35(2): 189-193.
- Catania JR, McGarrigle BP, Rittenhouse-Olson K, Olson JR. (2007) Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium. Toxicol In Vitro (Feb), 21(1): 109-115.
- Kransler KM, Tonucci DA, McGarrigle BP, Napoli JL and Olson JR . (2007) Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters Retinoid Homeostasis in Maternal and Perinatal Tissues of the Holtzman Rat. Toxicology and Applied Pharmacology (Jan).
- Kransler KM, McGarrigle BP, Olson JR. (2007) Comparative developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the hamster, rat and guinea pig. Toxicology (Jan), 229(3): 214-225.
- McCann, S. E., Wactawski-Wende, J., Olson, J. R., Ovando, B.J., Nowell, S., Davis, W., Carter, L., Muti, P., Shields, P.G. and J. L. Freudenheim. (2007) Changes in 2- and 16a-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype. Cancer Epidemiology, Biomarkers and Prevention (Jan), 16(2): 256-262.
- Ovando BJ, Vezina CM, McGarrigle BP, Olson JR. (2006) Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci (Dec), 94(2): 428-438.
- Harrigan JA, McGarrigle BP, Sutter TR, Olson JR. (2006) Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. Toxicol In Vitro (Jun), 20(4): 426-438.
- Harrigan JA, McGarrigle BP, Sutter TR, Olson JR. (2006) Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liverand lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. Toxicol In Vitro (Jun), 20(4): 426-438.
- Bloom M, Vena J, Olson J, Moysich K. (2006) Chronic exposure to dioxin-like compounds and thyroid function among New York anglers. Environmental toxicology and pharmacology (May), 21(3): 260-7.
- Schecter A, Päpke O, Harris TR, Tung KC, Musumba A, Olson J, and Birnbaum L. (2006) Polybrominated Diphenyl Ether (PBDE) Levels in an Expanded Market Basket Survey of United States (U.S) Food and Estimated PBDE Dietary Intake by Age and Gender. Environmental Health Perspectives (Jan), 114: 1515-1520.
- Bloom M, Vena J, Olson J, Moysich K. (2006) Chronic exposure to dioxin-like compounds and thyroid function among New York anglers. Environmental Toxicology and Pharmacology (Jan), 21(3): 260-267.
- Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. (2005) Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicol Sci (Dec), 88(2): 400-411.
- Kim SY, Suzuki N, Laxmi YR, McGarrigle BP, Olson JR, Sharma M, Sharma M, Shibutani S. (2005) Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen. Chem Res Toxicol (May), 18(5): 889-895.
- Bloom MS, Vena JE, Swanson MK, Moysich KB, Olson JR. (2005) Profiles of ortho-polychlorinated biphenyl congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex among male Lake Ontario sportfish consumers: the New York State Angler cohort study. Environ Res (Feb), 97(2): 178-194.
- Vezina CM, Walker NJ, Olson JR. (2004) Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Environ Health Perspect (Nov), 112(16): 1636-1644.
- Harrigan JA, Vezina CM, McGarrigle BP, Ersing N, Box HC, Maccubbin AE, Olson JR. (2004) DNA adduct formation in precision-cut rat liver and lung slices exposed to benzo[a]pyrene. Toxicol Sci (Feb), 77(2): 307-314.
- Harrigan JA, Vezina CM, McGarrigle BP, Ersing N, Box HC, Maccubbin AE, Olson JR. (2004) DNA adduct formation in precision-cut rat liver and lung slices exposed tobenzo[a]pyrene. Toxicol Sci (Feb), 77(2): 307-314.
- Sharma M, Shubert DE, Sharma M, Lewis J, McGarrigle BP, Bofinger DP, Olson JR. (2003) Biotransformation of tamoxifen in a human endometrial explant culture model. Chem Biol Interact (Dec), 146(3): 237-249.
- Sharma M, Shubert DE, Sharma M, Rodabaugh KJ, McGarrigle BP, Vezina CM, Bofinger DP, Olson JR. (2003) Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture. Biochem Biophys Res Commun (Jul), 307(1): 157-164.
- Vezina, CM and Olson JR. (2003) Comparison of the Hepatic Gene Expression Profiles in Female Rats Exposed Subchronically to TCDD, PeCDF, PCB126 and PCB153 Using DNA Microarray. Organohalogen Compounds (Jan), 64: 339-341.
- Olson, JR, Vezina, CM, Malek, RL, Sajadi, H, Lee, NH, Luu, TV, and Wang, H. (2003) Temporal Changes in the Hepatic Gene Expression Profiles of Female Rats Exposed to TCDD, PeCDF, PCB126, and PCB153 for 14 or 53 Weeks. Organohalogen Compounds (Jan), 64: 267-269.
- Buck GM, Vena JE, Greizerstein HB, Weiner JM, McGuinness B, Mendola P, Kostyniak PJ, Swanson M, Bloom MS, Olson JR. (2002) PCB congeners and pesticides and female fecundity, New York State Angler Prospective Pregnancy Study. Environ Toxicol Pharmacol (Sep), 12(2): 83-92.
- Germaine Buck, John Vena, Hebe Greizerstein, John Weiner, Bridget McGuinness, Pauline Mendola, Paul Kostyniak, Mya Swanson, Michael Bloom, James Olson. (2002) PCB congeners and pesticides and female fecundity, New York State Angler Propective Pregnancy Study. Environmental Toxicology and Pharmacology (Aug), 12: 83-92.
- Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR. (2001) Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium. Toxicol Sci (Aug), 62(2): 299-314.
- Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR. (2001) Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant culturesof human endometrium. Toxicol Sci (Aug), 62(2): 299-314.
- Schecter, A, Cramer, P, Boggess, K, Stanley, J, Papke, O, James Olson, Sliver, A, Schmits, M. (2001) Intake of Dioxins and Related Compounds from Food in the U.S. Population. Journal of Toxicology and Environmental Health Part A (May), 63: 101-118.
- Buck GM, John Vena, Schisterman EF, Jacek Dmochowski, Mendola P, Sever LE, Fitzgerald E, Paul Kostyniak, Greizerstein H, James Olson. (2000) Parental consumption of contaminated sport fish from Lake Ontario and predicted fecundability. Epidemiology (Jul), 11(4): 388-393.
- Honey S, O‘Keefe P, Drahushuk AT, Olson JR, Kumar S, Sikka HC. (2000) Metabolism of benzo(a)pyrene by duck liver microsomes. Comp Biochem Physiol C Toxicol Pharmacol (Jul), 126(3): 285-292.
- Drahushuk AT, McGarrigle BP, Slezak BP, Stegeman JJ, Olson JR. (1999) Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (Mar), 155(2): 127-138.
- Buck, GM, Mendola, P, John Vena, Sever, LE, Paul Kostyniak, Greizerstein, H, James Olson, Stephen, FD. (1999) Paternal Lake Ontario Fish Consumption and Risk of Conception Delay, New York State Angler Cohort. Environmental Research (Feb), 80: S13-S18.
- Schecter, A, Dellarco, M, Papke, O, James Olson. (1998) A Comparison of Dioxins, Dibenzofurans, and Coplanar PCBs in Uncooked and Broiled Ground Beef, Catfish, and Bacon. Chemosphere (Oct), 37: 1723-1730.
- Drahushuk AT, McGarrigle BP, Larsen KE, Stegeman JJ, Olson JR. (1998) Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture. Carcinogenesis (Aug), 19(8): 1361-1368.
- Pelosi, GD, Oberdoerster, J, James Olson, Knaak, JB, Smith, LW, Newton, PE. (1998) Characterization of Rat Hepatic Cytochrome P450 Activities Following Inhalation Exposure to p-Chlorobenzotrifluoride (PCBTF). Inhalation Toxicology (Jan), 10: 49-63.
- Knaak, JB, Smith, LW, Fitzpatrick, RD, James Olson, Newton, PE. (1998) In Vitro Hepatic Metabolism of PCBTF: Development of Vmax, Km Values, Partition Coefficients and Their Use in an Inhalation PBPK Model. Inhalation Toxicology (Jan), 10: 65-85.
- Stephen FD, Drahushuk AT, Olson JR. (1997) Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C. Toxicology (Dec), 124(1): 39-51.
- Drahushuk AT, Choy CO, Kumar S, McReynolds JH, Olson JR. (1997) Modulation of cytochrome P450 by 5,5'-bis-trifluoromethyl-2,2'-dichlorobiphenyl, a unique environmental contaminant. Toxicology (Jul), 120(3): 197-205.
- Drahushuk AT, Choy CO, Kumar S, McReynolds JH, Olson JR. (1997) Modulation of cytochrome P450 by 5,5‘-bis-trifluoromethyl-2,2‘-dichlorobiphenyl,a unique environmental contaminant. Toxicology (Jul), 120(3): 197-205.
- Geyer HJ, Schramm KW, Scheunert I, Schughart K, Buters J, Wurst W, Greim H, Kluge R, Steinberg CE, Kettrup A, Madhukar B, Olson JR, Gallo MA. (1997) Considerations on genetic and environmental factors that contribute to resistance or sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Part 1: Genetic factors affecting the toxicity o. Ecotoxicol Environ Saf (Apr), 36(3): 213-230.
- Geyer HJ, Schramm KW, Scheunert I, Schughart K, Buters J, Wurst W, Greim H, Kluge R, Steinberg CE, Kettrup A, Madhukar B, Olson JR, Gallo MA. (1997) Considerations on genetic and environmental factors that contribute to resistanceor sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)and related compounds. Ecotoxicol Environ Saf (Apr), 36(3): 213-230.
- Schecter A, Olson JR. (1997) Cancer risk assessment using blood dioxin levels and daily dietary TEQ intake in general populations of industrial and non-industrial countries. Chemosphere (Mar), 34(5-7): 1569-1577.
- Schecter A, Olson JR. (1997) Cancer risk assessment using blood dioxin levels and daily dietary TEQ intakein general populations of industrial and non-industrial countries. Chemosphere (Mar), 34(5-7): 1569-1577.
- Schecter A, Cramer P, Boggess K, Stanley J, Olson JR. (1997) Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samples collected in 1995 at supermarkets across the United States. Chemosphere (Mar), 34(5-7): 1437-1447.
- Schecter A, Cramer P, Boggess K, Stanley J, Olson JR. (1997) Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samplescollected in 1995 at supermarkets across the United States. Chemosphere (Mar), 34(5-7): 1437-1447.
- Drahushuk AT, McGarrigle BP, Tai HL, Kitareewan S, Goldstein JA, Olson JR. (1996) Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction. Toxicol Appl Pharmacol (Oct), 140(2): 393-403.
- Schecter A, Papke O, Lis A, Ball M, Ryan JJ, Olson JR, Li L, Kessler H. (1996) Decrease in milk and blood dioxin levels over two years in a mother nursing twins: estimates of decreased maternal and increased infant dioxin body burden from nursing. Chemosphere (Feb), 32(3): 543-549.
- John Vena, Buck, GM, Paul Kostyniak, Mendola, P, Fitzgerald, E, Sever, L, Jo Freudenheim, Greizerstein, H, Zielezny, M, McReynolds, J, James Olson. (1996) The New York Angler Cohort Study: Exposure Characterization and Reproductive and Developmental Health. Toxicology and Industrial Health (Jan), 12(3/4): 327-334.
- Fiorella PD, Olson JR, Napoli JL. (1995) 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces diverse retinoic acid metabolites in multiple tissues of the Sprague-Dawley rat. Toxicol Appl Pharmacol (Oct), 134(2): 222-228.
- Schecter A, Startin J, Wright C, Kelly M, Päpke O, Lis A, Ball M, Olson JR. (1994) Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake. Environ Health Perspect (Nov), 102(11): 962-966.
- Schecter A, Startin J, Wright C, Kelly M, Päpke O, Lis A, Ball M, Olson JR. (1994) Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimateddaily dioxin toxic equivalent intake. Environ Health Perspect (Nov), 102(11): 962-966.
- Olson JR, McGarrigle BP, Gigliotti PJ, Kumar S, McReynolds JH. (1994) Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran. Fundam Appl Toxicol (May), 22(4): 631-640.
- Van den Berg M, De Jongh J, Poiger H, Olson JR. (1994) The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol (Jan), 24(1): 1-74.
- Van den Berg M, De Jongh J, Poiger H, Olson JR. (1994) The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs)and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol (Jan), 24(1): 1-74.
- Tai HL, McReynolds JH, Goldstein JA, Eugster HP, Sengstag C, Alworth WL, Olson JR. (1993) Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human. Toxicol Appl Pharmacol (Nov), 123(1): 34-42.
- Nosek JA, Craven SR, Sullivan JR, Olson JR, Peterson RE. (1992) Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in ring-necked pheasant hens, chicks, and eggs. J Toxicol Environ Health (Mar), 35(3): 153-164.
- Walker, MK, Spitsbergen, JM, James Olson, Peterson, RE. (1991) 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity during early life stage development of lake trout. Can J Fish Aquat Sci (May), 48: 875-883.
- Clapp RW, Olson JR. (1991) A new review of the dioxin literature. New Solut (Apr), 1(4): 31-37.
- Shen ES, Gutman SI, Olson JR. (1991) Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity in C57BL/6J and DBA/2J mice. J Toxicol Environ Health (Apr), 32(4): 367-381.
- Shen ES, Gutman SI, Olson JR. (1991) Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity inC57BL/6J and DBA/2J mice. J Toxicol Environ Health (Apr), 32(4): 367-381.
- Spitsbergen, JM, James Olson, Walker, MK, Peterson, RE. (1991) Pathologic lesions in early life stages of lake trout, Salvelinus namaycush, exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin as fertilized eggs. Aquatic Toxicol (Feb), 19: 41-72.
- James Olson, McGarrigle, BP. (1991) Comparative Developmental Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Chemosphere (Jan), 25: 71-74.
- James Olson, McGarrigle, BP, Tonucci, DA, Schecter, A, Eichelberger, H. (1990) Developmental Toxicology of 2,3,7,8-TCDD in the rat and hamster. Chemosphere (Jan), 20: 1117-1123.
- Aleo MD, Taub ML, Olson JR, Kostyniak PJ. (1990) Primary cultures of rabbit renal proximal tubule cells: II. Selected phase I and phase II metabolic capacities. Toxicol In Vitro (Jan), 4(6): 727-733.
- Aleo, MD, Mary Taub, James Olson, Paul Kostyniak. (1990) Primary cultures of rabbit renal tubule cells: II. Selected phase I and phase II metabolic capacities. Toxicol In Vitro (Jan), 4: 727-733.
- Shen ES, Guengerich FP, Olson JR. (1989) Biphasic response for hepatic microsomal enzyme induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Biochem Pharmacol (Nov), 38(22): 4075-4084.
- Shen ES, Guengerich FP, Olson JR. (1989) Biphasic response for hepatic microsomal enzyme induction by 2,3,7,8-tetrachlorodibenzo-p-dioxinin C57BL/6J and DBA/2J mice. Biochem Pharmacol (Nov), 38(22): 4075-4084.
- Hruska RE, Olson JR. (1989) Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Lett (Sep), 48(3): 289-299.
- Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Roth JA. (1989) Effect of chronic exposure to hexachlorophene on rat brain cell specific marker enzymes. Neurotoxicology (Jun), 10(2): 201-210.
- Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth JA. (1989) Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to methylmercury. Neurotoxicology (Jan), 10(1): 41-52.
- James Olson, Bellin, JS, Barnes, DG. (1989) Reexamination of data used for establishing Toxicity Equivalence Factors (TEFs) for Chlorinated Dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs). Chemosphere (Jan), 18: 371-381.
- James Olson, Gutman, SI, Shen, ES. (1989) Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD. Chemosphere (Jan), 18: 363-370.
- Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. (1988) Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fundam Appl Toxicol (Oct), 11(3): 519-527.
- Wroblewski VJ, Gessner T, Olson JR. (1988) Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster. Biochem Pharmacol (Apr), 37(8): 1509-1517.
- Wroblewski VJ, Gessner T, Olson JR. (1988) Qualitative and quantitative differences in the induction and inhibition ofhepatic benzo[a]pyrene metabolism in the rat and hamster. Biochem Pharmacol (Apr), 37(8): 1509-1517.
- Kleeman JM, Olson JR, Peterson RE. (1988) Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish. Fundam Appl Toxicol (Feb), 10(2): 206-213.
- Kleeman JM, Olson JR, Peterson RE. (1988) Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformationin fish. Fundam Appl Toxicol (Feb), 10(2): 206-213.
- Wroblewski VJ, Olson JR. (1988) Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster. Drug Metab Dispos (Jan), 16(1): 43-51.
- Wroblewski VJ, Olson JR. (1988) Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster. Drug Metab Dispos (Jan), 16(1): 43-51.
- Shen ES, Olson JR. (1987) Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab Dispos (Sep), 15(5): 653-660.
- Shen ES, Olson JR. (1987) Relationship between the murine Ah phenotype and the hepatic uptake and metabolismof 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab Dispos (Sep), 15(5): 653-660.
- Kung MP, Kostyniak P, Olson J, Malone M, Roth JA. (1987) Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes. J Appl Toxicol (Apr), 7(2): 119-121.
- Olson JR. (1986) Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs. Toxicol Appl Pharmacol (Sep), 85(2): 263-273.
- Kleeman JM, Olson JR, Chen SM, Peterson RE. (1986) Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rainbow trout. Toxicol Appl Pharmacol (May), 83(3): 391-401.
- Kleeman JM, Olson JR, Chen SM, Peterson RE. (1986) 2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Toxicol Appl Pharmacol (May), 83(3): 402-411.
- James Olson, Wroblewski, VJ. (1985) Metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in isolated hepatocytes from guinea pigs and rats. Chemosphere (Nov), 14: 979-982.
- Wroblewski VJ, Olson JR. (1985) Hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig. Toxicol Appl Pharmacol (Nov), 81(2): 231-240.
- Sawahata T, Olson JR, Neal RA. (1982) Identification of metabolites of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin (TCDD) formed on incubation with isolated rat hepatocytes. Biochem Biophys Res Commun (Mar), 105(1): 341-346.
- Neal RA, Olson JR, Gasiewicz TA, Geiger LE. (1982) The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems. Drug Metab Rev (Jan), 13(3): 355-385.
- Olson JR, Gasiewicz TA, Neal RA. (1980) Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster. Toxicol Appl Pharmacol (Oct), 56(1): 78-85.
- Olson JR, Holscher MA, Neal RA. (1980) Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster. Toxicol Appl Pharmacol (Aug), 55(1): 67-78.
- Jansen MA, Olson JR, Fujimoto JM. (1980) Taurolithocholate-induced increase in the intrabiliary pressure generated during retrograde intrabiliary infusion of saline in rats: antagonism by taurocholate and glycocholate. Toxicol Appl Pharmacol (Jun), 54(1): 9-19.
- Olson JR, Fujimoto JM. (1980) Evaluation of hepatobiliary function in the rat by the segmented retrograde intrabiliary injection technique. Biochem Pharmacol (Feb), 29(2): 205-211.
- Olson JR, Fujimoto JM. (1980) Demonstration of a D-glucose transport system in the biliary tree of the rat by use of the segmented retrograde intrabiliary injection technique. Biochem Pharmacol (Feb), 29(2): 213-219.
- Olson JR, Hosko MJ, Fujimoto JM. (1979) Alterations in the liver cell transmembrane potential following CC14 and bile salt treatment of rats. Life Sci (Dec), 25(24-25): 2043-2050.
- Olson JR, Fujimoto JM, Peterson RE. (1977) Three methods for measuring the increase in the capacity of the distended biliary tree in the rat produced by alpha-naphthylisothiocyanate treatment. Toxicol Appl Pharmacol (Oct), 42(1): 33-43.
- Peterson RE, Olson JR, Fujimoto JM. (1976) Measurement and alteration of the capacity of the distended biliary tree in the rat. Toxicol Appl Pharmacol (May), 36(2): 353-368.
- Singleton ST, Lein PJ, Farahat FM, Farahat T, Bonner MR, Knaak JB, Olson JR. (1900) Characterization of a-cypermethrin exposure in Egyptian agricultural workers. International journal of hygiene and environmental health (Jan), 217(4-5): 538-45. doi:10.1016/j.ijheh.2013.10.003
Professional Memberships:
- American Society for Pharmacology and Experimental Therapeutics (1990–present)
- Society of Toxicology (1984–present)
Presentations:
- "Predictors of human serum polychlorinated biphenyls (pcbs) concentrations in the Anniston Community Health Survey" 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
- "Soil-serum PCB associations in the Anniston Community Health Survey" 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
- "Spatial distribution and determinants of PCB contamination in residential soil in Anniston, Alabama." 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
- "Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers" Society of Toxicology; Society of Toxicology (2010)
- "Biomarkers of organophosphorus pesticide-induced neurotoxicity" Society of Toxicology (2010)
- "Developing a monoclonal antibody based capture assay to quantify cytosolic AHR." Society of Toxicology (2010)
- "Exposure Estimates and PBPK Modeling of Chlorpyrifos in Rats and Humans" Society of Toxicology (2010)
- "Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in human blood following in vitro and in vivo exposure to chlorpyrifos" Society of Toxicology (2010)
- "Oxidative DNA adducts in the livers of female Srague-Dawley rats chronically exposed to polyhalogenated aromatic hydrocarbons (PHAHs)." Society of Toxicology (2010)
- "Strain and dose-related effects of subchronic chlorpyrifos (CPF) exposure on biomarkers of exposure and oxidative stress in rats." Society of Toxicology (2010)
Service Activities:
- Faculty Facilitator Interprofessional Forum (2021)