James R. Olson PhD
James R. Olson
PhD
Professor
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Toxicology and Xenobiotics
Professional Summary:
Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides
• Characterization of the in vitro and in vivo metabolism and disposition of OP pesticides in animal models and humans.
• Identify new biomarkers of susceptibility to OPs by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification.
• Investigate the relationship between biomarkers of exposure, effect and susceptibility in human populations with environmental and occupational exposures to pesticides.
• Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of OPs.
Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs).
• Assessing Human Exposures to dioxins, PBDEs, and PCBs
• Characterize the metabolism and disposition of dioxins, PBDEs, and PCBs in humans.
• Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs that are ligands for the Ah receptor and mechanisms for their adverse health effects.
Education and Training:
- PhD, Pharmacology-Toxicology, Medical College of Wisconsin (1978)
- MS, Pharmacology, Medical College of Wisconsin (1976)
- BA, Chemistry, Illinois Wesleyan University (1974)
Employment:
- Director, Social and Preventive Medicine, University at Buffalo (2010-present)
- Research Professor, Social and Preventive Medicine, University at Buffalo (2010-present)
- Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1994-present)
- Associate Director, Toxicology Research Center, State University of New York at Buffalo (1984-present)
- Clinical Professor, Social and Preventive Medicine, State University of New York at Buffalo (1994–2010)
- Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1986–1994)
- Assistant Professor, Pharmacology and Toxicology, University at Buffalo (1980–1986)
Awards and Honors:
- UB Distinguished Professor (2012)
- Sustained Achievement Award (2007)
- Visionary Innovator (2005)
Research Expertise:
- Toxicology and Environmental Health: Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides • Characterization of the in vitro and in vivo metabolism and disposition of OP pesticides in animal models and humans. • Identify new biomarkers of susceptibility to OPs by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification. • Investigate the relationship between biomarkers of exposure, effect and susceptibility in human populations with environmental and occupational exposures to pesticides. • Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of OPs. Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs). • Assessing Human Exposures to dioxins, PBDEs, and PCBs • Characterize the metabolism and disposition of dioxins, PBDEs, and PCBs in humans. • Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs that are ligands for the Ah receptor and mechanisms for their adverse health effects. • Characterizing the adverse effects of dioxin on lung development and the role of the AhR pathway in the developing lung.
Grants and Sponsored Research:
- April 2012–March 2014
Bioactivation of PBDEs by Human Cytochrome P-450
NIEHS
Role: Co-Principal Investigator
$433,483 - February 2012–January 2014
The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos, NRSA Predoctoral Fellowship on behalf of Alice Crane, MD/PhD student
NIEHS
Role: Co-Investigator
$64,438 - June 2008–May 2013
Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity
NIEHS
Role: Co-Investigator
$777,129 - September 2007–August 2012
CYP-Specific PBPK/PD Models to Interpret Biomarkers for Organophosphate Pesticides
US EPA
Role: Principal Investigator
$749,722 - July 2009–June 2012
Assessing Vulnerability of the Adolescent Brain to Organophosphorus Pesticides
NIEHS
Role: Co-Investigator
$50,674 - May 2009–April 2012
Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity: Research Supplement to Promote Diversity in Health-Related Research on behalf ofCorie Ellison, Ph.D. Candidate, University at Buffalo, James Olson, Major Advisor
NIEHS
Role: Co-Investigator
$187,458 - September 2007–August 2010
Interpretation of Biomarkers Using Physiologically Based PharmacokineticModeling Environmental Protection Agency
EPA
Role: Principal Investigator
$749,280 - December 2006–November 2008
Dietary Isothiocyanates in Cancer Prevention: Effects on Estrogen
NCI
Role: Co-Investigator - March 2007–February 2008
Research Reagents for Human Serum Paraoxonase 1
NYSTAR Technology Transfer Incentive Program
Role: Co-Investigator - October 2003–September 2007
University-Community Consortium for Anniston Environmental Health Research
ATSDR/CDC
Role: Principal Investigator - June 2004–March 2007
Identification of functional peptide ligands for the AhR
NIEHS
Role: Principal Investigator - February 2003–December 2006
Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans
U.S. EPA
Role: Principal Investigator
Journal Articles:
- Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. Toxicol Appl Pharmacol. 2012.
- Crane AL, Klein K, Olson JR. Bioactivation of chlorpyrifos by CYP2B6 variants. Xenobiotica. 2012.
- Crane AL, Klein K, Zanger UM, Olson JR. Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism. Toxicology. 2012; 293(1-3).
- Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR. Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers. J Toxicol Environ Health A. 2012; 75(4).
- Lein PJ, Bonner MR, Farahat FM, Olson JR, Rohlman DS, Fenske RA, Lattal KM, Lasarev MR, Galvin K, Farahat TM, Anger WK. Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. Neurotoxicology. 2012.
- Ellison CA, Tian Y, Knaak JB, Kostyniak PJ, Olson JR. Human hepatic cytochrome p450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon. Drug Metab Dispos. 2012; 40(1).
- Foxenberg RJ, Ellison CA, Knaak JB, Ma C, Olson JR. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology. 2011; 285(1-2).
- Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, Lasarev MR, Rohlman DS, Anger WK, Lein PJ, Olson JR. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environ Health Perspect. 2011; 119(6).
- Yang D, Lauridsen H, Buels K, Chi LH, La Du J, Bruun DA, Olson JR, Tanguay RL, Lein PJ. Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicol Sci. 2011; 121(1).
- Ovando BJ, Ellison CA, Vezina CM, Olson JR. Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands. BMC Genomics. 2010; 11.
- Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, Farahat TM, Lein PJ, Anger WK. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology. 2010; 31(3).
- Bloom MS, Vena JE, Olson JR, Kostyniak PJ. Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York state anglers. Int J Hyg Environ Health. 2009; 212(6).
- Kransler KM, McGarrigle BP, Swartz DD, Olson JR. Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2009; 107(2).
- Kransler KM, McGarrigle BP, Russell RJ, Olson JR. Effects of Helicobacter infection on developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats. Lab Anim (NY). 2008; 37(4).
- Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR. Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos. 2007; 35(2).
- Catania JR, McGarrigle BP, Rittenhouse-Olson K, Olson JR. Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium. Toxicol In Vitro. 2007; 21(1).
- Kransler KM, McGarrigle BP, Olson JR. Comparative developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the hamster, rat and guinea pig. Toxicology. 2007; 229(3).
- McCann, S. E., Wactawski-Wende, J., Olson, J. R., Ovando, B.J., Nowell, S., Davis, W., Carter, L., Muti, P., Shields, P.G. and J. L. Freudenheim.. Changes in 2- and 16a-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype.. Cancer Epidemiology, Biomarkers and Prevention. 2007; 16(2).
- Kransler KM, Tonucci DA, McGarrigle BP, Napoli JL and Olson JR. Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters Retinoid Homeostasis in Maternal and Perinatal Tissues of the Holtzman Rat. Toxicology and Applied Pharmacology. 2007.
- Ovando BJ, Vezina CM, McGarrigle BP, Olson JR. Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2006; 94(2).
- Harrigan JA, McGarrigle BP, Sutter TR, Olson JR. Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liverand lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. Toxicol In Vitro. 2006; 20(4).
- Schecter A, Päpke O, Harris TR, Tung KC, Musumba A, Olson J, and Birnbaum L. Polybrominated Diphenyl Ether (PBDE) Levels in an Expanded Market Basket Survey of United States (U.S) Food and Estimated PBDE Dietary Intake by Age and Gender.. Environmental Health Perspectives. 2006; 114.
- Bloom M, Vena J, Olson J, Moysich K. Chronic exposure to dioxin-like compounds and thyroid function among New York anglers.. Environmental Toxicology and Pharmacology. 2006; 21(3).
- Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicol Sci. 2005; 88(2).
- Kim SY, Suzuki N, Laxmi YR, McGarrigle BP, Olson JR, Sharma M, Sharma M, Shibutani S. Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen. Chem Res Toxicol. 2005; 18(5).
- Bloom MS, Vena JE, Swanson MK, Moysich KB, Olson JR. Profiles of ortho-polychlorinated biphenyl congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex among male Lake Ontario sportfish consumers: the New York State Angler cohort study. Environ Res. 2005; 97(2).
- Vezina CM, Walker NJ, Olson JR. Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Environ Health Perspect. 2004; 112(16).
- Harrigan JA, Vezina CM, McGarrigle BP, Ersing N, Box HC, Maccubbin AE, Olson JR. DNA adduct formation in precision-cut rat liver and lung slices exposed tobenzo[a]pyrene. Toxicol Sci. 2004; 77(2).
- Sharma M, Shubert DE, Sharma M, Lewis J, McGarrigle BP, Bofinger DP, Olson JR. Biotransformation of tamoxifen in a human endometrial explant culture model. Chem Biol Interact. 2003; 146(3).
- Sharma M, Shubert DE, Sharma M, Rodabaugh KJ, McGarrigle BP, Vezina CM, Bofinger DP, Olson JR. Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture. Biochem Biophys Res Commun. 2003; 307(1).
- Olson, JR, Vezina, CM, Malek, RL, Sajadi, H, Lee, NH, Luu, TV, and Wang, H. Temporal Changes in the Hepatic Gene Expression Profiles of Female Rats Exposed to TCDD, PeCDF, PCB126, and PCB153 for 14 or 53 Weeks.. Organohalogen Compounds. 2003; 64.
- Vezina, CM and Olson JR. Comparison of the Hepatic Gene Expression Profiles in Female Rats Exposed Subchronically to TCDD, PeCDF, PCB126 and PCB153 Using DNA Microarray. Organohalogen Compounds. 2003; 64.
- Buck GM, Vena JE, Greizerstein HB, Weiner JM, McGuinness B, Mendola P, Kostyniak PJ, Swanson M, Bloom MS, Olson JR. PCB congeners and pesticides and female fecundity, New York State Angler Prospective Pregnancy Study. Environ Toxicol Pharmacol. 2002; 12(2).
- Germaine Buck, John Vena, Hebe Greizerstein, John Weiner, Bridget McGuinness, Pauline Mendola, Paul Kostyniak, Mya Swanson, Michael Bloom, James Olson. PCB congeners and pesticides and female fecundity, New York State Angler Propective Pregnancy Study. Environmental Toxicology and Pharmacology. 2002; 12.
- Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR. Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium. Toxicol Sci. 2001; 62(2).
- Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR. Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant culturesof human endometrium. Toxicol Sci. 2001; 62(2).
- Schecter, A, Cramer, P, Boggess, K, Stanley, J, Papke, O, James Olson, Sliver, A, Schmits, M. Intake of Dioxins and Related Compounds from Food in the U.S. Population. Journal of Toxicology and Environmental Health Part A. 2001; 63.
- Buck GM, John Vena, Schisterman EF, Jacek Dmochowski, Mendola P, Sever LE, Fitzgerald E, Paul Kostyniak, Greizerstein H, James Olson. Parental consumption of contaminated sport fish from Lake Ontario and predicted fecundability.. Epidemiology. 2000; 11(4).
- Honey S, O‘Keefe P, Drahushuk AT, Olson JR, Kumar S, Sikka HC. Metabolism of benzo(a)pyrene by duck liver microsomes.. Comp Biochem Physiol C Toxicol Pharmacol. 2000; 126(3).
- Drahushuk AT, McGarrigle BP, Slezak BP, Stegeman JJ, Olson JR. Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1999; 155(2).
- Buck, GM, Mendola, P, John Vena, Sever, LE, Paul Kostyniak, Greizerstein, H, James Olson, Stephen, FD. Paternal Lake Ontario Fish Consumption and Risk of Conception Delay, New York State Angler Cohort. Environmental Research. 1999; 80.
- Schecter, A, Dellarco, M, Papke, O, James Olson. A Comparison of Dioxins, Dibenzofurans, and Coplanar PCBs in Uncooked and Broiled Ground Beef, Catfish, and Bacon. Chemosphere. 1998; 37.
- Drahushuk AT, McGarrigle BP, Larsen KE, Stegeman JJ, Olson JR. Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture. Carcinogenesis. 1998; 19(8).
- Pelosi, GD, Oberdoerster, J, James Olson, Knaak, JB, Smith, LW, Newton, PE. Characterization of Rat Hepatic Cytochrome P450 Activities Following Inhalation Exposure to p-Chlorobenzotrifluoride (PCBTF). Inhalation Toxicology. 1998; 10.
- Knaak, JB, Smith, LW, Fitzpatrick, RD, James Olson, Newton, PE. In Vitro Hepatic Metabolism of PCBTF: Development of Vmax, Km Values, Partition Coefficients and Their Use in an Inhalation PBPK Model. Inhalation Toxicology. 1998; 10.
- Stephen FD, Drahushuk AT, Olson JR. Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C. Toxicology. 1997; 124(1).
- Drahushuk AT, Choy CO, Kumar S, McReynolds JH, Olson JR. Modulation of cytochrome P450 by 5,5‘-bis-trifluoromethyl-2,2‘-dichlorobiphenyl,a unique environmental contaminant. Toxicology. 1997; 120(3).
- Geyer HJ, Schramm KW, Scheunert I, Schughart K, Buters J, Wurst W, Greim H, Kluge R, Steinberg CE, Kettrup A, Madhukar B, Olson JR, Gallo MA. Considerations on genetic and environmental factors that contribute to resistanceor sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)and related compounds. Ecotoxicol Environ Saf. 1997; 36(3).
- Geyer HJ, Schramm KW, Scheunert I, Schughart K, Buters J, Wurst W, Greim H, Kluge R, Steinberg CE, Kettrup A, Madhukar B, Olson JR, Gallo MA. Considerations on genetic and environmental factors that contribute to resistance or sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Part 1: Genetic factors affecting the toxicity o Ecotoxicol Environ Saf. 1997; 36(3).
- Schecter A, Olson JR. Cancer risk assessment using blood dioxin levels and daily dietary TEQ intake in general populations of industrial and non-industrial countries. Chemosphere. 1997; 34(5-7).
- Schecter A, Cramer P, Boggess K, Stanley J, Olson JR. Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samples collected in 1995 at supermarkets across the United States. Chemosphere. 1997; 34(5-7).
- Schecter A, Olson JR. Cancer risk assessment using blood dioxin levels and daily dietary TEQ intakein general populations of industrial and non-industrial countries. Chemosphere. 1997; 34(5-7).
- Schecter A, Cramer P, Boggess K, Stanley J, Olson JR. Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samplescollected in 1995 at supermarkets across the United States. Chemosphere. 1997; 34(5-7).
- Drahushuk AT, McGarrigle BP, Tai HL, Kitareewan S, Goldstein JA, Olson JR. Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction. Toxicol Appl Pharmacol. 1996; 140(2).
- Schecter A, Papke O, Lis A, Ball M, Ryan JJ, Olson JR, Li L, Kessler H. Decrease in milk and blood dioxin levels over two years in a mother nursing twins: estimates of decreased maternal and increased infant dioxin body burden from nursing. Chemosphere. 1996; 32(3).
- John Vena, Buck, GM, Paul Kostyniak, Mendola, P, Fitzgerald, E, Sever, L, Jo Freudenheim, Greizerstein, H, Zielezny, M, McReynolds, J, James Olson. The New York Angler Cohort Study: Exposure Characterization and Reproductive and Developmental Health. Toxicology and Industrial Health. 1996; 12(3/4).
- Fiorella PD, Olson JR, Napoli JL. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces diverse retinoic acid metabolites in multiple tissues of the Sprague-Dawley rat. Toxicol Appl Pharmacol. 1995; 134(2).
- Schecter A, Startin J, Wright C, Kelly M, Päpke O, Lis A, Ball M, Olson JR. Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimateddaily dioxin toxic equivalent intake. Environ Health Perspect. 1994; 102(11).
- Olson JR, McGarrigle BP, Gigliotti PJ, Kumar S, McReynolds JH. Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran.. Fundam Appl Toxicol. 1994; 22(4).
- Van den Berg M, De Jongh J, Poiger H, Olson JR. The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol. 1994; 24(1).
- Van den Berg M, De Jongh J, Poiger H, Olson JR. The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs)and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol. 1994; 24(1).
- Tai HL, McReynolds JH, Goldstein JA, Eugster HP, Sengstag C, Alworth WL, Olson JR. Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human. Toxicol Appl Pharmacol. 1993; 123(1).
- Nosek JA, Craven SR, Sullivan JR, Olson JR, Peterson RE. Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in ring-necked pheasant hens, chicks, and eggs. J Toxicol Environ Health. 1992; 35(3).
- Walker, MK, Spitsbergen, JM, James Olson, Peterson, RE. 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity during early life stage development of lake trout. Can J Fish Aquat Sci. 1991; 48.
- Shen ES, Gutman SI, Olson JR. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity inC57BL/6J and DBA/2J mice. J Toxicol Environ Health. 1991; 32(4).
- Clapp RW, Olson JR. A new review of the dioxin literature. New Solut. 1991; 1(4).
- Spitsbergen, JM, James Olson, Walker, MK, Peterson, RE. Pathologic lesions in early life stages of lake trout, Salvelinus namaycush, exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin as fertilized eggs. Aquatic Toxicol. 1991; 19.
- James Olson, McGarrigle, BP. Comparative Developmental Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Chemosphere. 1991; 25.
- James Olson, McGarrigle, BP, Tonucci, DA, Schecter, A, Eichelberger, H. Developmental Toxicology of 2,3,7,8-TCDD in the rat and hamster. Chemosphere. 1990; 20.
- Aleo, MD, Mary Taub, James Olson, Paul Kostyniak. Primary cultures of rabbit renal tubule cells: II. Selected phase I and phase II metabolic capacities. Toxicol In Vitro. 1990; 4.
- Aleo MD, Taub ML, Olson JR, Kostyniak PJ. Primary cultures of rabbit renal proximal tubule cells: II. Selected phase I and phase II metabolic capacities. Toxicol In Vitro. 1990; 4(6).
- Shen ES, Guengerich FP, Olson JR. Biphasic response for hepatic microsomal enzyme induction by 2,3,7,8-tetrachlorodibenzo-p-dioxinin C57BL/6J and DBA/2J mice. Biochem Pharmacol. 1989; 38(22).
- Hruska RE, Olson JR. Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.. Toxicol Lett. 1989; 48(3).
- Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Roth JA. Effect of chronic exposure to hexachlorophene on rat brain cell specific marker enzymes.. Neurotoxicology. 1989; 10(2).
- Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth JA. Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to methylmercury.. Neurotoxicology. 1989; 10(1).
- James Olson, Gutman, SI, Shen, ES. Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD. Chemosphere. 1989; 18.
- James Olson, Bellin, JS, Barnes, DG. Reexamination of data used for establishing Toxicity Equivalence Factors (TEFs) for Chlorinated Dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs). Chemosphere. 1989; 18.
- Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes.. Fundam Appl Toxicol. 1988; 11(3).
- Wroblewski VJ, Gessner T, Olson JR. Qualitative and quantitative differences in the induction and inhibition ofhepatic benzo[a]pyrene metabolism in the rat and hamster. Biochem Pharmacol. 1988; 37(8).
- Kleeman JM, Olson JR, Peterson RE. Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformationin fish. Fundam Appl Toxicol. 1988; 10(2).
- Wroblewski VJ, Olson JR. Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster. Drug Metab Dispos. 1988; 16(1).
- Wroblewski VJ, Olson JR. Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster.. Drug Metab Dispos. 1988; 16(1).
- Shen ES, Olson JR. Relationship between the murine Ah phenotype and the hepatic uptake and metabolismof 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab Dispos. 1987; 15(5).
- Shen ES, Olson JR. Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab Dispos. 1987; 15(5).
- Kung MP, Kostyniak P, Olson J, Malone M, Roth JA. Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes.. J Appl Toxicol. 1987; 7(2).
- Olson JR. Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs.. Toxicol Appl Pharmacol. 1986; 85(2).
- Kleeman JM, Olson JR, Chen SM, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch.. Toxicol Appl Pharmacol. 1986; 83(3).
- Kleeman JM, Olson JR, Chen SM, Peterson RE. Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rainbow trout. Toxicol Appl Pharmacol. 1986; 83(3).
- Wroblewski VJ, Olson JR. Hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig. Toxicol Appl Pharmacol. 1985; 81(2).
- James Olson, Wroblewski, VJ. Metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in isolated hepatocytes from guinea pigs and rats. Chemosphere. 1985; 14.
- Sawahata T, Olson JR, Neal RA. Identification of metabolites of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin (TCDD) formed on incubation with isolated rat hepatocytes.. Biochem Biophys Res Commun. 1982; 105(1).
- Neal RA, Olson JR, Gasiewicz TA, Geiger LE. The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems.. Drug Metab Rev. 1982; 13(3).
- Olson JR, Gasiewicz TA, Neal RA. Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.. Toxicol Appl Pharmacol. 1980; 56(1).
- Olson JR, Holscher MA, Neal RA. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster.. Toxicol Appl Pharmacol. 1980; 55(1).
- Jansen MA, Olson JR, Fujimoto JM. Taurolithocholate-induced increase in the intrabiliary pressure generated during retrograde intrabiliary infusion of saline in rats: antagonism by taurocholate and glycocholate. Toxicol Appl Pharmacol. 1980; 54(1).
- Olson JR, Fujimoto JM. Evaluation of hepatobiliary function in the rat by the segmented retrograde intrabiliary injection technique. Biochem Pharmacol. 1980; 29(2).
- Olson JR, Fujimoto JM. Demonstration of a D-glucose transport system in the biliary tree of the rat by use of the segmented retrograde intrabiliary injection technique. Biochem Pharmacol. 1980; 29(2).
- Olson JR, Hosko MJ, Fujimoto JM. Alterations in the liver cell transmembrane potential following CC14 and bile salt treatment of rats.. Life Sci. 1979; 25(24-25).
- Olson JR, Fujimoto JM, Peterson RE. Three methods for measuring the increase in the capacity of the distended biliary tree in the rat produced by alpha-naphthylisothiocyanate treatment. Toxicol Appl Pharmacol. 1977; 42(1).
- Peterson RE, Olson JR, Fujimoto JM. Measurement and alteration of the capacity of the distended biliary tree in the rat. Toxicol Appl Pharmacol. 1976; 36(2).
Evaluative Studies and Case Reports:
- Lupton SJ, McGarrigle BP, Olson JR, Wood TD, Aga DS. Analysis of hydroxylated polybrominated diphenyl ether metabolites by liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2010; 24(15).
Professional Memberships:
- American Society for Pharmacology and Experimental Therapeutics (1990–present)
- Society of Toxicology (1984–present)
Presentations:
- "Predictors of human serum polychlorinated biphenyls (pcbs) concentrations in the Anniston Community Health Survey" 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
- "Soil-serum PCB associations in the Anniston Community Health Survey" 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
- "Spatial distribution and determinants of PCB contamination in residential soil in Anniston, Alabama." 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
- "Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers" Society of Toxicology, Society of Toxicology (2010)
- "Biomarkers of organophosphorus pesticide-induced neurotoxicity" Society of Toxicology (2010)
- "Developing a monoclonal antibody based capture assay to quantify cytosolic AHR." Society of Toxicology (2010)
- "Exposure Estimates and PBPK Modeling of Chlorpyrifos in Rats and Humans" Society of Toxicology (2010)
- "Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in human blood following in vitro and in vivo exposure to chlorpyrifos" Society of Toxicology (2010)
- "Oxidative DNA adducts in the livers of female Srague-Dawley rats chronically exposed to polyhalogenated aromatic hydrocarbons (PHAHs)." Society of Toxicology (2010)
- "Strain and dose-related effects of subchronic chlorpyrifos (CPF) exposure on biomarkers of exposure and oxidative stress in rats." Society of Toxicology (2010)