Suzanne Laychock, PhD, is senior associate dean for faculty affairs, and professor of pharmacology and toxicology. She is responsible for overseeing faculty development, and undergraduate biomedical education programs.
Dr. Laychock earned a bachelor’s degree in biology from Brooklyn College, a master’s degree in biology from the City University of New York and a doctorate in pharmacology & toxicology from the Medical College of Virginia/Virginia Commonwealth University.
An accomplished scientist, Dr. Laychock’s research focuses on endocrine pharmacology with an emphasis on signal transduction mechanisms involved in insulin secretion and models of diabetes mellitus.
The author of numerous journal articles, book chapters, and reviews, she has served as associate editor of the research journal LIPIDS, and on the editorial boards of Diabetes and the Journal of Pharmacology and Experimental Therapeutics. She is the recipient of research grants from, among others, the Juvenile Diabetes Research Foundation, the National Institutes of Health, and the American Diabetes Association.
Dr. Laychock was Council Member and has chaired the Women in Pharmacology Committee of the American Society for Pharmacology and Experimental Therapeutics. She has served the university as a member and chair of the President’s Review Board, and as co-director of the Institute for Research and Education on Women and Gender.
Education and Training:
Fellowship, Postdoctoral Fellow, Department of Pharmacology, Vanderbilt University School of Medicine (1978)
PhD, Pharmacology & Toxicology, Medical College of Virginia, Virginia Commonwealth University (1976)
MA, Biology, Brooklyn College, City University of New York (1973)
BS, Biology, Brooklyn College, City University of New York (1971)
Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1989-present)
Facilities Planning Officer, University at Buffalo, Jacobs School of Medicine (2002–2019)
Professor and Associate Chair, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1995–2002)
Affiliate Professor, Pharmacology & Toxicology, Medical College of Virginia, Virginia Commonwealth University (1990–1995)
Associate Professor, Pharmacology & Toxicology, Medical College of Virginia, Virginia Commonwealth University (1985–1989)
Assistant Professor, Pharmacology & Toxicology, Medical College of Virginia, Virginia Commonwealth University (1978–1985)
Awards and Honors:
Dean's Award, School of Medicine and Biomedical Sciences, University at Buffalo (2010)
Stockton-Kimball Award, School of Medicine and Biomedical Sciences, University at Buffalo (2007)
UB Exceptional Scholar Program - Sustained Achievement Award (2002)
Distinguished Alumnus Award, School of Basic Health Sciences, Medical College of Virginia (1990)
Virginia Commonwealth University Alumni STAR Award (1990)
Outstanding Young Research Investigator of the American Diabetes Association (1989)
Sandra Tate Russell Memorial Award ($1200) - Virginia Commonwealth University (1989)
Outstanding Faculty Member in Dept. of Pharmacology & Toxicology, Medical College of Virginia/ VCU (1983)
NIH F32 Postdoctoral Research Fellowship (NHLBI) (1977)
National Merit Scholarship (1967)
New York State Regents Scholarship (1967)
gene regulation: mRNA analysis, RT-PCR
metabolism: glycolysis, glucose oxidation
secretion: insulin secretion
signal transduction: second messenger analysis,cyclic AMP,prostaglandins,calcium,lipids,phospholipids,cyclic GMP, inositol trisphosphate
Grants and Sponsored Research:
September 2009–August 2012 Scalable Expansion and Directed Differentiation of Human Embryonic Stem Cells to Pancreatic Progeny NYS Department of Health Role: Co-Principal Investigator $179,246
January 2006–December 2007 Growth Factors and Angiogenesis in Pancreatic Islet Transplantation. Juvenile Diabetes Research Foundation International Role: Principal Investigator $125,000
August 2004–July 2006 Regulated Insulin Secretion from Tissue Engineered Skin for Type-1 Diabetes NIH Role: Co-Principal Investigator $75,000
August 2002–July 2005 EDG Receptor and Sphingosine-1-Phosphate EFfects in Pancreatic Islets Juvenile Diabetes Research Foundation Role: Principal Investigator $370,197
July 1979–June 2002 Putative Mediators of Insulin Secretion NIH Role: Principal Investigator $289,746
July 1998–June 2001 Regulation of Expression of Receptors for Inositol Trisphosphate and Ryanodine in Pancreatic Islets American Diabetes Association Role: Principal Investigator $150,000
September 1996–April 1998 Diet-induced hyperinsulinemia and beta cell function National Institute of Diabetes and Digestive and Kidney Diseases Role: Co-Principal Investigator $160,000
Lei, P., Ogunade, A., Kirkwood, K. L., Laychock, S. G., and Andreadis, S. T. (2007) Efficient production of bioactive insulin from human epidermal keratinocytes and tissue engineered skin substitutes: implications for treatment of diabetes. Tissue Engineering (Jan), 13: 2119-2131.
Mastrandrea LD, Laychock SG. (2005) Sphingosine kinase activity and sphingosine-1-phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. Diabetes 54:1429-1436 (Jan), 54: 1429-1436.
Laychock S, Tian Y, Sessanna S. (2003) Endothelial differentiation gene (EDG) receptors in pancreatic islets and INS-1 cells. Diabetes (Jan), 52: 1986-1993.
Tian Y, and Laychock SG. (2003) Prolactin regulates adenylyl cyclase and insulin secretion in rat pancreatic islets. Molecular and Cellular Endocrinology (Jan), 204: 75-84.
Srinivasan, M., Hill, D.J., Laychock, S.G., Patel, M.S. (2003) Neonatal nutrition: metabolic programming of pancreatic islets and obesity. Experimental Biology & Medicine (Jan), 228: 15-23.
Lee, B.S., Sessanna, S., Laychock, S.G., & Rubin, R.P. (2002) Expression and Cellular Localization of a Modified Type 1 Ryanodine Receptor and L-Type Channel Proteins in Non-Muscle Cells. J. Membrane Biol. 189: 181-190 (2002) (Jan), 189: 181-190.
Srinivasan M, Laychock SG, Hill DJ, Patel MS. (2002) Neonatal Nutrition: Metabolic programming of pancreatic islets and obesity. Experimental Biology & Medicine (Jan), 228(1): 15-23.
Tian Y, Laychock SG. (2001) Protein kinase C and calcium regulation of adenylyl cyclase in isolated rat pancreatic islets. Diabetes (Nov), 50(11): 2505-2513.
Lee B, Gai W, Laychock SG. (2001) Proteasomal activation mediates down-regulation of inositol 1,4,5-trisphosphate receptor and calcium mobilization in rat pancreatic islets. Endocrinology (May), 142(5): 1744-1751.
Lee B, Srinivasan M, Aalinkeel R, Patel MS, Laychock SG. (2001) Mitochondrial-encoded gene regulation in rat pancreatic islets. Metabolism (Feb), 50(2): 200-206.
Lee B, Laychock SG. (2001) Inositol 1,4,5-trisphosphate receptor isoform expression in mouse pancreatic islets: effects of carbachol. Biochem Pharmacol (Feb), 61(3): 327-336.
Laychock SG, Duzen J, Simpkins CO. (2000) Metallothionein induction in islets of Langerhans and insulinoma cells. Mol Cell Endocrinol (Jul), 165(1-2): 179-187.
Lee B, Laychock SG. (2000) Regulation of inositol trisphosphate receptor isoform expression in glucose-desensitized rat pancreatic islets: role of cyclic adenosine 3',5'-monophosphate and calcium. Endocrinology (Apr), 141(4): 1394-1402.
Aalinkeel R, Srinivasan M, Kalhan SC, Laychock SG, Patel MS. (1999) A dietary intervention (high carbohydrate) during the neonatal period causes islet dysfunction in rats. Am J Physiol (Dec), 277(6 Pt): 1061-1069.
Lee B, Jonas JC, Weir GC, Laychock SG. (1999) Glucose regulates expression of inositol 1,4,5-trisphosphate receptor isoforms in isolated rat pancreatic islets. Endocrinology (May), 140(5): 2173-2182.
Ye J, Laychock SG. (1998) A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1beta. Endocrinology (Oct), 139(10): 4155-4163.
Laychock SG. (1998) Rat pancreatic islet and RINm5F cell responses to epiandrosterone, dehydroepiandrosterone and interleukin-1 beta. Biochem Pharmacol (May), 55(9): 1453-1464.
Lee B, Bradford PG, Laychock SG. (1998) Characterization of inositol 1,4,5-trisphosphate receptor isoform mRNA expression and regulation in rat pancreatic islets, RINm5F cells and betaHC9 cells. J Mol Endocrinol (Jan), 21(1): 31-39.
Lee B, Laychock SG. (1997) Atrial natriuretic peptide and cyclic nucleotides affect glucose-induced Ca2+ responses in single pancreatic islet beta-cells: correlation with (Ca[2+] + Mg2+)-ATPase activity. Diabetes (Aug), 46(8): 1312-1318.
Laychock SG. (1996) Modulation of glyceraldehyde 3-phosphate dehydrogenase activity in isolated pancreatic islets. Biochem Pharmacol (Sep), 52(5): 793-799.
Laychock SG, Bauer AL. (1996) Epiandrosterone and dehydroepiandrosterone affect glucose oxidation and interleukin-1 beta effects in pancreatic islets. Endocrinology (Aug), 137(8): 3375-3385.
Laychock SG, Vadlamudi S, Patel MS. (1995) Neonatal rat dietary carbohydrate affects pancreatic islet insulin secretion in adults and progeny. Am J Physiol (Oct), 269(4 Pt): 739-744.
Laychock SG. (1995) Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets. Mol Cell Endocrinol (Aug), 113(1): 19-28.
Desole MS, Kim WK, Rabin RA, Laychock SG. (1994) Nitric oxide reduces depolarization-induced calcium influx in PC12 cells by a cyclic GMP-mediated mechanism. Neuropharmacology (Feb), 33(2): 193-198.
Chang MC, Berkery D, Schuel R, Laychock SG, Zimmerman AM, Zimmerman S, Schuel H. (1993) Evidence for a cannabinoid receptor in sea urchin sperm and its role in blockade of the acrosome reaction. Mol Reprod Dev (Dec), 36(4): 507-516.
Xia M, Laychock SG. (1993) Insulin secretion, myo-inositol transport, and Na(+)-K(+)-ATPase in glucose-desensitized rat islets. Diabetes (Oct), 42(10): 1392-1400.
Laychock SG. (1993) Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res (Jan), 19(2-3): 113-122.
Khalaf LJ, Laychock SG. (1992) Phosphatidylinositol availability and polyphosphoinositide synthesis in pancreatic islet cell membranes. Biochem Pharmacol (Mar), 43(6): 1303-1310.
Laychock SG, Modica ME, Cavanaugh CT. (1991) L-arginine stimulates cyclic guanosine 3',5'-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine:nitric oxide synthase. Endocrinology (Dec), 129(6): 3043-3052.
Chang MC, Berkery D, Laychock SG, Schuel H. (1991) Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. III. Activation of phospholipase A2 in sperm homogenate by delta 9-tetrahydrocannabinol. Biochem Pharmacol (Jul), 42(4): 899-904.
Conway BR, Laychock SG, Rubin RP. (1991) Comparative effects of epidermal growth factor and carbachol on phosphoinositide synthesis and breakdown in pancreatic acinar cells. Biochem Biophys Res Commun (Jul), 178(2): 780-785.
Rubin RP, Withiam-Leitch M, Laychock SG. (1991) Modulation of phospholipase A2 activity in zymogen granule membranes by GTP[S]; evidence for GTP-binding protein regulation. Biochem Biophys Res Commun (May), 177(1): 22-26.
Rubin RP, Thompson RH, Laychock SG. (1990) Characterization of phospholipase A2 and acyltransferase activities in purified zymogen granule membranes. Biochim Biophys Acta (Aug), 1045(3): 245-251.
Laychock SG. (1990) Fatty acids and cyclooxygenase and lipoxygenase pathway inhibitors modulate inositol phosphate formation in pancreatic islets. Mol Pharmacol (Jun), 37(6): 928-936.
Laychock SG, Bilgin S. (1989) Calcium mobilization, prostaglandin E2 and alpha 2-adrenoceptor modulation of glucose utilization and insulin secretion in pancreatic islets. Biochem Pharmacol (Aug), 38(15): 2511-2520.
Chaudhry A, Conway BR, Laychock SG, Rubin RP. (1989) Analysis of the regulation of phosphatidylinositol-4,5-bisphosphate synthesis by arachidonic acid in exocrine pancreas. Arch Biochem Biophys (Aug), 272(2): 488-495.
Laychock SG. (1989) Prostaglandin E2 and alpha 2 adrenoceptor agonists inhibit the pentose phosphate shunt in pancreatic islets. Arch Biochem Biophys (Feb), 269(1): 354-358.
Hoffman JM, Laychock SG. (1988) Choline turnover in phosphatidylcholine of pancreatic islets. Implications for CDP-choline pathway. Diabetes (Nov), 37(11): 1489-1498.
Chaudhry A, Thompson RH, Rubin RP, Laychock SG. (1988) Relationship between delta-9-tetrahydrocannabinol-induced arachidonic acid release and secretagogue-evoked phosphoinositide breakdown and Ca2+ mobilization of exocrine pancreas. Mol Pharmacol (Oct), 34(4): 543-548.
Morgan RO, Laychock SG. (1988) Biosynthesis of peptidyl leukotrienes and other lipoxygenase products by rat pancreatic islets. Comparison with macrophages and neutrophils. Prostaglandins (Apr), 35(4): 609-623.
Chaudhry A, Laychock SG, Rubin RP. (1987) The effects of fatty acids on phosphoinositide synthesis and myo-inositol accumulation in exocrine pancreas. J Biol Chem (Dec), 262(36): 17426-17431.
Laychock SG. (1987) Alpha 2-adrenoceptor stimulation affects total glucose utilization in isolated islets of Langerhans. Mol Pharmacol (Aug), 32(1): 241-248.
Laychock SG, Bilgin S. (1987) Alpha 2-adrenergic inhibition of pancreatic islet glucose utilization is mediated by an inhibitory guanine nucleotide regulatory protein. FEBS Lett (Jun), 218(1): 7-10.
Laychock SG. (1987) Effects of guanosine 3',5'-monophosphate on glucose utilization in isolated islets of Langerhans. Endocrinology (Feb), 120(2): 517-524.
Laychock SG, Hoffman JM, Meisel E, Bilgin S. (1986) Pancreatic islet arachidonic acid turnover and metabolism and insulin release in response to delta-9-tetrahydrocannabinol. Biochem Pharmacol (Jun), 35(12): 2003-2008.
Laychock SG. (1985) Effects of hydroxyeicosatetraenoic acids on fatty acid esterification in phospholipids and insulin secretion in pancreatic islets. Endocrinology (Sep), 117(3): 1011-1019.
Laychock SG. (1985) Phosphatidylethanolamine N-methylation and insulin release in isolated pancreatic islets of the rat. Mol Pharmacol (Jan), 27(1): 66-73.
Kelly KL, Laychock SG. (1984) Activity of prostaglandin biosynthetic pathways in rat pancreatic islets. Prostaglandins (Jun), 27(6): 925-938.
Laychock SG. (1983) Mediation of insulin release by cGMP and cAMP in a starved animal model. Mol Cell Endocrinol (Oct), 32(2-3): 157-170.
Laychock SG. (1983) Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans. Biochem J (Oct), 216(1): 101-106.
Laychock SG. (1983) Fatty acid incorporation into phospholipids of isolated pancreatic islets of the rat. Relationship to insulin release. Diabetes (Jan), 32(1): 6-13.
Rubin RP, Kelly KL, Halenda SP, Laychock SG. (1982) Arachidonic acid metabolism in rat pancreatic acinar cells: calcium-mediated stimulation of the lipoxygenase system. Prostaglandins (Aug), 24(2): 179-193.
Laychock SG. (1982) Phospholipase A2 activity in pancreatic islets is calcium-dependent and stimulated by glucose. Cell Calcium (Mar), 3(1): 43-54.
Garcia R, Laychock SG, Rubin RP. (1982) Inhibition of dibutyryl cyclic AMP induced steroidogenesis in rat adrenocortical cells by the putative calcium antagonist TMB-8. J Steroid Biochem (Feb), 16(2): 317-322.
Kelly KL, Laychock SG. (1981) Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. Prostaglandins (May), 21(5): 759-769.
Laychock SG. (1981) Evidence for guanosine 3',5'-monophosphate as a putative mediator of insulin secretion from isolated rat islets. Endocrinology (Apr), 108(4): 1197-1205.
Laychock SG, Walker L. (1979) Evidence for 6-keto-PGF1 alpha in adrenal cortex of the rat and effects of 6-keto-PGF1 alpha and PGI2 on adrenal cAMP levels and steroidogenesis. Prostaglandins (Nov), 18(5): 793-811.
Laychock SG, Harada E, Rubin RP. (1979) Isoproterenol and nucleotide induced stimulation of Ca2+ uptake by microsomal fractions from kidney and isolated glomeruli. Biochem Pharmacol (Nov), 28(21): 3205-3211.
Laychock SG, Landon EJ, Hardman JG. (1978) The effect of adrenocorticotropin and nucleotides on Ca2+ uptake in adrenal cortical microsomal vesicles. Endocrinology (Dec), 103(6): 2198-2206.
Laychock SG, Hardman JG. (1978) Effects of sodium nitroprusside and ascorbic acid on rat adrenocortical cell cGMP levels and steroidogenesis. J Cyclic Nucleotide Res (Oct), 4(5): 335-344.
Harada E, Laychock SG, Rubin RP. (1978) Parathyroid hormone induced stimulation of calcium uptake by renal microsomes. Biochem Biophys Res Commun (Sep), 84(2): 396-402.
Rubin RP, Laychock SG. (1978) Prostaglandins and calcium-membrane interactions in secretory glands. Ann N Y Acad Sci (Apr), 307: 377-390.
Laychock SG, Shen JC, Carmines EL, Rubin RP. (1978) The effect of corticotropin on phospholipid metabolism in isolated adrenocortical cells. Biochim Biophys Acta (Mar), 528(3): 355-363.
Laychock SG, Franson RC, Weglicki WB, Rubin RP. (1977) Identification and partial characterization of phospholipases in isolated adrenocortical cells. The effects of synacthen [corticotropin-(1--24)-tetracosapeptide] and calcium ions. Biochem J (Jun), 164(3): 753-756.
Laychock SG, Rubin RP. (1977) Regulation of steroidogenesis and prostaglandin formation in isolated adrenocortical cells: the effects of pregnenolone and cycloheximide. J Steroid Biochem (Jun), 8(6): 663-667.
Rubin RP, Laychock SG, End DW. (1977) On the role of cyclic AMP and cyclic GMP in steroid production by bovine cortical cells. Biochim Biophys Acta (Feb), 496(2): 329-338.
Gemmell RT, Laychock SG, Rubin RP. (1977) Ultrastructural and biochemical evidence for a steroid-containing secretory organelle in the perfused cat adrenal gland. J Cell Biol (Jan), 72(1): 209-215.
Laychock SG, Warner W, Rubin RP. (1977) Further studies on the mechanisms controlling prostaglandin biosynthesis in the cat adrenal cortex: the role of calcium and cyclic AMP. Endocrinology (Jan), 100(1): 74-81.
Laychock SG, Rubin RP. (1976) Indomethacin-induced alterations in corticosteroid and prostaglandin release by isolated adrenocortical cells of the cat. Br J Pharmacol (Jun), 57(2): 273-278.
Laychock SG, Rubin RP. (1976) Radioimmunoassay measurement of ACTH-facilitated PGE2 and PGF2alpha release from isolated cat adrenocortical cells. Prostaglandins (Apr), 11(4): 753-767.
Laychock SG, Rubin RP. (1975) ACTH-induced prostaglandin biosynthesis from 3H-arachidonic acid by adrenocortical cells. Prostaglandins (Sep), 10(3): 529-540.
Rubin RP, Sheid B, McCauley R, Laychock SG. (1974) ACTH-induced protein release from the perfused cat adrenal gland: evidence for exocytosis?. Endocrinology (Aug), 95(2): 370-378.
Laychock SG, Rubin RP. (1974) Isolation of ACTH-induced protein from adrenal perfusate. Steroids (Aug), 24(2): 177-184.
Laychock SG. (1900) Glucose metabolism, second messengers and insulin secretion. Life Sci (Jan), 47(25): 2307-2316.
Laychock SG. (1900) Coordinate interactions of cyclic nucleotide and phospholipid metabolizing pathways in calcium-dependent cellular processes. Curr Top Cell Regul (Jan), 30: 203-242.
Laychock SG. (1900) The biochemistry of cell activation as related to the putative actions of flavonoids. Prog Clin Biol Res (Jan), 213: 215-229.
Patel, M.S., Srinivasan, M., Laychock, S.G. (2005) The Impact of Maternal Nutrition on the Offspring. In: Nutrient Induced Maternal Hyperinsulinemia and Metabolic Programming in the Progeny. Karger, 137-152.
Laychock SG. (2004) In: The Pancreas and Pancreatic Hormones.