Mikhail V. Pletnikov M.D. Ph.D.
Mikhail V. Pletnikov
M.D. Ph.D.
Professional Summary:
My research focuses the mechanisms of neuron-glia interaction in the pathophysiology of behavioral alterations and cognitive impairment in neuropsychiatric disorders. We are interested in the role of astrocytes and astrocyte bioenergetics in mediating avderse neurodevelopmental effects of environmental factors, including microbial pathogens, cannabis and stress. These mechanisms are studied using mouse genetics, molecular, cellular and systems approaches and in vivo imaging technologies.
Education and Training:
- PhD, P.K. Anokhin Institute of Normal Physiology (1990)
- MD, medicine and Physiology, I.M. Sechenov Moscow Medical Institute, Cum Laude (1986)
Employment:
- Department Chair, Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences (2020-present)
- Professor, Physiology and Biophysics, The State University of New York, The University at Buffalo, the Jacobs School of Medicine and Biomedical Sciences (2020-present)
- Professor, Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine (2014–2020)
- Associate Professor, Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine (2008–2014)
- Assistant Professor, Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine (2000–2008)
- Instructor, Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine (1999–2000)
- Postdoctoral fellow, Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine (1996–1999)
Awards and Honors:
- Fellow (2018)
- Fellow (2010)
- Guest Professor (2009)
- Dr Mortimer D. Sackler Developmental Psychobiology Investigator (2008)
- Independent Investigator Award (2008)
Grants and Sponsored Research:
- Astrocytes Bioenergetics in Brain Development
NIMH
Role: Principal Investigator
$358,982 - Gene-Environment Interactions for Cortical Development and Schizophrenia
NIMH
Role: Co-Investigator
$1,345,709 - Molecular mechanism of astrocytic vulnerability to adolescent cannabis use
NIDA
Role: Principal Investigator
$336,938
Journal Articles:
- Shakir J, Pedicini M, Bullock BC, Hoen PW, Macias LK, Freiman J, Pletnikov MV, Tamashiro KLK, Cordner ZA. (2024) Effects of psilocybin on body weight, body composition, and metabolites in male and female mice. Physiology & behavior (Oct), 284: 114627. doi:10.1016/j.physbeh.2024.114627
- Hasegawa Y, Kim J, Ursini G, Jouroukhin Y, Zhu X, Miyahara Y, Xiong F, Madireddy S, Obayashi M, Lutz B, Sawa A, Brown SP, Pletnikov MV, Kamiya A. (2023) Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication. Nature communications (Oct), 14(1): 6559. doi:10.1038/s41467-023-42276-5
- Zhang M, Zhang Y, Xu Q, Crawford J, Qian C, Wang GH, Qian J, Dong XZ, Pletnikov MV, Liu CM, Zhou FQ. (2023) Neuronal Histone Methyltransferase EZH2 Regulates Neuronal Morphogenesis, Synaptic Plasticity, and Cognitive Behavior in Mice. Neuroscience bulletin (Oct), 39(10): 1512-1532. doi:10.1007/s12264-023-01074-1
- Murlanova K, Pletnikov MV. (2023) Modeling psychotic disorders: Environment x environment interaction. Neuroscience and biobehavioral reviews (Sep), 152: 105310.
- Hasegawa Y, Kim J, Ursini G, Jouroukhin Y, Zhu X, Miyahara Y, Xiong F, Madireddy S, Obayashi M, Lutz B, Sawa A, Brown SP, Pletnikov MV, Kamiya A. (2023) Microglial cannabinoid receptor type 1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication. bioRxiv : the preprint server for biology (Jul). doi:10.1101/2023.07.24.550212
- Murlanova K, Jouroukhin Y, Novototskaya-Vlasova K, Huseynov S, Pletnikova O, Morales MJ, Guan Y, Kamiya A, Bergles DE, Dietz DM, Pletnikov MV. (2023) Loss of Astrocytic µ Opioid Receptors Exacerbates Aversion Associated with Morphine Withdrawal in Mice: Role of Mitochondrial Respiration. Cells (May), 12(10). doi:10.3390/cells12101412
- Maly IV, Hofmann WA, Pletnikov MV. (2022) Experimental and computational analyses of calcium dynamics in 22q11.2 deletion model astrocytes. Neuroscience letters (Jul), 783: 136711.
- Murlanova K, Jouroukhin Y, Huseynov S, Pletnikova O, Morales MJ, Guan Y, Baraban JM, Bergles DE, Pletnikov MV. (2022) Deficient mitochondrial respiration in astrocytes impairs trace fear conditioning and increases naloxone-precipitated aversion in morphine-dependent mice. Glia (Jul), 70(7): 1289-1300. doi:10.1002/glia.24169
- Alexandrov YI, Pletnikov MV. (2022) Neuronal metabolism in learning and memory: The anticipatory activity perspective. Neuroscience and biobehavioral reviews (Jun), 137: 104664.
- Murlanova K, Cohen N, Pinkus A, Vinnikova L, Pletnikov M, Kirby M, Gorelick J, Drori E, Pinhasov A. (2022) Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract. Scientific reports (Mar), 12(1): 3647. doi:10.1038/s41598-022-04840-9
- Kim J, Kim DW, Lee A, Mason M, Jouroukhin Y, Woo H, Yolken RH, Pletnikov MV. (2022) Homeostatic regulation of neuronal excitability by probiotics in male germ-free mice. Journal of neuroscience research (Feb), 100(2): 444-460.
- Murlanova K, Kirby M, Libergod L, Pletnikov M, Pinhasov A. (2022) Multidimensional nature of dominant behavior: Insights from behavioral neuroscience. Neuroscience and biobehavioral reviews (Jan), 132: 603-620.
- Murlanova K, Begmatova D, Weber-Stadlbauer U, Meyer U, Pletnikov M, Pinhasov A. (2022) Double trouble: Prenatal immune activation in stress sensitive offspring. Brain, behavior, and immunity (Jan), 99: 3-8.
- Vaccari Cardoso B, Shevelkin AV, Terrillion C, Mychko O, Mosienko V, Kasparov S, Pletnikov MV, Teschemacher AG. (2021) Reducing l-lactate release from hippocampal astrocytes by intracellular oxidation increases novelty induced activity in mice. Glia (May), 69(5): 1241-1250. doi:10.1002/glia.23960
- Hurley MM, Murlanova K, Macias LK, Sabir AI, O'Brien SC, Bhasin H, Tamashiro KL, Pletnikov MV, Moran TH. (2021) Activity-based anorexia disrupts systemic oxidative state and induces cortical mitochondrial fission in adolescent female rats. The International journal of eating disorders (Apr), 54(4): 639-645.
- Murlanova K, Michaelevski I, Kreinin A, Terrillion C, Pletnikov M, Pinhasov A. (2021) Link between temperament traits, brain neurochemistry and response to SSRI: insights from animal model of social behavior. Journal of affective disorders (Mar), 282: 1055-1066.
- Mejias R, Rodriguez-Gotor JJ, Niwa M, Krasnova IN, Adamczyk A, Han M, Thomas GM, Xi ZX, Huganir RL, Pletnikov MV, Sawa A, Cadet JL, Wang T. (2021) Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice. Translational psychiatry (Jan), 11(1): 65. doi:10.1038/s41398-020-01194-6
- Philips T, Mironova YA, Jouroukhin Y, Chew J, Vidensky S, Farah MH, Pletnikov MV, Bergles DE, Morrison BM, Rothstein JD. (2021) MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration. Cell reports (Jan), 34(2): 108610. doi:10.1016/j.celrep.2020.108610
- Maly IV, Morales MJ, Pletnikov MV. (2021) Astrocyte Bioenergetics and Major Psychiatric Disorders. Advances in neurobiology (Jan), 26: 173-227.
- Rattner A, Terrillion CE, Jou C, Kleven T, Hu SF, Williams J, Hou Z, Aggarwal M, Mori S, Shin G, Goff LA, Witter MP, Pletnikov M, Fenton AA, Nathans J. (2020) Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. eLife (Oct), 9. doi:10.7554/eLife.62766
- Shevelkin AV, Terrillion CE, Hasegawa Y, Mychko OA, Jouroukhin Y, Sawa A, Kamiya A, Pletnikov MV. (2020) Astrocyte DISC1 contributes to cognitive function in a brain region-dependent manner. Human molecular genetics (Oct), 29(17): 2936-2950. doi:10.1093/hmg/ddaa180
- Gong NJ, Dibb R, Pletnikov M, Benner E, Liu C. (2020) Imaging microstructure with diffusion and susceptibility MR: neuronal density correlation in Disrupted-in-Schizophrenia-1 mutant mice. NMR in biomedicine (Oct), 33(10): e4365.
- Hollander JA, Cory-Slechta DA, Jacka FN, Szabo ST, Guilarte TR, Bilbo SD, Mattingly CJ, Moy SS, Haroon E, Hornig M, Levin ED, Pletnikov MV, Zehr JL, McAllister KA, Dzierlenga AL, Garton AE, Lawler CP, Ladd-Acosta C. (2020) Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. Neuropsychopharmacology (Jun), 45(7): 1086-1096.
- Li YC, Panikker P, Xing B, Yang SS, Alexandropoulos C, McEachern EP, Akumuo R, Zhao E, Gulchina Y, Pletnikov MV, Urs NM, Caron MG, Elefant F, Gao WJ. (2020) Deletion of Glycogen Synthase Kinase-3ß in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity. Biological psychiatry (Apr), 87(8): 745-755. doi:10.1016/j.biopsych.2019.10.025
- Khambadkone SG, Cordner ZA, Dickerson F, Severance EG, Prandovszky E, Pletnikov M, Xiao J, Li Y, Boersma GJ, Talbot CC, Campbell WW, Wright CS, Siple CE, Moran TH, Tamashiro KL, Yolken RH. (2020) Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats. Molecular psychiatry (Mar), 25(3): 560-571. doi:10.1038/s41380-018-0105-6
- Lei X, Liu L, Terrillion CE, Karuppagounder SS, Cisternas P, Lay M, Martinelli DC, Aja S, Dong X, Pletnikov MV, Wong GW. (2019) FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Dec), 33(12): 14734-14747. doi:10.1096/fj.201901232RR
- Itoh K, Murata D, Kato T, Yamada T, Araki Y, Saito A, Adachi Y, Igarashi A, Li S, Pletnikov M, Huganir RL, Watanabe S, Kamiya A, Iijima M, Sesaki H. (2019) Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. eLife (Oct), 8. doi:10.7554/eLife.44739
- Hurd YL, Manzoni OJ, Pletnikov MV, Lee FS, Bhattacharyya S, Melis M. (2019) Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects. J Neurosci (Oct), 39(42): 8250-8258.
- Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD. (2019) Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nature neuroscience (May), 22(5): 741-752. doi:10.1038/s41593-019-0366-7
- Sullivan CR, Mielnik CA, Funk A, O'Donovan SM, Bentea E, Pletnikov M, Ramsey AJ, Wen Z, Rowland LM, McCullumsmith RE. (2019) Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia. Scientific reports (Mar), 9(1): 5087. doi:10.1038/s41598-019-41572-9
- Katsel P, Roussos P, Fam P, Khan S, Tan W, Hirose T, Nakagawa S, Pletnikov MV, Haroutunian V. (2019) The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription. NPJ schizophrenia (Jan), 5(1): 3. doi:10.1038/s41537-019-0071-2
- Jouroukhin Y, Zhu X, Shevelkin AV, Hasegawa Y, Abazyan B, Saito A, Pevsner J, Kamiya A, Pletnikov MV. (2019) Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood. Biol Psychiatry (Jan), 85(11): 891-903.
- Kentner AC, Bilbo SD, Brown AS, Hsiao EY, McAllister AK, Meyer U, Pearce BD, Pletnikov MV, Yolken RH, Bauman MD. (2019) Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model. Neuropsychopharmacology (Jan), 44(2): 245-258.
- Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko AV, Dannals RF, Pletnikov MV, Pomper MG. (2019) PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A (Jan), 116(5): 1686-1691.
- Niño DF, Zhou Q, Yamaguchi Y, Martin LY, Wang S, Fulton WB, Jia H, Lu P, Prindle T, Zhang F, Crawford J, Hou Z, Mori S, Chen LL, Guajardo A, Fatemi A, Pletnikov M, Kannan RM, Kannan S, Sodhi CP, Hackam DJ. (2018) Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain. Science translational medicine (Dec), 10(471). doi:10.1126/scitranslmed.aan0237
- Vivas-Buitrago T, Pinilla-Monsalve G, Jusué-Torres I, Oishi K, Robison J, Crawford JA, Pletnikov M, Xu J, Baledént O, Lokossou A, Hung AL, Blitz AM, Lu J, Herzka DA, Guerrero-Cazares H, Oishi K, Mori S, Quiñones-Hinojosa A, Rigamonti D. (2018) Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model. World neurosurgery (Dec), 120: e1120-e1127.
- Li Y, Viscidi RP, Kannan G, McFarland R, Pletnikov MV, Severance EG, Yolken RH, Xiao J. (2018) Chronic Toxoplasma gondii Infection Induces Anti-N-Methyl-d-Aspartate Receptor Autoantibodies and Associated Behavioral Changes and Neuropathology. Infection and immunity (Oct), 86(10). doi:10.1128/IAI.00398-18
- Xiao J, Prandovszky E, Kannan G, Pletnikov MV, Dickerson F, Severance EG, Yolken RH. (2018) Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia. Schizophrenia bulletin (Aug), 44(5): 983-992. doi:10.1093/schbul/sby082
- Katsel P, Fam P, Tan W, Khan S, Yang C, Jouroukhin Y, Rudchenko S, Pletnikov MV, Haroutunian V. (2018) Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development. Schizophrenia bulletin (Apr), 44(3): 515-524. doi:10.1093/schbul/sbx106
- Jouroukhin Y, Kageyama Y, Misheneva V, Shevelkin A, Andrabi S, Prandovszky E, Yolken RH, Dawson VL, Dawson TM, Aja S, Sesaki H, Pletnikov MV. (2018) DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. Transl Psychiatry (Jan), 8(1): 76-76.
- Prandovszky E, Li Y, Sabunciyan S, Steinfeldt CB, Avalos LN, Gressitt KL, White JR, Severance EG, Pletnikov MV, Xiao J, Yolken RH. (2018) Toxoplasma gondii-Induced Long-Term Changes in the Upper Intestinal Microflora during the Chronic Stage of Infection. Scientifica (Jan), 2018: 2308619. doi:10.1155/2018/2308619
- Kannan G, Prandovszky E, Severance E, Yolken RH, Pletnikov MV. (2018) A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease. Scientifica (Jan), 2018: 7590958. doi:10.1155/2018/7590958
- McFarland R, Wang ZT, Jouroukhin Y, Li Y, Mychko O, Coppens I, Xiao J, Jones-Brando L, Yolken RH, Sibley LD, Pletnikov MV. (2018) AAH2 gene is not required for dopamine-dependent neurochemical and behavioral abnormalities produced by Toxoplasma infection in mouse. Behav Brain Res (Jan), 347: 193-200.
- Umanah GKE, Pignatelli M, Yin X, Chen R, Crawford J, Neifert S, Scarffe L, Behensky AA, Guiberson N, Chang M, Ma E, Kim JW, Castro CC, Mao X, Chen L, Andrabi SA, Pletnikov MV, Pulver AE, Avramopoulos D, Bonci A, Valle D, Dawson TM, Dawson VL. (2017) Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel. Science translational medicine (Dec), 9(420). doi:10.1126/scitranslmed.aah4985
- Shevelkin AV, Terrillion CE, Abazyan BN, Kajstura TJ, Jouroukhin YA, Rudow GL, Troncoso JC, Linden DJ, Pletnikov MV. (2017) Corrigendum to "Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice" [Neurobiol. Dis. 103 (2017) 144-153]. Neurobiology of disease (Dec), 108: 362. doi:10.1016/j.nbd.2017.07.021
- Terrillion CE, Abazyan B, Yang Z, Crawford J, Shevelkin AV, Jouroukhin Y, Yoo KH, Cho CH, Roychaudhuri R, Snyder SH, Jang MH, Pletnikov MV. (2017) DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice. Neuropsychopharmacology (Oct), 42(11): 2242-2251.
- Zhu S, Cordner ZA, Xiong J, Chiu CT, Artola A, Zuo Y, Nelson AD, Kim TY, Zaika N, Woolums BM, Hess EJ, Wang X, Chuang DM, Pletnikov MM, Jenkins PM, Tamashiro KL, Ross CA. (2017) Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Proceedings of the National Academy of Sciences of the United States of America (Sep), 114(39): 10479-10484. doi:10.1073/pnas.1700689114
- Kannan G, Gressitt KL, Yang S, Stallings CR, Katsafanas E, Schweinfurth LA, Savage CLG, Adamos MB, Sweeney KM, Origoni AE, Khushalani S, Bahn S, Leweke FM, Dickerson FB, Yolken RH, Pletnikov MV, Severance EG. (2017) Pathogen-mediated NMDA receptor autoimmunity and cellular barrier dysfunction in schizophrenia. Translational psychiatry (Aug), 7(8): e1186. doi:10.1038/tp.2017.162
- Shevelkin AV, Terrillion CE, Abazyan BN, Kajstura TJ, Jouroukhin YA, Rudow GL, Troncoso JC, Linden DJ, Pletnikov MV. (2017) Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice. Neurobiology of disease (Jul), 103: 144-153. doi:10.1016/j.nbd.2017.04.008
- Katsel P, Roussos P, Pletnikov M, Haroutunian V. (2017) Microvascular anomaly conditions in psychiatric disease. Schizophrenia - angiogenesis connection. Neuroscience and biobehavioral reviews (Jun), 77: 327-339. doi:10.1016/j.neubiorev.2017.04.003
- Adam A, Robison J, Lu J, Jose R, Badran N, Vivas-Buitrago T, Rigamonti D, Sattar A, Omoush O, Hammad M, Dawood M, Maghaslah M, Belcher T, Carson K, Hoffberger J, Jusué Torres I, Foley S, Yasar S, Thai QA, Wemmer J, Klinge P, Al-Mutawa L, Al-Ghamdi H, Carson KA, Asgari M, de Zélicourt D, Kurtcuoglu V, Garnotel S, Salmon S, Balédent O, Lokossou A, Page G, Balardy L, Czosnyka Z, Payoux P, Schmidt EA, Zitoun M, Sevestre MA, Alperin N, Baudracco I, Craven C, Matloob S, Thompson S, Haylock Vize P, Thorne L, Watkins LD, Toma AK, Bechter K, Pong AC, Jugé L, Bilston LE, Cheng S, Bradley W, Hakim F, Ramón JF, Cárdenas MF, Davidson JS, García C, González D, Bermúdez S, Useche N, Mejía JA, Mayorga P, Cruz F, Martinez C, Matiz MC, Vallejo M, Ghotme K, Soto HA, Riveros D, Buitrago A, Mora M, Murcia L, Bermudez S, Cohen D, Dasgupta D, Curtis C, Domínguez L, Remolina AJ, Grijalba MA, Whitehouse KJ, Edwards RJ, Eleftheriou A, Lundin F, Fountas KN, Kapsalaki EZ, Smisson HF, Robinson JS, Fritsch MJ, Arouk W, Garzon M, Kang M, Sandhu K, Baghawatti D, Aquilina K, James G, Thompson D, Gehlen M, Schmid Daners M, Eklund A, Malm J, Gomez D, Guerra M, Jara M, Flores M, Vío K, Moreno I, Rodríguez S, Ortega E, Rodríguez EM, McAllister JP, Guerra MM, Morales DM, Sival D, Jimenez A, Limbrick DD, Ishikawa M, Yamada S, Yamamoto K, Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V, Kehler U, Lilja-Lund O, Kockum K, Larsson EM, Riklund K, Söderström L, Hellström P, Laurell K, Kojoukhova M, Sutela A, Vanninen R, Vanha KI, Timonen M, Rummukainen J, Korhonen V, Helisalmi S, Solje E, Remes AM, Huovinen J, Paananen J, Hiltunen M, Kurki M, Martin B, Loth F, Luciano M, Luikku AJ, Hall A, Herukka SK, Mattila J, Lötjönen J, Alafuzoff I, Jurjevic I, Miyajima M, Nakajima M, Murai H, Shin T, Kawaguchi D, Akiba C, Ogino I, Karagiozov K, Arai H, Reis RC, Teixeira MJ, Valêncio CG, da Vigua D, Almeida-Lopes L, Mancini MW, Pinto FCG, Maykot RH, Calia G, Tornai J, Silvestre SSS, Mendes G, Sousa V, Bezerra B, Dutra P, Modesto P, Oliveira MF, Petitto CE, Pulhorn H, Chandran A, McMahon C, Rao AS, Jumaly M, Solomon D, Moghekar A, Relkin N, Hamilton M, Katzen H, Williams M, Bach T, Zuspan S, Holubkov R, Rigamonti A, Clemens G, Sharkey P, Sanyal A, Sankey E, Rigamonti K, Naqvi S, Hung A, Schmidt E, Ory-Magne F, Gantet P, Guenego A, Januel AC, Tall P, Fabre N, Mahieu L, Cognard C, Gray L, Buttner-Ennever JA, Takagi K, Onouchi K, Thompson SD, Thorne LD, Tully HM, Wenger TL, Kukull WA, Doherty D, Dobyns WB, Moran D, Vakili S, Patel MA, Elder B, Goodwin CR, Crawford JA, Pletnikov MV, Xu J, Blitz A, Herzka DA, Guerrero-Cazares H, Quiñones-Hinojosa A, Mori S, Saavedra P, Treviño H, Maitani K, Ziai WC, Eslami V, Nekoovaght-Tak S, Dlugash R, Yenokyan G, McBee N, Hanley DF. (2017) Abstracts from Hydrocephalus 2016. Fluids and barriers of the CNS (Jun), 14(Suppl 1): 15. doi:10.1186/s12987-017-0054-5
- Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, Sockanathan S. (2017) GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Molecular neurodegeneration (Jan), 12(1): 8. doi:10.1186/s13024-017-0148-1
- Jusué-Torres I, Jeon LH, Sankey EW, Lu J, Vivas-Buitrago T, Crawford JA, Pletnikov MV, Xu J, Blitz A, Herzka DA, Crain B, Hulbert A, Guerrero-Cazares H, Gonzalez-Perez O, McAllister JP, Quiñones-Hinojosa A, Rigamonti D. (2016) A Novel Experimental Animal Model of Adult Chronic Hydrocephalus. Neurosurgery (Nov), 79(5): 746-756.
- Xiao J, Li Y, Gressitt KL, He H, Kannan G, Schultz TL, Svezhova N, Carruthers VB, Pletnikov MV, Yolken RH, Severance EG. (2016) Cerebral complement C1q activation in chronic Toxoplasma infection. Brain, behavior, and immunity (Nov), 58: 52-56. doi:10.1016/j.bbi.2016.04.009
- Xia M, Abazyan S, Jouroukhin Y, Pletnikov M. (2016) Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia. Schizophrenia research (Sep), 176(1): 72-82. doi:10.1016/j.schres.2014.10.044
- Xia M, Zhu S, Shevelkin A, Ross CA, Pletnikov M. (2016) DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders. Journal of neurochemistry (Aug), 138(4): 518-24.
- Jin Y, Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ. (2016) Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury. Neuron (Aug), 91(4): 748-762. doi:10.1016/j.neuron.2016.07.024
- Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. (2016) Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological psychiatry (Jul), 80(2): 84-86. doi:10.1016/j.biopsych.2016.05.004
- Hayes LN, Shevelkin A, Zeledon M, Steel G, Chen PL, Obie C, Pulver A, Avramopoulos D, Valle D, Sawa A, Pletnikov MV. (2016) Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders. Molecular neuropsychiatry (Jul), 2(2): 79-87. doi:10.1159/000445836
- Kannan G, Crawford JA, Yang C, Gressitt KL, Ihenatu C, Krasnova IN, Cadet JL, Yolken RH, Severance EG, Pletnikov MV. (2016) Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii. Neurobiology of disease (Jul), 91: 307-14. doi:10.1016/j.nbd.2016.03.005
- Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. (2016) HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nature reviews. Neurology (May), 12(5): 309. doi:10.1038/nrneurol.2016.53
- Xia M, Broek JA, Jouroukhin Y, Schoenfelder J, Abazyan S, Jaaro-Peled H, Sawa A, Bahn S, Pletnikov M. (2016) Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study. Molecular neuropsychiatry (May), 2(1): 28-36. doi:10.1159/000444587
- Xiao J, Li Y, Prandovszky E, Kannan G, Viscidi RP, Pletnikov MV, Yolken RH. (2016) Behavioral Abnormalities in a Mouse Model of Chronic Toxoplasmosis Are Associated with MAG1 Antibody Levels and Cyst Burden. PLoS neglected tropical diseases (Apr), 10(4): e0004674. doi:10.1371/journal.pntd.0004674
- Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. (2016) HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nature reviews. Neurology (Apr), 12(4): 234-48. doi:10.1038/nrneurol.2016.27
- Gancarz A, Jouroukhin Y, Saito A, Shevelkin A, Mueller LE, Kamiya A, Dietz DM, Pletnikov MV. (2016) DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity. Neuroscience research (Apr), 105: 70-4. doi:10.1016/j.neures.2015.09.001
- Nomura J, Jaaro-Peled H, Lewis E, Nuñez-Abades P, Huppe-Gourgues F, Cash-Padgett T, Emiliani F, Kondo MA, Furuya A, Landek-Salgado MA, Ayhan Y, Kamiya A, Takumi T, Huganir R, Pletnikov M, O'Donnell P, Sawa A. (2016) Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Molecular psychiatry (Mar), 21(3): 386-93. doi:10.1038/mp.2015.61
- Storozheva ZI, Kirenskaya AV, Novototsky-Vlasov VY, Telesheva KY, Pletnikov M. (2016) Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population. The Spanish journal of psychology (Mar), 19: E8.
- Loth MK, Choi J, McGlothan JL, Pletnikov MV, Pomper MG, Guilarte TR. (2016) TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. Neurobiology of disease (Jan), 85: 174-186. doi:10.1016/j.nbd.2015.11.001
- Ayhan Y, McFarland R, Pletnikov MV. (2016) Animal models of gene-environment interaction in schizophrenia: A dimensional perspective. Progress in neurobiology (Jan), 136: 1-27. doi:10.1016/j.pneurobio.2015.10.002
- Breu M, Zhang J, Porambo M, Pletnikov MV, Goeral K, Kakara M, Johnston MV, Fatemi A. (2016) Diffusion Tensor Imaging Abnormalities in the Cerebral White Matter Correlate with Sex-Dependent Neurobehavioral Deficits in Adult Mice with Neonatal Ischemia. Developmental neuroscience (Jan), 38(2): 83-95.
- Severance EG, Xiao J, Jones-Brando L, Sabunciyan S, Li Y, Pletnikov M, Prandovszky E, Yolken R. (2016) Toxoplasma gondii-A Gastrointestinal Pathogen Associated with Human Brain Diseases. International review of neurobiology (Jan), 131: 143-163. doi:10.1016/bs.irn.2016.08.008
- Ballinger MD, Saito A, Abazyan B, Taniguchi Y, Huang CH, Ito K, Zhu X, Segal H, Jaaro-Peled H, Sawa A, Mackie K, Pletnikov MV, Kamiya A. (2015) Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory. Neurobiology of disease (Oct), 82: 176-184. doi:10.1016/j.nbd.2015.06.006
- Fu C, Xu J, Li RJ, Crawford JA, Khan AB, Ma TM, Cha JY, Snowman AM, Pletnikov MV, Snyder SH. (2015) Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin. The Journal of neuroscience : the official journal of the Society for Neuroscience (Aug), 35(31): 11056-67. doi:10.1523/JNEUROSCI.1069-15.2015
- Kim J, Horti AG, Mathews WB, Pogorelov V, Valentine H, Brasic JR, Holt DP, Ravert HT, Dannals RF, Zhou L, Jedynak B, Kamiya A, Pletnikov MV, Wong DF. (2015) Quantitative Multi-modal Brain Autoradiography of Glutamatergic, Dopaminergic, Cannabinoid, and Nicotinic Receptors in Mutant Disrupted-In-Schizophrenia-1 (DISC1) Mice. Molecular imaging and biology (Jun), 17(3): 355-63.
- Li YE, Kannan G, Pletnikov MV, Yolken RH, Xiao J. (2015) Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner. Parasitology (Apr), 142(4): 623-32. doi:10.1017/S003118201400167X
- Porambo M, Phillips AW, Marx J, Ternes K, Arauz E, Pletnikov M, Wilson MA, Rothstein JD, Johnston MV, Fatemi A. (2015) Transplanted glial restricted precursor cells improve neurobehavioral and neuropathological outcomes in a mouse model of neonatal white matter injury despite limited cell survival. Glia (Mar), 63(3): 452-65. doi:10.1002/glia.22764
- Abazyan S, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M. (2014) Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism. Journal of neuroscience research (Dec), 92(12): 1659-68. doi:10.1002/jnr.23459
- Yolken RH, Jones-Brando L, Dunigan DD, Kannan G, Dickerson F, Severance E, Sabunciyan S, Talbot CC, Prandovszky E, Gurnon JR, Agarkova IV, Leister F, Gressitt KL, Chen O, Deuber B, Ma F, Pletnikov MV, Van Etten JL. (2014) Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice. Proceedings of the National Academy of Sciences of the United States of America (Nov), 111(45): 16106-11. doi:10.1073/pnas.1418895111
- Kannan G, Prandovszky E, Steinfeldt CB, Gressitt KL, Yang C, Yolken RH, Severance EG, Jones-Brando L, Pletnikov MV. (2014) One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response. Experimental parasitology (Oct), 145: 110-7. doi:10.1016/j.exppara.2014.08.001
- Abazyan B, Dziedzic J, Hua K, Abazyan S, Yang C, Mori S, Pletnikov MV, Guilarte TR. (2014) Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study. Schizophrenia bulletin (May), 40(3): 575-84. doi:10.1093/schbul/sbt071
- Dada T, Rosenzweig JM, Al Shammary M, Firdaus W, Al Rebh S, Borbiev T, Tekes A, Zhang J, Alqahtani E, Mori S, Pletnikov MV, Johnston MV, Burd I. (2014) Mouse model of intrauterine inflammation: sex-specific differences in long-term neurologic and immune sequelae. Brain, behavior, and immunity (May), 38: 142-50. doi:10.1016/j.bbi.2014.01.014
- Horti AG, Gao Y, Kuwabara H, Wang Y, Abazyan S, Yasuda RP, Tran T, Xiao Y, Sahibzada N, Holt DP, Kellar KJ, Pletnikov MV, Pomper MG, Wong DF, Dannals RF. (2014) 18F-ASEM, a radiolabeled antagonist for imaging the a7-nicotinic acetylcholine receptor with PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine (Apr), 55(4): 672-7. doi:10.2967/jnumed.113.132068
- Shevelkin AV, Ihenatu C, Pletnikov MV. (2014) Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum. Reviews in the neurosciences (Jan), 25(2): 177-94. doi:10.1515/revneuro-2013-0049
- Kannan G, Sawa A, Pletnikov MV. (2013) Mouse models of gene-environment interactions in schizophrenia. Neurobiology of disease (Sep), 57: 5-11. doi:10.1016/j.nbd.2013.05.012
- Ma TM, Abazyan S, Abazyan B, Nomura J, Yang C, Seshadri S, Sawa A, Snyder SH, Pletnikov MV. (2013) Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Molecular psychiatry (May), 18(5): 557-67. doi:10.1038/mp.2012.97
- Holley SM, Wang EA, Cepeda C, Jentsch JD, Ross CA, Pletnikov MV, Levine MS. (2013) Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia. Schizophrenia research (May), 146(1-3): 264-72. doi:10.1016/j.schres.2013.02.007
- Saito A, Ballinger MD, Pletnikov MV, Wong DF, Kamiya A. (2013) Endocannabinoid system: potential novel targets for treatment of schizophrenia. Neurobiology of disease (May), 53: 10-7. doi:10.1016/j.nbd.2012.11.020
- Xiao J, Viscidi RP, Kannan G, Pletnikov MV, Li Y, Severance EG, Yolken RH, Delhaes L. (2013) The Toxoplasma MAG1 peptides induce sex-based humoral immune response in mice and distinguish active from chronic human infection. Microbes and infection (Jan), 15(1): 74-83. doi:10.1016/j.micinf.2012.10.016
- Rahn KA, Watkins CC, Alt J, Rais R, Stathis M, Grishkan I, Crainiceau CM, Pomper MG, Rojas C, Pletnikov MV, Calabresi PA, Brandt J, Barker PB, Slusher BS, Kaplin AI. (2012) Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America (Dec), 109(49): 20101-6. doi:10.1073/pnas.1209934109
- Kannan G, Pletnikov MV. (2012) Toxoplasma gondii and cognitive deficits in schizophrenia: an animal model perspective. Schizophrenia bulletin (Nov), 38(6): 1155-61. doi:10.1093/schbul/sbs079
- Meulendyke KA, Pletnikov MV, Engle EL, Tarwater PM, Graham DR, Zink MC. (2012) Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (Jun), 7(2): 454-64. doi:10.1007/s11481-011-9332-1
- Guilarte TR, Opler M, Pletnikov M. (2012) Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses. Neurotoxicology (Jun), 33(3): 560-74. doi:10.1016/j.neuro.2011.11.008
- Adamczyk A, Mejias R, Takamiya K, Yocum J, Krasnova IN, Calderon J, Cadet JL, Huganir RL, Pletnikov MV, Wang T. (2012) GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum. Behavioural brain research (Apr), 229(1): 265-72. doi:10.1016/j.bbr.2012.01.007
- Xiao J, Kannan G, Jones-Brando L, Brannock C, Krasnova IN, Cadet JL, Pletnikov M, Yolken RH. (2012) Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice. Neuroscience (Mar), 206: 39-48.
- Pogorelov VM, Nomura J, Kim J, Kannan G, Ayhan Y, Yang C, Taniguchi Y, Abazyan B, Valentine H, Krasnova IN, Kamiya A, Cadet JL, Wong DF, Pletnikov MV. (2012) Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model. Neuropharmacology (Mar), 62(3): 1242-51. doi:10.1016/j.neuropharm.2011.02.003
- Waldron-Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, Graham RK, Hayden MR, Hou Z, Mori S, Swing D, Pletnikov M, Duan W, Tessarollo L, Ross CA. (2012) Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin. The Journal of neuroscience : the official journal of the Society for Neuroscience (Jan), 32(1): 183-93. doi:10.1523/JNEUROSCI.1305-11.2012
- Kamiya A, Sedlak TW, Pletnikov MV. (2012) DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders. Frontiers in psychiatry (Jan), 3: 25. doi:10.3389/fpsyt.2012.00025
- Severance EG, Kannan G, Gressitt KL, Xiao J, Alaedini A, Pletnikov MV, Yolken RH. (2012) Anti-gluten immune response following Toxoplasma gondii infection in mice. PloS one (Jan), 7(11): e50991. doi:10.1371/journal.pone.0050991
- Kirenskaya AV, Myamlin VV, Novototsky-Vlasov VY, Pletnikov MV, Kozlovskaya IB. (2011) The contingent negative variation laterality and dynamics in antisaccade task in normal and unmedicated schizophrenic subjects. The Spanish journal of psychology (Nov), 14(2): 869-83.
- Katsel P, Tan W, Abazyan B, Davis KL, Ross C, Pletnikov MV, Haroutunian V. (2011) Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. Schizophrenia research (Aug), 130(1-3): 238-49. doi:10.1016/j.schres.2011.04.021
- Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. (2011) The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Molecular biology of the cell (Jul), 22(13): 2235-45. doi:10.1091/mbc.E10-12-0933
- Zoubovsky SP, Pogorelov VM, Taniguchi Y, Kim SH, Yoon P, Nwulia E, Sawa A, Pletnikov MV, Kamiya A. (2011) Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function. Biochemical and biophysical research communications (May), 408(4): 707-12. doi:10.1016/j.bbrc.2011.04.097
- Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL. (2011) The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell (Apr), 145(2): 284-99. doi:10.1016/j.cell.2011.03.016
- Mejias R, Adamczyk A, Anggono V, Niranjan T, Thomas GM, Sharma K, Skinner C, Schwartz CE, Stevenson RE, Fallin MD, Kaufmann W, Pletnikov M, Valle D, Huganir RL, Wang T. (2011) Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proceedings of the National Academy of Sciences of the United States of America (Mar), 108(12): 4920-5. doi:10.1073/pnas.1102233108
- Ayhan Y, Abazyan B, Nomura J, Kim R, Ladenheim B, Krasnova IN, Sawa A, Margolis RL, Cadet JL, Mori S, Vogel MW, Ross CA, Pletnikov MV. (2011) Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Molecular psychiatry (Mar), 16(3): 293-306. doi:10.1038/mp.2009.144
- Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N. (2011) Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (Feb), 69(3): 437-44. doi:10.1016/j.neuron.2011.01.004
- Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F, Pogorelov V, Ladenheim B, Yang C, Krasnova IN, Cadet JL, Pardo C, Mori S, Kamiya A, Vogel MW, Sawa A, Ross CA, Pletnikov MV. (2010) Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biological psychiatry (Dec), 68(12): 1172-81. doi:10.1016/j.biopsych.2010.09.022
- Gadad BS, Daher JP, Hutchinson EK, Brayton CF, Dawson TM, Pletnikov MV, Watson J. (2010) Effect of fenbendazole on three behavioral tests in male C57BL/6N mice. Journal of the American Association for Laboratory Animal Science : JAALAS (Nov), 49(6): 821-5.
- Kannan G, Moldovan K, Xiao JC, Yolken RH, Jones-Brando L, Pletnikov MV. (2010) Toxoplasma gondii strain-dependent effects on mouse behaviour. Folia parasitologica (Jun), 57(2): 151-5.
- Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA. (2010) Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human molecular genetics (Jun), 19(11): 2087-98. doi:10.1093/hmg/ddq086
- Jaaro-Peled H, Ayhan Y, Pletnikov MV, Sawa A. (2010) Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophrenia bulletin (Mar), 36(2): 301-13. doi:10.1093/schbul/sbp133
- Ayhan Y, Sawa A, Ross CA, Pletnikov MV. (2009) Animal models of gene-environment interactions in schizophrenia. Behavioural brain research (Dec), 204(2): 274-81. doi:10.1016/j.bbr.2009.04.010
- Singer HS, Morris C, Gause C, Pollard M, Zimmerman AW, Pletnikov M. (2009) Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. Journal of neuroimmunology (Jun), 211(1-2): 39-48.
- Pletnikov MV. (2009) Inducible and conditional transgenic mouse models of schizophrenia. Progress in brain research (Jan), 179: 35-47.
- Ovanesov MV, Ayhan Y, Wolbert C, Moldovan K, Sauder C, Pletnikov MV. (2008) Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection. Journal of neuroinflammation (Nov), 5: 50. doi:10.1186/1742-2094-5-50
- Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, Crow M, Ross CA, Mattson MP, Rabb H. (2008) Acute kidney injury leads to inflammation and functional changes in the brain. Journal of the American Society of Nephrology : JASN (Jul), 19(7): 1360-70. doi:10.1681/ASN.2007080901
- Ovanesov MV, Moldovan K, Smith K, Vogel MW, Pletnikov MV. (2008) Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus. Journal of neuroinflammation (May), 5: 16. doi:10.1186/1742-2094-5-16
- Qi L, Carbone KM, Ye Z, Liu T, Ovanesov M, Pletnikov M, Sauder C, Rubin SA. (2008) Genetic contributions to influenza virus attenuation in the rat brain. Journal of neurovirology (Apr), 14(2): 136-42.
- Pletnikov MV, Ayhan Y, Xu Y, Nikolskaia O, Ovanesov M, Huang H, Mori S, Moran TH, Ross CA. (2008) Enlargement of the lateral ventricles in mutant DISC1 transgenic mice. Molecular psychiatry (Feb), 13(2): 115.
- Pletnikov MV, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov MV, Huang H, Mori S, Moran TH, Ross CA. (2008) Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Molecular psychiatry (Feb), 13(2): 173-86, 115.
- Easterbrook JD, Kaplan JB, Glass GE, Pletnikov MV, Klein SL. (2007) Elevated testosterone and reduced 5-HIAA concentrations are associated with wounding and hantavirus infection in male Norway rats. Hormones and behavior (Nov), 52(4): 474-81. doi:10.1016/j.yhbeh.2007.07.001
- Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A. (2007) Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences of the United States of America (Sep), 104(36): 14501-6. doi:10.1073/pnas.0704774104
- Pletnikov MV, Xu Y, Ovanesov MV, Kamiya A, Sawa A, Ross CA. (2007) PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation. Neuroscience research (Jul), 58(3): 234-44.
- Zerrate MC, Pletnikov M, Connors SL, Vargas DL, Seidler FJ, Zimmerman AW, Slotkin TA, Pardo CA. (2007) Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. The Journal of pharmacology and experimental therapeutics (Jul), 322(1): 16-22.
- Ovanesov MV, Vogel MW, Moran TH, Pletnikov MV. (2007) Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum. Journal of neurovirology (Jun), 13(3): 185-94.
- Olson LE, Roper RJ, Sengstaken CL, Peterson EA, Aquino V, Galdzicki Z, Siarey R, Pletnikov M, Moran TH, Reeves RH. (2007) Trisomy for the Down syndrome 'critical region. Human molecular genetics (Apr), 16(7): 774-82.
- Lancaster K, Dietz DM, Moran TH, Pletnikov MV. (2007) Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behavioural brain research (Jan), 176(1): 141-8.
- Ovanesov MV, Sauder C, Rubin SA, Richt J, Nath A, Carbone KM, Pletnikov MV. (2006) Activation of microglia by borna disease virus infection: in vitro study. Journal of virology (Dec), 80(24): 12141-8. doi:10.1128/JVI.01648-06
- Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. (2006) Neurobiology of schizophrenia. Neuron (Oct), 52(1): 139-53.
- Kaplin AI, Deshpande DM, Scott E, Krishnan C, Carmen JS, Shats I, Martinez T, Drummond J, Dike S, Pletnikov M, Keswani SC, Moran TH, Pardo CA, Calabresi PA, Kerr DA. (2005) IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. The Journal of clinical investigation (Oct), 115(10): 2731-41. doi:10.1172/JCI25141
- Rubin S, Liu D, Pletnikov M, McCullers J, Ye Z, Levandowski R, Johannessen J, Carbone K. (2004) Wild-type and attenuated influenza virus infection of the neonatal rat brain. Journal of neurovirology (Oct), 10(5): 305-14.
- Dietz D, Vogel M, Rubin S, Moran T, Carbone K, Pletnikov M. (2004) Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis. Journal of neurovirology (Oct), 10(5): 267-77.
- Sawa A, Pletnikov MV, Kamiya A. (2004) Neuron-glia interactions clarify genetic-environmental links in mental illness. Trends in neurosciences (Jun), 27(6): 294-7.
- Dietz DM, Pletnikov MV. (2003) Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection. Physiology & behavior (Nov), 80(2-3): 359-66.
- Rubin SA, Amexis G, Pletnikov M, Li Z, Vanderzanden J, Mauldin J, Sauder C, Malik T, Chumakov K, Carbone KM. (2003) Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype. Journal of virology (Nov), 77(21): 11616-24. doi:10.1128/JVI.77.21.11616-11624.2003
- Pletnikov MV, Rubin SA, Moran TH, Carbone KM. (2003) Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain. Cerebellum (London, England) (Jan), 2(1): 62-70.
- Nishino Y, Kobasa D, Rubin SA, Pletnikov MV, Carbone KM. (2002) Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes. Journal of virology (Sep), 76(17): 8650-8. doi:10.1128/JVI.76.17.8650-8658.2002
- Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone KM. (2002) Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments. Brain research (Jul), 944(1-2): 108-23.
- Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone KM. (2002) Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits. Brain research (Jul), 944(1-2): 97-107.
- Pletnikov MV, Moran TH, Carbone KM. (2002) Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. Frontiers in bioscience : a journal and virtual library (Mar), 7: d593-607.
- Carbone KM, Rubin SA, Pletnikov M. (2002) Borna disease virus (BDV)-induced model of autism: application to vaccine safety test design. Molecular psychiatry (Jan), 7 Suppl 2: S36-7.
- Carbone KM, Rubin SA, Nishino Y, Pletnikov MV. (2001) Borna disease: virus-induced neurobehavioral disease pathogenesis. Current opinion in microbiology (Aug), 4(4): 467-75.
- Pletnikov MV, Jones ML, Rubin SA, Moran TH, Carbone KM. (2001) Rat model of autism spectrum disorders. Genetic background effects on Borna disease virus-induced developmental brain damage. Annals of the New York Academy of Sciences (Jun), 939: 318-9.
- Pletnikov MV, Rubin SA, Carbone KM, Moran TH, Schwartz GJ. (2001) Neonatal Borna disease virus infection (BDV)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis rats. Brain research. Developmental brain research (Jan), 126(1): 1-12.
- Rubin SA, Pletnikov M, Taffs R, Snoy PJ, Kobasa D, Brown EG, Wright KE, Carbone KM. (2000) Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans. Journal of virology (Jun), 74(11): 5382-4. doi:10.1128/jvi.74.11.5382-5384.2000
- Pletnikov MV, Rubin SA, Schwartz GJ, Carbone KM, Moran TH. (2000) Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems. Brain research. Developmental brain research (Feb), 119(2): 179-85.
- Pletnikov MV, Rubin SA, Schwartz GJ, Moran TH, Sobotka TJ, Carbone KM. (1999) Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. Physiology & behavior (Jul), 66(5): 823-31.
- Pletnikov MV, Rubin SA, Vasudevan K, Moran TH, Carbone KM. (1999) Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism. Behavioural brain research (Apr), 100(1-2): 43-50.
- Rubin SA, Sylves P, Vogel M, Pletnikov M, Moran TH, Schwartz GJ, Carbone KM. (1999) Borna disease virus-induced hippocampal dentate gyrus damage is associated with spatial learning and memory deficits. Brain research bulletin (Jan), 48(1): 23-30.
Professional Memberships:
- Association of Chairs of Departments of Physiology (2021–present)
- The Society of Biological Psychiatry (2010–present)
- The Society for Neuroscience (1998–present)
- The International Behavioral Neuroscience Society (1997–present)