Marc Halterman MD, PhD FAHA
Marc Halterman
MD, PhD FAHA
Senior Associate Dean for Research Director, Office of Research Professor, Department of Neurology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Blood-Brain Barrier and Drug Delivery; Brain Research; Brain-Immune System-Gut Axis; Drug Development; Immunology; Inflammation; Molecular Basis of Disease; Neuroscience; Stroke
Professional Summary:
Marc W. Halterman, MD, PhD, is professor of Neurology and the Senior Associate Dean and Executive Director of the Office of Research at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. In this capacity, he is responsible for fostering the growth of the school's research initiatives, enhancing research activities, increasing funding opportunities, and supporting faculty recruitment.
Dr. Halterman earned a bachelor's degree in chemistry from Georgetown University, later completing the Medical Scientist Training Program at the University of Rochester, receiving honors and induction into AOA. Dr. Halterman remained in Rochester to pursue his neurology residency and post-doctoral training in experimental therapeutics and translational neuroscience. He later joined the faculty in the Department of Neurology. Before his current role as senior associate dean, he was chair of the Department of Neurology and co-director of the Neurosciences Institute at the Renaissance School of Medicine at Stony Brook University.
Dr. Halterman's work focuses on the mechanisms of neural damage after stroke and cardiac arrest, focusing on cellular and immune signaling pathways and the identification of small molecules to reduce stroke-related injury. Dr. Halterman has been awarded grants for his research from the National Institutes of Health, the Department of Defense, and the American Heart Association (AHA). He has served as a mentor on post-doctoral and physician-scientist training awards and continues as a reviewer for the NIH and AHA study sections.
Education and Training:
- Fellowship, Cellular Neuroscience, University of Rochester (2008)
- Residency, Neurology, Chief Resident, University of Rochester (2006)
- Residency, Neurology, University of Rochester (2005)
- Internship, Internal Medicine, University of Rochester (2003)
- MD, MD with Distinction in Research, University of Rochester (2002)
- PhD, Microbiology & Immunology, University of Rochester (2002)
- MS, Microbiology & Immunology, University of Rochester (1999)
- BS, Chemistry, Georgetown University (1992)
Employment:
- Interim Director MD-PhD Program, Jacobs School of Medicine, University at Buffalo (2024-present)
- Professor of Neurology with continuing appointment (tenure), University at Buffalo (2024-present)
- Executive Director, Office of Research, Jacobs School of Medicine, University at Buffalo (2023-present)
- Senior Associate Dean for Research, Jacobs School of Medicine, University at Buffalo (2023-present)
- Adjunct Professor, University of Rochester (2020-present)
- Professor of Neurology with Unlimited Tenure, University of Rochester (2020-present)
- Director, LINCATS Translational Workforce Development, Stony Brook University (2021–2023)
- Professor of Neurology with continuing appointment (tenure), Stony Brook University (2021–2023)
- Co-Director, Stony Brook Neurosciences Institute, Stony Brook University (2020–2023)
- Professor and Chair, Department of Neurology, Stoney Brook University (2020–2023)
- Interim Chair, Department of Psychiatry & Behavioral Health, Stony Brook University (2021–2022)
- Associate Professor, Aab Cardiovascular Research Institute, University of Rochester (2019–2020)
- Associate Professor of Neurology with Tenure, University of Rochester (2017–2020)
- Associate Professor of Neuroscience, University of Rochester (2016–2020)
- Attending, Neurology, Strong Memorial Hospital, inpatient stroke service, University of Rochester (2014–2020)
- Member, Center for Neurotherapeutic Discovery, University of Rochester (2007–2020)
- Associate Professor of Neurology & Pediatrics, University of Rochester (2012–2017)
- Attending, Stroke Division, University of Rochester (2007–2017)
- Assistant Professor of Neurology & Pediatrics, University of Rochester (2007–2012)
- Senior Instructor in Neurology, University of Rochester (2006–2007)
Awards and Honors:
- Fellow, American Heart Association (2021)
- Dean’s Professorship (2019)
- NINDS Landis Award for Outstanding Mentorship, Finalist (2018)
- Doctor of Medicine with Distinction in Research (2002)
- Alpha Omega Alpha Medical Honors Society (2001)
- Gilbert B. Forbes Prize in Pediatric Research, (1994)
- Sigma Xi Scientific Research Society (1992)
- Phi Eta Sigma National Honor Society (1990)
Grants and Sponsored Research:
- May 2021–June 2026
Lung-brain coupling and the immune response to acute ischemic stroke
NIH/NINDS
Role: Principal Investigator - March 2023–March 2025
NeuroTag: GFP-tagging the ER-stress proteome to address bottlenecks in stroke therapeutics discovery
SUNY Research Foundation
Role: Principal Investigator - April 2023–October 2024
NeuroTag: GFP-tagging the ER-stress proteome to address bottlenecks in stroke therapeutics discovery
Stony Brook OVPR Seed Program
Role: Co-Principal Investigator - July 2021–June 2022
Modeling platelet-mediated cortical ischemia to develop next-gen antiplatelet agents for stroke
American Heart Association / Collaborative Scientist Award
Role: Principal Investigator - September 2019–August 2021
Hemostatic Hydrogels from Self-Assembling Amino Acid Derivatives
Department of Defense
Role: Consultant - May 2015–September 2020
Mechanisms of lung-dependent neutrophil priming in global cerebral ischemia reperfusion injury
NIH/NINDS
Role: Principal Investigator - July 2018–August 2020
GFP-tagging the ER-stress proteome to address bottlenecks in stroke therapeutics discovery
American Heart Association / Innovative Project Award
Role: Principal Investigator - July 2019–June 2020
Gut permeability, systemic inflammation, and penumbral collapse in acute ischemic stroke
Schmitt Program in Integrative Neuroscience (SPIN)
Role: Principal Investigator
$50,000 - July 2018–June 2020
Lung-brain coupling regulates neurovascular unit responses to stroke
American heart Association
Role: Co-Principal Investigator - July 2018–June 2020
BDNF-TrkB Regulation of ER-Dependent Death in the Peri-Ischemic Cortex
American heart Association
Role: Co-Principal Investigator - September 2016–May 2020
Neuroprotectant Therapeutic Interventions to Prevent Neurological Consequences in Combat
DOD / Peer-Reviewed Medical Research Program
Role: Principal Investigator - July 2019–August 2019
Comparative analysis of 9-TB, Doxycycline, and Minocycline in a mouse model of post-cardiac arrest syndrome (PCAS)
AHA Founders Affiliate Undergraduate Summer Fellowship
Role: Co-Principal Investigator - April 2015–March 2019
Role of Lung-Brain coupling on PMN Priming & Reperfusion Injury Following Global Cerebral Ischemia
NIH/NINDS
Role: Co-Principal Investigator - September 2011–August 2017
Targeting phosphatase regulated cleavage of HIF-1? in ischemic brain injury
NIH/NINDS
Role: Principal Investigator - August 2013–July 2017
Defining CHOP-10 Dependent Adaptive ER Stress Pathways in Neurons
NIH/NINDS
Role: Co-Principal Investigator - July 2013–June 2017
MKP-1 Effects on HIF-1? and Glycolytic Metabolism in Glioblastoma Multiforme
NIH/NCI
Role: Co-Principal Investigator - April 2014–December 2016
Lung-brain coupling in neutrophil-dependent injury after global ischemia
Schmitt Program on Integrative Brain Research (SPIBR)
Role: Principal Investigator - May 2015–December 2015
The effects of arousal on microglial behavior during stroke
Schmitt Program on Integrative Brain Research (SPIBR)
Role: Co-Principal Investigator - April 2010–March 2013
Defining Neurotherapeutic targets in hypoxia-induced CHOP-10 Signaling Networks
NIH/NINDS
Role: Principal Investigator - March 2008–March 2010
Defining Neurotherapeutic targets in hypoxia-induced CHOP-10 Signaling Networks
NIH/NINDS
Role: Principal Investigator - July 2007–June 2008
Defining Neurotherapeutic targets in hypoxia-induced CHOP-10 Signaling Networks
Buswell Fellowship
Role: Principal Investigator - July 2006–December 2006
Experimental Therapeutics Fellowship
NIH/NINDS
Role: Co-Principal Investigator - December 1998–February 2002
Sensing hypoxia in the CNS using herpes vectors
NIH/NIMH
Role: Principal Investigator
Patents:
- Methods of Treatment and Screening Assays for HIF-1-Alpha Regulation (2015)
- Herpes amplicon particles (2005)
- An Improved Method for the Study of Apoptosis-Related Genes Using 9-TB Regulated Expression from the TET-On System
- Crowdsourcing Medical Expertise", medical software application facilitating collaborative decision-making and medical education at the point of care
Journal Articles:
- Li Y, Schappell LE, Polizu C, DiPersio J, Tsirka SE, Halterman MW, Nadkarni NA. (2023) Evolving Clinical-Translational Investigations of Cerebroprotection in Ischemic Stroke. Journal of clinical medicine (Oct), 12(21). doi:10.3390/jcm12216715
- Li Y, Schor J, Bartko J, Albert G, Halterman MW. (2022) The transcription factor C/EBPß promotes vascular endothelial growth factor A expression and neural stem cell expansion. FEBS letters (Jul), 596(13): 1661-1671. doi:10.1002/1873-3468.14405
- Li Y, Halterman MW. (2021) The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy. Biomolecules (Dec), 11(12). doi:10.3390/biom11121871
- Mai N, Knowlden SA, Miller-Rhodes K, Prifti V, Sims M, Grier M, Nelson M, Halterman MW. (2021) Effects of 9-t-butyl doxycycline on the innate immune response to CNS ischemia-reperfusion injury. Experimental and molecular pathology (Feb), 118: 104601. doi:10.1016/j.yexmp.2020.104601
- Bartko JC, Li Y, Sun G, Halterman MW. (2020) Phosphorylation within the bipartite NLS alters the localization and toxicity of the ER stress response factor DDIT3/CHOP. Cellular signalling (Oct), 74: 109713. doi:10.1016/j.cellsig.2020.109713
- Mai N, Prifti V, Lim K, O'Reilly MA, Kim M, Halterman MW. (2020) Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Sep), 29(9): 104942. doi:10.1016/j.jstrokecerebrovasdis.2020.104942
- Mai N, Prifti V, Kim M, Halterman MW. (2020) Characterization of neutrophil-neuronal co-cultures to investigate mechanisms of post-ischemic immune-mediated neurotoxicity. Journal of neuroscience methods (Jul), 341: 108782. doi:10.1016/j.jneumeth.2020.108782
- Sims MH, Hodges Shaw M, Gilbertson S, Storch J, Halterman MW. (2019) Legal and ethical issues surrounding the use of crowdsourcing among healthcare providers. Health informatics journal (Dec), 25(4): 1618-1630.
- Trzeciak A, Lerman YV, Kim TH, Kim MR, Mai N, Halterman MW, Kim M. (2019) Long-Term Microgliosis Driven by Acute Systemic Inflammation. Journal of immunology (Baltimore, Md. : 1950) (Dec), 203(11): 2979-2989. doi:10.4049/jimmunol.1900317
- Mai N, Miller-Rhodes K, Knowlden S, Halterman MW. (2019) The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Jun), 39(6): 939-958. doi:10.1177/0271678X19835552
- Mai N, Miller-Rhodes K, Prifti V, Kim M, O'Reilly MA, Halterman MW. (2019) Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia. Journal of the American Heart Association (May), 8(9): e011801. doi:10.1161/JAHA.118.011801
- Buczynski BW, Mai N, Yee M, Allen JL, Prifti L, Cory-Slechta DA, Halterman MW, O'Reilly MA. (2018) Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia. Frontiers in medicine (Jan), 5: 334. doi:10.3389/fmed.2018.00334
- Mills BN, Albert GP, Halterman MW. (2017) Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer microenvironment : official journal of the International Cancer Microenvironment Society (Dec), 10(1-3): 57-68. doi:10.1007/s12307-017-0197-6
- Mai N, Prifti L, Rininger A, Bazarian H, Halterman MW. (2017) Endotoxemia induces lung-brain coupling and multi-organ injury following cerebral ischemia-reperfusion. Experimental neurology (Nov), 297: 82-91. doi:10.1016/j.expneurol.2017.07.016
- Pröschel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, Halterman MW, Paciorkowski AR. (2017) Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology. European journal of human genetics : EJHG (Feb), 25(2): 216-221. doi:10.1038/ejhg.2016.145
- Sims MH, Fagnano M, Halterman JS, Halterman MW. (2016) Provider impressions of the use of a mobile crowdsourcing app in medical practice. Health informatics journal (Jun), 22(2): 221-31.
- Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR. (2015) De novo mutations in SIK1 cause a spectrum of developmental epilepsies. American journal of human genetics (Apr), 96(4): 682-90. doi:10.1016/j.ajhg.2015.02.013
- Sims MH, Bigham J, Kautz H, Halterman MW. (2014) Crowdsourcing medical expertise in near real time. Journal of hospital medicine (Jul), 9(7): 451-6.
- Matthews TA, Abel A, Demme C, Sherman T, Pan PW, Halterman MW, Parkkila S, Nehrke K. (2014) Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia. Brain research (Jan), 1543: 28-37. doi:10.1016/j.brainres.2013.11.018
- Rininger A, Dejesus C, Totten A, Wayland A, Halterman MW. (2012) MKP-1 antagonizes C/EBPß activity and lowers the apoptotic threshold after ischemic injury. Cell death and differentiation (Oct), 19(10): 1634-43. doi:10.1038/cdd.2012.41
- Rininger A, Wayland A, Prifti V, Halterman MW. (2012) Assessment of CA1 injury after global ischemia using supervised 2D analyses of nuclear pyknosis. Journal of neuroscience methods (Jun), 207(2): 181-8. doi:10.1016/j.jneumeth.2012.04.010
- Halterman MW. (2011) An improved method for the study of apoptosis-related genes using the tet-on system. Journal of biomolecular screening (Mar), 16(3): 332-7.
- Qazi A, Halterman MW, Mi Z, Zhang T, Schor NF. (2011) Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress. Oxidative medicine and cellular longevity (Jan), 2011: 391659. doi:10.1155/2011/391659
- Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. (2010) The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. The Journal of biological chemistry (Jul), 285(28): 21329-40. doi:10.1074/jbc.M109.095299
Professional Memberships:
- Sigma Xi, National Academy of Scientific Research
- American Society for Gene Therapy
- AOA, Medical Honors Society
- Society for Neuroscience
- American Heart Association
- American Academy of Neurology
- International Society for Cerebral Blood Flow & Metabolism
Service Activities:
- ; CTSI KL2 Scholars Program, Reviewer (2024)
- ; Executive Committee, CTSI Academic Research Track, Member (2024)
- ; Faculty Mentor, Strong Children’s Research Program (SCRC) (2024)
- ; Faculty search committee, Division Chief in Nephrology, Member (2024)
- ; Institutional Biosafety Committee (IBC), Member (2024)
- ; Medical Faculty Council, CNDD Representative (2024)
- ; Medical Scientist Training Program (MSTP), Interviewer (2024)
- ; MSTP Admissions Committee, Co-Chair (2024)
- ; MSTP Program Leadership, Associate Director (2024)
- ; Reviewer, University of Rochester CTSI KL2 Program (2024)
- ; Schmitt Program in Neuroscience Pilot Grants, Reviewer (2024)
- ; U Rochester Research Compliance Committee, Member (2024)
- ; Undergraduate Research Placement Program (UR-UPP), Co-Director (2024)
- ; UR Alumni Faculty Council, Member (2024)
- ; UR Board of Trustees Academic Affairs Committee Meeting, Session Leader (2024)
- ; URMC Medical Faculty Council (MFC) Travel Awards, Reviewer (2024)