Nikolaos G. Almyroudis MD
Nikolaos G. Almyroudis
MD
Clinical Associate Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Infectious Disease; Internal Medicine
Professional Summary:
I am an attending physician on the Infectious Diseases service at Roswell Park Cancer Institute (RPCI). My clinical duties include inpatient and outpatient consultations at RPCI and on-call duties at Buffalo General Medical Center. In addition to providing clinical care, I teach medical students, residents and fellows in daily rounds and through formal didactic lectures.
My primary research interest focuses on the epidemiology, pathogenesis, prevention and treatment of opportunistic infections in patients with hematologic malignancies and recipients of hematopoietic stem cell transplantation. In addition, I study the epidemiology, pathogenesis and transmission of colonization and infection by vancomycin resistant Enterococcus in patients with hematologic malignancies. My long-term goal is to define strategies to prevent transmission, determine virulence and decrease the mortality associated with these infections.
Finally, I participate as a site principal investigator in several multicenter clinical trials.
Education and Training:
- Memorial Sloan Kettering Cancer Center, Stem Cell Transplants (2003)
- Infectious Diseases, University of South Florida (2002)
- Medicine, University of Pittsburgh-McKeesport (2000)
- Saint Savvas Oncology Hospital (1997)
- MD, National University of Athens (1992)
Employment:
- Associate Professor, Medicine, University at Buffalo, The State University of New York Jacobs School of Medicine & Biomedical Sciences
Awards and Honors:
- Fellow of Infectious Diseases Society of America, (2010)
- Fellow of American College of Physicians, (2008)
Research Expertise:
- Epidemiology of vancomycin resistant Enterococcus infections in patients with malignancies
- Opportunistic infections in the immunocompromised host
- Resistant bacteria in patients with malignancies
Journal Articles:
- Almyroudis NG, Osawa R, Samonis G, Wetzler M, Wang ES, McCarthy PL, Segal BH. (2016) Discontinuation of Systematic Surveillance and Contact Precautions for Vancomycin-Resistant Enterococcus (VRE) and Its Impact on the Incidence of VRE faecium Bacteremia in Patients with Hematologic Malignancies. Infect Control Hosp Epidemiol (Apr), 37(4): 398-403.
- Neofytos D, Railkar R, Mullane KM, Fredricks DN, Granwehr B, Marr KA, Almyroudis NG, Kontoyiannis DP, Maertens J, Fox R, Douglas C, Iannone R, Kauh E, Shire N. (2015) Correlation between Circulating Fungal Biomarkers and Clinical Outcome in Invasive Aspergillosis. PLoS One (Jun).
- Röhm M, Grimm MJ, D‘Auria AC, Almyroudis NG, Segal BH, Urban CF. (2014) NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infect Immun (May).
- Röhm M, Grimm MJ, D'Auria AC, Almyroudis NG, Segal BH, Urban CF. (2014) NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infect Immun (May), 82(5): 1766-1777.
- Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D'Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. (2013) Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol (Apr).
- Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D‘Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. (2013) Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol (Apr), 190(8): 4175-4184.
- Almyroudis NG, Grimm MJ, Davidson BA, Röhm M, Urban CF, Segal BH. (2013) NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol (Mar).
- Almyroudis NG, Grimm MJ, Davidson BA, Röhm M, Urban CF, Segal BH. (2013) NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol (Mar), 4: 45-45.
- Swaika A, Paulus A, Miller KC, Sher T, Almyroudis NG, Ball D, Wood M, Masood A, Lee K, Chanan-Khan AA. (2012) Acyclovir prophylaxis against varicella zoster virus reactivation in multiple myeloma patients treated with bortezomib-based therapies: a retrospective analysis of 100 patients. J Support Oncol (Jul), 10(4): 155-159.
- Vethanayagam RR, Almyroudis NG, Grimm MJ, Lewandowski DC, Pham CT, Blackwell TS, Petraitiene R, Petraitis V, Walsh TJ, Urban CF, Segal BH. (2011) Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One (Dec), 6(12): 28149-28149.
- Almyroudis NG, Lesse AJ, Hahn T, Samonis G, Hazamy PA, Wongkittiroch K, Wang ES, McCarthy PL, Wetzler M, Segal BH. (2011) Molecular epidemiology and risk factors for colonization by vancomycin-resistant enterococcus in patients with hematologic malignancies. Infect Control Hosp Epidemiol (May), 32(5): 490-496.
- Grimm MJ, Vethanayagam RR, Almyroudis NG, Lewandowski D, Rall N, Blackwell TS, Segal BH. (2011) Role of NADPH oxidase in host defense against aspergillosis. Med Mycol (Apr), 49 Su: 144-149.
- Jarkowski A, Forrest A, Sweeney RP, Tan W, Segal BH, Almyroudis N, Wang ES, Wetzler M. (2011) Characterization of vancomycin pharmacokinetics in the adult acute myeloid leukemia population. J Oncol Pharm Pract (Apr).
- Almyroudis NG, Segal BH. (2010) Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients. Expert Rev Anti Infect Ther (Dec), 8(12): 1451-1466.
- Partridge-Hinckley K, Liddell GM, Almyroudis NG, Segal BH. (2009) Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients. Mycopathologia (Dec), 168(6): 329-337.
- Almyroudis NG, Fabian J, Hahn T, Segal BH, Wetzler M, McCarthy PL. (2009) Late infectious complications after cord blood stem cell transplantation. Eur J Clin Microbiol Infect Dis (Nov), 28(11): 1405-1408.
- Almyroudis NG, Segal BH. (2009) Prevention and treatment of invasive fungal diseases in neutropenic patients. Curr Opin Infect Dis (Aug), 22(4): 385-393.
- Parameswaran GI, Segal BH, Almyroudis NG, Parameswaran G. (2008) Antifungal agents in hematopoietic stem cell transplantation. Curr Pharm Des (Jan), 14(20): 2011-2021.
- Almyroudis NG, Jakubowski A, Jaffe D, Sepkowitz K, Pamer E, O'Reilly RJ, Papanicolaou GA. (2007) Predictors for persistent cytomegalovirus reactivation after T-cell-depleted allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis (Dec).
- Almyroudis NG, Sutton DA, Fothergill AW, Rinaldi MG, Kusne S. (2007) In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. Antimicrob Agents Chemother (Jul), 51(7): 2587-2590.
- Battiwalla M, Wu Y, Bajwa RP, Radovic M, Almyroudis NG, Segal BH, Wallace PK, Nakamura R, Padmanabhan S, Hahn T, McCarthy PL. (2007) Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Biol Blood Marrow Transplant (Jul), 13(7): 765-770.
- Gupta S, Almyroudis NG, Battiwalla M, Bambach BJ, McCarthy PL, Proefrock AD, Ball D, Paplham P, Varma A, Kwon-Chung J, Segal BH. (2007) Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis (Jun), 9(2): 156-160.
- Padmanabhan S, Battiwalla M, Hahn T, Ball D, Paplham P, Brown K, Segal BH, McCarthy P Jr, Almyroudis NG. (2007) Two cases of hepatic zygomycosis in allogeneic stem cell transplant recipients and review of literature. Transpl Infect Dis (Jun).
- Battiwalla M, Paplham P, Almyroudis NG, McCarthy A, Abdelhalim A, Elefante A, Smith P, Becker J, McCarthy PL, Segal BH. (2007) Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. Transpl Infect Dis (Mar), 9(1): 28-32.
- Segal BH, Almyroudis NG, Battiwalla M, Herbrecht R, Perfect JR, Walsh TJ, Wingard JR. (2007) Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts. Clin Infect Dis (Feb), 44(3): 402-409.
- Almyroudis NG, Kontoyiannis DP, Sepkowitz KA, DePauw BE, Walsh TJ, Segal BH. (2006) Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection. Clin Infect Dis (Dec), 43(11): 1449-1455.
- Anaissie EJ, Segal BH, Graybill JR, Arndt C, Perfect JR, Kleinberg M, Pappas P, Benjamin D, Rubin R, Aberg JA, Adderson EE, Adler-Shohet FC, Akan H, Akova M, Almyroudis NG, Alexander BD, Andes D, Arrieta A, Baddley JW, Barron MA, Belzberg H, Boucher HW, Boyce TG, Casadevall A, Chandrasekar PH, Cleary JD, Cordonnier C, Cornely OA, Cuenca-Estrella M, Daly JS, Daoura N, Denning DW, dePauw B, de Repentigny L, Dignani MC, Dismukes WE, Donnelly JP, Donowitz GR, Dupont B, Drusano G, Ellis M, Espinel-Ingroff A, Fishman JA, Fleming R, Forrest G, Ghannoum M, Goldman M, Grazziutti M, Greene JN, Greenberg RN, Gubbins PO, Hadley S, Herbrecht R, Hiemenz JW, Hope W, Hospenthal DR, Husain S, Ito JI, Jacobson RM, Johnson M, Keating MR, Kett DH, Knapp K, Kontoyiannis DP, Krcmery VC, Larsen R, Laverdiere M, Ljungman P, Lortholary O, Maertens J, Marriott D, Mattiuzzi G, McGinnis MR, Morris M, Nucci M, Odds FC, Pankey GA, Patterson T, Pfaller M, Razonable RR, Reboli AC, Rinaldi MG, Roberts GD, Rodriguez Tudela JL, Rotstein C, Ruhnke M, Schuster M, Shoham S, Sia IG, Siebel N, Silviera F, Singh N, Sobel J, Solomkin JS, Sorrell TC, Steinbach WJ, Temesgen Z, Tortorano A, Vartivarian S, VerWeij P, Viscoli C, Viviani MA, Walker RC, Wheat JL, Wiley J, Williamson P, Wingard JR, Yu VL, Zaoutis T. (2006) Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. Clin Infect Dis (Oct), 43(8): 1031-1039.
- Almyroudis NG, Sutton DA, Linden P, Rinaldi MG, Fung J, Kusne S. (2006) Zygomycosis in solid organ transplant recipients in a tertiary transplant center and review of the literature. Am J Transplant (Oct), 6(10): 2365-2374.
- Bhatti Z, Shaukat A, Almyroudis NG, Segal BH. (2006) Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients. Mycopathologia (Jul), 162(1): 1-15.
- Dunford LM, Roy DM, Hahn TE, Padmanabhan S, Segal BH, Almyroudis N, McCarthy PL, Battiwalla M. (2006) Dapsone-induced methemoglobinemia after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (Feb), 12(2): 241-242.
- Segal BH, Kwon-Chung J, Walsh TJ, Klein BS, Battiwalla M, Almyroudis NG, Holland SM, Romani L. (2006) Immunotherapy for fungal infections. Clin Infect Dis (Feb), 42(4): 507-515.
- Tuma R, Almyroudis N, Sohn S, Panageas K, Rice R, Galinkin D, Blain M, Montefusco M, Pamer E, Nimer S, Kewalramani T. (2006) The serum IL-12:IL-6 ratio reliably distinguishes infectious from non-infectious causes of fever during autologous stem cell transplantation. Cytotherapy (Jan).
- Almyroudis N, Holland SM, Segal BH. (2005) Invasive aspergillosis in primary immunodeficiencies. Med Mycol. (May), 43(1): S247-S259.
- Almyroudis N, Fuller A, Jakubowski A, Sepkowitz K, Jaffe D, Small T N, Kiehn T E, Pamer E, Papanicolaou G A. (2005) Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients. Transpl Infect Dis (Mar), 7(1): 11-7.