Olga Pletnikova M.D.
Olga Pletnikova
M.D.
Research Associate Professor
Department of Pathology and Anatomical Sciences
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Brain Research; Histology
Professional Summary:
My professional expertise is in autopsy neuropathology, with focus on neurodegenerative disorders and forensic neuropathology, and brain banking. In the diagnostic domain, I am familiar with all major neurodegenerations to a level that allows me to teach pathology and neuropathology trainees. I gained this expertise through 20 years of examining cases from the Johns Hopkins Alzheimer’s Disease Research Center, Baltimore Longitudinal Study of Aging, Udall Center of Excellence for Parkinson’s Disease Research, Huntington Disease Center, Fronto-temporal dementia study, and BIOCARD study. My experience in forensic pathology began in 1987 at the Bureau of Forensic Medicine in Moscow, Russia, and continued thereafter with 20 years of assisting in forensic neuropathology consultations at the Office of the Chief Medical Examiner in Baltimore, Maryland.
I have 15 years of experience managing the Johns Hopkins Brain Resource Center (BRC) a repository with approximately 2500 postmortem brain specimens of neurodegenerative cases and controls. As manager of the BRC, I was responsible for dissection and preparation of tissues for research, supervised the safe storage of these valuable tissues, and provided tissue samples for research to investigators at Hopkins and extramurally. The provision of these tissues included discussions and advice to requesting investigators in terms of case selection, anatomical regions, and histological and immunohistochemical methods.
My professional experience also includes the preparation and participation in clinical pathological conferences, and the teaching of neuroanatomy and brain cutting demonstration to medical and graduate students.
Education and Training:
- Internship, forensic pathology, The Moscow Bureau of the Forensic Pathology (1987)
- MD, internal medicine, I.M. Sechenov First Moscow Medical Institute (1986)
Employment:
- Research Associate Professor, Dept. of Pathology and Anatomical Sciences, University at Buffalo Jacobs School of Medicine and Biomedical Sciences (2020-present)
- Research Associate, Department of Pathology, Johns Hopkins University School of Medicine (2005–2020)
- Volunteer Faculty, Department of Pathology, Johns Hopkins University School of Medicine , (1999–2020)
- Research Technician, Department of Pathology, Johns Hopkins University School of Medicine (2000–2005)
- Attending Staff, The Bureau of Forensic Medicine of the Moscow Health Department (1987–1997)
- Intern, The Bureau of Forensic Medicine of the Moscow Health Department (1986–1987)
Research Expertise:
- brain banking
- neuropathology: - The neuropathology of normal aging and neurodegenerative disorders, such as Alzheimer's disease, Frontotemporal Dementia, Parkinson's disease and Lewy body disease and Huntington's disease - Forensic neuropathology - Basic neuropathological methods and analysis
Grants and Sponsored Research:
- January 2022–December 2026
Immunomodulatory Therapy After Resuscitation From Cardiac Arrest
NIH
Role: Consultant - January 2024–December 2024
Buffalo Bioimaging Brain Bank for Neurological Disorders (B4ND)
Translational Pilot Studies Program University at Buffalo Clinical and Translational Science Institute Clinical and Translational Science Award (CTSA)
Role: Co-Principal Investigator
$68,000 - August 2018–April 2023
Biomarker Discovery and Validation in PSP
NIH
Role: Contributor
$576,476 - April 2016–March 2021
TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker The goal of this study to clarify mechanism of TDP-43 proteinopathy and perform target validation studies and develop biomarkers for ALS-FTD.
NIH
Role: Contributor
$250,000 - April 2017–March 2020
Alzheimer’s Disease before plaques and tangles: Abeta-Amyloid Oligomers and the Glymphatic Pathway The goal of this study is to generate novel information on very early development of Alzheimer’s disease to help identify new biomarkers for prevention and
NIH
Role: Contributor
$150,000 - April 2015
Johns Hopkins Alzheimer’s Disease Research Center
NIA/NIH
Role: Contributor
$1,173,896 - September 2009
Parkinson’s Disease Research Center of Excellence
NINDS
Role: Contributor
$1,237,499
Journal Articles:
- Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez-Atienzar S, Reho P, Kaivola K, Walton RL, Reynolds RH, Karra R, Sait S, Akcimen F, Diez-Fairen M, Alvarez I, Fanciulli A, Stefanova N, Seppi K, Duerr S, Leys F, Krismer F, Sidoroff V, Zimprich A, Pirker W, Rascol O, Foubert-Samier A, Meissner WG, Tison F, Pavy-Le Traon A, Pellecchia MT, Barone P, Russillo MC, Marín-Lahoz J, Kulisevsky J, Torres S, Mir P, Periñán MT, Proukakis C, Chelban V, Wu L, Goh YY, Parkkinen L, Hu MT, Kobylecki C, Saxon JA, Rollinson S, Garland E, Biaggioni I, Litvan I, Rubio I, Alcalay RN, Kwei KT, Lubbe SJ, Mao Q, Flanagan ME, Castellani RJ, Khurana V, Ndayisaba A, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Moore A, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Kim C, Iba M, Masliah E, Dawson TM, Rosenthal LS, Pantelyat A, Albert MS, Pletnikova O, Troncoso JC, Infante J, Lage C, Sánchez-Juan P, Serrano GE, Beach TG, Pastor P, Morris HR, Albani D, Clarimon J, Wenning GK, Hardy JA, Ryten M, Topol E, Torkamani A, Chiò A, Bennett DA, De Jager PL, Low PA, Singer W, Cheshire WP, Wszolek ZK, Dickson DW, Traynor BJ, Gibbs JR, Dalgard CL, Ross OA, Houlden H, Scholz SW. (2024) Genome sequence analyses identify novel risk loci for multiple system atrophy. Neuron (Apr).
- Scholz SW, Moroz BE, Saez-Atienzar S, Chia R, Cahoon EK, Dalgard CL, , , Freedman DM, Pfeiffer RM. (2024) Association of cardiovascular disease management drugs with Lewy body dementia: a case-control study. Brain communications (Jan), 6(1): fcad346. doi:10.1093/braincomms/fcad346
- Reho P, Saez-Atienzar S, Ruffo P, Solaiman S, Shah Z, Chia R, Kaivola K, Traynor BJ, Tilley BS, Gentleman SM, Hodges AK, Aarsland D, Monuki ES, Newell KL, Woltjer R, Albert MS, Dawson TM, Rosenthal LS, Troncoso JC, Pletnikova O, Serrano GE, Beach TG, Easwaran HP, Scholz SW. (2024) Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies. Communications biology (Jan), 7(1): 35. doi:10.1038/s42003-023-05725-x
- Wu LY, Real R, Martinez-Carrasco A, Chia R, Lawton MA, Shoai M, Bresner C, Blauwendraat C, Singleton AB, Ryten M, , Scholz SW, Traynor BJ, Williams NM, Hu MTM, Ben-Shlomo Y, Grosset DG, Hardy J, Morris HR. (2024) Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Brain communications (Jan), 6(4): fcae190. doi:10.1093/braincomms/fcae190
- Stein-O'Brien GL, Palaganas R, Meyer EM, Redding-Ochoa J, Pletnikova O, Guo H, Bell WR, Troncoso JC, Huganir RL, Morris M. (2023) Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences (Sep). doi:10.1101/2023.09.12.23295440
- Huang Y, Driedonks TAP, Cheng L, Turchinovich A, Pletniková O, Redding-Ochoa J, Troncoso JC, Hill AF, Mahairaki V, Zheng L, Witwer KW. (2023) Small RNA Profiles of Brain Tissue-Derived Extracellular Vesicles in Alzheimer's Disease. Journal of Alzheimer's disease : JAD (Sep).
- Kaivola K, Chia R, Ding J, Rasheed M, Fujita M, Menon V, Walton RL, Collins RL, Billingsley K, Brand H, Talkowski M, Zhao X, Dewan R, Stark A, Ray A, Solaiman S, Alvarez Jerez P, Malik L, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Masellis M, Keith J, Black SE, Ferrucci L, Resnick SM, Tanaka T, , , , , Topol E, Torkamani A, Tienari P, Foroud TM, Ghetti B, Landers JE, Ryten M, Morris HR, Hardy JA, Mazzini L, D'Alfonso S, Moglia C, Calvo A, Serrano GE, Beach TG, Ferman T, Graff-Radford NR, Boeve BF, Wszolek ZK, Dickson DW, Chiò A, Bennett DA, De Jager PL, Ross OA, Dalgard CL, Gibbs JR, Traynor BJ, Scholz SW. (2023) Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias. Cell genomics (Jun), 3(6): 100316. doi:10.1016/j.xgen.2023.100316
- Huang Y, Arab T, Russell AE, Mallick ER, Nagaraj R, Gizzie E, Redding-Ochoa J, Troncoso JC, Pletnikova O, Turchinovich A, Routenberg DA, Witwer KW. (2023) Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles. bioRxiv : the preprint server for biology (May). doi:10.1101/2023.05.06.539665
- Murlanova K, Jouroukhin Y, Novototskaya-Vlasova K, Huseynov S, Pletnikova O, Morales MJ, Guan Y, Kamiya A, Bergles DE, Dietz DM, Pletnikov MV. (2023) Loss of Astrocytic µ Opioid Receptors Exacerbates Aversion Associated with Morphine Withdrawal in Mice: Role of Mitochondrial Respiration. Cells (May), 12(10). doi:10.3390/cells12101412
- Jang Y, Pletnikova O, Troncoso JC, Pantelyat AY, Dawson TM, Rosenthal LS, Na CH. (2023) Mass Spectrometry-Based Proteomics Analysis of Human Substantia Nigra From Parkinson's Disease Patients Identifies Multiple Pathways Potentially Involved in the Disease. Molecular & cellular proteomics : MCP (Jan), 22(1): 100452. doi:10.1016/j.mcpro.2022.100452
- Jang Y, Thuraisamy T, Redding-Ochoa J, Pletnikova O, Troncoso JC, Rosenthal LS, Dawson TM, Pantelyat AY, Na CH. (2022) Mass spectrometry-based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways. Clinical and translational medicine (Nov), 12(11): e1076.
- Morris M, Moghekar A, Guo H, Pletnikova O, Redding-Ochoa J, Albert M, Resnick SM, Chen L. (2022) Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease. Acta neuropathologica communications (Nov), 10(1): 164. doi:10.1186/s40478-022-01464-y
- Huang Y, Driedonks TAP, Cheng L, Rajapaksha H, Routenberg DA, Nagaraj R, Redding J, Arab T, Powell BH, Pletniková O, Troncoso JC, Zheng L, Hill AF, Mahairaki V, Witwer KW. (2022) Brain Tissue-Derived Extracellular Vesicles in Alzheimer's Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers. Journal of Alzheimer's disease : JAD (Oct).
- Kaivola K, Shah Z, Chia R, , Scholz SW. (2022) Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology (Jun), 145(5): 1757-1762.
- Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. (2022) Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease. Neuron (May).
- Hinkle JT, Patel J, Panicker N, Karuppagounder SS, Biswas D, Belingon B, Chen R, Brahmachari S, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. (2022) STING mediates neurodegeneration and neuroinflammation in nigrostriatal a-synucleinopathy. Proceedings of the National Academy of Sciences of the United States of America (Apr), 119(15): e2118819119.
- Murlanova K, Jouroukhin Y, Huseynov S, Pletnikova O, Morales MJ, Guan Y, Baraban JM, Bergles DE, Pletnikov MV. (2022) Deficient mitochondrial respiration in astrocytes impairs trace fear conditioning and increases naloxone-precipitated aversion in morphine-dependent mice. Glia (Mar).
- Roberts JA, Varma VR, An Y, Varma S, Candia J, Fantoni G, Tiwari V, Anerillas C, Williamson A, Saito A, Loeffler T, Schilcher I, Moaddel R, Khadeer M, Lovett J, Tanaka T, Pletnikova O, Troncoso JC, Bennett DA, Albert MS, Yu K, Niu M, Haroutunian V, Zhang B, Peng J, Croteau DL, Resnick SM, Gorospe M, Bohr VA, Ferrucci L, Thambisetty M. (2021) A brain proteomic signature of incipient Alzheimer. Science advances (Nov), 7(46): eabi8178.
- Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU, Kam TI, Kim K, Karuppagounder SS, Kang BG, Lee S, Park H, Kim S, Yan W, Li YS, Kuo SH, Redding-Ochoa J, Pletnikova O, Troncoso JC, Lee G, Mao X, Dawson VL, Dawson TM, Ko HS. (2021) TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson. Neuron (Oct).
- Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, Shatunov A, Iacoangeli A, Al Khleifat A, Ticozzi N, Silani V, Gellera C, Blair IP, Dobson-Stone C, Kwok JB, Bonkowski ES, Palvadeau R, Tienari PJ, Morrison KE, Shaw PJ, Al-Chalabi A, Brown RH, Calvo A, Mora G, Al-Saif H, Gotkine M, Leigh F, Chang IJ, Perlman SJ, Glass I, Scott AI, Shaw CE, Basak AN, Landers JE, Chiò A, Crawford TO, Smith BN, Traynor BJ, , Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp SD, Scotter EL, Kenna KP, Keagle P, Tiloca C, Vance C, Troakes C, Colombrita C, King A, Pensato V, Castellotti B, Baas F, Ten Asbroek ALMA, McKenna-Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Pérez J, Stevic Z, D. (2021) Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. JAMA neurology (Aug). doi:10.1001/jamaneurol.2021.2598
- Varma VR, Büsra Lüleci H, Oommen AM, Varma S, Blackshear CT, Griswold ME, An Y, Roberts JA, O. (2021) Abnormal brain cholesterol homeostasis in Alzheimer. NPJ aging and mechanisms of disease (Jun), 7(1): 11. doi:10.1038/s41514-021-00064-9
- Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O. (2021) Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study. PLoS medicine (May), 18(5): e1003615. doi:10.1371/journal.pmed.1003615
- Park JS, Kam TI, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ, Pomper MG, Pletnikova O, Troncoso JC, Ko HS, Dawson VL, Dawson TM, Lee S. (2021) Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer. Acta neuropathologica communications (Apr), 9(1): 78. doi:10.1186/s40478-021-01180-z
- Dewan R, Chia R, Ding J, Hickman RA, Stein TD, Abramzon Y, Ahmed S, Sabir MS, Portley MK, Tucci A, Ibáñez K, Shankaracharya FNU, Keagle P, Rossi G, Caroppo P, Tagliavini F, Waldo ML, Johansson PM, Nilsson CF; American Genome Center (TAGC); FALS Sequencing Consortium; Genomics England Research Consortium; International ALS/FTD Genomics Consortium (iAFGC); International FTD Genetics Consortium (IFGC); International LBD Genomics Consortium (iLBDGC); NYGC ALS Consortium; PROSPECT Consortium, Rowe JB, Benussi L, Binetti G, Ghidoni R, Jabbari E, Viollet C, Glass JD, Singleton AB, Silani V, Ross OA, Ryten M, Torkamani A, Tanaka T, Ferrucci L, Resnick SM, Pickering-Brown S, Brady CB, Kowal N, Hardy JA, Van Deerlin V, Vonsattel JP, Harms MB, Morris HR, Ferrari R, Landers JE, Chiò A, Gibbs JR, Dalgard CL, Scholz SW, Traynor BJ. (2021) Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron (Feb), 109(3): 448-460.
- Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner TT, Jaunmuktane Z, Galasko D, Santana I, Tienari PJ, Myllykangas L, Oinas M, Cairns NJ, Morris JC, Halliday GM, Van Deerlin VM, Trojanowski JQ, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Brett F, Gan-Or Z, Geiger JT, Moore A, May P, Krüger R, Goldstein DS, Lopez G, Tayebi N, Sidransky E, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Shakkottai VG, Perkins M, Newell KL, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim RC, Caraway CA, Monuki ES, Brunetti M, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Flanagan ME, Mao Q, Bigio EH, RodrÃguez-RodrÃguez E, Infante J, Lage C, González-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black SE, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett MJ, Tilley BS, Gentleman S, Logroscino G, Serrano GE, Beach TG, McKeith IG, Thomas AJ, Attems J, Morris CM, Palmer L, Love S, Troakes C, Al-Sarraj S, Hodges AK, Aarsland D, Klein G, Kaiser SM, Woltjer R, Pastor P, Bekris LM, Leverenz JB, Besser LM, Kuzma A, Renton AE, Goate A, Bennett DA, Scherzer CR, Morris HR, Ferrari R, Albani D, Pickering-Brown S, Faber K, Kukull WA, Morenas-Rodriguez E, Lleó A, Fortea J, Alcolea D, Clarimon J, Nalls MA, Ferrucci L, Resnick SM, Tanaka T, Foroud TM, Graff-Radford NR, Wszolek ZK, Ferman T, Boeve BF, Hardy JA, Topol EJ, Torkamani A, Singleton AB, Ryten M, Dickson DW, Chiò A, Ross OA, Gibbs JR, Dalgard CL, Traynor BJ, Scholz SW. (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet (Feb).
- Jabbari E, Koga S, Valentino RR, Reynolds RH, Ferrari R, Tan MMX, Rowe JB, Dalgard CL, Scholz SW, Dickson DW, Warner TT, Revesz T, Höglinger GU, Ross OA, Ryten M, Hardy J, Shoai M, Morris HR; PSP Genetics Group. (2021) Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study. Lancet Neurology (Feb), 20(2): 107-116.
- Fischer NM, Hinkle JT, Perepezko K, Bakker CC, Morris M, Broen MPG, Butala A, Dawson TM, Leentjens AFG, Mari Z, Marvel CL, Mills KA, Rosenthal LS, Shepard MD, Pantelyat A, Bakker A, Pletnikova O, Troncoso JC, Wang J, Pontone GM. (2021) Brainstem Pathologies Correlate With Depression and Psychosis in Parkinson's Disease. Am J Geriatr Psychiatry (Jan).
- Mahajan UV, Varma VR, Griswold ME, Blackshear CT, An Y, Oommen AM, Varma S, Troncoso JC, Pletnikova O, O'Brien R, Hohman TJ, Legido-Quigley C, Thambisetty M. (2020) Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. PLoS Med (Oct), 17(10): 1003439-1003439.
- Huang Y, Cheng L, Turchinovich A, Mahairaki V, Troncoso JC, Pletniková O, Haughey NJ, Vella LJ, Hill AF, Zheng L, Witwer KW. (2020) Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles. J Extracell Vesicles (Jun), 9(1)
- Tisza MJ, Pastrana DV, Welch NL, Stewart B, Peretti A, Starrett GJ, Pang YS, Krishnamurthy SR, Pesavento PA, McDermott DH, Murphy PM, Whited JL, Miller B, Brenchley J, Rosshart SP, Rehermann B, Doorbar J, Ta'ala BA, Pletnikova O, Troncoso JC, Resnick SM, Bolduc B, Sullivan MB, Varsani A, Segall AM, Buck CB. (2020) Discovery of several thousand highly diverse circular DNA viruses. Elife (Feb), 9.
- van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-RodrÃguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, RodrÃguez RodrÃguez E, Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H. (2020) Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathol (Jan), 139(5): 959-962.
- Mahajan UV, Varma VR, Griswold ME, Blackshear CT, An Y, Oommen AM, Varma S, Troncoso JC, Pletnikova O, O'Brien R, Hohman TJ, Legido-Quigley C, Thambisetty M. (2020) Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. PLoS Med (Jan), 17(1): 1003012-1003012.
- Allnutt MA, Johnson K, Bennett DA, Connor SM, Troncoso JC, Pletnikova O, Albert MS, Resnick SM, Scholz SW, De Jager PL, Jacobson S. (2020) Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts. Neuron (Jan), 105(6): 1027-1035.
- Karim MR, Liao EE, Kim J, Meints J, Martinez HM, Pletnikova O, Troncoso JC, Lee MK. (2020) α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment. Mol Neurodegener (Jan), 15(1): 27-27.
- Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard HL, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, Pantelyat A, Hillis AE, Dawson TM, Rosenthal LS, Albert MS, Resnick SM, Ferrucci L, Morris CM, Pletnikova O, Troncoso J, Grosset D, Lesage S, Corvol JC, Brice A, Noyce AJ, Masliah E, Wood N, Hardy J, Shulman LM, Jankovic J, Shulman JM, Heutink P, Gasser T, Cannon P, Scholz SW, Morris H, Cookson MR, Nalls MA, Gan-Or Z, Singleton AB. (2020) Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain (Jan), 143(1): 234-248.
- Ahmed S, Fairen MD, Sabir MS, Pastor P, Ding J, Ispierto L, Butala A, Morris CM, Schulte C, Gasser T, Jabbari E, Pletnikova O, Morris HR, Troncoso J, Gelpi E, Pantelyat A, Scholz SW. (2019) MAPT p.V363I mutation: A rare cause of corticobasal degeneration. Neurol Genet (Aug), 5(4): 347-347.
- Hishimoto A, Pletnikova O, Lang DL, Troncoso JC, Egan JM, Liu QR. (2019) Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease. Alzheimers Research and Therapy (May), 11(1): 39.
- Hishimoto A, Pletnikova O, Lang DL, Troncoso JC, Egan JM, Liu QR. (2019) Correction to: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease. Alzheimers Res Ther (May), 11(1): 39-39.
- Hishimoto A, Pletnikova O, Lang DL, Troncoso JC, Egan JM, Liu QR. (2019) Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease. Alzheimer's research & therapy (Mar), 11(1): 28. doi:10.1186/s13195-019-0475-2
- Snowden SG, Ebshiana AA, Hye A, Pletnikova O, O'Brien R, Yang A, Troncoso J, Legido-Quigley C, Thambisetty M. (2019) Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology. Journal of Alzheimer's disease : JAD (Jan), 72(1): 35-43.
- Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko AV, Dannals RF, Pletnikov MV, Pomper MG. (2019) PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A (Jan), 116(5): 1686-1691.
- Bell WR, An Y, Kageyama Y, English C, Rudow GL, Pletnikova O, Thambisetty M, O'Brien R, Moghekar AR, Albert MS, Rabins PV, Resnick SM, Troncoso JC. (2019) Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. Alzheimers Dement. (Jan), 15(1): 8-16.
- Blauwendraat C, Pletnikova O, Geiger JT, Murphy NA, Abramzon Y, Rudow G, Mamais A, Sabir MS, Crain B, Ahmed S, Rosenthal LS, Bakker CC, Faghri F, Chia R, Ding J, Dawson TM, Pantelyat A, Albert MS, Nalls MA, Resnick SM, Ferrucci L, Cookson MR, Hillis AE, Troncoso JC, Scholz SW. (2019) Genetic analysis of neurodegenerative diseases in a pathology cohort. Neurobiol Aging (Jan), 76: 214-214.
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- Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, Dawson TM, Rosenthal LS, Houlden H, Pletnikova O, Troncoso J, Scholz SW. (2019) Assessment of APOE in atypical parkinsonism syndromes. Neurobiol Dis (Jan), 127: 142-146.
- Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A. (2019) Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. J Exp Med (Jan), 216(6): 1411-1430.
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- Kageyama Y, Saito A, Pletnikova O, Rudow GL, Irie Y, An Y, Murakami K, Irie K, Resnick SM, Fowler DR, Martin LJ, Troncoso JC. (2018) Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep (Nov), 8(1): 16895-16895.
- Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. (2018) Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease. Science (Nov), 362(6414).
- Pletnikova O, Kageyama Y, Rudow G, LaClair KD, Albert M, Crain BJ, Tian J, Fowler D, Troncoso JC. (2018) The spectrum of preclinical Alzheimer‘s disease pathology and its modulation by ApoE genotype. Neurobiol Aging (Nov), 71: 72-80.
- Todd KL, Brighton T, Norton ES, Schick S, Elkins W, Pletnikova O, Fortinsky RH, Troncoso JC, Molfese PJ, Resnick SM, Conover JC. (2018) Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain. Front Aging Neurosci (Jan), 9: 445-445.
- Hinkle JT, Perepezko K, Bakker CC, Broen MPG, Chin K, Dawson TM, Johnson V, Mari Z, Marvel CL, Mills KA, Pantelyat A, Pletnikova O, Rosenthal LS, Shepard MD, Stevens DA, Troncoso JC, Wang J, Pontone GM. (2018) Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers. Mov Disord Clin Pract (Jan), 5(1): 31-38.
- Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Serrano GE, Beach TG, Lesage S, Galasko D, Masliah E, Santana I, Pastor P, Diez-Fairen M, Aguilar M, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Pickering-Brown S, Mann D, Halliday GM, Hardy J, Trojanowski JQ, Dickson DW, Singleton A, Stone DJ, Bras J. (2018) Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol (Jan), 17(1): 64-74.
- Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M. (2018) Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med (Jan), 15(1): 1002482-1002482.
- An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M. (2018) Evidence for brain glucose dysregulation in Alzheimer's disease. Alzheimers Dement (Jan), 14(3): 318-329.
- Na CH, Barbhuiya MA, Kim MS, Verbruggen S, Eacker SM, Pletnikova O, Troncoso JC, Halushka MK, Menschaert G, Overall CM, Pandey A. (2018) Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini. Genome Res (Jan), 28(1): 25-36.
- Chiang ACA, Fowler SW, Reddy R, Pletnikova O, Troncoso JC, Sherman MA, Lesne SE, Jankowsky JL. (2018) Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol (Jan), 188(3): 739-756.
- Hinkle JT, Perepezko K, Bakker CC, Dawson TM, Johnson V, Mari Z, Marvel CL, Mills KA, Pantelyat A, Pletnikova O, Rosenthal LS, Shepard MD, Stevens DA, Troncoso JC, Wang J, Pontone GM. (2018) Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis. Int J Geriatr Psychiatry (Jan), 33(1): 131-139.
- Kim H, Ham S, Lee JY, Jo A, Lee GH, Lee YS, Cho M, Shin HM, Kim D, Pletnikova O, Troncoso JC, Shin JH, Lee YI, Lee Y. (2017) Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models. Oncotarget (Dec), 8(63): 106721-106739.
- Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LP, Thompson LM, Lloyd TE, Ross CA, Rothstein JD. (2017) Mutant Huntingtin disrupts the nuclear pore complex. Neuron (Apr)93-107.
- Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LPW, Thompson LM, Lloyd TE, Ross CA, Rothstein JD. (2017) Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron (Apr), 94(1): 93-107.
- Snowden SG, Ebshiana AA, Hye A, An Y, Pletnikova O, O'Brien R, Troncoso J, Legido-Quigley C, Thambisetty M. (2017) Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLoS Med (Mar), 14(3): 1002266-1002266.
- Blauwendraat C, Nalls MA, Federoff M, Pletnikova O, Ding J, Letson C, Geiger JT, Gibbs JR, Hernandez DG, Troncoso JC, Simón-Sánchez J, Scholz SW. (2017) ADORA1 mutations are not a common cause of Parkinson's disease and dementia with Lewy bodies. Mov Disord (Feb), 32(2): 298-299.
- Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. (2017) Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry (Jan), 22(1): 13-23.
- Sun M, Bell W, LaClair KD, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, Wong PC, Chen LL. (2017) Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathol (Jan), 133(6): 923-931.
- Husain N, Yuan Q, Yen YC, Pletnikova O, Sally DQ, Worley P, Bichler Z, Shawn Je H. (2017) TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation. Aging Cell (Jan), 16(2): 281-292.
- Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. (2017) NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife (Jan), 6.
- Mills KA, Mari Z, Bakker C, Johnson V, Pontone GM, Pantelyat A, Troncoso JC, Pletnikova O, Dawson TM, Rosenthal LS. (2016) Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients. Parkinsonism Relat Disord (Dec), 33: 102-106.
- Geiger JT, Ding J, Crain B, Pletnikova O, Letson C, Dawson TM, Rosenthal LS, Pantelyat A, Gibbs JR, Albert MS, Hernandez DG, Hillis AE, Stone DJ, Singleton AB, Hardy JA, Troncoso JC, Scholz SW. (2016) Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies. Neurobiol Dis (Oct), 94: 55-62.
- Jiang H, Kang SU, Zhang S, Karuppagounder S, Xu J, Lee YK, Kang BG, Lee Y, Zhang J, Pletnikova O, Troncoso JC, Pirooznia S, Andrabi SA, Dawson VL, Dawson TM. (2016) Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons. eNeuro (Jul), 3(4).
- Geiger JT, Arthur KC, Dawson TM, Rosenthal LS, Pantelyat A, Albert M, Hillis AE, Crain B, Pletnikova O, Troncoso JC, Scholz SW. (2016) C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies. Neurodegener Dis (May), 16(5-6): 370-372.
- Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Shin JH, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. (2016) Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration. J Clin Invest (Jan), 126(8): 2970-2988.
- Tabbarah AZ, Robert Bell W, Sun M, Gelwan E, Pletnikova O, Hillis AE, Troncoso JC, Lin MT, Chen L. (2016) A rapidly progressive dementia case with pathological diagnosis of FTLD-UPS. Acta Neuropathol (Jan), 132(2): 309-311.
- Ratovitski T, Chaerkady R, Kammers K, Stewart JC, Zavala A, Pletnikova O, Troncoso JC, Rudnicki DD, Margolis RL, Cole RN, Ross CA. (2016) Quantitative Proteomic Analysis Reveals Similarities between Huntington's Disease (HD) and Huntington's Disease-Like 2 (HDL2) Human Brains. J Proteome Res (Jan), 15(9): 3266-3283.
- Lin L, Park JW, Ramachandran S, Zhang Y, Tseng YT, Shen S, Waldvogel HJ, Curtis MA, Faull RL, Troncoso JC, Pletnikova O, Ross CA, Davidson BL, Xing Y. (2016) Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease. Hum Mol Genet (Jan), 25(16): 3454-3466.
- Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, Dawson TM, Smith W, Lim KL, Ross CA. (2016) Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nat Commun (Jan), 7: 11792-11792.
- Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. (2015) Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS One (Dec), 10(12): 0143854-0143854.
- Nam JH, Park ES, Won SY, Lee YA, Kim KI, Jeong JY, Baek JY, Cho EJ, Jin M, Chung YC, Lee BD, Kim SH, Kim EG, Byun K, Lee B, Woo DH, Lee CJ, Kim SR, Bok E, Kim YS, Ahn TB, Ko HW, Brahmachari S, Pletinkova O, Troconso JC, Dawson VL, Dawson TM, Jin BK. (2015) TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF. Brain (Dec), 138(Pt 12): 3610-3622.
- Bañez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP. (2015) RAN Translation in Huntington Disease. Neuron (Nov), 88(4): 667-677.
- Bañez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP. (2015) RAN Translation in Huntington Disease. Neuron (Nov), 88(4): 667-677.
- O'Hearn EE, Hwang HS, Holmes SE, Rudnicki DD, Chung DW, Seixas AI, Cohen RL, Ross CA, Trojanowski JQ, Pletnikova O, Troncoso JC, Margolis RL. (2015) Neuropathology and Cellular Pathogenesis of Spinocerebellar Ataxia Type 12. Mov Disord (Nov), 30(13): 1813-1824.
- Pletnikova O, Rudow GL, Hyde TM, Kleinman JE, Ali SZ, Bharadwaj R, Gangadeen S, Crain BJ, Fowler DR, Rubio AI, Troncoso JC. (2015) Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age. Cognitive and Behavioral Neurology (Sep), 28(3): 144-152.
- Ling JP, Pletnikova O, Troncoso JC, Wong PC. (2015) TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science (Aug), 349(6248): 650-655.
- Savonenko AV, Melnikova T, Wang Y, Ravert H, Gao Y, Koppel J, Lee D, Pletnikova O, Cho E, Sayyida N, Hiatt A, Troncoso J, Davies P, Dannals RF, Pomper MG, Horti AG. (2015) Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. PLoS One (Jun), 10(6): 0129618-0129618.
- Iacono D, Zandi P, Gross M, Markesbery WR, Pletnikova O, Rudow G, Troncoso JC. (2015) APO?2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study. Oncotarget (Jun), 6(16): 14082-14091.
- Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM. (2015) PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology (Mar), 84(10): 972-980.
- Daniel G, Musso A, Tsika E, Fiser A, Glauser L, Pletnikova O, Schneider BL, Moore DJ. (2015) α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9). Neurobiol Dis (Jan), 73: 229-243.
- Miller MI, Younes L, Ratnanather JT, Brown T, Trinh H, Lee DS, Tward D, Mahon PB, Mori S, Albert M.BIOCARD Research Team: Marilyn Albert, Barbara Rodzon, Selnes Ola, Marilyn Albert, Rebecca Gottesman, Ned Sacktor, Anja Soldan, Guy McKhann, Scott Turner, Leonie Farrington, Maura Grega, Daniel D'Agostino, Sydney Feagen, David Dolan, Hillary Dolan, Michael Miller, Susumu Mori, Tilak Ratnanather, Timothy Brown, Hayan Chi, Anthony Kolasny, Kenichi Oishi, Thomas Reigel, Elizabeth Postell, William Schneider, Laurent Younes, Richard O'Brien, Abhay Moghekar, Richard Meehan, Roberta Scherer, Curt Meinert, David Shade, Ann Ervin, Jennifer Jones, Matt Toepfner, Lauren Parlett, April Patterson, Lisa Lassiter, Mei-Cheng Wang, Shanshan Li, Yi Lu, Juan Troncoso, Barbara Crain, Olga Pletnikova, Gay Rudow, Karen Fisher, John Csernansky, David Holtzman, David Knopman, Walter Kukull, John McArdle, Neil Buckholtz, John Hsiao, Laurie Ryan, Jovier Evans, Constantine Lyketsos, Carlos Pardo, Gerard Schellenberg, Leslie Shaw, Madhav Thambisetty, John Trojanowski, Trey Sunderland. (2015) Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort. Neurobiology of Aging (Jan)
- Ryu J, Horkayne-Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, Troncoso JC, Koliatsos VE. (2014) The problem of axonal injury in the brains of veterans with histories of blast exposure. Acta Neuropathol Commun (Nov), 2: 153-153.
- Pletnikova O, Sloane KL, Renton AE, Traynor BJ, Crain BJ, Reid T, Zu T, Ranum LP, Troncoso JC, Rabins PV, Onyike CU.Pletnikova O. (2014) Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion. Neurobiollogy of Aging (Oct), 35(10)
- Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, Resnick SM, de Cabo R, Mattson MP, Gorospe M. (2014) HuD regulates coding and noncoding RNA to induce APP→Aβ processing. Cell Rep (Jun), 7(5): 1401-1409.
- Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR. (2014) Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases. Acta Neuropathol Commun (May), 2: 55-55.
- Iacono D, Resnick SM, O'Brien R, Zonderman AB, An Y, Pletnikova O, Rudow G, Crain B, Troncoso JC. (2014) Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. J Neuropathol Exp Neurol (Apr), 73(4): 295-304.
- Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP. (2013) RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proc Natl Acad Sci U S A (Dec), 110(51): 4968-4977.
- Riudavets MA, Bartoloni L, Troncoso JC, Pletnikova O, St George-Hyslop P, Schultz M, Sevlever G, Allegri RF. (2013) Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation. Brain Pathol (Sep), 23(5): 595-600.
- Aggarwal M, Zhang J, Pletnikova O, Crain B, Troncoso J, Mori S. (2013) Feasibility of creating a high-resolution 3D diffusion tensor imaging based atlas of the human brainstem: a case study at 11.7 T. Neuroimage (Jul), 74: 117-127.
- Onyike CU, Pletnikova O, Sloane KL, Sullivan C, Troncoso JC, Rabins PV. (2013) Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration. Dement Neuropsychol (Mar), 7(1): 83-87.
- Driscoll I, Troncoso JC, Rudow G, Sojkova J, Pletnikova O, Zhou Y, Kraut MA, Ferrucci L, Mathis CA, Klunk WE, O'Brien RJ, Davatzikos C, Wong DF, Resnick SM. (2012) Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. Acta Neuropathol (Dec), 124(6): 823-831.
- Guo Z, Rudow G, Pletnikova O, Codispoti KE, Orr BA, Crain BJ, Duan W, Margolis RL, Rosenblatt A, Ross CA, Troncoso JC. (2012) Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease. Mov Disord (Sep), 27(11): 1379-1386.
- Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ. (2012) Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Hum Mol Genet (Jun), 21(11): 2420-2431.
- Codispoti KE, Beason-Held LL, Kraut MA, O'Brien RJ, Rudow G, Pletnikova O, Crain B, Troncoso JC, Resnick SM. (2012) Longitudinal brain activity changes in asymptomatic Alzheimer disease. Brain Behav (May), 2(3): 221-230.
- Ramonet D, Podhajska A, Stafa K, Sonnay S, Trancikova A, Tsika E, Pletnikova O, Troncoso JC, Glauser L, Moore DJ. (2012) PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Hum Mol Genet (Apr), 21(8): 1725-1743.
- Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK. (2012) Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci (Mar), 32(10): 3306-3320.
- Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. (2012) Accumulation of toxic -synuclein oligomer within endoplasmic reticulum occurs in alfa-synucleinopathy in vivo. Journal of Neuroscience (Mar), 32(10): 3301-3305.
- Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. (2012) Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J Neurosci (Mar), 32(10): 3301-3305.
- Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR. (2011) Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem (Dec), 286(52): 45093-45102.
- Johnson MW, Stoll L, Rubio A, Troncoso J, Pletnikova O, Fowler DR, Li L. (2011) Axonal injury in young pediatric head trauma: a comparison study of β-amyloid precursor protein (β-APP) immunohistochemical staining in traumatic and nontraumatic deaths. J Forensic Sci (Sep), 56(5): 1198-1205.
- Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, Jenkins NA, Copeland NG, Galter D, Thomas B, Lee MK, Dawson TM, Dawson VL, Moore DJ. (2011) Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (Apr), 6(4): 18568-18568.
- Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM. (2011) PARIS (ZNF746) repression of PGC-1? contributes to neurodegeneration in Parkinson's disease. Cell (Mar), 144(5): 689-702.
- Sojkova J, Driscoll I, Iacono D, Zhou Y, Codispoti KE, Kraut MA, Ferrucci L, Pletnikova O, Mathis CA, Klunk WE, O'Brien RJ, Wong DF, Troncoso JC, Resnick SM. (2011) In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults. Arch Neurol (Feb), 68(2): 232-240.
- Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. (2010) Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci U S A (Sep), 107(38): 16691-16696.
- Chiocco MJ, Zhu X, Walther D, Pletnikova O, Troncoso JC, Uhl GR, Liu QR. (2010) Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. Subst Use Misuse (Sep), 45(11): 1809-1826.
- Iacono D, Markesbery WR, Gross M, Pletnikova O, Rudow G, Zandi P, Troncoso JC. (2009) The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology (Sep), 73(9): 665-673.
- Bandaru VV, Troncoso J, Wheeler D, Pletnikova O, Wang J, Conant K, Haughey NJ. (2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiol Aging (Apr), 30(4): 591-599.
- Tsang AH, Lee YI, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KK. (2009) S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease. Proc Natl Acad Sci U S A (Mar), 106(12): 4900-4905.
- O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L, Crain BJ, Pletnikova O, Rudow G, Iacono D, Riudavets MA, Driscoll I, Price DL, Martin LJ, Troncoso JC. (2009) Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). J Alzheimers Dis (Jan), 18(3): 665-675.
- Troncoso JC, Zonderman AB, Resnick SM, Crain B, Pletnikova O, O'Brien RJ. (2008) Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol (Aug), 64(2): 168-176.
- Iacono D, O'Brien R, Resnick SM, Zonderman AB, Pletnikova O, Rudow G, An Y, West MJ, Crain B, Troncoso JC. (2008) Neuronal hypertrophy in asymptomatic Alzheimer disease. J Neuropathol Exp Neurol (Jun), 67(6): 578-589.
- Rudow G, O'Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso JC. (2008) Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathol (Apr), 115(4): 461-470.
- Rudnicki DD, Pletnikova O, Vonsattel JP, Ross CA, Margolis RL. (2008) A comparison of huntington disease and huntington disease-like 2 neuropathology. J Neuropathol Exp Neurol (Apr), 67(4): 366-374.
- Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, Dawson VL, Dawson TM, Lim KL. (2008) Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum Mol Genet (Feb), 17(3): 431-439.
- Hishimoto A, Liu QR, Drgon T, Pletnikova O, Walther D, Zhu XG, Troncoso JC, Uhl GR. (2007) Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum Mol Genet (Dec), 16(23): 2880-2891.
- Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC. (2007) Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiol Aging (Oct), 28(10): 1484-1492.
- Chang SY, Yong TF, Yu CY, Liang MC, Pletnikova O, Troncoso J, Burgunder JM, Soong TW. (2007) Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand. Neuroscience (Mar), 145(3): 1026-1036.
- Pletnikova O. (2006) Spinocerebellar Ataxia Type 12 and Huntington’s Disease-Like 2: Clues to Pathogenesis, in: Human Nucleotide Expansion Disorders, Nucleic Acids and Molecular Biology. (Jan), 19: 253-276.
- Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL. (2005) Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Hum Mol Genet (Dec), 14(24): 3885-3897.
- Pletnikova O, West N, Lee MK, Rudow GL, Skolasky RL, Dawson TM, Marsh L, Troncoso JC. Pletnikova O. (2005) Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiology of Aging (Aug), 26((8)): 2162-2167.
- Ko HS, von Coelln R, Sriram SR, Kim SW, Chung KK, Pletnikova O, Troncoso J, Johnson B, Saffary R, Goh EL, Song H, Park BJ, Kim MJ, Kim S, Dawson VL, Dawson TM. (2005) Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J Neurosci (Aug), 25(35): 7968-7978.
- Li W, West N, Colla E, Pletnikova O, Troncoso JC, Marsh L, Dawson TM, Jäkälä P, Hartmann T, Price DL, Lee MK. (2005) Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A (Feb), 102(6): 2162-2167.
- Mikolaenko I, Pletnikova O, Kawas CH, O'Brien R, Resnick SM, Crain B, Troncoso JC. (2005) Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuropathol Exp Neurol (Feb), 64(2): 156-162.
- Hatanpaa KJ, Blass DM, Pletnikova O, Crain BJ, Bigio EH, Hedreen JC, White CL, Troncoso JC. (2004) Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology (Aug), 63(3): 538-542.
- Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science (May), 304(5675): 1328-1331.
Books and Book Chapters:
- Troncoso JC, Rubio A, Fowler D. (2009) Neurodegenerative Diseases, in: Essential Forensic Neuropathology. In: Essential Forensic Neuropathology. Lippincott Williams & Wilkins, 247-263.
- Margolis RL, Holmes SE, O’Hearn E, Rudnicki DD, Hwang J, Cortez-Apreza N, Pletnikova O, Troncoso JC. (2006) Nucleic Acids and Spinocerebellar Ataxia Type 12 and Huntington’s Disease-Like 2: Clues to Pathogenesis, in: ; Nucleic Acids and Molecular Biology. In: Human Nucleotide Expansion Disorders. Springer, 253-276.
Service Activities:
- JSMBS faculty council alternate for PAS (2023–2024)
- JSMBS faculty council alternate for PAS (2023–2024)
- I am working on organizing a human brain tissue samples repository as an integral part of the Biorepository in the department. I am expanding my collaborative efforts with the brain bank at JHU to establish a long-term interaction between two banking systems and ensure an uninterrupted exchange of postmortem human brain samples to be used for research and teaching purposes. Going forward, this service will significantly stimulate basic and translational studies of neurodegenerative and neuropsychiatric conditions at UB, a promising and highly fundable research direction. (2020–present)
- 2/12/2014 Presentation “Movement and neurodegenerative disorders” and brain cutting demonstration to the staff at Copper Ridge Peak Healthcare Skilled Nursing Facility at Copper Ridge 710 Obrecht Rd, Sykesville, MD (2014)
- 10/6/2010 Presentation “Movement and neurodegenerative disorders” and brain cutting demonstration to the staff at Copper Ridge Peak Healthcare Skilled Nursing Facility at Copper Ridge 710 Obrecht Rd, Sykesville, MD 2/12/2014 Presentation “Movement and neurodegenerative disorders” and brain cutting demonstration to the staff at Copper Ridge Peak Healthcare Skilled Nursing Facility at Copper Ridge 710 Obrecht Rd, Sykesville, MD