Raphael Fraser

Raphael Fraser

Raphael Fraser

Research Associate Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Artificial Intelligence; Diabetes; Health Services Research; Mathematical Modeling; Racial Disparities Health Research; Technology

Contact Information
320K UB Downtown Gateway
77 Goodell Street
Buffalo, New York 14203
Phone: 716-829-5733
rfraser@buffalo.edu



Professional Summary:

As an associate professor of medicine in the Division of Population Health, my academic pursuits are centered on the intersection of data science, artificial intelligence, and wearable technologies to improve health outcomes for individuals living with Type 2 diabetes mellitus. My work is dedicated to developing innovative, data-driven solutions that leverage wearable devices to predict and manage glycemic control, ultimately aiming to transform diabetes care through real-time monitoring, predictive analytics, and tailored interventions. By bridging the latest advances in technology with practical healthcare applications, my research seeks to make meaningful, evidence-based improvements in diabetes management, thereby addressing a pressing public health challenge.

Building on this focus, my prior background in clinical trials, where I conducted significant work in bone marrow transplant studies, provides an essential foundation for my current work in diabetes care. Notably, as part of a collaborative team, I contributed to a phase 3, multicenter, randomized controlled trial that examined the efficacy of cyclophosphamide-tacrolimus-mycophenolate mofetil, an experimental prophylaxis regimen, in comparison with the standard regimen of tacrolimus-methotrexate for preventing graft-versus-host disease (GVHD) in patients undergoing their first allogeneic hematopoietic stem cell transplantation for hematologic cancers. Among 431 adults receiving peripheral-blood grafts from HLA-matched related or matched/mismatched unrelated donors, the experimental regimen yielded a significantly higher rate of GVHD-free, relapse-free survival at one year. As a result, cyclophosphamide-tacrolimus-mycophenolate mofetil has become the new standard of care for GVHD prophylaxis in adults undergoing reduced-intensity conditioning allogeneic transplants, marking a critical advancement in this field.

In addition to my clinical trials work, complex sample surveys play a crucial role in healthcare by providing comprehensive data that informs policy-making, resource allocation, and health interventions at both population and individual levels. These surveys often involve intricate design features such as stratification, clustering, and unequal probability sampling, posing challenges for accurate data analysis and inference. I have made substantial contributions to the field of complex sample surveys, with a particular emphasis on improving the precision of variance estimation. Traditional ordinary least squares mean regression methods often struggle with highly skewed outcomes, leading to biased and inefficient parameter estimates. To address this challenge, I have developed and applied median regression techniques specifically designed for complex sample surveys, providing a more robust and reliable method for analyzing skewed outcomes—a common characteristic in survey datasets. This work ensures accurate statistical inference and strengthens the utility of complex survey data for generating actionable, policy-relevant insights across multiple sectors.

Together, these threads of research reflect my commitment to leveraging data-driven approaches to enhance health outcomes, bridge technological innovation with healthcare practice, and improve the accuracy and utility of data-driven insights for better public health decision-making.

Education and Training:

  • PhD, Statistics, Florida State University (2015)
  • MS, Statistics, Florida State University (2012)
  • MS, Biostatistics, University of the West Indies (2006)
  • BS, Mathematics, University of the West Indies (2001)

Employment:

  • Associate Professor & Co-Program Director, Health Services Research Training, Division of Population Health | Department of Medicine, Jacobs School of Medicine & Biomedical Sciences University at Buffalo (2024-present)
  • Assistant Professor of Biostatistics, Division of Biostatistics, Institute for Health & Equity, Medical College of Wisconsin (2015–2024)
  • Lecturer of Biostatistics, Tropical Medicine Research Institute, Sickle Cell Unit, University of the West Indies, Kingston, Jamaica (2004–2010)

Awards and Honors:

  • Joint Statistical Meeting Best Student Paper Competition Award Recipient (2016)

Research Expertise:

  • Data Science
  • Design & Analysis of Clinical Trials
  • Type 2 Diabetes Mellitus
  • Wearable Technology

UB 2020 Strategic Strengths:

  • Civic Engagement and Public Policy
  • Health and Wellness Across the Lifespan
  • Information and Computing Technology

Grants and Sponsored Research:

  • A Novel Continuous Glucose Monitoring Enhanced DPP Intervention to Prevent Type 2 diabetes in Adults with Prediabetes
    American Diabetes Association
    Role: Principal Investigator
    $600,000
  • Enhancing PrEP Access for At-Risk Young People through Pharmacy-delivered Oral PrEP in Nigeria
    National Institutes of Health
    Role: Co-Principal Investigator
    $80,000
  • Cardiovascular Risk Reduction for Adults with Food Insecurity Using Structured Incentives (CVD-FIT)
    National Institute on Minority Health and Health Disparities
    Role: Co-Investigator
    $3,275,405

Journal Articles:

See all (34 more)

Professional Memberships:

  • American Diabetes Association; The American Diabetes Association (ADA) is a leading organization dedicated to preventing and curing diabetes while improving the lives of those affected by the disease. Through research, advocacy, education, and professional resources, the ADA advances scientific discovery and promotes evidence-based care for diabetes management. The organization supports healthcare professionals, researchers, and policymakers in addressing diabetes-related challenges and improving patient outcomes. (2024–present)
  • American Statistical Association; The American Statistical Association (ASA), founded in 1839, is the premier professional association for statisticians and data scientists. It promotes the practice and profession of statistics through education, advocacy, publications, and professional development. ASA supports research and innovation in statistical science across diverse fields, including healthcare, biostatistics, data science, and artificial intelligence. (2007–present)

Service Activities:

  • Conduct peer reviews of manuscripts in internal medicine, clinical epidemiology, and health services research, with a focus on statistical methodologies and AI applications in healthcare. Provide constructive feedback to ensure rigor, clarity, and clinical relevance, contributing to the journal’s high standards and the advancement of evidence-based medicine.; Peer Reviewer, Journal of General Internal Medicine (JGIM) (2024–present)

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Contact Information

320K UB Downtown Gateway
77 Goodell Street
Buffalo, New York 14203
Phone: 716-829-5733
rfraser@buffalo.edu