Randall L. Rasmusson PhD

Randall Rasmusson

Randall L. Rasmusson
PhD

Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Biomedical Engineering; Biophysical Modeling; Computational Biology; Drug Development; Drug Discovery; Electrophysiology; Ion channel kinetics and structure; Ion Transport; Membrane Biophysics; Membrane Transport (Ion Transport); Neuroscience; Stem Cells

Contact Information
355 BRB
University at Buffalo, South Campus
Buffalo, New York 14120
Phone: 716-829-2668
rr32@buffalo.edu



Education and Training:

  • PhD, Physiology, Duke University (1991)
  • MS, Electrical Engineering, Rice University (1986)
  • BS, Electrical Engineering, Computer Science, Rice University (1983)

Employment:

  • Professor, Biomedical Engineering, SUNY, University at Buffalo School of Engineering and Applied Sciences (2010-present)
  • Professor, Physiology and Biophysics, SUNY, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2006-present)
  • President, Cytocybernetics Inc. (2013–2022)
  • Associate Professor, Department of Physiology and Biophysics, State University of New York at Buffalo (2000–2006)
  • Associate Professor, Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine (1999–2000)
  • Adjunct Assistant Professor, Program in Biomedical Engineering, Carnegie-Mellon University (1999)
  • Assistant Professor, Department of Medicine and Physiology, Allegheny Universiy of Health Sciences (1998–1999)
  • Research Assistant Professor, Department of Biomedical Engineering, Duke University (1991–1997)

Awards and Honors:

  • UB Exceptional Scholar, Sustained Achievement Award (2011)
  • Whitaker Foundation Researcher
  • Established Investigator, American Heart Association
  • Fellow of the American Heart Association
  • National Merit Scholarship
  • NIH,NRSA Training Grant HL-07063-12
  • Proctor & Gamble, Alternatives to Animal Research Finalist

Research Centers:

  • Center for Research in Cardiovascular Medicine

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • May 2011–April 2012
    Device to treat postpartum hemorrhage
    Bill and Melinda Gates Foundation
    Role: Co-Principal Investigator
    $100,000
  • August 2014
    Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit.
    UBCAT
    Role: Principal Investigator
    $60,000
  • A Model of the Ferret Ventricular Action Potential
    Whitaker Foundation
    Role: Principal Investigator
  • K+ Channel Inactivation and Antiarrhythmic Drug Action
    NIH
    Role: Principal Investigator
  • N-terminal and beta-subunit modulation of cloned cardiac K+ channels
    American Heart Association
    Role: Principal Investigator
  • Modulation of Ca2+ channels by dihydropyridines and Ca2+
    Role: Consultant
  • Cardiac pacemaker activity
    Role: Co-Investigator
  • Cardiac transient outward current
    Role: Co-Investigator

Journal Articles:

See all (91 more)

Books and Book Chapters:

  • Bett GCL, Rasmusson RL. (2006) Fundamentals of Cellular Electrophysiology.
  • Bett GC, Rasmussson RL. (2002) In: Models of Cardiac Ion Channels. , 1-60.
  • Rasmusson RL. (2001) In: Voltage-gated sodium and potassium channels. In: The Corsini encyclopedia of psychology and behavioral science 3rd edition. , 1749-1753.
  • Rasmusson RL, Liu S, Strauss HC. (1999) In: Pharmacology of K+ channels. In: Cardiac electrophysiology: from cell to bedside. , 156-167.
  • Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss H. (1995) Potassium Channels in Normal and Pathological Conditions. In: Molecular biology and physiology of a cardiac voltage-gated K+ channel ß subunit. Leuven University Press, 205-208.
  • Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss HC. (1995) In: A voltage-gated K+ channel ß -subunit cloned from ferret ventricle: Implications for cardiac K+ channel function. In: Potassium channels in normal and pathological conditions. , 205-220.
  • Rasmusson RL, Campbell DL, Qu Y, Strauss HC. (1994) In: Conformation dependent drug binding to cardiac potassium channels. Ion channels in the cardiovascular system. , 387-414.
  • Campbell DL, Rasmusson RL, Comer MB, Strauss HC. (1994) In: The cardiac calcium-independent transient outward potassium current: Kinetics, molecular properties and possible role in ventricular repolarization. In: Cardiac electrophysiology: from cell to bedside. , 83-95.
  • Campbell DL, Rasmusson RL, Strauss HC. (1991) In: Electrophysiology and pharmacology of the heart: A clinical guide. , 59-108.
  • Shen WK, Hill JA, Rasmusson RL, Strauss HC. (1990) In: Reconstitution of the K channel of cardiac sarcoplasmic reticulum. , 205-230.

Abstracts:

  • A. COSTANTINO, B. K. PANAMA, M. W. NOWAK, R. L. RASMUSSON, G. C. L. BETT. (2021) Calibration of optical measurement of membrane potential in eukaryotic cells. Annual Meeting of the Society for Neuroscience. (Nov) Poster
  • Anthony Costantino, Brian K. Panama, Mark W. Nowak, Randall L. Rasmusson, Glenna CL. Bett. (2021) Calibration of optical measurement of membrane potential in eukaryotic cells. Annual Meeting of the Society for Neuroscience. (Nov)
  • Mark W Nowak, Brian K Panama, Leigh Korbel, Randall L Rasmusson, Glenna Bett. (2021) Electronic Expression of Background and Delayed Rectifier Currents via Dynamic Clamp Produces Physiological Action Potentials in Stem Cell Derived Glutamatergic Neurons. Biophysical Journal, Annual Meeting of the Biophysical Society. (Feb) 352a
  • Bett GC, Duffey ME, Rasumsson RL. (2005) Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1. Biophys J, (Jan)
  • Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. (2005) Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. Proceedings of the 35th Meeting of the International Union of Physiological Sciences, (Jan)
  • Bett GC, Morales M, Rasmusson R. (2005) KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. Biophys J, (Jan)
  • Bett GC, Rasmusson RL. (2005) Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current. Proceedings of the 35th Meeting of the International Union of Physiological Sciences, (Jan)
  • Bett GC, Rasmusson RL. (2004) Proton Modification of HERG channels: two sites of functional regulation. Biophy J, (Jan) 281-282
  • Bett GC, Bondarenko VE, Rasmusson RL. (2004) Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation. Proceedings of the 25th Meeting of the North American Society for Pacing and Electrophyisology - Heart Rhythm Society, (Jan)
  • Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. (2004) A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings of the12th Annual National McNair Research Conference, (Jan)
  • Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2004) A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. Biophys J, (Jan) 298
  • Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2003) A mathematical model of the action potential of mouse ventricular myocytes. Biomedical Engineering in NY, Alfred University, (Jan)
  • Bett GC, Cyr V, Rasmusson RL. (2003) A mathematicl model of potassium channels permeation with two binding sites. Proceeding B-SURE Conference, SUNY@Buffalo, (Jan)
  • Bett GC, Bondarenko VE, Rasmusson RL. (2003) A model of Ca2 handling in ferret cardiac myocytes. Proceedings Biomedical Engineering in NY, Alfred University, (Jan)
  • Bett GC, Madou ID, Rasmusson RL. (2003) A computer model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
  • Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. (2003) C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. Biophys J, (Jan) 221
  • Bett GC, Bondarenko VE, Rasmusson RL. (2003) Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
  • Bett GC, Cyr V, Rasmusson RL. (2003) A mathematical model of potassium channels permiation with two binding sites and drug block. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. (2003) Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. Biophys J, (Jan) 76A
  • Bett GC, Yoo K, Rasmusson RL. (2003) Site directed mutagenesis in a cloned Kv1.4 channel. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Kaushal V, Rasmusson RL. (2003) Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. Proceedings Biomedical Engineering in NY, Alfred University, (Jan)
  • Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. (2002) Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, Buffalo, NY, (Jan)
  • Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. (2002) C-type inactivation: a pH0 and K sensitive transmembrane mechanism. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
See all (15 more)

Professional Memberships:

  • AHA Basic Sciences Council
  • American Physiological Society
  • Biophysical Society
  • IEEE
  • NASPE
  • Physiological Society

Service Activities:

  • ; Panel Member

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

355 BRB
University at Buffalo, South Campus
Buffalo, New York 14120
Phone: 716-829-2668
rr32@buffalo.edu