Umesh Sharma M.D., Ph.D.

Umesh Sharma

Umesh Sharma
M.D., Ph.D.

Associate Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cardiac pharmacology; Cardiology; Cardiovascular Disease; Drug Development; Gene Expression; Inflammation; Internal Medicine; Preclinical MRI; Radiation Oncology; Translational imaging

Contact Information
Clinical & Translational Research Center
875 Ellicott Street
Room 7030
Buffalo, New York 14203
Phone: 716-829-2663
Fax: 716-854-1840
sharmau@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Professional Summary:

I am a cardiologist with specialized training in advanced cardiac MRI and a focused interest in cardio-oncology. My clinical and research work centers on cancer therapy–related cardiotoxicity, including immune checkpoint inhibitor–associated myocarditis and cardiovascular complications of CAR T cell therapy. I provide inpatient cardiovascular care at Buffalo General Medical Center and lead MRI-based imaging services at the Gates Vascular Institute.

My translational research program integrates magnetic resonance imaging, immunology, and molecular biology to investigate inflammatory cardiomyopathies. At UB’s Clinical and Translational Research Center, my laboratory develops tissue-targeted MRI techniques and applies them to preclinical and human models to study immune-driven myocardial injury. We are currently investigating T and B cell–mediated mechanisms using engineered cell-based assays, single-cell transcriptomics, and cardiac imaging to identify therapeutic targets in immune checkpoint inhibitor–induced myocarditis.

I actively serve on NIH study sections and editorial boards for cardiovascular journals. Equally important, I mentor medical students, residents, and fellows in both clinical and research settings and precept cardiology fellows at the Heart and Lung Center at BGMC. This mentorship is deeply interwoven with my academic mission: while advancing my own work in cardio-oncology and cardiac imaging, I support the career development of trainees whose research is routinely published in peer-reviewed journals and presented at national and international conferences.

Education and Training:

  • Fellowship, Advanced Cardiac Imaging, Massachusetts General Hospital (2013)
  • Fellowship, Cardiovascular Medicine, University of Louisville (2012)
  • Residency, Internal Medicine, Chicago Medical School (2009)
  • PhD, Molecular mechanisms of heart failure, University of Maasricht (2005)
  • MS, Medical Immunology, University of London (2002)
  • Tribhuvan University (2000)

Employment:

  • Associate Professor, Medicine, University at Buffalo, State University Of New York (2022-present)
  • Assistant Professor, Medicine, University at Buffalo, State University of New York (2013–2022)

Awards and Honors:

  • Annual Meeting of the Central Society for Clinical and Translational Research-Travel Award (2018)
  • Emerging Investigator: Circulation Heart Failure (2018)
  • Outstanding Resident (2009)
  • Professionalism Award (2009)

Research Expertise:

  • Biomarkers
  • Cardiac fibrosis and remodeling
  • Cardiac MRI and CT
  • Cardio-Oncology
  • Galectin-3 as a Risk-Predictor of Sudden Cardiac Arrest
  • Post-Infarct Myocardial Remodeling
  • Prevention of Radiation-Induced Cardiomyopathy

Research Centers:

  • Center for Research in Cardiovascular Medicine
  • Clinical and Translational Research Center (CTRC)

Grants and Sponsored Research:

  • March 2021–March 2026
    Immunomodulation of Galectin-3 to Prevent Radiation-Induced Myocardial Fibrogenesis
    NHLBI
    Role: Principal Investigator
    $1,726,588
  • July 2017–June 2022
    National Institutes of Health/NHLBI, K08
    NHLBI
    Role: Principal Investigator
    $986,850
  • July 2018–June 2020
    Activating Adrenergic Receptors to Suppress the Anti-graft Immune Response and Improve Survival of Composite Tissue Allografts.
    National Institutes of Health/SBIB
    Role: Consultant
    $356,467
  • April 2018–February 2020
    Liposomal Delivery of a Novel Peptide N-Acetyl-Ser-Asp-Lys-Pro to Inhibit Cancer Radiotherapy-Induced Cardiac Damage.
    National Institutes of Health/NHLBI
    Role: Consultant
    $462,000
  • April 2014–April 2015
    Innovative Micro-Programs Accelerating Collaboration in Themes (IMPACT)
    University of Buffalo
    Role: Principal Investigator
    $29,000
  • January 2006–June 2006
    American Heart Association, Pre-Doctoral Fellowship Grant
    Americah Heart Association
    Role: Principal Investigator
    $50,000

Journal Articles:

See all (61 more)

Abstracts:

  • Papadopoulos G, Vakkalanka S, Adib K, Sharma U,Page BJ. (2016) Clinical utility of coronary computed tomography angiography to evaluate patients with mildly elevated troponins without clinically manifest acute coronary syndrome. J Am College of Card, (Jan)

Presentations:

  • "Cancer Therapy-Induced Cardiotoxicities: Virtuous Intentions, Malign Consequences" Research Conference-University of Minnesota (2023)
  • "Radiation-Induced Cardiac Damage and Its Management" American Physiological Society Annual Conference (2023)
  • "Early Detection and Therapeutic Modulation of Radiation-Induced Heart Disease" First International Society of Cardio-Oncology (2022)

Service Activities:

  • KL2 Leadership Team Member; Buffalo Translational Consortium.; Member (2019–present)
  • Central Society for Clinical and Translational Research; Member (2018–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Clinical & Translational Research Center
875 Ellicott Street
Room 7030
Buffalo, New York 14203
Phone: 716-829-2663
Fax: 716-854-1840
sharmau@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD