Vincent M. Tutino Ph.D
Vincent M. Tutino
Ph.D
Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Aneurysms – Intracranial; Biomedical Engineering; Biomedical Imaging; Biomedical Imaging; Cardiovascular Disease; Cerebrovascular (Stroke); Gene Expression; Gene Sequencing; Hematology; Hemostasis / Thrombosis; Inflammation; Quantitative Histology; RNA; Stroke; Transcription and Translation; Transcriptomics; Translational Research; Vascular and Interventional Radiology; Vascular Malformations
Professional Summary:
I am passionate about conducting translational research in the field of neurovascular diseases, with a specific focus on ischemic stroke, intracranial aneurysm, subarachnoid hemorrhage, and reperfusion injury. My research interests lie at the intersection of biomarker development, computational biology, and big data analysis. I strive to leverage cutting-edge technologies such as transcriptomics, systems biology, and experimental models of vascular disease to gain a comprehensive understanding of these complex conditions.
In my research, I also explore the application of advanced imaging techniques, such as CT imaging and digital pathology, to enhance diagnostics and prognostics in neurovascular diseases. I have a keen interest in developing novel methods for image processing and segmentation, leveraging machine learning and deep learning algorithms to extract meaningful information from medical images. By integrating spatial sequencing data and utilizing biobanking resources, I strive to uncover molecular signatures and identify potential therapeutic targets for improved patient outcomes.
Furthermore, I am broadly interested in the field of hematology and the role of the circulating blood, as a tissue, in the pathophysiology of stroke and aneurysm, their endovascular treatment, and their healing. In addition, investigating systems biology, and how the blood can be used as a surrogate biomarker tissue of the disease, I am also interested in blood clotting and its role in aneurysm and stroke. Along with collaborators in the field of mechanical engineering, I use simulation to conduct research on the efficacy of endovascular devices, such as mechanical thrombectomy, in treating ischemic strokes by removing complex blood clots. I am enthusiastic about utilizing numerical simulations to model and optimize these devices' performance, contributing to advancements in the field of neurovascular interventions.
Overall, my research interests span a diverse range of areas, including biomarker development, computational biology, big data analysis, image processing, and machine learning, all with a specific focus on neurovascular diseases. I am committed to making significant contributions to the field through a multidisciplinary approach that integrates clinical insights, experimental models, and advanced technologies.
Education and Training:
- Other, National Science Foundation, I-Corps Shor Course, QAS.AI, Inc. (2020)
- Certificate, Fundamentals & Applications of Clinical and Translational Research, Harvard University (2019)
- PhD, Biomedical Engineering, University at Buffalo (2018)
- Other, National Science Foundation, I-Corps Short Course, Neurovascular Diagnostics, Inc. (2017)
- MS, Biomedical Engineering, University at Buffalo (2014)
- BS, Chemistry, St. John Fisher University, Magna Cum Laude (2010)
- Internship, Chemical Engineering University of Rochester, University of Rochester (2005)
Employment:
- Member, Board of Directors, Brain Aneurysm Foundation (2023-present)
- Member, Board of Directors, QAS.AI, Inc. (2020-present)
- Vice-President and CFO, QAS.AI, Inc. (2020-present)
- Affiliated Assistant Professor, Biomedical Engineering, University at Buffalo (2018-present)
- Affiliated Assistant Professor, Mechanical and Aerospace Engineering, University at Buffalo (2018-present)
- Member, Board of Directors, Neurovascular Diagnostics, Inc. (2016-present)
- President and CEO, Neurovascular Diagnostics, Inc. (2016-present)
- Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo (2022-present)
- Research Assistant Professor, Neurosurgery, University at Buffalo (2018–2022)
Awards and Honors:
- National NSF I-Corps Program, Atlanta-Winter Cohort, Industry Mentor (2021)
- REU program, National Science Foundation (2021)
- 200K Challenge 2nd Place Winner (2019)
- Emerging Company (2017)
- MEDTECH 2017 Invitee (2017)
- New York Small Business Development Center (NYSBDC) Pilot SBIR/STTR Acceleration Contest (2016)
- OutputLinks Winner (2013)
- Transfer Achievement Scholarship (2007)
- Dean's List (2007)
- Advanced Placement Scholar Award (2006)
Research Expertise:
- Animal models of vascular disease: Rat, rabbit and mouse models of brain aneurysm and stroke
- Biobanking: Biobank of tissue and liquid biopsy for stroke, aneurysms, and brain tumors
- Gene expression profiling: transcriptomics of vascular diseases towards biomarker development
- Medical image analysis: CTA, nCCT, MRI, MRA, DSA
Research Centers:
- Center of Excellence in Bioinformatics and Life Sciences
- Clinical and Translational Research Center (CTRC)
- Toshiba Stroke Research Center
UB 2020 Strategic Strengths:
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- September 2023–August 2027
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
National Institutes of Health – NHLBI
Role: Co-Investigator
$4,000,000 - October 2023–September 2026
Liquid and endovascular coil biopsy for understanding sex differences in Intracranial Aneurysms
CNS – Joint CV Section/CNSF Young Investigator’s Award
Role: Co-Investigator
$150,000 - May 2023–April 2025
An AI-Enhanced Angiographic System to Guide Endovascular Treatment of Intracranial Aneurysms
National Science Foundation
Role: Co-Investigator
$1,000,000 - September 2023–August 2024
Development of a Molecular Diagnostic to Identify Dangerous Intracranial Aneurysms
National Institutes of Health – NINDS
Role: Co-Principal Investigator
$2,900,000 - July 2022–August 2024
Hemodynamically-Induced Molecules Regulating the Initiation of Intracranial Aneurysm
National Institutes of Health – NINDS
Role: Co-Principal Investigator
$475,000 - June 2022–June 2024
Validation of a Blood-Based Diagnostic Assay for Rupture Risk Assessment of Intracranial Aneurysms
Center for Advanced Technology (NYSTAR)
Role: Principal Investigator
$117,000 - November 2020–November 2023
An AI-Enhanced Angiographic System to Guide Endovascular Treatment of Intracranial Aneurysms
National Science Foundation
Role: Co-Investigator
$256,000 - August 2019–November 2023
A Blood-Based Test to Identify Patients with Intracranial Aneurysm
National Science Foundation
Role: Co-Principal Investigator
$750,000 - September 2022–August 2023
Combination Blood and MRI Biomarkers for Rupture Risk Assessment of Brain Aneurysms
Brain Aneurysm Foundation
Role: Co-Investigator
$50,000 - August 2020–August 2023
Exploring Mechanisms of Intracranial Aneurysm Rupture through Magnetic Vessel Wall Imaging
SUNY Research Seed Grant Program
Role: Principal Investigator
$30,000 - October 2021–August 2022
Finite Element Analysis for Flow Diverter Simulation
MEDTRONIC
Role: Principal Investigator
$24,000 - September 2021–August 2022
Blood-Based Biomarkers Associated with Aneurysm Vessel Wall Enhancement on Post-Contrast MRI
Brain Aneurysm Foundation
Role: Principal Investigator
$30,000 - July 2021–June 2022
Validation of AneuScreenTM, a Novel Blood-Based Diagnostic Prototype for Detection of Unruptured Brain Aneurysms
Center for Advanced Technology (NYSTAR)
Role: Principal Investigator
$93,000 - May 2021–April 2022
Small RNA Biomarkers for Brain Injury
UB – Buffalo Blue Sky Grant
Role: Co-Investigator
$25,000 - November 2019–November 2021
Molecular Biomarkers of Dangerous Intracranial Aneurysms
National Institutes of Health – NINDS
Role: Principal Investigator
$225,000 - September 2020–August 2021
A Whole Blood RNA Diagnostic for Unruptured Brain Aneurysm: Risk Assessment Prototype Development and Testing
Brain Aneurysm Foundation
Role: Principal Investigator
$40,000 - September 2019–August 2020
Circulating Molecular Markers of High-Risk Brain Aneurysms from Circulating Neutrophil Gene Expression
Brain Aneurysm Foundation
Role: Principal Investigator
$45,000 - July 2019–June 2020
Validation of a Blood-Based Diagnostic Prototype for Detection of Unruptured Brain Aneurysms
Center for Advanced Technology (NYSTAR)
Role: Principal Investigator
$26,000 - September 2018–August 2019
A Prototype Blood Test for Detecting Unruptured Brain Aneurysms
Brain Aneurysm Foundation
Role: Principal Investigator
$50,000 - July 2018–June 2019
Development of Whole Blood RNA Expression-Based Assay for Detecting Unruptured Brain Aneurysms
Center for Advanced Technology (NYSTAR).
Role: Principal Investigator
$43,500 - May 2018–May 2019
Biomarkers for Ischemic Stroke Origin
UB CTSI – Clinical and Translational Science Award: Pilot Study
Role: Co-Investigator
$50,000 - January 2018–January 2019
A Blood-Based Test to Identify Patients with Intracranial Aneurysm
National Science Foundation
Role: Principal Investigator
$224,000 - June 2018–December 2018
Blood Testing for Detecting Brain Aneurysm
UB – Small Business Innovation Award
Role: Principal Investigator
$13,500 - October 2017–October 2018
Tissue Bank to Facilitate Translational Research in Stroke Diagnostics
James H. Cummings Foundation
Role: Co-Investigator
$25,000 - September 2017–August 2018
Feasibility of Detecting Brain Aneurysm Biomarkers in Whole Blood on a Diagnostic Platform
Brain Aneurysm Foundation
Role: Principal Investigator
$45,000 - January 2018–June 2018
Detecting Brain Aneurysm Biomarkers in Whole Blood on a Diagnostic Platform
Center for Advanced Technology (NYSTAR)
Role: Principal Investigator
$23,300 - September 2015–August 2016
MicroRNA in Unruptured Intracranial Aneurysm: Fostering a Mechanism of Early Detection
Brain Aneurysm Foundation
Role: Co-Investigator
$25,000 - January 2019
BIG Incentive Proposal
Buffalo Institute of Genomics (NYSTAR)
Role: Principal Investigator
$50,000 - Brain Aneurysm Research in the Tutino Lab
The Ascanio and Jean Boccuti Family Charitable Fund
Role: Principal Investigator
$27,000
Patents:
- Biomarkers for intracranial aneurysm Provided are methods for determining a presence of an intracranial aneurysm in a subject suspected of having an intracranial aneurysm or at risk for developing an intracra nial aneurysm, or a subject in need of aneurysm monitoring. The method involves analyzing a biological sample from the subject for expression of a combination of biomarkers that provide a signature of an aneurism. Specification includes a Sequence Listing. (2020)
Journal Articles:
- Yang K, Musio F, Ma Y, Juchler N, Paetzold JC, Al-Maskari R, Höher L, Li HB, Hamamci IE, Sekuboyina A, Shit S, Huang H, Waldmannstetter D, Kofler F, Navarro F, Menten M, Ezhov I, Rueckert D, Vos I, Ruigrok Y, Velthuis B, Kuijf H, Hämmerli J, Wurster C, Bijlenga P, Westphal L, Bisschop J, Colombo E, Baazaoui H, Makmur A, Hallinan J, Wiestler B, Kirschke JS, Wiest R, Montagnon E, Letourneau-Guillon L, Galdran A, Galati F, Falcetta D, Zuluaga MA, Lin C, Zhao H, Zhang Z, Ra S, Hwang J, Park H, Chen J, Wodzinski M, Müller H, Shi P, Liu W, Ma T, Yalçin C, Hamadache RE, Salvi J, Llado X, Maria Lal-Trehan Estrada U, Abramova V, Giancardo L, Oliver A, Liu J, Huang H, Cui Y, Lin Z, Liu Y, Zhu S, Patel TR, Tutino VM, Orouskhani M, Wang H, Mossa-Basha M, Zhu C, Rokuss MR, Kirchhoff Y, Disch N, Holzschuh J, Isensee F, Maier-Hein K, Sato Y, Hirsch S, Wegener S, Menze B. (2024) TopCoW: Benchmarking Topology-Aware Anatomical Segmentation of the Circle of Willis (CoW) for CTA and MRA. ArXiv (Jan).
- Waqas M, Monteiro A, Tutino VM, Cappuzzo JM, Vakharia K, Winograd EK, Goulenko V, Gong AD, Snyder KV, Davies JM, Levy EI, Prasad D, Siddiqui AH. (2024) Preradiosurgical Embolization of Arteriovenous Malformations Reduces Target Volume - The Main Determinant for Complete Obliteration. World neurosurgery (Jan), 181: e117-e125.
- Dmytriw AA, Musmar B, Salim H, Aslan A, Cancelliere NM, McLellan RM, Algin O, Ghozy S, Dibas M, Lay SV, Guenego A, Renieri L, Carnevale JA, Saliou G, Mastorakos P, El Naamani K, Shotar E, Premat K, Möhlenbruch MA, Kral M, Doron O, Chung C, Salem MM, Lylyk I, Foreman PM, Vachhani JA, Shaikh H, Župancic V, Hafeez MU, Catapano JS, Waqas M, Tutino VM, Ibrahim MK, Mohammed MA, Imamoglu C, Bayrak A, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kuhn AL, Michelozzi C, Elens S, Hasan Z, Starke RM, Hassan AE, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Nawka MT, Psychogios MN, Ulfert C, Diestro JDB, Pukenas B, Burkhardt JK, Huynh TJ, Martinez-Gutierrez JC, Essibayi MA, Sheth SA, Spiegel G, Tawk R, Lubicz B, Panni P, Puri AS, Pero G, Nossek E, Raz E, Killer-Oberpfalzer M, Griessenauer CJ, Asadi H, Siddiqui AH, Brook AL, Altschul D, Ducruet AF, Albuquerque FC, Regenhardt RW, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu SR, Knopman J, Aziz-Sultan MA, Tjoumakaris SI, Clarençon F, Limbucci N, Cuellar HH, Jabbour PM, Pereira VM, Patel AB, Adeeb N. (2024) The impact of postoperative aspirin in patients undergoing Woven EndoBridge: a multicenter, institutional, propensity score-matched analysis. Journal of neurointerventional surgery (Jan).
- Tumenbayar BI, Tutino VM, Brazzo JA, Yao P, Bae Y. (2024) FAK and p130Cas modulate stiffness-mediated early transcription and cellular metabolism. bioRxiv : the preprint server for biology (Jan). doi:10.1101/2024.01.15.575789
- Santo BA, Jenkins TD, Ciecierska SK, Baig AA, Levy EI, Siddiqui AH, Tutino VM. (2024) MicroCT and Histological Analysis of Clot Composition in Acute Ischemic Stroke : A Comparative Study of MT-Retrieved Clots and Clot Analogs. Clinical neuroradiology (Jan).
- Santo BA, Janbeh Sarayi SMM, McCall AD, Monteiro A, Donnelly B, Siddiqui AH, Tutino VM. (2023) Multimodal CT imaging of ischemic stroke thrombi identifies scale-invariant radiomic features that reflect clot biology. Journal of neurointerventional surgery (Dec), 15(12): 1257-1263. doi:10.1136/jnis-2022-019967
- Biber JC, Sullivan A, Brazzo JA, Heo Y, Tumenbayar BI, Krajnik A, Poppenberg KE, Tutino VM, Heo SJ, Kolega J, Lee K, Bae Y. (2023) Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cells. APL bioengineering (Dec), 7(4): 046108. doi:10.1063/5.0150532
- Diestro JDB, Dibas M, Adeeb N, Regenhardt RW, Vranic JE, Guenego A, Lay SV, Renieri L, Balushi AA, Shotar E, Premat K, Namaani KE, Saliou G, Möhlenbruch MA, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Rai H, Tutino VM, Mirshahi S, Ghozy S, Harker P, Alotaibi NM, Rabinov JD, Ren Y, Schirmer CM, Goren O, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Salehani A, Nguyen A, Jones J, Psychogios M, Spears J, Marotta T, Pereira V, Parra-Fariñas C, Bres-Bullrich M, Mayich M, Salem MM, Burkhardt JK, Jankowitz BT, Domingo RA, Huynh T, Tawk R, Ulfert C, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet AF, Albuquerque FC, Patel N, Kan P, Kalousek V, Lylyk P, Boddu S, Stapleton CJ, Knopman J, Jabbour P, Tjoumakaris S, Clarençon F, Limbucci N, Aziz-Sultan MA, Cuellar-Saenz HH, Cognard C, Patel AB, Dmytriw AA. (2023) Stent-assisted Woven EndoBridge device for the treatment of intracranial aneurysms: an international multicenter study. Journal of neurosurgery (Oct)1-9.
- Patel TR, Patel A, Veeturi SS, Shah M, Waqas M, Monteiro A, Baig AA, Pinter N, Levy EI, Siddiqui AH, Tutino VM. (2023) Evaluating a 3D deep learning pipeline for cerebral vessel and intracranial aneurysm segmentation from computed tomography angiography-digital subtraction angiography image pairs. Neurosurgical focus (Jun), 54(6): E13.
- El Naamani K, Mastorakos P, Adeeb N, Lan M, Castiglione J, Khanna O, Diestro JDB, McLellan RM, Dibas M, Vranic JE, Aslan A, Cuellar-Saenz HH, Guenego A, Carnevale J, Saliou G, Ulfert C, Möhlenbruch M, Foreman PM, Vachhani JA, Hafeez MU, Waqas M, Tutino VM, Rabinov JD, Ren Y, Michelozzi C, Spears J, Panni P, Griessenauer CJ, Asadi H, Regenhardt RW, Stapleton CJ, Ghozy S, Siddiqui A, Patel NJ, Kan P, Boddu S, Knopman J, Aziz-Sultan MA, Zanaty M, Ghosh R, Abbas R, Amllay A, Tjoumakaris SI, Gooch MR, Cancelliere NM, Herial NA, Rosenwasser RH, Zarzour H, Schmidt RF, Pereira VM, Patel AB, Jabbour P, Dmytriw AA, . (2023) Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge (WEB) Device: a Retrospective Multicenter Observational Study. Translational stroke research (May).
- Lim J, Baig AA, Donnelly BM, Chaves LD, Pol SU, Koenigsknecht C, Pionessa D, Levy BR, Gutierrez L, Tutino VM, Levy EI, Siddiqui AH. (2023) The first endovascular rat glioma model for pre-clinical evaluation of intra-arterial therapeutics. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (May)15910199231169597.
- Patel TR, Santo BA, Baig AA, Waqas M, Monterio A, Levy EI, Siddiqui AH, Tutino VM. (2023) Histologically interpretable clot radiomic features predict treatment outcomes of mechanical thrombectomy for ischemic stroke. Neuroradiology (Apr), 65(4): 737-749.
- Santo BA, Ciecierska SK, Mousavi Janbeh Sarayi SM, Jenkins TD, Baig AA, Monteiro A, Koenigsknecht C, Pionessa D, Gutierrez L, King RM, Gounis M, Siddiqui AH, Tutino VM. (2023) Tectonic infarct analysis: A computational tool for automated whole-brain infarct analysis from TTC-stained tissue. Heliyon (Apr), 9(4): e14837. doi:10.1016/j.heliyon.2023.e14837
- Yoshida T, Latt KZ, Santo BA, Shrivastav S, Zhao Y, Fenaroli P, Chung JY, Hewitt SM, Tutino VM, Sarder P, Rosenberg AZ, Winkler CA, Kopp JB. (2023) APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice. bioRxiv : the preprint server for biology (Mar). doi:10.1101/2023.03.27.534273
- Poppenberg KE, Chien A, Santo BA, Baig AA, Monteiro A, Dmytriw AA, Burkhardt JK, Mokin M, Snyder KV, Siddiqui AH, Tutino VM. (2023) RNA Expression Signatures of Intracranial Aneurysm Growth Trajectory Identified in Circulating Whole Blood. Journal of personalized medicine (Jan), 13(2). doi:10.3390/jpm13020266
- Poppenberg KE, Chien A, Santo BA, Chaves L, Veeturi SS, Waqas M, Monteiro A, Dmytriw AA, Burkhardt JK, Mokin M, Snyder KV, Siddiqui AH, Tutino VM. (2023) Profiling of Circulating Gene Expression Reveals Molecular Signatures Associated with Intracranial Aneurysm Rupture Risk. Molecular diagnosis & therapy (Jan), 27(1): 115-127. doi:10.1007/s40291-022-00626-x
- Veeturi SS, Patel TR, Baig AA, Chien A, Monteiro A, Waqas M, Snyder KV, Siddiqui AH, Tutino VM. (2022) Hemodynamic Analysis Shows High Wall Shear Stress Is Associated with Intraoperatively Observed Thin Wall Regions of Intracranial Aneurysms. Journal of cardiovascular development and disease (Nov), 9(12). doi:10.3390/jcdd9120424
- Dmytriw AA, Dibas M, Ghozy S, Adeeb N, Diestro JDB, Phan K, Cuellar-Saenz HH, Sweid A, Lay SV, Guenego A, Renieri L, Al Balushi A, Saliou G, Möhlenbruch M, Regenhardt RW, Vranic JE, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Tutino VM, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Sporns P, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Du R, Kan P, Kalousek V, Lylyk P, Boddu S, Tjoumakaris S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB. (2022) The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium. Translational stroke research (Sep).
- Adeeb N, Dibas M, Diestro JDB, Cuellar-Saenz HH, Sweid A, Kandregula S, Lay SV, Guenego A, Renieri L, Sundararajan SH, Saliou G, Aslan A, Möhlenbruch M, Vranic JE, Regenhardt RW, Savardekar A, Mamilly A, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Parra Farinas C, Tutino VM, Inoue Y, Mirshahi S, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Sporns P, Brehm A, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. (2022) Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge (WEB). Radiology (Aug), 304(2): 372-382.
- Diestro JDB, Dibas M, Adeeb N, Regenhardt RW, Vranic JE, Guenego A, Lay SV, Renieri L, Al Balushi A, Shotar E, Premat K, El Naamani K, Saliou G, Möhlenbruch MA, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Rai H, Tutino VM, Mirshani S, Ghozy S, Harker P, Alotaibi NM, Rabinov JD, Ren Y, Schirmer CM, Goren O, Piano M, Kuhn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Nguyen A, Jones J, Psychogios M, Spears J, Parra-Fariñas C, Bres Bullrich M, Mayich M, Salem MM, Burkhardt JK, Jankowitz BT, Domingo RA, Huynh T, Tawk R, Ulfert C, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet AF, Albuquerque FC, Du R, Kan P, Kalousek V, Lylyk P, Boddu SR, Stapleton CJ, Knopman J, Jabbour P, Tjoumakaris S, Clarençon F, Limbucci N, Aziz-Sultan MA, Cuellar-Saenz HH, Cognard C, Patel AB, Dmytriw AA. (2022) Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study. Journal of neurointerventional surgery (Jul).
- Dmytriw AA, Ghozy S, Sweid A, Piotin M, Bekelis K, Sourour N, Raz E, Vela-Duarte D, Linfante I, Dabus G, Kole M, Martínez-Galdámez M, Nimjee SM, Lopes DK, Hassan AE, Kan P, Ghorbani M, Levitt MR, Escalard S, Missios S, Shapiro M, Clarençon F, Elhorany M, Tahir RA, Youssef PP, Pandey AS, Starke RM, El Naamani K, Abbas R, Mansour OY, Galvan J, Billingsley JT, Mortazavi A, Walker M, Dibas M, Settecase F, Heran MKS, Kuhn AL, Puri AS, Menon BK, Sivakumar S, Mowla A, D'Amato S, Zha AM, Cooke D, Vranic JE, Regenhardt RW, Rabinov JD, Stapleton CJ, Goyal M, Wu H, Cohen J, Turkel-Parella D, Xavier A, Waqas M, Tutino V, Siddiqui A, Gupta G, Nanda A, Khandelwal P, Tiu C, Portela PC, Perez de la Ossa N, Urra X, de Lera M, Arenillas JF, Ribo M, Requena M, Piano M, Pero G, De Sousa K, Al-Mufti F, Hashim Z, Nayak S, Renieri L, Du R, Aziz-Sultan MA, Liebeskind D, Nogueira RG, Abdalkader M, Nguyen TN, Vigilante N, Siegler JE, Grossberg JA, Saad H, Gooch MR, Herial NA, Rosenwasser RH, Tjoumakaris S, Patel AB, Tiwari A, Jabbour P, . (2022) International controlled study of revascularization and outcomes following COVID-positive mechanical thrombectomy. European journal of neurology (Jul). doi:10.1111/ene.15493
- Tutino VM, Fricano S, Chien A, Patel TR, Monteiro A, Rai HH, Dmytriw AA, Chaves LD, Waqas M, Levy EI, Poppenberg KE, Siddiqui AH. (2022) Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology. Journal of neurointerventional surgery (Jun).
- Jabbour P, Dmytriw AA, Sweid A, Piotin M, Bekelis K, Sourour N, Raz E, Linfante I, Dabus G, Kole M, Martínez-Galdámez M, Nimjee SM, Lopes DK, Hassan AE, Kan P, Ghorbani M, Levitt MR, Escalard S, Missios S, Shapiro M, Clarençon F, Elhorany M, Vela-Duarte D, Tahir RA, Youssef PP, Pandey AS, Starke RM, El Naamani K, Abbas R, Hammoud B, Mansour OY, Galvan J, Billingsley JT, Mortazavi A, Walker M, Dibas M, Settecase F, Heran MKS, Kuhn AL, Puri AS, Menon BK, Sivakumar S, Mowla A, D'Amato S, Zha AM, Cooke D, Goyal M, Wu H, Cohen J, Turkel-Parrella D, Xavier A, Waqas M, Tutino VM, Siddiqui A, Gupta G, Nanda A, Khandelwal P, Tiu C, Portela PC, Perez de la Ossa N, Urra X, de Lera M, Arenillas JF, Ribo M, Requena M, Piano M, Pero G, De Sousa K, Al-Mufti F, Hashim Z, Nayak S, Renieri L, Aziz-Sultan MA, Nguyen TN, Feineigle P, Patel AB, Siegler JE, Badih K, Grossberg JA, Saad H, Gooch MR, Herial NA, Rosenwasser RH, Tjoumakaris S, Tiwari A. (2022) Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study. Neurosurgery (Jun), 90(6): 725-733.
- Adeeb N, Dibas M, Diestro JDB, Phan K, Cuellar-Saenz HH, Sweid A, Lay SV, Guenego A, Aslan A, Renieri L, Sundararajan SH, Saliou G, Möhlenbruch M, Regenhardt RW, Vranic JE, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Tutino VM, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kuhn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Brehm A, MohammedAli M, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet A, Albuquerque FC, Du R, Kan P, Kalousek V, Lylyk P, Stapleton CJ, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. (2022) Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device. Journal of neurointerventional surgery (Apr).
- Waqas M, Monteiro A, Cappuzzo JM, Tutino VM, Levy EI. (2022) Evolution of the patient-first approach: a dual-trained, single-neurosurgeon experience with 2002 consecutive intracranial aneurysm treatments. Journal of neurosurgery (Apr)1-7.
- Waqas M, Li W, Patel TR, Chin F, Tutino VM, Dossani RH, Ren Z, Guerrero WR, Borlongan CV, Pressman E, Snyder K, Davies JM, Ley EI, Ionita CN, Siddiqui AH, Mokin M. (2022) Clot imaging characteristics predict first pass effect of aspiration-first approach to thrombectomy. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (Apr), 28(2): 152-159. doi:10.1177/15910199211019174
- Waqas M, Tutino VM, Cappuzzo JM, Lazarov V, Popoola D, Patel TR, Levy BR, Monteiro A, Mokin M, Rai AT, Mocco J, Turk AS, Snyder KV, Davies JM, Levy EI, Siddiqui AH. (2022) Stroke thrombectomy volume, rather than stroke center accreditation status of hospitals, is associated with mortality and discharge disposition. Journal of neurointerventional surgery (Mar).
- Dmytriw AA, Dibas M, Adeeb N, Salem MM, Salehani A, Waqas M, Saad Aldine A, Tutino VM, Ogilvy CS, Siddiqui AH, Harrigan MR, Thomas AJ, Cuellar H, Griessenauer CJ. (2022) The Pipeline Embolization Device: a decade of lessons learned in the treatment of posterior circulation aneurysms in a multicenter cohort. Journal of neurosurgery (Mar)1-8.
- Tutino VM, Kuo CC, Avasthi N, Rai HH, Waqas M, Siddiqui AH, Jarvis JN, Poppenberg KE. (2022) Chromatin architecture around stroke haplotypes provides evidence that genetic risk is conferred through vascular cells. Epigenomics (Mar), 14(5): 243-259.
- Shlobin NA, Baig AA, Waqas M, Patel TR, Dossani RH, Wilson M, Cappuzzo JM, Siddiqui AH, Tutino VM, Levy EI. (2022) Artificial Intelligence for Large-Vessel Occlusion Stroke: A Systematic Review. World neurosurgery (Mar), 159: 207-220.e1. doi:10.1016/j.wneu.2021.12.004
- Rajabzadeh-Oghaz H, Siddiqui AH, Asadollahi A, Kolega J, Tutino VM. (2022) The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review. Neurosurgical review (Feb), 45(1): 49-61.
- Dibas M, Adeeb N, Diestro JDB, Cuellar HH, Sweid A, Lay SV, Guenego A, Aslan A, Renieri L, Sundararajan SH, Saliou G, Möhlenbruch M, Regenhardt RW, Vranic JE, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Tutino VM, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Salehani A, Sporns P, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. (2022) Transradial versus transfemoral access for embolization of intracranial aneurysms with the Woven EndoBridge device: a propensity score-matched study. Journal of neurosurgery (Feb)1-8.
- Aldstadt J, Waqas M, Yasumiishi M, Mokin M, Tutino VM, Rai HH, Chin F, Levy BR, Rai AT, Mocco J, Snyder KV, Davies JM, Levy EI, Siddiqui AH. (2022) Mapping access to endovascular stroke care in the USA and implications for transport models. Journal of neurointerventional surgery (Jan), 14(1).
- Shields A, Williams K, Veeturi SS, Tutino V, Ionita C, Bednarek DR, Rudin S. (2022) Initial evaluation of 2D and 3D simulated high-speed 1000 fps vascular contrast-flow image sequences using computational fluid dynamics (CFD). Proceedings of SPIE--the International Society for Optical Engineering (Jan), 12036. doi:10.1117/12.2611170
- Crinzi EA, Haley EK, Poppenberg KE, Jiang K, Tutino VM, Jarvis JN. (2022) Analysis of chromatin data supports a role for CD14+ monocytes/macrophages in mediating genetic risk for juvenile idiopathic arthritis. Frontiers in immunology (Jan), 13: 913555. doi:10.3389/fimmu.2022.913555
- Mousavi J S SM, Faghihi D, Sommer K, Bhurwani MMS, Patel TR, Santo B, Waqas M, Ionita C, Levy EI, Siddiqui AH, Tutino VM. (2021) Realistic computer modelling of stent retriever thrombectomy: a hybrid finite-element analysis-smoothed particle hydrodynamics model. Journal of the Royal Society, Interface (Dec), 18(185): 20210583. doi:10.1098/rsif.2021.0583
- Patel TR, Pinter N, Sarayi SMMJ, Siddiqui AH, Tutino VM, Rajabzadeh-Oghaz H. (2021) Automated Cerebral Vessel Segmentation of Magnetic Resonance Imaging in Patients with Intracranial Atherosclerotic Diseases. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (Nov), 2021: 3920-3923.
- Veeturi SS, Rajabzadeh-Oghaz H, Pintér NK, Waqas M, Hasan DM, Snyder KV, Siddiqui AH, Tutino VM. (2021) Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms. Royal Society open science (Nov), 8(11): 211119. doi:10.1098/rsos.211119
- Tutino VM, Zebraski HR, Rajabzadeh-Oghaz H, Chaves L, Dmytriw AA, Siddiqui AH, Kolega J, Poppenberg KE. (2021) RNA Sequencing Data from Human Intracranial Aneurysm Tissue Reveals a Complex Inflammatory Environment Associated with Rupture. Molecular diagnosis & therapy (Nov), 25(6): 775-790.
- Patel TR, Waqas M, Sarayi SMMJ, Ren Z, Borlongan CV, Dossani R, Levy EI, Siddiqui AH, Snyder KV, Davies JM, Mokin M, Tutino VM. (2021) Revascularization Outcome Prediction for A Direct Aspiration-First Pass Technique (ADAPT) from Pre-Treatment Imaging and Machine Learning. Brain sciences (Oct), 11(10). doi:10.3390/brainsci11101321
- Tutino VM, Rajabzadeh-Oghaz H, Veeturi SS, Poppenberg KE, Waqas M, Mandelbaum M, Liaw N, Siddiqui AH, Meng H, Kolega J. (2021) Endogenous animal models of intracranial aneurysm development: a review. Neurosurgical review (Oct), 44(5): 2545-2570. doi:10.1007/s10143-021-01481-w
- Tutino VM, Fricano S, Frauens K, Patel TR, Monteiro A, Rai HH, Waqas M, Chaves L, Poppenberg KE, Siddiqui AH. (2021) Isolation of RNA from Acute Ischemic Stroke Clots Retrieved by Mechanical Thrombectomy. Genes (Oct), 12(10). doi:10.3390/genes12101617
- Veeturi SS, Pinter NK, Monteiro A, Baig AA, Rai HH, Waqas M, Siddiqui AH, Rajabzadeh-Oghaz H, Tutino VM. (2021) An Image-Based Workflow for Objective Vessel Wall Enhancement Quantification in Intracranial Aneurysms. Diagnostics (Basel, Switzerland) (Sep), 11(10). doi:10.3390/diagnostics11101742
- Sommer KN, Bhurwani MMS, Tutino V, Siddiqui A, Davies J, Snyder K, Levy E, Mokin M, Ionita CN. (2021) Use of patient specific 3D printed neurovascular phantoms to simulate mechanical thrombectomy. 3D printing in medicine (Sep), 7(1): 32. doi:10.1186/s41205-021-00122-8
- Kolega J, Poppenberg KE, Lim HW, Gutierrez LC, Veeturi SS, Siddiqui AH, Rajabzadeh-Oghaz H, Tutino VM. (2021) Identification of intima-to-media signals for flow-induced vascular remodeling using correlative gene expression analysis. Scientific reports (Aug), 11(1): 16142. doi:10.1038/s41598-021-95403-x
- Tutino VM, Lu Y, Ishii D, Poppenberg KE, Rajabzadeh-Oghaz H, Siddiqui AH, Hasan DM. (2021) Aberrant Whole Blood Gene Expression in the Lumen of Human Intracranial Aneurysms. Diagnostics (Basel, Switzerland) (Aug), 11(8). doi:10.3390/diagnostics11081442
- Tutino VM, Zebraski HR, Rajabzadeh-Oghaz H, Waqas M, Jarvis JN, Bach K, Mokin M, Snyder KV, Siddiqui AH, Poppenberg KE. (2021) Identification of Circulating Gene Expression Signatures of Intracranial Aneurysm in Peripheral Blood Mononuclear Cells. Diagnostics (Basel, Switzerland) (Jun), 11(6). doi:10.3390/diagnostics11061092
- Poppenberg KE, Zebraski HR, Avasthi N, Waqas M, Siddiqui AH, Jarvis JN, Tutino VM. (2021) Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression. BMC medical genomics (Jun), 14(1): 162. doi:10.1186/s12920-021-01007-9
- Waqas M, Gong AD, Levy BR, Dossani RH, Vakharia K, Cappuzzo JM, Becker A, Sonig A, Tutino VM, Almayman F, Davies JM, Snyder KV, Siddiqui AH, Levy EI. (2021) Is Endovascular Therapy for Stroke Cost-Effective Globally? A Systematic Review of the Literature. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Apr), 30(4): 105557.
- Poppenberg KE, Tutino VM, Tarbell E, Jarvis JN. (2021) Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes. BMC medical genomics (Apr), 14(1): 114. doi:10.1186/s12920-021-00964-5
- Griessenauer CJ, Enriquez-Marulanda A, Xiang S, Hong T, Zhang H, Taussky P, Grandhi R, Waqas M, Tutino VM, Siddiqui AH, Levy EI, Ogilvy CS, Thomas AJ, Ulfert C, Möhlenbruch MA, Renieri L, Limbucci N, Parra-Fariñas C, Burkhardt JK, Kan P, Rinaldo L, Lanzino G, Brinjikji W, Spears J, Müller-Thies-Broussalis E, Killer-Oberpfalzer M, Islak C, Kocer N, Sonnberger M, Engelhorn T, Ghuman M, Yang VX, Salehani A, Harrigan MR, Radovanovic I, Pereira VM, Krings T, Matouk CC, Chen K, Aziz-Sultan MA, Ghorbani M, Schirmer CM, Goren O, Dalal SS, Koch MJ, Stapleton CJ, Patel AB, Finkenzeller T, Holtmannspötter M, Buhk JH, Foreman PM, Cress M, Hirschl R, Reith W, Simgen A, Janssen H, Marotta TR, Dmytriw AA. (2021) Comparison of PED and FRED flow diverters for posterior circulation aneurysms: a propensity score matched cohort study. Journal of neurointerventional surgery (Feb), 13(2): 153-158.
- Patel TR, Fricano S, Waqas M, Tso M, Dmytriw AA, Mokin M, Kolega J, Tomaszewski J, Levy EI, Davies JM, Snyder KV, Siddiqui AH, Tutino VM. (2021) Increased Perviousness on CT for Acute Ischemic Stroke is Associated with Fibrin/Platelet-Rich Clots. AJNR. American journal of neuroradiology (Jan), 42(1): 57-64. doi:10.3174/ajnr.A6866
- Tutino VM, Poppenberg KE, Damiano RJ, Patel TR, Waqas M, Dmytriw AA, Snyder KV, Siddiqui AH, Jarvis JN. (2020) Characterization of Long Non-coding RNA Signatures of Intracranial Aneurysm in Circulating Whole Blood. Molecular diagnosis & therapy (Dec), 24(6): 723-736.
- Poppenberg KE, Tutino VM, Li L, Waqas M, June A, Chaves L, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. (2020) Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm. Journal of translational medicine (Oct), 18(1): 392. doi:10.1186/s12967-020-02550-2
- Damiano RJ, Tutino VM, Paliwal N, Patel TR, Waqas M, Levy EI, Davies JM, Siddiqui AH, Meng H. (2020) Aneurysm characteristics, coil packing, and post-coiling hemodynamics affect long-term treatment outcome. Journal of neurointerventional surgery (Jul), 12(7): 706-713. doi:10.1136/neurintsurg-2019-015422
- Rajabzadeh-Oghaz H, van Ooij P, Veeturi SS, Tutino VM, Zwanenburg JJ, Meng H. (2020) Inter-patient variations in flow boundary conditions at middle cerebral artery from 7T PC-MRI and influence on Computational Fluid Dynamics of intracranial aneurysms. Computers in biology and medicine (May), 120: 103759.
- Dmytriw AA, Kapadia A, Enriquez-Marulanda A, Parra-Fariñas C, Kühn AL, Nicholson PJ, Waqas M, Renieri L, Michelozzi C, Foreman PM, Phan K, Yang IH, Tutino VM, Ogilvy CS, Radovanovic I, Harrigan MR, Siddiqui AH, Levy EI, Limbucci N, Cognard C, Krings T, Pereira VM, Thomas AJ, Marotta TR, Griessenauer CJ. (2020) Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversion. Journal of neurosurgery (Mar), 134(3): 961-970.
- Poppenberg KE, Li L, Waqas M, Paliwal N, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H, Tutino VM. (2020) Whole blood transcriptome biomarkers of unruptured intracranial aneurysm. PloS one (Jan), 15(11): e0241838. doi:10.1371/journal.pone.0241838
- Tutino VM, Yan AJ, Veeturi SS, Patel TR, Rajabzadeh-Oghaz H, Waqas M, Siddiqui AH, Tseng J, Kolega J. (2020) Landmark-Based Shape Analysis on Middle Cerebral Intracranial Aneurysms: A Geometric Morphometrics Approach to Infer Natural History. Current neurovascular research (Jan), 17(5): 725-735.
- Maragkos GA, Dmytriw AA, Salem MM, Tutino VM, Meng H, Cognard C, Machi P, Krings T, Mendes Pereira V. (2020) Overview of Different Flow Diverters and Flow Dynamics. Neurosurgery (Jan), 86(Suppl 1): S21-S34.
- Lamooki SR, Tutino VM, Paliwal N, Damiano RJ, Waqas M, Nagesh SSV, Rajabzadeh-Oghaz H, Vakharia K, Siddiqui AH, Meng H. (2020) Evaluation of Two Fast Virtual Stenting Algorithms for Intracranial Aneurysm Flow Diversion. Current neurovascular research (Jan), 17(1): 58-70.
- Poppenberg KE, Jiang K, Tso MK, Snyder KV, Siddiqui AH, Kolega J, Jarvis JN, Meng H, Tutino VM. (2019) Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium. BMC medical genomics (Oct), 12(1): 149. doi:10.1186/s12920-019-0591-7
- Waqas M, Rajabzadeh-Oghaz H, Tutino VM, Vakharia K, Poppenberg KE, Mowla A, Meng H, Siddiqui AH. (2019) Morphologic Parameters and Location Associated with Rupture Status of Intracranial Aneurysms in Elderly Patients. World neurosurgery (Sep), 129: e831-e837.
- Jiang K, Poppenberg KE, Wong L, Chen Y, Borowitz D, Goetz D, Sheehan D, Frederick C, Tutino VM, Meng H, Jarvis JN. (2019) RNA sequencing data from neutrophils of patients with cystic fibrosis reveals potential for developing biomarkers for pulmonary exacerbations. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (Mar), 18(2): 194-202. doi:10.1016/j.jcf.2018.05.014
- Paliwal N, Tutino VM, Shallwani H, Beecher JS, Damiano RJ, Shakir HJ, Atwal GS, Fennell VS, Natarajan SK, Levy EI, Siddiqui AH, Davies JM, Meng H. (2019) Ostium Ratio and Neck Ratio Could Predict the Outcome of Sidewall Intracranial Aneurysms Treated with Flow Diverters. AJNR. American journal of neuroradiology (Feb), 40(2): 288-294. doi:10.3174/ajnr.A5953
- Damiano RJ, Tutino VM, Lamooki SR, Paliwal N, Dargush GF, Davies JM, Siddiqui AH, Meng H. (2019) Improving accuracy for finite element modeling of endovascular coiling of intracranial aneurysm. PloS one (Jan), 14(12): e0226421. doi:10.1371/journal.pone.0226421
- Tutino VM, Poppenberg KE, Li L, Shallwani H, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. (2018) Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms. Journal of translational medicine (Dec), 16(1): 373. doi:10.1186/s12967-018-1749-3
- Paliwal N, Jaiswal P, Tutino VM, Shallwani H, Davies JM, Siddiqui AH, Rai R, Meng H. (2018) Outcome prediction of intracranial aneurysm treatment by flow diverters using machine learning. Neurosurgical focus (Nov), 45(5): E7. doi:10.3171/2018.8.FOCUS18332
- Rajabzadeh-Oghaz H, Varble N, Shallwani H, Tutino VM, Mowla A, Shakir HJ, Vakharia K, Atwal GS, Siddiqui AH, Davies JM, Meng H. (2018) Computer-Assisted Three-Dimensional Morphology Evaluation of Intracranial Aneurysms. World neurosurgery (Nov), 119: e541-e550. doi:10.1016/j.wneu.2018.07.208
- Varble N, Tutino VM, Yu J, Sonig A, Siddiqui AH, Davies JM, Meng H. (2018) Shared and Distinct Rupture Discriminants of Small and Large Intracranial Aneurysms. Stroke (Apr), 49(4): 856-864. doi:10.1161/STROKEAHA.117.019929
- Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H. (2018) Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. PloS one (Jan), 13(1): e0191407. doi:10.1371/journal.pone.0191407
- Tutino VM, Rajabzadeh-Oghaz H, Chandra AR, Gutierrez LC, Schweser F, Preda M, Chien A, Vakharia K, Ionita C, Siddiqui A, Kolega J. (2018) 9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics. Current neurovascular research (Jan), 15(4): 312-325.
- Paliwal N, Damiano RJ, Varble NA, Tutino VM, Dou Z, Siddiqui AH, Meng H. (2017) Methodology for Computational Fluid Dynamic Validation for Medical Use: Application to Intracranial Aneurysm. Journal of biomechanical engineering (Dec), 139(12). doi:10.1115/1.4037792
- Damiano RJ, Tutino VM, Paliwal N, Ma D, Davies JM, Siddiqui AH, Meng H. (2017) Compacting a Single Flow Diverter versus Overlapping Flow Diverters for Intracranial Aneurysms: A Computational Study. AJNR. American journal of neuroradiology (Mar), 38(3): 603-610. doi:10.3174/ajnr.A5062
- Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ. (2016) C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology (Aug), 148(4): 407-19. doi:10.1111/imm.12619
- Tutino VM, Liaw N, Spernyak JA, Ionita CN, Siddiqui AH, Kolega J, Meng H. (2016) Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats. Current neurovascular research (Jan), 13(1): 82-92. doi:10.2174/1567202612666151027143149
- Tutino VM, Mandelbaum M, Takahashi A, Pope LC, Siddiqui A, Kolega J, Meng H. (2015) Hypertension and Estrogen Deficiency Augment Aneurysmal Remodeling in the Rabbit Circle of Willis in Response to Carotid Ligation. Anatomical record (Hoboken, N.J. : 2007) (Nov), 298(11): 1903-10. doi:10.1002/ar.23205
- Xiang J, Tutino VM, Snyder KV, Meng H. (2014) CFD: computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment. AJNR. American journal of neuroradiology (Oct), 35(10): 1849-57. doi:10.3174/ajnr.A3710
- Meng H, Tutino VM, Xiang J, Siddiqui A. (2014) High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: toward a unifying hypothesis. AJNR. American journal of neuroradiology (Jul), 35(7): 1254-62. doi:10.3174/ajnr.A3558
- Tutino VM, Mandelbaum M, Choi H, Pope LC, Siddiqui A, Kolega J, Meng H. (2014) Aneurysmal remodeling in the circle of Willis after carotid occlusion in an experimental model. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Mar), 34(3): 415-24. doi:10.1038/jcbfm.2013.209
Professional Memberships:
- Congress of Neurological Surgeons; Associate Member (2023–present)
- Society of Vascular and Interventional Neurology (2022–present)
- American Association for Clinical Chemistry (2016–present)
- Biomedical Engineering Society; University at Buffalo Chapter (2013–2016)
- Collaborative Learning and Integrated Mentoring in the Biosciences (CLIMB) Program; CLIMB (2011–2016)
- American Association for the Advancement of Science (2010–2011)
- American Chemical Society (2007–2010)
- SB3C Foundation; The Summer Biomechanics Bioengineering and Biotransport Foundation
- American Heart Association; Stroke Council Council on Genomic and Precision Medicine (GPM)
Presentations:
- "Vessel Wall Imaging Radiomics as Biomarkers of Aneurysm Rupture Risk" AHA International Stroke Conference (2024)
- "Acute Ischemic Stroke Clot Analysis at the CSVRC" University College London, British Heart Foundation Lab Invitation Seminar (2023)
- "Circulating gene expression signatures as molecular markers for intracranial aneurysm detection and risk stratification" 19th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2023)
- "Molecular and Radiographic Signatures of Ischemic Stroke Etiology and Outcomes in Retrieved Thrombi" 19th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2023)
- "Aneurysm Biomarkers" 13th Cerebrovascular Complications Conference (3C) (2023)
- "Circulating Molecular Signatures of Intracranial Aneurysm" 16th International Conference on Subarachnoid Hemorrhage (2023)
- "Current Perspectives in Brain Aneurysm Research" Brain Aneurysm Foundation Seminar Series (2023)
- "A History of Brain Aneurysm Research" Brain Aneurysm Foundation Advocacy Day (2023)
- "Circulating transcriptome profiles reveal expression signatures of intracranial aneurysm rupture risk and potential role of fibronectin" 7th International Conference on Computational and Mathematical Biomedical Engineering (2022)
- "Development of a Blood-Based Diagnostic for Brain Aneurysms" Clinical and Translational Research Center Seminar Series (2021)
- "Developing Molecular Diagnostics of Intracranial Aneurysm: A Collision of Translational Research and Entrepreneurship." Mayo Clinic Neuroscience Grand Rounds (2021)
- "Translational Stroke Research" The “Circle of Willis” Webinar/Podcast (2021)
- "Development of Biological and Imaging Markers for Hemorrhagic and Ischemic Strokes" Geneva University Hospitals, Department of Clinical Neurosciences – Grand Rounds (2020)
- "A Blood-Based Diagnostic to Detect Brain Aneurysm: Translational Science Meets Entrepreneurship" Grand Rounds, Department of Pathology and Anatomical Sciences (2019)
- "Circulating Expression Biomarkers to Detect Unruptured Aneurysms" 16th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2019)
- "RNA Sequencing for Identification of Circulating Biomarkers to Detect Unruptured Intracranial Aneurysms" Upstate New York Illumina Next-Generation Sequencing (NGS) Seminar - UofR (2019)
- "Building Biomarkers of Brain Aneurysm" Department of Mechanical and Aerospace Engineering Spring Seminar Series (2019)
- "Blood Tests for Brain Aneurysms: My Experience in Translational Research" Mechanical and Aerospace Engineering, Department Advisory Board Annual Meeting (2018)
- "Machine Learning for Classification of Unruptured Intracranial Aneurysms" 15th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2018)
- "Circulating RNA Profiles of Intracranial Aneurysm as a Potential Diagnostic Biomarker" Lecture, 2nd International Neurovascular Exploratory Workshop (2018)
- "Epigenetic Landscapes in Regulatory Regions of Genetic Risk for Intracranial Aneurysm" Lecture, 2nd International Neurovascular Exploratory Workshop (2018)
- "Neurovascular Diagnostics: Better Care through Personalized Medicine" MEDTECH 2017 (2017)
- "High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis" Lecture, 1st International Neurovascular Exploratory Workshop (2017)
- "Imprints of Intracranial Aneurysm on Circulating Neutrophils" Lecture, 1st International Neurovascular Exploratory Workshop (2017)
- "Cerebrovascular Symposium. Complex Role of Hemodynamics in Intracranial Aneurysm Initiation, Growth, and Rupture" Lecture, 13th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2016)
- "Cerebral Aneurysms: How They Form and How We Study Them" SEAS Seminar (2014)
Service Activities:
- Awards Committee; Member (2032–present)
- NIH, NINDS SBIR Review Panel; Reviewer (2024)
- International Stroke Conference (AHA), Imaging Biomarkers of Aneurysm Biology. Phoenix, Arizona, USA; Conference Invited Panel Member (2024–present)
- PPBS Admission Committee; PPBS Admission Committee (2024–present)
- PAS new faculty; Search committee (2023–present)
- Detection and Classification of Intracranial Aneurysm. 19th Interdisciplinary Cerebrovascular Symposium. Forum Genève. Geneva, Switzerland.; Session Chair/Moderator (2023–present)
- JSMBS Faculty Senate – University Shared Governance; Member (2023–2024)
- Consultant-Speakers Bureau (Honorarium), Canon Medical Systems, USA, Inc.; Consultancy (2023–present)
- For Special Issue: “Proceedings from the 2023 International Conference on Subarachnoid Hemorrhage”; Guest Editor for Special Issue, Translational Stroke Research (2023–present)
- Unruptured Aneurysms – 1. 16th International Conference on Subarachnoid Hemorrhage. Duke University. Durham, NC.; Session Chair/Moderator (2023–present)
- Admission Committee of the Graduate Program; Member (2022–present)
- Graduate Program Committee; Member (2022–present)
- R230049, R230054, R230064, R220158, R220259,U2100017, R2100074, R2000011, U2000004, R1900296; Search committee (2019–2024)
- “Omics” Session. 2nd International Neurovascular Exploratory Workshop. Zurich, Switzerland.; Session Chair/Moderator (2018–present)
- Advocate to promote brain aneurysm awareness and research-related bills, resolutions, and appropriations language. Washington, D.C.; Brain Aneurysm Foundation (2018–present)
- Hemodynamics and Vascular Biology Lab, Canon Stroke and Vascular Research Center; Director (2018–present)
- Destructive Remodeling Session. Inflammatory Aneurysm Wall Remodeling Session. 1st International Neurovascular Exploratory Workshop. Zurich, Switzerland.; Session Chair/Moderator (2017–present)
- SNF Symposium. 13th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium. Kobe, Japan.; Conference Invited Panel Member (2016–present)
- Helped introduce elementary and middle school aged children to biomedical research of brain disorders, such as aneurysm and stroke. Buffalo, NY; Jacobs Institute Brain Bootcamp (2016–present)
- Sponsor for the program; Kenmore West High School Career Exploration Internship Program (2015–present)
- Testing /Modeling and Design Challenges Session. 7th Frontiers in Biomedical Devices, ASME 2014 International Design and Engineering Conference. Buffalo, NY.; Session Chair/Moderator (2014–present)
- Worked with doctors and nurses from ProHealth, a Nigerian health NGO, to provide free health-care services in Africa. Bundung, Republic of the Gambia; Jammeh Foundation for Peace (2009–present)
- Brain Aneurysm Foundation at NIH; Academic Ambassador
- Scientific Reports; Reviewer
- Circulation Research; Reviewer
- Stroke and Vascular Neurology; Reviewer
- Stroke; Reviewer
- European Journal of Neurology; Reviewer
- Journal of Thrombosis and Thrombolysis; Reviewer
- BMC Medical Genomics; Reviewer
- Neurosurgical Focus; Reviewer
- Annals of Biomedical Engineering; Reviewer
- Neuropsychiatric Disease and Treatment; Reviewer
- American Journal of Neuroradiology; Reviewer
- EMBO Molecular Medicine; Reviewer
- Journal of Neurointerventional Surgery; Reviewer
- Journal of the American Heart Association; Reviewer
- Stroke: Vascular and Interventional Neurology; Reviewer
- Acta Neuropathologica; Reviewer
- Computers in Biology and Medicine; Reviewer
- Journal of Translational Research; Reviewer
- Translational Stroke Research; Reviewer
- Brain Research Bulletin; Reviewer