Vincent M. Tutino Ph.D
Vincent M. Tutino
Ph.D
Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Aneurysms – Intracranial; Biomedical Engineering; Biomedical Imaging; Biomedical Imaging; Cardiovascular Disease; Cerebrovascular (Stroke); Gene Expression; Gene Sequencing; Hematology; Hemostasis / Thrombosis; Inflammation; Quantitative Histology; RNA; Stroke; Transcription and Translation; Transcriptomics; Translational Research; Vascular and Interventional Radiology; Vascular Malformations
Professional Summary:
My lab resides in the Canon Stroke and Vascular Research Center (CSVRC), where I direct the Hemodynamics and Vascular Biology Lab, leading a multidisciplinary group of graduate students, post-docs and technicians. There, I am also the Study Director for GLP research, where I interface with corporate entities to execute industry-sponsored research. My research uses a broad array of analytical techniques to study neurovascular disease, namely ischemic stroke and brain aneurysms. The lab implements combinations of histology, medical imaging, optical imaging, computational fluid dynamics, and mechanical testing to characterize progressive, mal-adaptive remodeling of the brain’s arterial system induced during these diseases in small animal models. Other areas of my lab focus on translational science. Here, we are developing clinically-useful biomarkers, software, and simulation tools for brain aneurysms and stroke. State-of-the-art technology, such as next-generation RNA sequencing, spatial sequencing, and machine and deep learning tools are routinely implemented. As part of these endeavors, I have also founded the Stroke and Brain Tumor Biobank at the CTRC, which is becoming a cornerstone for the CSVRC’s human subjects research.
Education and Training:
- Certificate, Fundamentals & Applications of Clinical and Translational Research, Harvard University (2019)
- PhD, Biomedical Engineering, University at Buffalo (2018)
- MS, Biomedical Engineering, University at Buffalo (2014)
- BS, Chemistry, St. John Fisher University, Magna Cum Laude (2010)
Employment:
- Affiliated Assistant Professor, Biomedical Engineering, University at Buffalo
- Affiliated Assistant Professor, Mechanical and Aerospace Engineering, University at Buffalo
- Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo
- President and CEO, Neurovascular Diagnostics, Inc.
- Research Assistant Professor, Neurosurgery, University at Buffalo
- Vice-President and CFO, QAS.AI, Inc.
Research Expertise:
- Animal models of vascular disease: Rat, rabbit and mouse models of brain aneurysm and stroke
- Biobanking: Biobank of tissue and liquid biopsy for stroke, aneurysms, and brain tumors
- Gene expression profiling: transcriptomics of vascular diseases towards biomarker development
- Medical image analysis: CTA, nCCT, MRI, MRA, DSA
Research Centers:
- Center of Excellence in Bioinformatics and Life Sciences
- Clinical and Translational Research Center (CTRC)
- Toshiba Stroke Research Center
Grants and Sponsored Research:
- Exploring Mechanisms of Intracranial Aneurysm Rupture through Magnetic Vessel Wall Imaging.
SUNY Research Seed Grant Program
Role: Principal Investigator
$30,000 - A Whole Blood RNA Diagnostic for Unruptured Brain Aneurysm: Risk Assessment Prototype Development and Testing.
Brain Aneurysm Foundation
Role: Principal Investigator
$40,000 - Molecular Biomarkers of Dangerous Intracranial Aneurysms.
NSF, NINDS
Role: Principal Investigator
$225,000 - Circulating Molecular Markers of High-Risk Brain Aneurysms from Circulating Neutrophil Gene Expression
Brain Aneurysm Foundation
Role: Principal Investigator
$45,000 - A Blood-Based Test to Identify Patients with Intracranial Aneurysm.
NSF
Role: Principal Investigator
$224,000 - Blood-Based Biomarkers Associated with Aneurysm Vessel Wall Enhancement on Post-Contrast MRI.
Role: Principal Investigator
$30,000 - Biomarkers for Ischemic Stroke Origin.
Clinical and Translational Science Award, Pilot Study
Role: Co-Principal Investigator
$50,000 - An AI-Enhanced Angiographic System to Guide Endovascular Treatment of Intracranial Aneurysms.
NSF
Role: Co-Investigator
$256,000
Patents:
- Biomarkers for intracranial aneurysm Provided are methods for determining a presence of an intracranial aneurysm in a subject suspected of having an intracranial aneurysm or at risk for developing an intracra nial aneurysm, or a subject in need of aneurysm monitoring. The method involves analyzing a biological sample from the subject for expression of a combination of biomarkers that provide a signature of an aneurism. Specification includes a Sequence Listing. (2020)
Journal Articles:
- Dmytriw AA, Dibas M, Ghozy S, Adeeb N, Diestro JDB, Phan K, Cuellar-Saenz HH, Sweid A, Lay SV, Guenego A, Renieri L, Al Balushi A, Saliou G, Möhlenbruch M, Regenhardt RW, Vranic JE, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Tutino VM, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Sporns P, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Du R, Kan P, Kalousek V, Lylyk P, Boddu S, Tjoumakaris S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB. (2022) The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium. Translational stroke research (Sep).
- Adeeb N, Dibas M, Diestro JDB, Cuellar-Saenz HH, Sweid A, Kandregula S, Lay SV, Guenego A, Renieri L, Sundararajan SH, Saliou G, Aslan A, Möhlenbruch M, Vranic JE, Regenhardt RW, Savardekar A, Mamilly A, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Parra Farinas C, Tutino VM, Inoue Y, Mirshahi S, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Sporns P, Brehm A, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. (2022) Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge (WEB). Radiology (Aug), 304(2): 372-382.
- Diestro JDB, Dibas M, Adeeb N, Regenhardt RW, Vranic JE, Guenego A, Lay SV, Renieri L, Al Balushi A, Shotar E, Premat K, El Naamani K, Saliou G, Möhlenbruch MA, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Rai H, Tutino VM, Mirshani S, Ghozy S, Harker P, Alotaibi NM, Rabinov JD, Ren Y, Schirmer CM, Goren O, Piano M, Kuhn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Nguyen A, Jones J, Psychogios M, Spears J, Parra-Fariñas C, Bres Bullrich M, Mayich M, Salem MM, Burkhardt JK, Jankowitz BT, Domingo RA, Huynh T, Tawk R, Ulfert C, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet AF, Albuquerque FC, Du R, Kan P, Kalousek V, Lylyk P, Boddu SR, Stapleton CJ, Knopman J, Jabbour P, Tjoumakaris S, Clarençon F, Limbucci N, Aziz-Sultan MA, Cuellar-Saenz HH, Cognard C, Patel AB, Dmytriw AA. (2022) Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study. Journal of neurointerventional surgery (Jul).
- Dmytriw AA, Ghozy S, Sweid A, Piotin M, Bekelis K, Sourour N, Raz E, Vela-Duarte D, Linfante I, Dabus G, Kole M, Martínez-Galdámez M, Nimjee SM, Lopes DK, Hassan AE, Kan P, Ghorbani M, Levitt MR, Escalard S, Missios S, Shapiro M, Clarençon F, Elhorany M, Tahir RA, Youssef PP, Pandey AS, Starke RM, El Naamani K, Abbas R, Mansour OY, Galvan J, Billingsley JT, Mortazavi A, Walker M, Dibas M, Settecase F, Heran MKS, Kuhn AL, Puri AS, Menon BK, Sivakumar S, Mowla A, D'Amato S, Zha AM, Cooke D, Vranic JE, Regenhardt RW, Rabinov JD, Stapleton CJ, Goyal M, Wu H, Cohen J, Turkel-Parella D, Xavier A, Waqas M, Tutino V, Siddiqui A, Gupta G, Nanda A, Khandelwal P, Tiu C, Portela PC, Perez de la Ossa N, Urra X, de Lera M, Arenillas JF, Ribo M, Requena M, Piano M, Pero G, De Sousa K, Al-Mufti F, Hashim Z, Nayak S, Renieri L, Du R, Aziz-Sultan MA, Liebeskind D, Nogueira RG, Abdalkader M, Nguyen TN, Vigilante N, Siegler JE, Grossberg JA, Saad H, Gooch MR, Herial NA, Rosenwasser RH, Tjoumakaris S, Patel AB, Tiwari A, Jabbour P, . (2022) International controlled study of revascularization and outcomes following COVID-positive mechanical thrombectomy. European journal of neurology (Jul). doi:10.1111/ene.15493
- Tutino VM, Fricano S, Chien A, Patel TR, Monteiro A, Rai HH, Dmytriw AA, Chaves LD, Waqas M, Levy EI, Poppenberg KE, Siddiqui AH. (2022) Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology. Journal of neurointerventional surgery (Jun).
- Jabbour P, Dmytriw AA, Sweid A, Piotin M, Bekelis K, Sourour N, Raz E, Linfante I, Dabus G, Kole M, Martínez-Galdámez M, Nimjee SM, Lopes DK, Hassan AE, Kan P, Ghorbani M, Levitt MR, Escalard S, Missios S, Shapiro M, Clarençon F, Elhorany M, Vela-Duarte D, Tahir RA, Youssef PP, Pandey AS, Starke RM, El Naamani K, Abbas R, Hammoud B, Mansour OY, Galvan J, Billingsley JT, Mortazavi A, Walker M, Dibas M, Settecase F, Heran MKS, Kuhn AL, Puri AS, Menon BK, Sivakumar S, Mowla A, D'Amato S, Zha AM, Cooke D, Goyal M, Wu H, Cohen J, Turkel-Parrella D, Xavier A, Waqas M, Tutino VM, Siddiqui A, Gupta G, Nanda A, Khandelwal P, Tiu C, Portela PC, Perez de la Ossa N, Urra X, de Lera M, Arenillas JF, Ribo M, Requena M, Piano M, Pero G, De Sousa K, Al-Mufti F, Hashim Z, Nayak S, Renieri L, Aziz-Sultan MA, Nguyen TN, Feineigle P, Patel AB, Siegler JE, Badih K, Grossberg JA, Saad H, Gooch MR, Herial NA, Rosenwasser RH, Tjoumakaris S, Tiwari A. (2022) Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study. Neurosurgery (Jun), 90(6): 725-733.
- Adeeb N, Dibas M, Diestro JDB, Phan K, Cuellar-Saenz HH, Sweid A, Lay SV, Guenego A, Aslan A, Renieri L, Sundararajan SH, Saliou G, Möhlenbruch M, Regenhardt RW, Vranic JE, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Tutino VM, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kuhn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Brehm A, MohammedAli M, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet A, Albuquerque FC, Du R, Kan P, Kalousek V, Lylyk P, Stapleton CJ, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. (2022) Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device. Journal of neurointerventional surgery (Apr).
- Waqas M, Monteiro A, Cappuzzo JM, Tutino VM, Levy EI. (2022) Evolution of the patient-first approach: a dual-trained, single-neurosurgeon experience with 2002 consecutive intracranial aneurysm treatments. Journal of neurosurgery (Apr)1-7.
- Waqas M, Li W, Patel TR, Chin F, Tutino VM, Dossani RH, Ren Z, Guerrero WR, Borlongan CV, Pressman E, Snyder K, Davies JM, Ley EI, Ionita CN, Siddiqui AH, Mokin M. (2022) Clot imaging characteristics predict first pass effect of aspiration-first approach to thrombectomy. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (Apr), 28(2): 152-159. doi:10.1177/15910199211019174
- Waqas M, Tutino VM, Cappuzzo JM, Lazarov V, Popoola D, Patel TR, Levy BR, Monteiro A, Mokin M, Rai AT, Mocco J, Turk AS, Snyder KV, Davies JM, Levy EI, Siddiqui AH. (2022) Stroke thrombectomy volume, rather than stroke center accreditation status of hospitals, is associated with mortality and discharge disposition. Journal of neurointerventional surgery (Mar).
- Dmytriw AA, Dibas M, Adeeb N, Salem MM, Salehani A, Waqas M, Saad Aldine A, Tutino VM, Ogilvy CS, Siddiqui AH, Harrigan MR, Thomas AJ, Cuellar H, Griessenauer CJ. (2022) The Pipeline Embolization Device: a decade of lessons learned in the treatment of posterior circulation aneurysms in a multicenter cohort. Journal of neurosurgery (Mar)1-8.
- Tutino VM, Kuo CC, Avasthi N, Rai HH, Waqas M, Siddiqui AH, Jarvis JN, Poppenberg KE. (2022) Chromatin architecture around stroke haplotypes provides evidence that genetic risk is conferred through vascular cells. Epigenomics (Mar), 14(5): 243-259.
- Shlobin NA, Baig AA, Waqas M, Patel TR, Dossani RH, Wilson M, Cappuzzo JM, Siddiqui AH, Tutino VM, Levy EI. (2022) Artificial Intelligence for Large-Vessel Occlusion Stroke: A Systematic Review. World neurosurgery (Mar), 159: 207-220.e1. doi:10.1016/j.wneu.2021.12.004
- Rajabzadeh-Oghaz H, Siddiqui AH, Asadollahi A, Kolega J, Tutino VM. (2022) The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review. Neurosurgical review (Feb), 45(1): 49-61.
- Dibas M, Adeeb N, Diestro JDB, Cuellar HH, Sweid A, Lay SV, Guenego A, Aslan A, Renieri L, Sundararajan SH, Saliou G, Möhlenbruch M, Regenhardt RW, Vranic JE, Lylyk I, Foreman PM, Vachhani JA, Župancic V, Hafeez MU, Rutledge C, Waqas M, Tutino VM, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Salehani A, Sporns P, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. (2022) Transradial versus transfemoral access for embolization of intracranial aneurysms with the Woven EndoBridge device: a propensity score-matched study. Journal of neurosurgery (Feb)1-8.
- Aldstadt J, Waqas M, Yasumiishi M, Mokin M, Tutino VM, Rai HH, Chin F, Levy BR, Rai AT, Mocco J, Snyder KV, Davies JM, Levy EI, Siddiqui AH. (2022) Mapping access to endovascular stroke care in the USA and implications for transport models. Journal of neurointerventional surgery (Jan), 14(1).
- Mousavi J S SM, Faghihi D, Sommer K, Bhurwani MMS, Patel TR, Santo B, Waqas M, Ionita C, Levy EI, Siddiqui AH, Tutino VM. (2021) Realistic computer modelling of stent retriever thrombectomy: a hybrid finite-element analysis-smoothed particle hydrodynamics model. Journal of the Royal Society, Interface (Dec), 18(185): 20210583. doi:10.1098/rsif.2021.0583
- Patel TR, Pinter N, Sarayi SMMJ, Siddiqui AH, Tutino VM, Rajabzadeh-Oghaz H. (2021) Automated Cerebral Vessel Segmentation of Magnetic Resonance Imaging in Patients with Intracranial Atherosclerotic Diseases. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (Nov), 2021: 3920-3923.
- Veeturi SS, Rajabzadeh-Oghaz H, Pintér NK, Waqas M, Hasan DM, Snyder KV, Siddiqui AH, Tutino VM. (2021) Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms. Royal Society open science (Nov), 8(11): 211119. doi:10.1098/rsos.211119
- Tutino VM, Zebraski HR, Rajabzadeh-Oghaz H, Chaves L, Dmytriw AA, Siddiqui AH, Kolega J, Poppenberg KE. (2021) RNA Sequencing Data from Human Intracranial Aneurysm Tissue Reveals a Complex Inflammatory Environment Associated with Rupture. Molecular diagnosis & therapy (Nov), 25(6): 775-790.
- Patel TR, Waqas M, Sarayi SMMJ, Ren Z, Borlongan CV, Dossani R, Levy EI, Siddiqui AH, Snyder KV, Davies JM, Mokin M, Tutino VM. (2021) Revascularization Outcome Prediction for A Direct Aspiration-First Pass Technique (ADAPT) from Pre-Treatment Imaging and Machine Learning. Brain sciences (Oct), 11(10). doi:10.3390/brainsci11101321
- Tutino VM, Rajabzadeh-Oghaz H, Veeturi SS, Poppenberg KE, Waqas M, Mandelbaum M, Liaw N, Siddiqui AH, Meng H, Kolega J. (2021) Endogenous animal models of intracranial aneurysm development: a review. Neurosurgical review (Oct), 44(5): 2545-2570. doi:10.1007/s10143-021-01481-w
- Tutino VM, Fricano S, Frauens K, Patel TR, Monteiro A, Rai HH, Waqas M, Chaves L, Poppenberg KE, Siddiqui AH. (2021) Isolation of RNA from Acute Ischemic Stroke Clots Retrieved by Mechanical Thrombectomy. Genes (Oct), 12(10). doi:10.3390/genes12101617
- Veeturi SS, Pinter NK, Monteiro A, Baig AA, Rai HH, Waqas M, Siddiqui AH, Rajabzadeh-Oghaz H, Tutino VM. (2021) An Image-Based Workflow for Objective Vessel Wall Enhancement Quantification in Intracranial Aneurysms. Diagnostics (Basel, Switzerland) (Sep), 11(10). doi:10.3390/diagnostics11101742
- Sommer KN, Bhurwani MMS, Tutino V, Siddiqui A, Davies J, Snyder K, Levy E, Mokin M, Ionita CN. (2021) Use of patient specific 3D printed neurovascular phantoms to simulate mechanical thrombectomy. 3D printing in medicine (Sep), 7(1): 32. doi:10.1186/s41205-021-00122-8
- Kolega J, Poppenberg KE, Lim HW, Gutierrez LC, Veeturi SS, Siddiqui AH, Rajabzadeh-Oghaz H, Tutino VM. (2021) Identification of intima-to-media signals for flow-induced vascular remodeling using correlative gene expression analysis. Scientific reports (Aug), 11(1): 16142. doi:10.1038/s41598-021-95403-x
- Tutino VM, Lu Y, Ishii D, Poppenberg KE, Rajabzadeh-Oghaz H, Siddiqui AH, Hasan DM. (2021) Aberrant Whole Blood Gene Expression in the Lumen of Human Intracranial Aneurysms. Diagnostics (Basel, Switzerland) (Aug), 11(8). doi:10.3390/diagnostics11081442
- Tutino VM, Zebraski HR, Rajabzadeh-Oghaz H, Waqas M, Jarvis JN, Bach K, Mokin M, Snyder KV, Siddiqui AH, Poppenberg KE. (2021) Identification of Circulating Gene Expression Signatures of Intracranial Aneurysm in Peripheral Blood Mononuclear Cells. Diagnostics (Basel, Switzerland) (Jun), 11(6). doi:10.3390/diagnostics11061092
- Poppenberg KE, Zebraski HR, Avasthi N, Waqas M, Siddiqui AH, Jarvis JN, Tutino VM. (2021) Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression. BMC medical genomics (Jun), 14(1): 162. doi:10.1186/s12920-021-01007-9
- Waqas M, Gong AD, Levy BR, Dossani RH, Vakharia K, Cappuzzo JM, Becker A, Sonig A, Tutino VM, Almayman F, Davies JM, Snyder KV, Siddiqui AH, Levy EI. (2021) Is Endovascular Therapy for Stroke Cost-Effective Globally? A Systematic Review of the Literature. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Apr), 30(4): 105557.
- Poppenberg KE, Tutino VM, Tarbell E, Jarvis JN. (2021) Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes. BMC medical genomics (Apr), 14(1): 114. doi:10.1186/s12920-021-00964-5
- Griessenauer CJ, Enriquez-Marulanda A, Xiang S, Hong T, Zhang H, Taussky P, Grandhi R, Waqas M, Tutino VM, Siddiqui AH, Levy EI, Ogilvy CS, Thomas AJ, Ulfert C, Möhlenbruch MA, Renieri L, Limbucci N, Parra-Fariñas C, Burkhardt JK, Kan P, Rinaldo L, Lanzino G, Brinjikji W, Spears J, Müller-Thies-Broussalis E, Killer-Oberpfalzer M, Islak C, Kocer N, Sonnberger M, Engelhorn T, Ghuman M, Yang VX, Salehani A, Harrigan MR, Radovanovic I, Pereira VM, Krings T, Matouk CC, Chen K, Aziz-Sultan MA, Ghorbani M, Schirmer CM, Goren O, Dalal SS, Koch MJ, Stapleton CJ, Patel AB, Finkenzeller T, Holtmannspötter M, Buhk JH, Foreman PM, Cress M, Hirschl R, Reith W, Simgen A, Janssen H, Marotta TR, Dmytriw AA. (2021) Comparison of PED and FRED flow diverters for posterior circulation aneurysms: a propensity score matched cohort study. Journal of neurointerventional surgery (Feb), 13(2): 153-158.
- Patel TR, Fricano S, Waqas M, Tso M, Dmytriw AA, Mokin M, Kolega J, Tomaszewski J, Levy EI, Davies JM, Snyder KV, Siddiqui AH, Tutino VM. (2021) Increased Perviousness on CT for Acute Ischemic Stroke is Associated with Fibrin/Platelet-Rich Clots. AJNR. American journal of neuroradiology (Jan), 42(1): 57-64. doi:10.3174/ajnr.A6866
- Tutino VM, Poppenberg KE, Damiano RJ, Patel TR, Waqas M, Dmytriw AA, Snyder KV, Siddiqui AH, Jarvis JN. (2020) Characterization of Long Non-coding RNA Signatures of Intracranial Aneurysm in Circulating Whole Blood. Molecular diagnosis & therapy (Dec), 24(6): 723-736.
- Poppenberg KE, Tutino VM, Li L, Waqas M, June A, Chaves L, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. (2020) Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm. Journal of translational medicine (Oct), 18(1): 392. doi:10.1186/s12967-020-02550-2
- Damiano RJ, Tutino VM, Paliwal N, Patel TR, Waqas M, Levy EI, Davies JM, Siddiqui AH, Meng H. (2020) Aneurysm characteristics, coil packing, and post-coiling hemodynamics affect long-term treatment outcome. Journal of neurointerventional surgery (Jul), 12(7): 706-713. doi:10.1136/neurintsurg-2019-015422
- Rajabzadeh-Oghaz H, van Ooij P, Veeturi SS, Tutino VM, Zwanenburg JJ, Meng H. (2020) Inter-patient variations in flow boundary conditions at middle cerebral artery from 7T PC-MRI and influence on Computational Fluid Dynamics of intracranial aneurysms. Computers in biology and medicine (May), 120: 103759.
- Dmytriw AA, Kapadia A, Enriquez-Marulanda A, Parra-Fariñas C, Kühn AL, Nicholson PJ, Waqas M, Renieri L, Michelozzi C, Foreman PM, Phan K, Yang IH, Tutino VM, Ogilvy CS, Radovanovic I, Harrigan MR, Siddiqui AH, Levy EI, Limbucci N, Cognard C, Krings T, Pereira VM, Thomas AJ, Marotta TR, Griessenauer CJ. (2020) Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversion. Journal of neurosurgery (Mar), 134(3): 961-970.
- Poppenberg KE, Li L, Waqas M, Paliwal N, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H, Tutino VM. (2020) Whole blood transcriptome biomarkers of unruptured intracranial aneurysm. PloS one (Jan), 15(11): e0241838. doi:10.1371/journal.pone.0241838
- Tutino VM, Yan AJ, Veeturi SS, Patel TR, Rajabzadeh-Oghaz H, Waqas M, Siddiqui AH, Tseng J, Kolega J. (2020) Landmark-Based Shape Analysis on Middle Cerebral Intracranial Aneurysms: A Geometric Morphometrics Approach to Infer Natural History. Current neurovascular research (Jan), 17(5): 725-735.
- Lamooki SR, Tutino VM, Paliwal N, Damiano RJ, Waqas M, Nagesh SSV, Rajabzadeh-Oghaz H, Vakharia K, Siddiqui AH, Meng H. (2020) Evaluation of Two Fast Virtual Stenting Algorithms for Intracranial Aneurysm Flow Diversion. Current neurovascular research (Jan), 17(1): 58-70.
- Maragkos GA, Dmytriw AA, Salem MM, Tutino VM, Meng H, Cognard C, Machi P, Krings T, Mendes Pereira V. (2020) Overview of Different Flow Diverters and Flow Dynamics. Neurosurgery (Jan), 86(Suppl 1): S21-S34.
- Poppenberg KE, Jiang K, Tso MK, Snyder KV, Siddiqui AH, Kolega J, Jarvis JN, Meng H, Tutino VM. (2019) Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium. BMC medical genomics (Oct), 12(1): 149. doi:10.1186/s12920-019-0591-7
- Waqas M, Rajabzadeh-Oghaz H, Tutino VM, Vakharia K, Poppenberg KE, Mowla A, Meng H, Siddiqui AH. (2019) Morphologic Parameters and Location Associated with Rupture Status of Intracranial Aneurysms in Elderly Patients. World neurosurgery (Sep), 129: e831-e837.
- Jiang K, Poppenberg KE, Wong L, Chen Y, Borowitz D, Goetz D, Sheehan D, Frederick C, Tutino VM, Meng H, Jarvis JN. (2019) RNA sequencing data from neutrophils of patients with cystic fibrosis reveals potential for developing biomarkers for pulmonary exacerbations. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (Mar), 18(2): 194-202. doi:10.1016/j.jcf.2018.05.014
- Paliwal N, Tutino VM, Shallwani H, Beecher JS, Damiano RJ, Shakir HJ, Atwal GS, Fennell VS, Natarajan SK, Levy EI, Siddiqui AH, Davies JM, Meng H. (2019) Ostium Ratio and Neck Ratio Could Predict the Outcome of Sidewall Intracranial Aneurysms Treated with Flow Diverters. AJNR. American journal of neuroradiology (Feb), 40(2): 288-294. doi:10.3174/ajnr.A5953
- Damiano RJ, Tutino VM, Lamooki SR, Paliwal N, Dargush GF, Davies JM, Siddiqui AH, Meng H. (2019) Improving accuracy for finite element modeling of endovascular coiling of intracranial aneurysm. PloS one (Jan), 14(12): e0226421. doi:10.1371/journal.pone.0226421
- Tutino VM, Poppenberg KE, Li L, Shallwani H, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. (2018) Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms. Journal of translational medicine (Dec), 16(1): 373. doi:10.1186/s12967-018-1749-3
- Rajabzadeh-Oghaz H, Varble N, Shallwani H, Tutino VM, Mowla A, Shakir HJ, Vakharia K, Atwal GS, Siddiqui AH, Davies JM, Meng H. (2018) Computer-Assisted Three-Dimensional Morphology Evaluation of Intracranial Aneurysms. World neurosurgery (Nov), 119: e541-e550. doi:10.1016/j.wneu.2018.07.208
- Paliwal N, Jaiswal P, Tutino VM, Shallwani H, Davies JM, Siddiqui AH, Rai R, Meng H. (2018) Outcome prediction of intracranial aneurysm treatment by flow diverters using machine learning. Neurosurgical focus (Nov), 45(5): E7. doi:10.3171/2018.8.FOCUS18332
- Varble N, Tutino VM, Yu J, Sonig A, Siddiqui AH, Davies JM, Meng H. (2018) Shared and Distinct Rupture Discriminants of Small and Large Intracranial Aneurysms. Stroke (Apr), 49(4): 856-864. doi:10.1161/STROKEAHA.117.019929
- Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H. (2018) Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. PloS one (Jan), 13(1): e0191407. doi:10.1371/journal.pone.0191407
- Tutino VM, Rajabzadeh-Oghaz H, Chandra AR, Gutierrez LC, Schweser F, Preda M, Chien A, Vakharia K, Ionita C, Siddiqui A, Kolega J. (2018) 9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics. Current neurovascular research (Jan), 15(4): 312-325.
- Paliwal N, Damiano RJ, Varble NA, Tutino VM, Dou Z, Siddiqui AH, Meng H. (2017) Methodology for Computational Fluid Dynamic Validation for Medical Use: Application to Intracranial Aneurysm. Journal of biomechanical engineering (Dec), 139(12). doi:10.1115/1.4037792
- Damiano RJ, Tutino VM, Paliwal N, Ma D, Davies JM, Siddiqui AH, Meng H. (2017) Compacting a Single Flow Diverter versus Overlapping Flow Diverters for Intracranial Aneurysms: A Computational Study. AJNR. American journal of neuroradiology (Mar), 38(3): 603-610. doi:10.3174/ajnr.A5062
- Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ. (2016) C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology (Aug), 148(4): 407-19. doi:10.1111/imm.12619
- Tutino VM, Liaw N, Spernyak JA, Ionita CN, Siddiqui AH, Kolega J, Meng H. (2016) Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats. Current neurovascular research (Jan), 13(1): 82-92. doi:10.2174/1567202612666151027143149
- Tutino VM, Mandelbaum M, Takahashi A, Pope LC, Siddiqui A, Kolega J, Meng H. (2015) Hypertension and Estrogen Deficiency Augment Aneurysmal Remodeling in the Rabbit Circle of Willis in Response to Carotid Ligation. Anatomical record (Hoboken, N.J. : 2007) (Nov), 298(11): 1903-10. doi:10.1002/ar.23205
- Xiang J, Tutino VM, Snyder KV, Meng H. (2014) CFD: computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment. AJNR. American journal of neuroradiology (Oct), 35(10): 1849-57. doi:10.3174/ajnr.A3710
- Meng H, Tutino VM, Xiang J, Siddiqui A. (2014) High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: toward a unifying hypothesis. AJNR. American journal of neuroradiology (Jul), 35(7): 1254-62. doi:10.3174/ajnr.A3558
- Tutino VM, Mandelbaum M, Choi H, Pope LC, Siddiqui A, Kolega J, Meng H. (2014) Aneurysmal remodeling in the circle of Willis after carotid occlusion in an experimental model. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Mar), 34(3): 415-24. doi:10.1038/jcbfm.2013.209
Professional Memberships:
- SB3C Foundation; The Summer Biomechanics Bioengineering and Biotransport Foundation
- American Heart Association; Stroke Council Council on Genomic and Precision Medicine (GPM)
Presentations:
- "RNA Sequencing for Identification of Circulating Biomarkers to Detect Unruptured Intracranial Aneurysms" Upstate New York Illumina Next-Generation Sequencing (NGS) Seminar
- "Developing Molecular Diagnostics of Intracranial Aneurysm: A Collision of Translational Research and Entrepreneurship." Mayo Clinic Neuroscience Grand Rounds
- "Development of Biological and Imaging Markers for Hemorrhagic and Ischemic Strokes" Geneva University Hospitals, Department of Clinical Neurosciences – Grand Rounds
- "Translational Stroke Research" The “Circle of Willis” Webinar/Podcast