Aneurysms – Intracranial; Biomedical Engineering; Biomedical Imaging; Biomedical Imaging; Cardiovascular Disease; Cerebrovascular (Stroke); Gene Expression; Gene Sequencing; Hematology; Hemostasis / Thrombosis; Inflammation; Quantitative Histology; RNA; Stroke; Transcription and Translation; Transcriptomics; Translational Research; Vascular and Interventional Radiology; Vascular Malformations
My lab resides in the Canon Stroke and Vascular Research Center (CSVRC), where I direct the Hemodynamics and Vascular Biology Lab, leading a multidisciplinary group of graduate students, post-docs and technicians. There, I am also the Study Director for GLP research, where I interface with corporate entities to execute industry-sponsored research. My research uses a broad array of analytical techniques to study neurovascular disease, namely ischemic stroke and brain aneurysms. The lab implements combinations of histology, medical imaging, optical imaging, computational fluid dynamics, and mechanical testing to characterize progressive, mal-adaptive remodeling of the brain’s arterial system induced during these diseases in small animal models. Other areas of my lab focus on translational science. Here, we are developing clinically-useful biomarkers, software, and simulation tools for brain aneurysms and stroke. State-of-the-art technology, such as next-generation RNA sequencing, spatial sequencing, and machine and deep learning tools are routinely implemented. As part of these endeavors, I have also founded the Stroke and Brain Tumor Biobank at the CTRC, which is becoming a cornerstone for the CSVRC’s human subjects research.