Bioinformatics; Cell growth, differentiation and development; Gene Expression; Genomics and proteomics; Molecular Basis of Disease; Molecular genetics; Neurobiology; RNA; Signal Transduction; Stem Cells; Transcription and Translation; Transgenic organisms; Vision science
We are interested in the fundamental mechanisms underlying the shift of cellular states in neural development. We address this issue by studying cell fate specification and differentiation in the developing retina. Our efforts are on identifying key regulators, uncovering their roles in individual cell lineages, and understanding how they carry out their functions. One major focus of our research is how transcription factors influence the epigenetic landscape along the developmental trajectory of retinal ganglion cells. We are also investigating how posttranscriptional control of gene expression affects retinal cell differentiation. We conduct our research using a combinatorial approach of genetics, molecular biology, genomics, single-cell techniques, and bioinformatics.