Event

Wild type and Mutant p53 activities - Guillermina Lozano, Ph.D.

The IMSD PhD Scholars are honored to present this seminar by Dr. Guillermina Lozano, a renowned geneticist recognized for studies of the p53 tumor suppressor pathway. This seminar will focus specifically on the p53 tumor suppressor pathway. The p53 tumor suppressor functions as a transcription factor to activate hundreds of genes. Dr. Lozano’s Team has cataloged p53 targets in vivo in several tissues and identified a pan-tissue p53 signature of seven commonly activated genes. Mutations in p53 commonly occur via missense mutations, many of which exhibit gain-of-function activities manifested as increased tumor aggressiveness and metastasis. Dr. Lozano’s Team has developed novel conditional mutant p53 alleles that switch wild type p53 to mutant in a Cre-specific manner to explore the role of the microenvironment in tumor development and progression. A model of triple negative breast cancer shows dependence on mutant p53 for tumor growth and survival through inhibition of ferroptosis. These models most closely simulate the genesis of somatic cancers and will thus be invaluable in testing novel therapeutic combinations.

DATE: Friday, March 21, 2025
TIME: 12:00 PM to 1:00 PM (In Person & Virtual)
LOCATION: Zebro Conference Room (Center for Genetics and Pharmacology CGP L1-401), Roswell Park Comprehensive Cancer Center

Email: imsdatub@buffalo.edu
Phone: (716) 829-3048