My project focuses on how oxygen limitation and CFTR dysfunction modulate host-pathogen interactions in the cystic fibrosis (CF) airway. Staphylococcus aureus is one of the most common pathogens isolated from the airways of patients with cystic fibrosis. Therefore, I aim to define how oxygen gradients and CFTR dysfunction remodel S. aureus colonization, epithelial metabolism, and immune signaling during airway infections.

Ryan Hunter, PhD