Amanda H. Klein PhD

Amanda Klein

Amanda H. Klein
PhD

Associate Professor

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Behavioral Neuroscience; Electrophysiology; Metabolism; Neurobiology; Neuropharmacology; Pain; Pharmacotherapy

Contact Information
955 Main Street
Suite 3219
Buffalo, New York 14203
Phone: 716-826-2453
ahklein2@buffalo.edu



Professional Summary:

My research lab focuses on the mechanisms of chronic pain and opioid signaling using in vitro and in vivo methods. My previous research training is comprehensive, covering fields of rodent behavior, metabolomics, spinal cord electrophysiology, cation imaging, histology, immunofluorescence, live-cell imaging, rodent and non-human primate nerve fiber recordings, compound action potential electrophysiology, and human psychophysics.

My research program targets several related topics related to changes in cell excitability and intracellular signaling during chronic pain and chronic drug exposure. Several lines of evidence suggest that common changes occur in the peripheral and central nervous system during these events. One key focus of my research program lies in answering questions regarding the development of opioid tolerance and opioid induced hypersensitivity. We are currently investigating how downstream effectors of opioid signaling, namely inwardly-rectifying potassium channels, contribute to analgesia and how loss of expression or function can change the maintenance and progression of enhanced sensitivity in the nervous system. The progression and persistence of chronic pain is a huge social and economic burden within the United States, and better understanding of the pathology of chronic pain, and ways to manage pain are desperately needed.

Alongside my bench work, a major priority of my research program is the development of novel therapeutics to treat pain and opioid induced tolerance and withdrawal.

Education and Training:

  • Fellowship, Postdoctoral, Johns Hopkins University (2015)
  • PhD, Molecular Cellular and Integrative Physiology, University of California Davis (2012)
  • MS, Cellular Biology, University of Minnesota (2007)
  • BS, Cellular Biology, University of Minnesota (2005)

Employment:

  • Associate Professor, Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota (2023)
  • Assistant Professor, Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota (2015–2023)


Journal Articles:

See all (16 more)

Professional Memberships:

  • American Society for Pharmacology and Experimental Therapeutics (2022–present)
  • International Association for the Study of Pain (2010–present)
  • Society for Neuroscience (2009–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

955 Main Street
Suite 3219
Buffalo, New York 14203
Phone: 716-826-2453
ahklein2@buffalo.edu