Brian R. Weil PhD

Brian Weil

Brian R. Weil
PhD

Assistant Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Apoptosis and cell death; Cardiac pharmacology; Cardiology; Cardiovascular Disease; Inflammation; Pathophysiology; Stem Cells; Translational imaging; Translational Research

Contact Information
Clinical and Translational Research Center
Suite 7030
875 Ellicott Street
Buffalo, New York 14203
Phone: 716-829-3599
Fax: 716-854-1840
bweil@buffalo.edu



Professional Summary:

My research program is focused on investigating mechanisms of cardiac dysfunction and structural remodeling in heart disease, as well as identifying novel therapeutic interventions to prevent or reverse left ventricular dysfunction caused by acute and chronic myocardial injury. These studies generally utilize non-invasive cardiovascular imaging techniques and invasive hemodynamic assessment to assess cardiac performance in vivo in preclinical experimental models, along with ex vivo analysis of myocardial tissue to examine cellular and molecular mechanisms underlying observed changes in physiological function. Using this approach, we aim to conduct impactful translational research with direct relevance to the pathophysiology and treatment of human heart disease.

Education and Training:

  • PhD, Integrative Physiology, University of Colorado - Boulder (2011)
  • MS, Exercise Science, Syracuse University (2007)
  • BS, Clinical Exercise Science, Ithaca College (2005)

Employment:

  • Assistant Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2019-present)
  • Research Assistant Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2016–2019)
  • Post Doctoral Fellow, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011–2016)

Awards and Honors:

  • Louis A. and Ruth Siegel Award for Excellence in Teaching, Honorable Mention; Teaching in the Preclinical Program (2021)
  • Harold Brody/Medical Emeritus Faculty Society Award for Translational Research (2015)
  • Cardiovascular Section; Clinical Science Young Investigator Award (2012)

Research Centers:

  • Center for Research in Cardiovascular Medicine

Grants and Sponsored Research:

  • January 2022–December 2025
    Immunomodulatory Therapy After Resuscitation From Cardiac Arrest
    National Institutes of Health (NHLBI)
    Role: Principal Investigator
    $1,822,516
  • October 2020–September 2024
    Preventing and Reversing Interstitial Fibrosis in HFpEF
    Veteran's Affairs Merit Review Award
    Role: Co-Investigator
    $709,984
  • January 2022–December 2022
    Investigation of Myocardial Sympathetic Denervation as a Novel Mechanism of Ischemia-Induced Pulseless Electrical Activity Cardiac Arrest
    The ZOLL Foundation
    Role: Principal Investigator
    $47,740
  • September 2020–August 2022
    Pathophysiology of Left Ventricular Stiffening in Heart Failure
    National Institutes of Health (NHLBI)
    Role: Principal Investigator
    $397,476
  • January 2021–December 2021
    Targeting Coronary Microvascular Dysfunction to Treat Heart Failure with Preserved Ejection Fraction
    UB CTSI Translational Pilot Studies Program
    Role: Principal Investigator
    $41,164
  • January 2020–August 2021
    T3np Neuroprotection Following Cardiac Arrest
    UB Center for Advanced Biomedical and Bioengineering Technology
    Role: Principal Investigator
    $20,890
  • July 2017–June 2020
    Pathophysiology of Myocardial Remodeling in Heart Failure With Preserved Ejection Fraction
    American Heart Association
    Role: Principal Investigator
    $231,000
  • December 2018–November 2019
    Preclinical Evaluation of Systemic Cellular Postconditioning as a Novel Cardioprotective and Neuroprotective Therapy Following Cardiac Arrest
    The ZOLL Foundation
    Role: Principal Investigator
    $30,775
  • July 2018–June 2019
    T3np in Cardiac Resuscitation – Pivotal Pre-Clinical Trial
    UB Center for Advanced Biomedical and Bioengineering Technology
    Role: Principal Investigator
    $182,528
  • June 2018–May 2019
    Quantitative Proteomics and Phosphoproteomics of Stretch-induced Myocardial Stunning and Adaptive Left Ventricular Stiffening in Swine
    Proteomics and Bioanalysis Core Seed Fund
    Role: Principal Investigator
    $15,000
  • April 2018–March 2019
    Pre-Clinical Evaluation of a Novel Antibody-Based Therapy to Improve Cardiac Repair After Acute Myocardial Infarction
    UB CTSI Translational Pilot Studies Program
    Role: Principal Investigator
    $48,746
  • November 2018
    Novel Biomarkers of Extracellular Matrix Expansion and Interstitial Fibrosis in Heart Failure
    The Community Foundation for Greater Buffalo
    Role: Principal Investigator
See all (2 more)

Journal Articles:

See all (35 more)

Abstracts:

  • Allen, S, Ang, S, Smith, C, Techiryan, G, Canty J, Weil BR. (2019) Deterioration of Hemodynamic Support During Prolonged Mechanical CPR in a Porcine Model of Cardiac Arrest. AHA Resuscitation Symposium 2019, (Nov) 2049-2064
  • Weil BR, Allen, S, Barbaccia, B, Young, R, Palka, B, Canty J. (2019) A Blinded, Randomized, Vehicle-Controlled Preclinical Trial of Novel Nanoparticle Formulations of Triiodothyronine in Cardiac Arrest. American Heart Association - Resuscitation Science Symposium 2019, (Nov)

Professional Memberships:

  • American Physiological Society (2017–present)
  • American Heart Association (2011–present)

Presentations:

  • "Novel Causes and Consequences of Myocardial Injury" University of Missouri Department of Biomedical Sciences Seminar Series (2021)
  • "Novel Causes and Consequences of Myocardial Injury" University at Buffalo Department of Physiology and Biophysics Seminar Series (2020)
  • "Pre-Clinical Evaluation of a Novel Antibody-Based Therapy to Improve Cardiac Repair After Acute Myocardial Infarction" University at Buffalo Clinical and Translational Science Institute Annual Research Colloquium (2020)
  • "Novel Mechanisms and Consequences of Cardiomyocyte Loss in Heart Disease" University at Buffalo Department of Exercise and Nutrition Sciences Seminar Series (2018)
  • "Lost in Clinical Translation: Cell-Based Therapy for Ischemic Heart Disease" Ithaca College Department of Biology Seminar Series; Seminar Title (2018)
  • "Therapeutic Strategies to Promote Cardiac Myocyte Survival and Regeneration in Ischemic Heart Disease" University at Buffalo Clinical and Translational Research Center Seminar Series (2017)
  • "Cell-Based Therapy to Promote Myocardial Repair in Ischemic Heart Disease" University at Buffalo Department of Physiology and Biophysics Seminar Series (2016)

Service Activities:

  • Veteran's Affairs Cardiovascular Studies (CAR-A) Review Panel; Peer Reviewer (2021–present)
  • National Institutes of Health, Clinical Integrative Cardiovascular and Hematological Sciences Study Section; Peer Reviewer (2021–present)
  • Phase 1 Committee; Committee Member (2020–present)
  • The Human Cardiovascular System (IMC602); Course Director (2020–present)
  • Veterans Affairs Medical Center Institutional Animal Care and Use Committee (IACUC) Review Committee; Member (2020–present)
  • American Heart Association; Peer Reviewer (2020–present)
  • Search Committee Member; School of Public Health and Health Professions; Department of Exercise and Nutrition Sciences, Assistant Professor (2019–2020)
  • PhD Program in Biomedical Sciences (PPBS) Admissions Committee; Committee Member (2019–2020)
  • Curriculum Committee; Committee Member (2018–2021)
  • Department of Physiology and Biophysics, Assistant to the Chair; Search Committee Member (2018)
  • Faculty Council; Committee Member (2018–2020)
  • Hermann Rahn Memorial Lectureship Committee; Committee Chair (2017–present)
  • Clean Air Coalition of Western New York; Board Member and Chair (2013–2017)
  • Circulation Research, Hypertension, Cardiovascular Research, American Journal of Physiology- Heart and Circulatory Physiology, Journal of Applied Physiology, Heart, Lung and Circulation, Journal of Internal Medicine, Journal of Stem Cell Research and Therapy, Expert Reviews of Cardiovascular Therapy, Annals of Biomedical Engineering; Manuscript Reviewer

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Contact Information

Clinical and Translational Research Center
Suite 7030
875 Ellicott Street
Buffalo, New York 14203
Phone: 716-829-3599
Fax: 716-854-1840
bweil@buffalo.edu