Department of Physiology and Biophysics
Jacobs School of Medicine & Biomedical Sciences
Apoptosis and cell death; Cardiac pharmacology; Cardiology; Cardiovascular Disease; Inflammation; Pathophysiology; Stem Cells; Translational imaging; Translational Research
My research program is focused on investigating mechanisms of cardiac dysfunction and structural remodeling in heart disease, as well as identifying novel therapeutic interventions to prevent or reverse left ventricular dysfunction caused by acute and chronic myocardial injury. These studies generally utilize non-invasive cardiovascular imaging techniques and invasive hemodynamic assessment to assess cardiac performance in vivo in preclinical experimental models, along with ex vivo analysis of myocardial tissue to examine cellular and molecular mechanisms underlying observed changes in physiological function. Using this approach, we aim to conduct impactful translational research with direct relevance to the pathophysiology and treatment of human heart disease.