University at Buffalo (UB)
Dahong Chen
Dahong Chen
Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Autism; Computational Biology; Developmental Biology; Gene Expression; Gene Sequencing; Genome-wide Screening; Molecular and Cellular Biology; Molecular Basis of Disease; Molecular genetics; Neurobiology; Neurodevelopmental Disorders; Neuroscience; Retina – retinal disease and therapy; Transcription - Gene; Transcription and Translation; Transcription Factors; Transcriptomics; Transgenic organisms
Education and Training:
- Fellowship, Postdoc, National Institutes of Health
- PhD, Cellular Behavioral Neurobiology, University of Oklahoma
Employment:
- Assistant Professor, Biochemistry, University at Buffalo (2024-present)
Grants and Sponsored Research:
- January 2024–January 2027
Chromatin architectural factor-mediated epigenetic regulation of neuronal remodeling during development
NIH
Role: Principal Investigator
$746,979 - September 2019–January 2024
Chromatin insulator-mediated epigenetic regulation of neuronal remodeling during development
NIH
Role: Principal Investigator
Journal Articles:
- Li Q, Chen D, Wang S. (2023) Character displacement of egg colors during tinamou speciation. Evolution; international journal of organic evolution (Jul), 77(8): 1874-1881.
- Rosin LF, Chen D, Chen Y, Lei EP. (2022) Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males. Proceedings of the National Academy of Sciences of the United States of America (Mar), 119(10): e2113374119. doi:10.1073/pnas.2113374119
- Chen D, McManus CE, Radmanesh B, Matzat LH, Lei EP. (2021) Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling. Nature communications (Nov), 12(1): 6366. doi:10.1038/s41467-021-26628-7
- Chen D, Lei EP. (2019) Function and regulation of chromatin insulators in dynamic genome organization. Current opinion in cell biology (Jun), 58: 61-68. doi:10.1016/j.ceb.2019.02.001
- Chen D, Brovkina M, Matzat LH, Lei EP. (2019) Shep RNA-Binding Capacity Is Required for Antagonism of gypsy Chromatin Insulator Activity. G3 (Bethesda, Md.) (Mar), 9(3): 749-754. doi:10.1534/g3.118.200923
- Chen D, Dale RK, Lei EP. (2018) Shep regulates Drosophila neuronal remodeling by controlling transcription of its chromatin targets. Development (Cambridge, England) (Jan), 145(1). doi:10.1242/dev.154047
- Chen D, Gu T, Pham TN, Zachary MJ, Hewes RS. (2017) Regulatory Mechanisms of Metamorphic Neuronal Remodeling Revealed Through a Genome-Wide Modifier Screen in Drosophila melanogaster. Genetics (Jul), 206(3): 1429-1443. doi:10.1534/genetics.117.200378
- Chen D, Qu C, Bjorum SM, Beckingham KM, Hewes RS. (2014) Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster. Genetics (Aug), 197(4): 1267-83. doi:10.1534/genetics.114.166181