Ding Xu PhD

Ding Xu

Ding Xu
PhD

Associate Professor

Department of Oral Biology

School of Dental Medicine


Specialty/Research Focus

Drug Development; Inflammation; Monoclonal Antibodies; Oral Biology; Pathophysiology; Protein Function and Structure; Structural Biology; Transgenic organisms

Contact Information
655 BRB
3435 Main St
Buffalo, New York 14214
Phone: 7168293509
Fax: www.xulab-heparan.org
dingxu@buffalo.edu



Education and Training:

  • Fellowship, Vascular Biology, Inflammation, University of California, San Diego (2011)
  • PhD, University of North Carolina (2007)
  • BS, Biochemistry, Central China Normal Universtiy (1999)

Employment:

  • Associate Professor, Oral Biology, University at Buffalo (2020-present)
  • Assistant Professor, Oral Biology, University at Buffalo (2014–2019)
  • Scientist, Assistant Project Scientist, Cellular and Molecular Medicine, University of California, San Diego School of Medicine (2011–2014)

Awards and Honors:

  • ASBMR 2019 Annual Meeting Research Team Travel Award (2019)
  • JBC/Herbert Tabor Young Investigator Award (2012)
  • Outstanding Poster Award at the Gordon Research Conference, Proteoglycans (2012)
  • The ASBMB 2012 Thematic Best Poster in Glycobiology, 2012 ASBMB Annual Meeting (2012)
  • American Heart Association postdoctoral Fellowship (2008)
  • American Heart Association Predoctoral Fellowship (2005)

Research Expertise:

  • Bone biology
  • Glycobiology
  • Heparan Sulfate
  • Inflammation
  • Structural Biology
  • www.xulab-heparan.org: Lab website

Patents:

  • Sulfated oligosaccharides decrease sterile inflammation damage in the live A new sulfated heparin sulfate oligosaccharide displays protective effect on drug-induced liver damage. The compound likely inhibits the function of HMGB1, a common protein in regulating immune responses. This discovery can be applied for a wide range of diseases that are caused by over reaction of inflammation responses.


Professional Memberships:

  • International Association for Dental Research (2023–present)
  • The American Society for Bone and Mineral Research (2015–present)
  • American Society for Biochemistry and Molecular Biology (2012–present)
  • Society for Glycobiology (2009–present)
  • American Society for Matrix Biology (2008–present)
  • American Heart Association (2004–present)

Presentations:

  • "Heparan sulfate is a master regulator of bone remodeling" National Institute of Environmental Health Sciences (2024)
  • "Heparan sulfate is a master regulator of bone remodeling" Emory School of Medicine (2024)
  • "Deciphering Heparan sulfate-protein interactions in Bone remodeling and inflammation" (2018)
  • "Deciphering Heparan sulfate-protein interactions in Bone remodeling" (2017)
  • "Deciphering Heparan sulfate-protein interactions in Bone remodeling" (2017)
  • "Heparan sulfate in bone remodeling" (AADR) Buffalo Section, Lunch and Learn Seminar Series; University at Buffalo (2015)
  • "Heparan sulfate in inflammation and bone remodeling" Inviated talk; Roswell Park Cancer Institute (2015)
  • "Heparan Sulfate–Dependent Oligomerization of RAGE is essential for signal transduction" Vasculata 2013; North American Vascular Biology Organization (2013)
  • "Heparan Sulfate–Dependent Oligomerization of RAGE is essential for signal transduction" Gordon Research Conference, Glycobiology; Gordon Research Conference (2013)
  • "Heparan Sulfate–Dependent Oligomerization of RAGE–a novel target for therapeutic intervention" Invited presentation; School of Pharmacy, University of Arizona (2013)
  • "Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice" 2012 ASBMB Annual Meeting; ASBMB (2012)
  • "Heparan Sulfate as a regulator of VEGF-induced vascular permeability" Gordon Research Conference, Vascular Cell Biology; ; Vascular Cell Biology (2009)
See all (2 more)

Service Activities:

  • Oral Biology Faculty Search committee (2023–2024)
  • School of Dental Medicine, Student Research and Honors Committee; Co-Chair (2022–2024)
  • Musculoskeletal, Oral and Skin Sciences IRG;; Ad Hoc Reviewer (2019)
  • Jacobs School of Medicine & Biomedical Sciences, Admissions Committee; Member (2017–2019)
  • NIH; Intercellular Interactions; Ad Hoc reviewer for R01 and R21 grants;; Ad Hoc Reviewer (2017)
  • School of Dental Medicine, Graduate Committee, Thesis; Member (2017–2020)
  • School of Dental Medicine, Graduate Committee, Admissions; Member (2017–2019)
  • School of Dental Medicine, Graduate Committee, Preliminary Exams; Fellow (2017–2018)
  • School of Dental Medicine, Student Research and Honors Committee; Member (2017–2022)
  • School of Dental Medicine, Graduate Committee, Preliminary Exams; Advisor (2016)
  • School of Dental Medicine, Graduate Committee, Preliminary Exams; Member (2015–2018)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

655 BRB
3435 Main St
Buffalo, New York 14214
Phone: 7168293509
Fax: www.xulab-heparan.org
dingxu@buffalo.edu