Garrett Neske Ph.D.

Garrett Neske

Garrett Neske
Ph.D.

Assistant Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Autism; Behavioral Neuroscience; Brain Research; Electrophysiology; Imaging In Vivo; Models - cell and animal; Molecular and Cellular Biology; Neurobiology; Neurodevelopmental Disorders; Neuropharmacology; Neuropsychiatric Disorders; Neuroscience; Parkinson’s disease; Schizophrenia; Vision science

Contact Information
Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences
955 Main Street, Room 3266
Buffalo, New York 14203
Phone: 716-829-5294
gneske@buffalo.edu



Professional Summary:

My research broadly focuses on the synaptic mechanisms of sensory, motor, and cognitive operations of the neocortex and thalamus. In my research, I use a multilevel approach, spanning from the study of synaptic physiology of cortical and thalamic circuits in isolated, ex vivo preparations to monitoring and manipulating neuronal population activity in animals performing decision-making tasks. Overall, my work is guided by the desire to understand how both local and long-range circuits in the cortex and thalamus dynamically orchestrate neuronal information processing according to behavioral context. I am also interested in understanding how these mechanisms are altered in neurological and psychiatric diseases associated with disrupted synaptic signaling.

Education and Training:

  • PhD, Neuroscience, Brown University (2015)
  • BS, Neuroscience, New York University (2009)

Employment:

  • Assistant professor, Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences (2023-present)
  • Postdoc, Neuroscience, Yale University (2015–2023)

Awards and Honors:

  • R00 award (2023)

Research Expertise:

  • Behavior: Training perceptual decision-making tasks in head-fixed mice
  • Electrophysiology: Ex vivo brain slice and awake in vivo whole-cell patch clamp recording
  • Imaging: 2-photon calcium imaging in awake, behaving animals
  • Optogenetics: Viral and transgenic approaches to opsin expression. Ex vivo and in vivo.

Grants and Sponsored Research:

  • Cortical and neuromodulatory mechanisms of state-dependent visual detection
    NINDS
    Role: Principal Investigator
    $143,279
  • Roles of higher-order visual thalamus in state-dependent corticocortical communication
    NEI
    Role: Principal Investigator
    $227,425
  • Roles of higher-order visual thalamus in state-dependent corticocortical communication
    NEI
    Role: Principal Investigator

Journal Articles:

See all (1 more)

Professional Memberships:

  • Society for Neuroscience; International association for neuroscience researchers (2010–present)

Service Activities:

  • Peer reviewer for manuscript submitted to Science Advances; Peer review (2023–2024)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences
955 Main Street, Room 3266
Buffalo, New York 14203
Phone: 716-829-5294
gneske@buffalo.edu