Jian Feng PhD
Jian Feng
PhD
UB Distinguished Professor
Department of Physiology and Biophysics
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Apoptosis and cell death; Cytoskeleton and cell motility; Gene Expression; Molecular and Cellular Biology; Molecular genetics; Neurobiology; Neurodegenerative disorders; Neurology; Pathophysiology; Protein Folding; Signal Transduction; Toxicology; Transcription and Translation
Professional Summary:
My research is aimed at finding the cause and a cure for Parkinson’s disease.
Parkinson’s disease (PD) is defined by a characteristic set of locomotor symptoms (rest tremor, rigidity, bradykinesia and postural instability) that are believed to be caused by the selective loss of dopaminergic (DA) neurons in substantia nigra. The persistent difficulties in using animals to model this human disease suggest that human nigral dopaminergic neurons have certain vulnerabilities that are unique to our species.
One of our unique features is the large size of the human brain (1350 grams on average) relative to the body. A single nigral dopaminergic neuron in a rat brain (2 grams) has a massive axon arbor with a total length of 45 centimeters. Assuming that all mammalian species share a similar brain wiring plan, we can estimate (using the cube root of brain weight) that a single human nigral dopaminergic neuron may have an axon with gigantic arborization that totals 4 meters.
Another unique feature of our species is our strictly bipedal movement, which is affected by Parkinson’s disease, in contrast to the quadrupedal movement of almost all other mammalian species. The much more unstable bipedal movement may require more dopamine, which supports the neural computation necessary for movement.
The landmark discovery of human induced pluripotent stem cells (iPSC) made it possible to generate patient-specific human midbrain dopaminergic neurons to study Parkinson’s disease. A key problem for dopaminergic neurons is the duality of dopamine as a signal required for neural computation and a toxin as its oxidation produces free radicals. Our study using iPSC-derived midbrain dopaminergic neurons from PD patients with parkin mutations and normal subjects shows that parkin sustains this necessary duality by maintaining the precision of the signal while suppressing the toxicity. Mutations of parkin cause increased spontaneous release of dopamine and reduced dopamine uptake, thereby disrupting the precision of dopaminergic transmission. On the other hand, transcription of monoamine oxidase is greatly increased when parkin is mutated. This markedly increases dopamine oxidation and oxidative stress. These phenomena have not been seen in parkin knockout mice, suggesting the usefulness of parkin-deficient iPSC-derived midbrain DA neurons as a cellular model for Parkinson’s disease.
Currently, we are using iPS cells and induced DA neurons to expand our studies on parkin to idiopathic Parkinson’s disease. We are also utilizing the molecular targets identified in our studies to find small-molecule compounds that can mimic the beneficial functions of parkin. The availability of human midbrain DA neurons should significantly speed up the discovery of a cure for Parkinson’s disease.
Education and Training:
- PhD, Biochemistry, University of Tennessee (1997)
- BS, Biochemistry, Nanjing University (1990)
Employment:
- UB Distinguished Professor, Department of Physiology and Biophysics, University at Buffalo, the State University of New York (2023-present)
- Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2010-present)
- Associate Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005–2010)
- Assistant Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2000–2005)
- Postdoctoral Research Associate, Laboratory of Molecular and Cellular Neuroscience, Rockefeller University (1997–2000)
Awards and Honors:
- UB Distinguished Professor (2023)
- National Research Council Prestigious Award (Society for Experimental Biology and Medicine Best Paper Award) (2022)
- State University of New York Chancellor’s Award for Excellence in Scholarship and Creative Activities (2021)
- University at Buffalo Exceptional Scholars – Sustained Achievement Award (2017)
Research Expertise:
- Parkinson's disease: I am a leading expert on the molecular and cellular mechanisms of Parkinson's disease.
- Stem Cell Biology: I have been developing novel stem cell technologies, such as induced pluripotent stem cells, transdifferentiation, and mouse-human chimeric embryos to study various human diseases.
Grants and Sponsored Research:
- February 2023–January 2028
Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells
NINDS
Role: Principal Investigator
$1,544,282 - December 2022–November 2027
Transcriptomic and Circuitry Aberrations in Alzheimer’s Disease
NIA
Role: Principal Investigator
$1,855,198 - April 2023–May 2025
Administrative Supplement to Molecular Segregation of Parkinson’s Disease by Patient-derived Neurons
NINDS
Role: Principal Investigator
$401,250 - June 2020–May 2025
Molecular Segregation of Parkinson’s Disease by Patient-derived Neurons
NINDS/NIH
Role: Principal Investigator
$2,244,925 - April 2020–March 2023
New Treatment Strategy for Alzheimer’s Disease
NIA/NIH
Role: Principal Investigator
$438,625 - September 2018–March 2023
Functions of parkin in Parkinson’s disease
NINDS/NIH
Role: Principal Investigator
$1,801,304 - April 2018–March 2022
Kinetic Barriers of Transdifferentiation
Department of Veterans Affairs
Role: Principal Investigator
$833,012 - March 2018–March 2022
The Interaction of parkin and environmental toxins in Parkinson’s disease
Department of Veterans Affairs
Role: Principal Investigator
$783,012 - April 2017–March 2022
A Novel Epigenetic Mechanism for Alzheimer's Disease
NIH
Role: Co-Investigator
$1,993,750 - April 2014–March 2018
Kinetic Barriers of Transdifferentiation
Department of Veterans Affairs
Role: Principal Investigator - June 2014–May 2017
Understand the Pathophysiology of Parkinson's Disease Using Genetically Modified iPS Cells
NYSTEM
Role: Principal Investigator - March 2013–February 2016
Redefining Idiopathic Parkinson’s Disease through Induced Pluriopotent Stem Cells
NYSTEM
Role: Principal Investigator - January 2009–December 2013
Cellular Functions of Parkin
NIH/NINDS
Role: Principal Investigator
$1,733,595
Patents:
- Method of Producing Naïve Pluripotent Stem Cells US Patent awarded (2023)
Journal Articles:
- Z Xu, H Jiang, P Zhong, Z Yan, S Chen, J Feng. (2015) Direct Conversion of Human Fibroblasts to Induced Serotonergic Neurons. Molecular Psychiatry (Jul)
- Zhu B, Fisher E, Li L, Zhong P, Yan Z, Feng J. (2023) PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes. Stem cell reports (Nov), 18(11): 2268-2282. doi:10.1016/j.stemcr.2023.09.012
- Pu J, Lin L, Jiang H, Hu Z, Li H, Yan Z, Zhang B, Feng J. (2023) Parkin Maintains Robust Pacemaking in Human Induced Pluripotent Stem Cell-Derived A9 Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society (Jul), 38(7): 1273-1281.
- Li H, Jiang H, Li H, Li L, Yan Z, Feng J. (2022) Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells. Molecular psychiatry (Nov), 27(11): 4407-4418. doi:10.1038/s41380-022-01628-1
- Fisher E, Feng J. (2022) RNA splicing regulators play critical roles in neurogenesis. Wiley interdisciplinary reviews. RNA (Nov), 13(6): e1728.
- Zhang B, Feng J. (2022) Mouse embryonic stem cells require multiple amino acids. Experimental biology and medicine (Maywood, N.J.) (Aug), 247(15): 1379-1387. doi:10.1177/15353702221096059
- Ren Y, Jiang H, Pu J, Li L, Wu J, Yan Y, Zhao G, Guttuso TJ, Zhang B, Feng J. (2022) Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society (Jan), 37(1): 70-79.
- Zhang B, Li H, Hu Z, Jiang H, Stablewski AB, Marzullo BJ, Yergeau DA, Feng J. (2021) Generation of mouse-human chimeric embryos. Nature protocols (Aug), 16(8): 3954-3980.
- Feng J. (2021) Modeling the pathophysiology of Parkinson's disease in patient-specific neurons. Experimental biology and medicine (Maywood, N.J.) (Feb), 246(3): 298-304. doi:10.1177/1535370220961788
- Li B, Jiang H, Li H, Zhang B, Slaughter M, Yan Z, Feng J. (2021) Direct conversion of adult human retinal pigmented epithelium cells to neurons with photoreceptor properties. Experimental biology and medicine (Maywood, N.J.) (Jan), 246(2): 240-248. doi:10.1177/1535370220963755
- Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carosi JM, Carra S, Carrier A, Carrier L, Carroll B, Carter AB, Carvalho AN, Casanova M, Casas C, Casas J, Cassioli C, Castillo EF, Castillo K, Castillo-Lluva S, Castoldi F, Castori M, Castro AF, Castro-Caldas M, Castro-Hernandez J, Castro-Obregon S, Catz SD, Cavadas C, Cavaliere F, Cavallini G, Cavinato M, Cayuela ML, Cebollada Rica P, Cecarini V, Cecconi F, Cechowska-Pasko M, Cenci S, Ceperuelo-Mallafré V, Cerqueira JJ, Cerutti JM, Cervia D, Cetintas VB, Cetrullo S, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chakrabarti O, Chakraborty T, Chakraborty T, Chami M, Chamilos G, Chan DW, Chan EYW, Chan ED, Chan HYE, Chan HH, Chan H, Chan MTV, Chan YS, Chandra PK, Chang CP, Chang C, Chang HC, Chang K, Chao J, Chapman T, Charlet-Berguerand N, Chatterjee S, Chaube SK, Chaudhary A, Chauhan S, Chaum E, Checler F, Cheetham ME, Chen CS, Chen GC, Chen JF, Chen LL, Chen L, Chen L, Chen M, Chen MK, Chen N, Chen Q, Chen RH, Chen S, Chen W, Chen W, Chen XM, Chen XW, Chen X, Chen Y, Chen YG, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen ZS, Chen Z, Chen ZH, Chen ZJ, Chen Z, Cheng H, Cheng J, Cheng SY, Cheng W, Cheng X, Cheng XT, Cheng Y, Cheng Z, Chen Z, Cheong H, Cheong JK, Chernyak BV, Cherry S, Cheung CFR, Cheung CHA, Cheung KH, Chevet E, Chi RJ, Chiang AKS, Chiaradonna F, Chiarelli R, Chiariello M, Chica N, Chiocca S, Chiong M, Chiou SH, Chiramel AI, Chiurchiù V, Cho DH, Choe SK, Choi AMK, Choi ME, Choudhury KR, Chow NS, Chu CT, Chua JP, Chua JJE, Chung H, Chung KP, Chung S, Chung SH, Chung YL, Cianfanelli V, Ciechomska IA, Cifuentes M, Cinque L, Cirak S, Cirone M, Clague MJ, Clarke R, Clementi E, Coccia EM, Codogno P, Cohen E, Cohen MM, Colasanti T, Colasuonno F, Colbert RA, Colell A, Colic M, Coll NS, Collins MO, Colombo MI, Colón-Ramos DA, Combaret L, Comincini S, Cominetti MR, Consiglio A, Conte A, Conti F, Contu VR, Cookson MR, Coombs KM, Coppens I, Corasaniti MT, Corkery DP, Cordes N, Cortese K, Costa MDC, Costantino S, Costelli P, Coto-Montes A, Crack PJ, Crespo JL, Criollo A, Crippa V, Cristofani R, Csizmadia T, Cuadrado A, Cui B, Cui J, Cui Y, Cui Y, Culetto E, Cumino AC, Cybulsky AV, Czaja MJ, Czuczwar SJ, D'Adamo S, D. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy (Jan), 17(1): 1-382. doi:10.1080/15548627.2020.1797280
- Li H, Hu Z, Jiang H, Pu J, Selli I, Qiu J, Zhang B, Feng J. (2020) TET1 Deficiency Impairs Morphogen-free Differentiation of Human Embryonic Stem Cells to Neuroectoderm. Scientific reports (Jun), 10(1): 10343. doi:10.1038/s41598-020-67143-x
- Hu Z, Li H, Jiang H, Ren Y, Yu X, Qiu J, Stablewski AB, Zhang B, Buck MJ, Feng J, Buck M. (2020) Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos. Sci Adv (May), 6(20): 0298-0298.
- Li H, Jiang H, Yin X, Bard JE, Zhang B, Feng J. (2019) Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. Biochemical and biophysical research communications (Aug), 516(3): 765-769. doi:10.1016/j.bbrc.2019.06.089
- Lin L, Liu A, Li H, Feng J, Yan Z. (2019) Inhibition of Histone Methyltransferases EHMT1/2 Reverses Amyloid-ß-Induced Loss of AMPAR Currents in Human Stem Cell-Derived Cortical Neurons. Journal of Alzheimer's disease : JAD (Jan), 70(4): 1175-1185. doi:10.3233/JAD-190190
- Li H, Jiang H, Zhang B, Feng J. (2018) Modeling Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells. Journal of Parkinson's disease (Jan), 8(4): 479-493. doi:10.3233/JPD-181353
- Zhong P, Hu Z, Jiang H, Yan Z, Feng J. (2017) Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations. Cell reports (May), 19(5): 1033-1044. doi:10.1016/j.celrep.2017.04.023
- Xu Z, Chu X, Jiang H, Schilling H, Chen S, Feng J. (2017) Induced dopaminergic neurons: A new promise for Parkinson's disease. Redox biology (Apr), 11: 606-612. doi:10.1016/j.redox.2017.01.009
- Jiang H, Xu Z, Zhong P, Ren Y, Liang G, Schilling HA, Hu Z, Zhang Y, Wang X, Chen S, Yan Z, Feng J. (2015) Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons. Nature communications (Dec), 6: 10100. doi:10.1038/ncomms10100
- Z Hu, J Pu, H Jiang, P Zhong, J Qiu, F Li, X Wang, B Zhang, Z Yan, J Feng. (2015) Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson’s Disease Patients for High Efficiency Genetic Manipulation and Disease Modeling. Stem Cells and Development (Jul)
- Ren Y, Jiang H, Hu Z, Fan K, Wang J, Janoschka S, Wang X, Ge S, Feng J. (2015) Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons. Stem Cells (Jan), 33(1): 68-78.
- Pu J, Jiang H, Zhang B, Feng J. (2012) Redefining Parkinson's disease research using induced pluripotent stem cells. Current neurology and neuroscience reports (Aug), 12(4): 392-8. doi:10.1007/s11910-012-0288-1
- Lee JB, Wei J, Liu W, Cheng J, Feng J, Yan Z. (2012) Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex. The Journal of physiology (Apr), 590(7): 1535-46. doi:10.1113/jphysiol.2011.224907
- Ren Y, Liu X, Lesage S, Cai M, Pu J, Zhang B, Brice A, Feng J. (2012) The normal parkin sequence. Mov Disord (Mar), 27(3): 463-464.
- Jiang H, Ren Y, Yuen EY, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J. (2012) Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nat Commun (Feb), 3: 668-668.
- Garrick MD, Zhao L, Roth JA, Jiang H, Feng J, Foot NJ, Dalton H, Kumar S, Garrick LM. (2012) Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation. Biometals (Feb), 25: 787-793.
- Liu W, Dou F, Feng J, Yan Z. (2011) RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission. Neurobiol Aging (Oct), 32(10): 1818-1826.
- Ren Y, Jiang H, Ma D, Nakaso K, Feng J. (2011) Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases. Hum Mol Genet (Mar), 20(6): 1074-1083.
- Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, Yan Z. (2011) Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Molecular psychiatry (Feb), 16(2): 156-70. doi:10.1038/mp.2010.50
- Jiang H, Cheng D, Liu W, Peng J, Feng J. (2010) Protein kinase C inhibits autophagy and phosphorylates LC3. Biochemical and biophysical research communications (May), 395(4): 471-6. doi:10.1016/j.bbrc.2010.04.030
- H. Jiang, D. Cheng, W. Liu, J. Peng, J. Feng. (2010) Protein Kinase C Inhibits Autophagy and Phosphorylates LC3. Biochem Biophys Res Commun (May), 395(4): 471-476.
- Roth JA Singleton S Feng J Garrick M Paradkar P. (2010) Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1. Journal of Neurochemistry (Apr), 113: 454-464.
- B. Porton, R.M. Rodriguiz, L.E. Phillips, J.W. Gilbert, J. Feng, P. Greengard, H.T. Kao, W.C. Wetsel. (2010) Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. Genes Brain Behav (Apr), 9(3): 257-268.
- Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. (2009) Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proc Natl Acad Sci U S A (Aug), 106(33): 14075-14079.
- Ren Y, Jiang H, Yang F, Nakaso K, Feng J. (2009) Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation. J Biol Chem (Feb), 284(6): 4009-4017.
- Chen G, Chen P, Tan H, Ma D, Dou F, Feng J, Yan Z. (2008) Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiology of aging (Dec), 29(12): 1795-804. doi:10.1016/j.neurobiolaging.2007.04.023
- Jiang Q, Ren Y, Feng J. (2008) Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J Neurosci (Nov), 28(48): 12993-13002.
- Yuen EY, Jiang Q, Chen P, Feng J, Yan Z. (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex. The Journal of biological chemistry (Jun), 283(25): 17194-204. doi:10.1074/jbc.M801713200
- Kao HT, Li P, Chao HM, Janoschka S, Pham K, Feng J, Mcewen BS, Greengard P, Pieribone VA, Porton B. (2008) Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. J Comp Neurol (Apr), 507(6): 1860-1870.
- Madden MM, Song W, Martell PG, Ren Y, Feng J, Lin Q. (2008) Substrate properties of ubiquitin carboxyl-terminally derived peptide probes for protein ubiquitination. Biochemistry (Mar), 47(12): 3636-3644.
- Chen G, Chen P, Tan H, Ma D, Dou F, Feng J, Yan Z. (2008) Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer’s disease. Neurobiol. Aging (Jan), 29: 1795-1804.
- Yuen EY, Jiang Q, Chen P, Feng J, Yan Z. (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of NMDA channels in pyramidal neurons of prefrontal cortex. J. Biol. Chem. (Jan), 283: 17194-17204.
- Feng J. (2006) Microtubule: a common target for parkin and Parkinson's disease toxins. Neuroscientist (Dec), 12(6): 469-476.
- Liu W, Yuen EY, Allen PB, Feng J, Greengard P, Yan Z. (2006) Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proceedings of the National Academy of Sciences of the United States of America (Nov), 103(48): 18338-43. doi:10.1073/pnas.0604560103
- Jiang Q, Yan Z, Feng J. (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience (Apr), 26(16): 4318-28. doi:10.1523/JNEUROSCI.0118-06.2006
- Jiang H, Jiang Q, Liu W, Feng J. (2006) Parkin suppresses the expression of monoamine oxidases. J Biol Chem (Mar), 281(13): 8591-8599.
- Wang X, Gu Z, Zhong P, Chen G, Feng J, Yan Z. (2006) Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure. Molecular and cellular neurosciences (Jan), 31(1): 15-25.
- Ren Y, Liu W, Jiang H, Jiang Q, Feng J. (2005) Selective vulnerability of dopaminergic neurons to microtubule depolymerization. The Journal of biological chemistry (Oct), 280(40): 34105-12.
- Yuen EY, Jiang Q, Feng J, Yan Z. (2005) Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons. The Journal of biological chemistry (Aug), 280(33): 29420-7.
- Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Z. (2005) Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience (Jun), 25(23): 5488-501. doi:10.1523/JNEUROSCI.1187-05.2005
- Yang F, Jiang Q, Zhao J, Ren Y, Sutton MD, Feng J. (2005) Parkin stabilizes microtubules through strong binding mediated by three independent domains. J Biol Chem (Apr), 280(17): 17154-17162.
- Jiang H, Jiang Q, Feng J. (2004) Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. J Biol Chem (Dec), 279(52): 54380-54386.
- Yan Z, Feng J. (2004) Alzheimer's disease: interactions between cholinergic functions and beta-amyloid. Current Alzheimer research (Nov), 1(4): 241-8.
- Jiang H, Ren Y, Zhao J, Feng J. (2004) Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Hum Mol Genet (Aug), 13(16): 1745-1754.
- Zhao J, Ren Y, Jiang Q, Feng J. (2003) Parkin is recruited to the centrosome in response to inhibition of proteasomes. J Cell Sci (Oct), 116(Pt 19): 4011-4019.
- Zhong P, Gu Z, Wang X, Jiang H, Feng J, Yan Z. (2003) Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J Biol Chem (Jul), 278(29): 26888-26896.
- Ren Y, Zhao J, Feng J. (2003) Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci (Apr), 23(8): 3316-3324.
- Ren Y, Zhao J, Feng J. (2003) Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience (Apr), 23(8): 3316-24. doi:10.1523/JNEUROSCI.23-08-03316.2003
- Ma XH, Zhong P, Gu Z, Feng J, Yan Z. (2003) Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortex. J Neurosci (Feb), 23(4): 1159-1168.
- Pieribone VA, Porton B, Rendon B, Feng J, Greengard P, Kao HT. (2002) Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. J Comp Neurol (Dec), 454(2): 105-114.
- Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN. (2002) Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol (Nov), 22(21): 7491-7500.
- Feng J, Chi P, Blanpied TA, Xu Y, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P. (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci (Jun), 22(11): 4372-4380.
- Cai X, Flores-Hernandez J, Feng J, Yan Z. (2002) Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. The Journal of physiology (May), 540(Pt 3): 743-59. doi:10.1113/jphysiol.2001.013391
- Cai X, Flores-Hernandez J, Feng J, Yan Z. (2002) Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. J Physiol (May), 540(Pt 3): 743-759.
- Feng J, Cai X, Zhao J, Yan Z. (2001) Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J Neurosci (Sep), 21(17): 6502-6511.
- Stafstrom-Davis CA, Ouimet CC, Feng J, Allen PB, Greengard P, Houpt TA. (2001) Impaired conditioned taste aversion learning in spinophilin knockout mice. Learn Mem (Jan), 8(5): 272-278.
- Feng J, Yan Z, Ferreira A, Tomizawa K, Liauw JA, Zhuo M, Allen PB, Ouimet CC, Greengard P. (2000) Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A (Aug), 97(16): 9287-9292.
- Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN. (2000) Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity (Jul), 13(1): 25-35.
- Ferreira A, Kao HT, Feng J, Rapoport M, Greengard P. (2000) Synapsin III: developmental expression, subcellular localization, and role in axon formation. J Neurosci (May), 20(10): 3736-3744.
- Wang D, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, Ihle JN. (2000) A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J (Feb), 19(3): 392-399.
- Yan Z, Feng J, Fienberg AA, Greengard P. (1999) D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. Proc Natl Acad Sci U S A (Sep), 96(20): 11607-11612.
- Allen PB, Hsieh-Wilson L, Yan Z, Feng J, Ouimet CC, Greengard P. (1999) Control of protein phosphatase-1 in the dendrite. Biochem. Soc. Trans (Aug), 27(4): 543-546.
- Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, Greengard P. (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nat Neurosci (Jan), 2(1): 13-17.
- Ihle JN, Thierfelder W, Teglund S, Stravapodis D, Wang D, Feng J, Parganas E. (1998) Signaling by the cytokine receptor superfamily. Ann N Y Acad Sci (Dec), 865: 1-9.
- Ihle JN, Stravapodis D, Parganas E, Thierfelder W, Feng J, Wang D, Teglund S. (1998) The roles of Jaks and Stats in cytokine signaling. Cancer J Sci Am (May), 4 Sup: 84-91.
- Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Häring M, Benfenati F, Greengard P. (1998) A third member of the synapsin gene family. Proc Natl Acad Sci U S A (Apr), 95(8): 4667-4672.
- Quelle FW, Wang J, Feng J, Wang D, Cleveland JL, Ihle JN, Zambetti GP. (1998) Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes Dev (Apr), 12(8): 1099-1107.
- Shimoda K, Feng J, Murakami H, Nagata S, Watling D, Rogers NC, Stark GR, Kerr IM, Ihle JN. (1997) Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor. Blood (Jul), 90(2): 597-604.
- Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, Ihle JN. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol Cell Biol (May), 17(5): 2497-2501.
- Kohlhuber F, Rogers NC, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn BA, Kotenko SV, Pestka S, Stark GR, Ihle JN, Kerr IM. (1997) A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses. Mol Cell Biol (Feb), 17(2): 695-706.
Abstracts:
- Feng J, Ren Y. (2007) Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism. J. Neurochem, (Oct) 303-311
- Feng J, Yan Z, Jiang Q. (2006) Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. (Sep) 29391-29400
Presentations:
- "Deconstructing Parkinson's Disease" The First Experimental Biology and Medicine Conference (2024)
- "Deconstructing Parkinson’s Disease in Human Models" Neuroscience Seminar at Pennsylvania State University (2023)
- "Deconstructing Parkinson’s Disease in Human Models" Seminar at the Department of Pharmacology, University of Tennessee Health Science Center (2023)
- "Generation of Mouse-Human Chimeric Embryos" The 7th International Experimental Biology and Medicine Conference on Regenerative Medicine (2022)
Service Activities:
- I am elected the Treasurer of the Society for Experimental Biology and Medicine; Treasurer (2024–2026)
- NIH Chronic Dysfunction and Integrative Neurodegeneration (CDIN) Study Section; Ad hoc reviewer (2024)
- NIH Development and Validation of Models for ADRD (ZNS1 SRB-M (17) SEP); Ad hoc reviewer (2023)
- NIH Chronic Dysfunction and Integrative Neurodegeneration (CDIN) Study Section; Ad hoc reviewer (2023)
- NINDS ZNS1 SRB-M (14) Special Emphasis Panel on Functional Target Validation for Alzheimer's Disease-Related Dementias; Ad hoc reviewer (2023)
- NIH Neurotoxicology and Alcohol Study Section (NAL) Study Section; Ad hoc reviewer (2023)
- I have been serving on the Organizing Committee for the First Experimental Biology and Medicine Conference in Orlando, FL, October 13-16, 2024; Member of the Organizing Committee for the First Experimental Biology and Medicine Conference in Orlando, FL, October 13-16, 2024 (2022–2024)
- I serve on the Finance and Investment Committee of the Society for Experimental Biology and Medicine and persuade the society to adopt index funds as investment strategy.; Member, Finance and Investment Committee (2017–2021)
- I have served on the Abstract Review Committee of the International Society for Stem Cell Research since 2017.; Member of the Abstract Review Committee (2017–present)
- Councilor, Society for Experimental Biology and Medicine I serve as a Councilor at the Society for Experimental Biology and Medicine for the term of 2015-2019.; Councilor (2015–2019)
- I have been serving on the Parkinson Foundation Grant Review Committee since 2015.; Reviewer (2015–present)
- I have served as the Associate Editor of Stem Cell Biology Section for the journal Experimental Biology and Medicine; Associate Editor, Stem Cell Biology (2012–2027)