Jungeun Won Ph.D.
Jungeun Won
Ph.D.
Assistant Professor of Research
Department of Biomedical Engineering
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Ageing; Artificial Intelligence; Bacterial Pathogenesis; Biomedical Imaging; Image Processing and Analysis; Imaging In Vivo; Retina – retinal disease and therapy; Translational Research
Professional Summary:
The goal of my research is to develop next-generation translational optical imaging technologies that are combined with computational and analytical methods to advance disease diagnosis, monitoring, and predicting treatment response. My research lab is broadly focused on developing optical coherence tomography (OCT) and microscopy methods to study middle ear infections and ear biofilm, retinal diseases, and non-destructive tissue characterization methods.
Education and Training:
- PhD, Bioengineering, University of Illinois Urbana-Champaign (2021)
- MS, Bioengineering, University of Illinois Urbana-Champaign (2017)
- BS, Biomedical Engineering and Minor in Optics, University of Rochester (2015)
Employment:
- Assistant Professor of Research, Biomedical Engineering, University at Buffalo (2024-present)
- Postdoctoral Associate, Electrical Engineering and Computer Science, Massachusetts Institute of Technology (2021–2023)
Awards and Honors:
- National Alliance for Eye and Vision Research Emerging Vision Scientist Program (2024)
- Bob Bilger Graduate Award for Hearing Research (2020)
- McGinnis Medical Innovation Graduate Fellowship (2020)
- Baxter Young Investigator Award (2019)
- Biannual Symposium Travel Scholarship Award (2019)
- Nadine Barrie Smith Memorial Fellowship (2017)
- Walt and Bobbi Makous Prize for Vision Research (2015)
- Xerox Engineering Research Fellowship (2014)
Research Expertise:
- Adult/pediatric middle ear OCT imaging to look inside middle ear cavity; Otitis media
- Machine learning methods for image/volumetric clinical datasets
- Non-destructive imaging and characterization of bacterial biofilm
- Optical coherence tomography (OCT) and OCT angiography (OCTA): instrumentation, prototype development, and image analysis
- Ultrahigh resolution imaging of retina: normal aging and age-related macular degeneration (AMD)
Journal Articles:
- Won J., Takahashi H., Ploner S., Karbole W., Abu-Qamar O., Yaghy A., Marmalidou A., Kaiser S., Hwang Y., Lin J., Witkin A., Desai S., Baumal C.R., Maier A., Curcio C., Waheed N., and Fujimoto J.G. (2024) Topographic measurement of the sub-retinal pigment epithelium space in normal aging and age-related macular degeneration using high-resolution OCT. Investigative Ophthalmology & Visual Science (Aug), 10(65): 18.
- Zhang C, Zaki FR, Won J, Boppart SA. (2024) A multimodal nonlinear optical microscopy study of the responses of Pseudomonas aeruginosa to blue light and antibiotic treatment. Journal of biophotonics (Mar), 17(3): e202300384. doi:10.1002/jbio.202300384
- Hwang Y, Won J, Yaghy A, Takahashi H, Girgis JM, Lam K, Chen S, Moult EM, Ploner SB, Maier A, Waheed NK, Fujimoto JG. (2023) Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited]. Biomedical optics express (Jun), 14(6): 2658-2677. doi:10.1364/BOE.488103
- Huang C, Clark GG, Zaki FR, Won J, Ning R, Boppart SA, Elbanna AE, Nguyen TH. (2023) Effects of phosphate and silicate on stiffness and viscoelasticity of mature biofilms developed with simulated drinking water. Biofouling (Jan), 39(1): 36-46. doi:10.1080/08927014.2023.2177538
- Deng YH, Ricciardulli T, Won J, Wade MA, Rogers SA, Boppart SA, Flaherty DW, Kong H. (2022) Self-locomotive, antimicrobial microrobot (SLAM) swarm for enhanced biofilm elimination. Biomaterials (Aug), 287: 121610. doi:10.1016/j.biomaterials.2022.121610
- Monroy GL, Won J, Shi J, Hill MC, Porter RG, Novak MA, Hong W, Khampang P, Kerschner JE, Spillman DR, Boppart SA. (2022) Automated classification of otitis media with OCT: augmenting pediatric image datasets with gold-standard animal model data. Biomedical optics express (Jun), 13(6): 3601-3614. doi:10.1364/BOE.453536
- Choi H, Zaki FR, Monroy GL, Won J, Boppart SA. (2022) Imaging and characterization of transitions in biofilm morphology via anomalous diffusion following environmental perturbation. Biomedical optics express (Mar), 13(3): 1654-1670. doi:10.1364/BOE.449131
- Monroy GL, Fitzgerald ST, Locke A, Won J, Spillman DR, Ho A, Zaki FR, Choi H, Chaney EJ, Werkhaven JA, Mason KM, Mahadevan-Jansen A, Boppart SA. (2022) Multimodal Handheld Probe for Characterizing Otitis Media - Integrating Raman Spectroscopy and Optical Coherence Tomography. Frontiers in photonics (Jan), 3. doi:10.3389/fphot.2022.929574
- Locke AK, Zaki FR, Fitzgerald ST, Sudhir K, Monroy GL, Choi H, Won J, Mahadevan-Jansen A, Boppart SA. (2022) Differentiation of otitis media-causing bacteria and biofilms via Raman spectroscopy and optical coherence tomography. Frontiers in cellular and infection microbiology (Jan), 12: 869761. doi:10.3389/fcimb.2022.869761
- Sun PP, Won J, Choo-Kang G, Li S, Chen W, Monroy GL, Chaney EJ, Boppart SA, Eden JG, Nguyen TH. (2021) Inactivation and sensitization of Pseudomonas aeruginosa by microplasma jet array for treating otitis media. NPJ biofilms and microbiomes (Jun), 7(1): 48. doi:10.1038/s41522-021-00219-2
- Won J, Monroy GL, Dsouza RI, Spillman DR, McJunkin J, Porter RG, Shi J, Aksamitiene E, Sherwood M, Stiger L, Boppart SA. (2021) Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections. Biosensors (May), 11(5). doi:10.3390/bios11050143
- Won J, Porter RG, Novak MA, Youakim J, Sum A, Barkalifa R, Aksamitiene E, Zhang A, Nolan R, Shelton R, Boppart SA. (2021) In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography. Journal of biophotonics (Apr), 14(4): e202000215. doi:10.1002/jbio.202000215
- Won J, Hong W, Khampang P, Spillman DR, Marshall S, Yan K, Porter RG, Novak MA, Kerschner JE, Boppart SA. (2021) Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy. Scientific reports (Mar), 11(1): 5176. doi:10.1038/s41598-021-84543-9
- Won J, Huang PC, Spillman DR, Chaney EJ, Adam R, Klukowska M, Barkalifa R, Boppart SA. (2020) Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva. Journal of biomedical optics (Nov), 25(11). doi:10.1117/1.JBO.25.11.116011
- Huang C, Sun PP, Won J, Wang Y, Boppart SA, Nguyen TH. (2020) Effect of Nonphosphorus Corrosion Inhibitors on Biofilm Pore Structure and Mechanical Properties. Environmental science & technology (Nov), 54(22): 14716-14724. doi:10.1021/acs.est.0c04645
- Won J, Huang PC, Boppart SA. (2020) Phase-based Eulerian motion magnification reveals eardrum mobility from pneumatic otoscopy without sealing the ear canal. JPhys photonics (Jul), 2(3). doi:10.1088/2515-7647/ab8a59
- Won J, Monroy GL, Huang PC, Hill MC, Novak MA, Porter RG, Spillman DR, Chaney EJ, Barkalifa R, Boppart SA. (2020) Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography. Ear and hearing (Jan), 41(4): 811-824. doi:10.1097/AUD.0000000000000796
- Monroy GL, Won J, Dsouza R, Pande P, Hill MC, Porter RG, Novak MA, Spillman DR, Boppart SA. (2019) Automated classification platform for the identification of otitis media using optical coherence tomography. NPJ digital medicine (Jan), 2: 22. doi:10.1038/s41746-019-0094-0
- Dsouza R, Won J, Monroy GL, Spillman DR, Boppart SA. (2018) Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications. Journal of biomedical optics (Sep), 23(9): 1-11. doi:10.1117/1.JBO.23.9.096003
- Dsouza R, Won J, Monroy GL, Hill MC, Porter RG, Novak MA, Boppart SA. (2018) In vivo detection of nanometer-scale structural changes of the human tympanic membrane in otitis media. Scientific reports (Jun), 8(1): 8777. doi:10.1038/s41598-018-26514-1
- Won J, Monroy GL, Huang PC, Dsouza R, Hill MC, Novak MA, Porter RG, Chaney E, Barkalifa R, Boppart SA. (2018) Pneumatic low-coherence interferometry otoscope to quantify tympanic membrane mobility and middle ear pressure. Biomedical optics express (Feb), 9(2): 397-409. doi:10.1364/BOE.9.000397
- Monroy GL, Won J, Spillman DR, Dsouza R, Boppart SA. (2017) Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements. Journal of biomedical optics (Dec), 22(12): 1-30. doi:10.1117/1.JBO.22.12.121715
- Tankam P, Won J, Canavesi C, Cox I, Rolland JP. (2016) Optical Assessment of Soft Contact Lens Edge-Thickness. Optometry and vision science : official publication of the American Academy of Optometry (Aug), 93(8): 987-96. doi:10.1097/OPX.0000000000000892
- Duma VF, Tankam P, Huang J, Won J, Rolland JP. (2015) Optimization of galvanometer scanning for optical coherence tomography. Applied optics (Jun), 54(17): 5495-507.
- Tankam P, He Z, Chu YJ, Won J, Canavesi C, Lepine T, Hindman HB, Topham DJ, Gain P, Thuret G, Rolland JP. (2015) Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases. Optics letters (Mar), 40(6): 1113-6. doi:10.1364/OL.40.001113
- Tankam P, Santhanam AP, Lee KS, Won J, Canavesi C, Rolland JP. (2014) Parallelized multi-graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy. Journal of biomedical optics (Jul), 19(7): 71410. doi:10.1117/1.JBO.19.7.071410