Jun-Xu Li MD, PhD
Jun-Xu Li
MD, PhD
Professor; Vice Chair for Research
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Behavioral pharmacology; Drug abuse; Neurobiology
Professional Summary:
I have two primary research interests. First, I use pharmacological approaches to seek novel therapeutics for pain. Pain is an agonizing symptom and disease that affects millions of people. Analgesics like opioids (e.g., OxyContin) are powerful for treating many pain conditions. However, opioids are not efficacious for some pain (e.g., neuropathic pain) and prolonged use of opioids has many side effects, including tolerance and dependence. The laboratory has been working on two interesting drug targets (imidazoline I2 receptors and GABAa receptors) for years in the hope that novel safer and effective analgesics can be developed from our preclinical research.
Second, I am interested in pharmacotherapy of drug abuse. We use powerful behavioral pharmacological approaches, in animal models that are predictive of human stimulant abuse conditions, to study novel drug targets and evaluate potential pharmacotherapies against addictions to opioids, psychostimulants and nicotine.
One unifying theme of the ongoing research in my laboratory is the application of receptor theory to the guidance and interpretation of the drug-receptor interactions in behaving animals.
Education and Training:
- PhD, Pharmacology, Peking University
Awards and Honors:
- ASPET-JH Woods Early Career Award in Behavioral Pharmacology (2019)
- CPDD Joseph Cochin Young Investigator Award (2016)
- UB Exceptional Scholar-Young Investigator Award (2014)
- Early Career Investigator Award (2007)
Research Expertise:
- Behavioral Pharmacology: We use various behavioral pharmacological procedures to understand how drugs work at the behavioral level. Procedures used include drug discrimination, schedule-controlled responding, drug self-administration, delay discounting, place conditioning, locomotor activity and various acute and chronic pain tests.
- Pain and Addiction: We are interested in understanding the neurobiological crosstalk between pain and addiction. To reach this goal, we are developing novel behaivoral procedures to simultaneously measure pain affect and addiction-related behaviors.
- Quantitative Pharmacological Analysis: The precise understanding of the interactions between drugs from the same or different classes requires quantitative analysis methods. These analytical strategies help to ascertain the behavioral effects of drugs in an quantitative manner.
Grants and Sponsored Research:
- July 2023–July 2025
Development of LPA5 Antagonists as Analgesics
NINDS/NIH
Role: Co-Principal Investigator
$407,125 - April 2019–February 2025
TAAR1 agonists for nicotine addiction
USPHS NIH
Role: Principal Investigator
$1,986,083 - September 2023–September 2024
Designing and validating optimal nonaddictive analgesics using the CANDO paradigm
USPHS NIH
Role: Co-Investigator
$90,000
Patents:
- Novel combination therapy for anxiety disorders, epilepsy, and pain (2019)
Journal Articles:
- Lewter LA, Woodhouse K, Tiruveedhula VVNPB, Cook JM, Li JX. (2024) Antinociceptive Effects of a2/a3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity. The Journal of pharmacology and experimental therapeutics (Nov), 391(3): 389-398. doi:10.1124/jpet.123.002070
- Peng L, Zhang J, Feng J, Ge J, Zou Y, Chen Y, Xu L, Zeng Y, Li JX, Liu J. (2024) Activation of trace amine-associated receptor 1 ameliorates PTSD-like symptoms. Biochemical pharmacology (Oct), 228: 116236.
- Siemian JN, Woodhouse K, Liu DH, Zhang Y, Li JX. (2024) The imidazoline I2 receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination. Psychopharmacology (Mar), 241(3): 479-487.
- Liu J, Wu R, Li JX. (2024) TAAR1 as an emerging target for the treatment of psychiatric disorders. Pharmacology & therapeutics (Jan), 253: 108580.
- Liu J, Wu R, Seaman R, Manz KM, Johnson B, Vu J, Huang Y, Zhang Y, Robison AJ, Neve R, Grueter BA, Dietz D, Li JX. (2022) TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIa activity in the NAc. Molecular psychiatry (Jan).
- Wu R, Liu J, Johnson B, Huang Y, Zhang Y, Li JX. (2022) Activation of trace amine-associated receptor 1 attenuates nicotine withdrawal-related effects. Addiction biology (Jan), 27(1): e13075. doi:10.1111/adb.13075
- Wu R, Liu J, Vu J, Huang Y, Dietz DM, Li JX. (2021) Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats. Brain, behavior, and immunity (Dec), 101: 37-48.
- Nguyen T, Gamage TF, Finlay DB, Decker AM, Langston TL, Barrus D, Glass M, Li JX, Kenakin TP, Zhang Y. (2021) Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior. Journal of medicinal chemistry (Dec).
- Wu R, Li JX. (2021) Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders. CNS drugs (Dec), 35(12): 1239-1248.
- Wu R, Liu J, Seaman R, Johnson B, Zhang Y, Li JX. (2021) The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice. Psychopharmacology (Nov), 238(11): 3221-3228. doi:10.1007/s00213-021-05937-1
- Lewter LA, Golani LK, Cook JM, Li JX. (2021) Blockade of a1 subtype GABAA receptors attenuates the development of tolerance to the antinociceptive effects of midazolam in rats. Behavioural pharmacology (Jun), 32(4): 345-350. doi:10.1097/FBP.0000000000000614
- Nguyen T, Marusich J, Li JX, Zhang Y. (2020) Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. Journal of medicinal chemistry (Nov), 63(21): 12387-12402.
- Liu J, Seaman R, Johnson B, Wu R, Vu J, Tian J, Zhang Y, Li JX, Li J. (2020) Activation of Trace Amine-Associated Receptor 1 Selectively Attenuates the Reinforcing Effects of Morphine. Br J Pharmacol (Nov).
- Wu R, Liu J, Wang K, Huang Y, Zhang Y, Li JX, Li J. (2020) Effects of A Trace Amine-Associated Receptor 1 Agonist RO 5263397 on Ethanol-induced Behavioral Sensitization. Behav Brain Res (May)112641-112641.
- Liu J, Johnson B, Wu R, Seaman R, Vu J, Zhu Q, Zhang Y, Li JX, Li J. (2020) TAAR 1 Agonists Attenuate Extended Access Cocaine Self-administration and Yohimbine-induced Reinstatement of Cocaine-seeking. Br J Pharmacol (Apr).
- Liu J, Wu R, Li JX. (2020) TAAR1 and Psychostimulant Addiction. Cellular and molecular neurobiology (Mar), 40(2): 229-238. doi:10.1007/s10571-020-00792-8
- Wu R, Li JX. (2020) Toll-Like Receptor 4 Signaling and Drug Addiction. Frontiers in pharmacology (Jan), 11: 603445. doi:10.3389/fphar.2020.603445
- Bousquet P, Hudson A, GarcÃa-Sevilla JA, Li JX, Li J. (2020) Imidazoline Receptor System: The Past, the Present, and the Future. Pharmacol Rev (Jan), 72(1): 50-79.
- Liu J, Wu R, Johnson B, Vu J, Bass C, Li JX, Li J. (2019) The Claustrum-Prefrontal Cortex Pathway Regulates Impulsive-Like Behavior. J Neurosci (Dec), 39(50): 10071-10080.
- Nguyen T, Gamage TF, Decker AM, Barrus D, Langston TL, Li JX, Thomas BF, Zhang Y. (2019) Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators. Journal of medicinal chemistry (Nov), 62(21): 9806-9823. doi:10.1021/acs.jmedchem.9b01161
- Martin JA, Werner CT, Mitra S, Zhong P, Wang ZJ, Gobira PH, Stewart AF, Zhang J, Erias K, Siemian JN, Hagarty D, Mueller LE, Neve RL, Li JX, Chandra R, Dietz KC, Lobo MK, Gancarz AM, Yan Z, Dietz DM. (2019) A novel role for the actin-binding protein drebrin in regulating opiate addiction. Nature communications (Sep), 10(1): 4140. doi:10.1038/s41467-019-12122-8
- Liu JF, Wu R, Li JX. (2019) Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System. Neuroscience bulletin (Aug), 35(4): 771-774. doi:10.1007/s12264-018-00335-8
- Xue Z, Siemian JN, Zhu Q, Blough BE, Li JX. (2019) Further pharmacological comparison of D-methamphetamine and L-methamphetamine in rats: abuse-related behavioral and physiological indices. Behavioural pharmacology (Aug), 30(5): 422-428. doi:10.1097/FBP.0000000000000453
- Siemian JN, Shang L, Seaman RW, Zhu Q, Zhang Y, Li JX. (2019) Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats. Behavioural pharmacology (Aug), 30(5): 429-434. doi:10.1097/FBP.0000000000000454
- Li JX. (2019) Combining opioids and non-opioids for pain management: Current status. Neuropharmacology (Apr).
- Liu JF, Li JX. (2018) Drug addiction: a curable mental disorder?. Acta pharmacologica Sinica (Dec), 39(12): 1823-1829. doi:10.1038/s41401-018-0180-x
- Werner CT, Viswanathan R, Martin JA, Gobira PH, Mitra S, Thomas SA, Wang ZJ, Liu JF, Stewart AF, Neve RL, Li JX, Gancarz AM, Dietz DM. (2018) E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking. Biological psychiatry (Dec), 84(12): 881-892. doi:10.1016/j.biopsych.2018.07.013
- Liu JF, Tian J, Li JX, Li J. (2018) Modulating reconsolidation and extinction to regulate drug reward memory. Eur J Neurosci (Aug).
- Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX. (2018) The imidazoline I2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochemical pharmacology (Jul), 153: 260-268. doi:10.1016/j.bcp.2018.01.032
- Siemian JN, Jia S, Liu JF, Zhang Y, Li JX. (2018) Neuroanatomical characterization of imidazoline I2 receptor agonist-induced antinociception. The European journal of neuroscience (May), 47(9): 1087-1095. doi:10.1111/ejn.13899
- Siemian JN, Wang K, Zhang Y, Li JX. (2018) Mechanisms of imidazoline I2 receptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission. British journal of pharmacology (May), 175(9): 1519-1534. doi:10.1111/bph.14161
- Bernosky-Smith KA, Qiu YY, Feja M, Lee YB, Loughlin B, Li JX, Bass CE. (2018) Ventral tegmental area D2 receptor knockdown enhances choice impulsivity in a delay-discounting task in rats. Behavioural brain research (Apr), 341: 129-134. doi:10.1016/j.bbr.2017.12.029
- Liu JF, Seaman R, Siemian JN, Bhimani R, Johnson B, Zhang Y, Zhu Q, Hoener MC, Park J, Dietz DM, Li JX, Li J. (2018) Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects. Neuropsychopharmacology (Feb).
- Siemian J, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li J. (2018) The imidazoline I2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochemical Pharmacology (Jan)1-9.
- Liu JF, Li JX. (2018) TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg. Frontiers in pharmacology (Jan), 9: 279. doi:10.3389/fphar.2018.00279
- Xue Z, Siemian JN, Johnson BN, Zhang Y, Li JX, Li J. (2017) Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397. Neuropharmacology (Nov).
- Siemian JN, Qiu Y, Zhang Y, Li JX. (2017) Role of intracellular Ca2+ signaling in the antinociceptive and discriminative stimulus effects of the imidazoline I2 receptor agonist 2-BFI in rats. Psychopharmacology (Nov), 234(22): 3299-3307. doi:10.1007/s00213-017-4719-1
- Nguyen T, Decker AM, Langston TL, Mathews KM, Siemian JN, Li JX, Harris DL, Runyon SP, Zhang Y. (2017) Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists. ACS chemical neuroscience (Oct), 8(10): 2290-2308. doi:10.1021/acschemneuro.7b00219
- Siemian JN, Zhang Y, Li JX. (2017) Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats. Behavioural pharmacology (Oct), 28(7): 590-593. doi:10.1097/FBP.0000000000000330
- Li JX. (2017) Imidazoline I2 receptors: An update. Pharmacology & therapeutics (Oct), 178: 48-56. doi:10.1016/j.pharmthera.2017.03.009
- Nguyen T, German N, Decker AM, Langston TL, Gamage TF, Farquhar CE, Li JX, Wiley JL, Thomas BF, Zhang Y. (2017) Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution. Journal of medicinal chemistry (Sep), 60(17): 7410-7424. doi:10.1021/acs.jmedchem.7b00707
- Thorn DA, Zhang Y, Li JX. (2017) Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I2 receptor agonist phenyzoline in adult male rats. Psychopharmacology (Jun), 234(12): 1871-1880. doi:10.1007/s00213-017-4599-4
- Siemian JN, Xue Z, Blough BE, Li JX, Li J. (2017) Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats. Psychopharmacology (Berl) (Apr).
- Perrey DA, Li JX, Zhang Y. (2017) Modified synthesis of NOP receptor antagonist SB612111. Synthesis (Mar), 49(6): 1394-1400. doi:10.1055/s-0036-1588379
- Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. (2017) Antinociceptive effects of a novel α2/α3-subtype selective GABAA receptor positive allosteric modulator. ACS Chem Neurosci (Feb).
- Liu JF, Siemian JN, Seaman R, Zhang Y, Li JX. (2017) Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior. J Neurosci (Jan), 37(4): 882-892.
- He M, Min JW, Kong WL, He XH, Li JX, Peng BW. (2016) A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia (Dec), 115: 74-85.
- Wang ZJ, Martin JA, Mueller LE, Caccamise A, Werner CT, Neve RL, Gancarz AM, Li JX, Dietz DM. (2016) BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior. Biological psychiatry (Nov), 80(9): 652-660. doi:10.1016/j.biopsych.2016.04.020
- Nguyen T, Li JX, Thomas BF, Wiley JL, Kenakin TP, Zhang Y. (2016) Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor. Med Res Rev (Nov).
- Thorn DA, Li J, Qiu Y, Li JX. (2016) Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats. Behavioural pharmacology (Sep), 27(6): 542-8. doi:10.1097/FBP.0000000000000244
- Li JX. (2016) Buprenorphine analogue BU08028 is one step closer to the Holy Grail of opioid research. Proc Natl Acad Sci U S A (Aug).
- Siemian JN, Obeng S, Zhang Y, Zhang Y, Li JX. (2016) Antinociceptive Interactions between the Imidazoline I2 Receptor Agonist 2-BFI and Opioids in Rats: Role of Efficacy at the µ-Opioid Receptor. The Journal of pharmacology and experimental therapeutics (Jun), 357(3): 509-19. doi:10.1124/jpet.116.232421
- Thorn DA, Qiu Y, Jia S, Zhang Y, Li JX. (2016) Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats. Behavioural pharmacology (Jun), 27(4): 377-83. doi:10.1097/FBP.0000000000000206
- Thorn DA, Zhang Y, Li JX. (2016) Effects of the imidazoline I2 receptor agonist 2-BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats. British journal of pharmacology (Apr), 173(8): 1363-72. doi:10.1111/bph.13435
- Qin WJ, Wang YT, Li PM, Wang XX, Li JX, Noori HR, Bernardi RE, Liang JH, Zhang XL. (2016) Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. Psychopharmacology (Apr), 233(7): 1147-55.
- Siemian JN, Li J, Zhang Y, Li JX. (2016) Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding. Psychopharmacology (Mar), 233(5): 873-82. doi:10.1007/s00213-015-4166-9
- Liu JF, Thorn DA, Zhang Y, Li JX. (2016) Effects of Trace Amine-associated Receptor 1 Agonists on the Expression, Reconsolidation, and Extinction of Cocaine Reward Memory. Int J Neuropsychopharmacol (Jan).
- Grandy DK, Miller GM, Li JX. (2015) “TAARgeting Addiction”—The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. Drug Alcohol Depend (Nov).
- Perrey DA, Decker AM, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y. (2015) The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Bioorganic & medicinal chemistry (Sep), 23(17): 5709-24. doi:10.1016/j.bmc.2015.07.013
- Thorn DA, Siemian JN, Zhang Y, Li JX. (2015) Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain: interactions with oxycodone. Psychopharmacology (Sep), 232(18): 3309-18. doi:10.1007/s00213-015-3983-1
- Jing L, Li JX. (2015) Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction. European journal of pharmacology (Aug), 761: 345-52. doi:10.1016/j.ejphar.2015.06.019
- Nguyen T, German N, Decker AM, Li JX, Wiley JL, Thomas BF, Kenakin TP, Zhang Y. (2015) Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. Bioorganic & medicinal chemistry (May), 23(9): 2195-2203. doi:10.1016/j.bmc.2015.02.058
- Perrey DA, German NA, Decker AM, Thorn D, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y. (2015) Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor. ACS chemical neuroscience (Apr), 6(4): 599-614. doi:10.1021/cn500330v
- Qiu Y, Zhang Y, Li JX. (2015) Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. European journal of pharmacology (Feb), 749: 133-41. doi:10.1016/j.ejphar.2015.01.013
- Abiraman K, Pol SU, O'Bara MA, Chen GD, Khaku ZM, Wang J, Thorn D, Vedia BH, Ekwegbalu EC, Li JX, Salvi RJ, Sim FJ. (2015) Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. The Journal of neuroscience : the official journal of the Society for Neuroscience (Feb), 35(8): 3676-88. doi:10.1523/JNEUROSCI.3510-14.2015
- Li JX. (2015) Pain and depression comorbidity: a preclinical perspective. Behavioural brain research (Jan), 276: 92-8. doi:10.1016/j.bbr.2014.04.042
- Ding Y, Qiu Y, Jing L, Thorn DA, Zhang Y, Li JX. (2014) Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats. Pharmacology research & perspectives (Dec), 2(6): e00069. doi:10.1002/prp2.69
- Qiu Y, He XH, Zhang Y, Li JX. (2014) Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats. Scientific reports (Oct), 4: 6605. doi:10.1038/srep06605
- Jing L, Qiu Y, Zhang Y, Li JX. (2014) Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Drug and alcohol dependence (Oct), 143: 251-6. doi:10.1016/j.drugalcdep.2014.08.004
- Jing L, Zhang Y, Li JX. (2014) Effects of the trace amine associated receptor 1 agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats. The international journal of neuropsychopharmacology (Oct), 18(4). doi:10.1093/ijnp/pyu060
- Zhang C, Flowers E, Li JX, Wang Q, Sun W. (2014) Loudness perception affected by high doses of salicylate--a behavioral model of hyperacusis. Behavioural brain research (Sep), 271: 16-22.
- Thorn DA, Jing L, Qiu Y, Gancarz-Kausch AM, Galuska CM, Dietz DM, Zhang Y, Li JX. (2014) Effects of the trace amine-associated receptor 1 agonist RO5263397 on abuse-related effects of cocaine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Sep), 39(10): 2309-16. doi:10.1038/npp.2014.91
- Li JX. (2014) Trace amines and cocaine abuse. ACS chemical neuroscience (Jul), 5(7): 497-8. doi:10.1021/cn500104s
- Li YL, Liu Q, Gong Q, Li JX, Wei SP, Wang YT, Liang H, Zhang M, Jing L, Yong Z, Lawrence AJ, Liang JH. (2014) Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats. Acta pharmacologica Sinica (Jul), 35(7): 853-61. doi:10.1038/aps.2014.28
- Thorn DA, Zhang C, Zhang Y, Li JX. (2014) The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats. Neuroscience letters (Apr), 566: 67-71. doi:10.1016/j.neulet.2014.02.024
- Qiu Y, Thorn DA, Zhang Y, He X, Li JX. (2014) Behavioral effects of the imidazoline I(2) receptor ligand BU99006 in rats. Behavioural pharmacology (Apr), 25(2): 130-6. doi:10.1097/FBP.0000000000000028
- Li JX, Thorn DA, Qiu Y, Peng BW, Zhang Y. (2014) Antihyperalgesic effects of imidazoline I(2) receptor ligands in rat models of inflammatory and neuropathic pain. British journal of pharmacology (Mar), 171(6): 1580-90. doi:10.1111/bph.12555
- Kong WL, Min JW, Liu YL, Li JX, He XH, Peng BW. (2014) Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice. Epilepsy & behavior : E&B (Feb), 31: 276-80.
- Jing L, Zhang M, Li JX, Huang P, Liu Q, Li YL, Liang H, Liang JH. (2014) Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice. Neuroscience letters (Feb), 560: 103-6. doi:10.1016/j.neulet.2013.12.024
- Min JW, Peng BW, He X, Zhang Y, Li JX. (2013) Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. European journal of pharmacology (Oct), 718(1-3): 81-6. doi:10.1016/j.ejphar.2013.09.016
- Perrey DA, German NA, Gilmour BP, Li JX, Harris DL, Thomas BF, Zhang Y. (2013) Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Journal of medicinal chemistry (Sep), 56(17): 6901-16. doi:10.1021/jm400720h
- Li JX. (2013) The application of conditioning paradigms in the measurement of pain. European journal of pharmacology (Sep), 716(1-3): 158-68. doi:10.1016/j.ejphar.2013.03.002
- Li JX, Shah AP, Patel SK, Rice KC, France CP. (2013) Modification of the behavioral effects of morphine in rats by serotonin 5-HT1A and 5-HT2A receptor agonists: antinociception, drug discrimination, and locomotor activity. Psychopharmacology (Feb), 225(4): 791-801. doi:10.1007/s00213-012-2870-2
- Maguire DR, Li JX, Koek W, France CP. (2013) Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys. Psychopharmacology (Jan), 225(1): 173-85. doi:10.1007/s00213-012-2803-0
- Li JX, Thorn DA, Jin C. (2013) The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. European journal of pharmacology (Jan), 698(1-3): 272-7.
- Li JX, Koek W, France CP. (2012) Interactions between ?(9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys. Behavioural pharmacology (Dec), 23(8): 754-61. doi:10.1097/FBP.0b013e32835a3907
- Thorn DA, An XF, Zhang Y, Pigini M, Li JX. (2012) Characterization of the hypothermic effects of imidazoline I2 receptor agonists in rats. British journal of pharmacology (Jul), 166(6): 1936-45. doi:10.1111/j.1476-5381.2012.01894.x
- Zhang M, Jing L, Liu Q, Wen RT, Li JX, Li YL, Gong Q, Liang JH. (2012) Tramadol induces conditioned place preference in rats: interactions with morphine and buprenorphine. Neuroscience letters (Jun), 520(1): 87-91.
- Liu Q, Zhang M, Qin WJ, Wang YT, Li YL, Jing L, Li JX, Lawrence AJ, Liang JH. (2012) Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats. Brain research (May), 1454: 90-9.
- An XF, Zhang Y, Winter JC, Li JX. (2012) Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats. Pharmacology, biochemistry, and behavior (May), 101(3): 354-9.
- Thorn DA, Winter JC, Li JX. (2012) Agmatine attenuates methamphetamine-induced conditioned place preference in rats. European journal of pharmacology (Apr), 680(1-3): 69-72.
- Li JX, Zhang Y. (2012) Emerging drug targets for pain treatment. European journal of pharmacology (Apr), 681(1-3): 1-5.
- Sampson C, Zhang Y, Del Bello F, Li JX. (2012) Effects of imidazoline I2 receptor ligands on acute nociception in rats. Neuroreport (Jan), 23(2): 73-7.
- Li JX, Ju S, Baladi MG, Koek W, France CP. (2011) Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction. Behavioural pharmacology (Dec), 22(8): 751-7. doi:10.1097/FBP.0b013e32834d0eeb
- Thorn DA, Zhang Y, Peng BW, Winter JC, Li JX. (2011) Effects of imidazoline I2 receptor ligands on morphine- and tramadol-induced antinociception in rats. European journal of pharmacology (Nov), 670(2-3): 435-40.
- Li JX, Zhang Y, Winter JC. (2011) Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I2 receptor ligands. European journal of pharmacology (Nov), 669(1-3): 59-65.
- Li JX, Zhang Y. (2011) Imidazoline I2 receptors: target for new analgesics?. European journal of pharmacology (May), 658(2-3): 49-56.
- Peng BW, Justice JA, Zhang K, Li JX, He XH, Sanchez RM. (2011) Gabapentin promotes inhibition by enhancing hyperpolarization-activated cation currents and spontaneous firing in hippocampal CA1 interneurons. Neuroscience letters (Apr), 494(1): 19-23.
- Li JX, Koek W, Rice KC, France CP. (2011) Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Apr), 36(5): 940-9. doi:10.1038/npp.2010.232
- Li JX, Crocker C, Koek W, Rice KC, France CP. (2011) Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies. Psychopharmacology (Feb), 213(2-3): 489-97. doi:10.1007/s00213-010-2136-9
- Li X, Li JX, France CP. (2010) Interactions between morphine, scopolamine and nicotine: schedule-controlled responding in rats. Pharmacology, biochemistry, and behavior (Jul), 96(1): 91-5. doi:10.1016/j.pbb.2010.04.011
- Li JX, Koek W, Rice KC, France CP. (2010) Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys. The Journal of pharmacology and experimental therapeutics (Apr), 333(1): 244-52. doi:10.1124/jpet.109.163451
- Becker GL, Gerak LR, Li JX, Koek W, France CP. (2010) Precipitated and conditioned withdrawal in morphine-treated rats. Psychopharmacology (Mar), 209(1): 85-94. doi:10.1007/s00213-009-1773-3
- Li X, Li JX, Zhu X, Cui R, Jiao J. (2010) Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats. Behavioural brain research (Jan), 206(2): 223-8.
- Li JX, Unzeitig A, Javors MA, Rice KC, Koek W, France CP. (2009) Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats. The Journal of pharmacology and experimental therapeutics (Nov), 331(2): 671-9. doi:10.1124/jpet.109.157560
- France CP, Li JX, Owens WA, Koek W, Toney GM, Daws LC. (2009) Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats. The international journal of neuropsychopharmacology (Jul), 12(6): 731-6. doi:10.1017/S1461145709000418
- Li JX, Koek W, France CP. (2009) Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats. European journal of pharmacology (Jun), 613(1-3): 60-3. doi:10.1016/j.ejphar.2009.04.027
- McMahon LR, Li JX, Carroll FI, France CP. (2009) Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys. Psychopharmacology (Apr), 203(2): 411-20. doi:10.1007/s00213-008-1242-4
- Li JX, Rice KC, France CP. (2009) Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses. The Journal of pharmacology and experimental therapeutics (Mar), 328(3): 976-81. doi:10.1124/jpet.108.145458
- May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, Young R, Li JX, Rice KC, France CP. (2009) Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. Pharmacology, biochemistry, and behavior (Jan), 91(3): 307-14. doi:10.1016/j.pbb.2008.07.015
- Li JX, McMahon LR, Gerak LR, Becker GL, France CP. (2008) Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception. Psychopharmacology (Aug), 199(2): 199-208. doi:10.1007/s00213-008-1157-0
- Li JX, France CP. (2008) Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats. Behavioural pharmacology (Jul), 19(4): 292-7. doi:10.1097/FBP.0b013e328308f1d6
- Li JX, Rice KC, France CP. (2008) Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys. The Journal of pharmacology and experimental therapeutics (Feb), 324(2): 827-33.
- Li JX, McMahon LR, France CP. (2008) Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys. Psychopharmacology (Jan), 195(4): 479-86.
- Li JX, Rice KC, France CP. (2007) Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. Behavioural pharmacology (Jul), 18(4): 283-8.
- Li JX, Becker GL, Traynor JR, Gong ZH, France CP. (2007) Thienorphine: receptor binding and behavioral effects in rhesus monkeys. The Journal of pharmacology and experimental therapeutics (Apr), 321(1): 227-36.
- Li JX, Han R, Deng YP, Chen SQ, Liang JH. (2005) Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. Behavioural brain research (Jun), 161(1): 125-32.
- Li JX, Zhao WL, Liang JH. (2004) Effects of carbamazepine on morphine-induced behavioral sensitization in mice. Brain research (Sep), 1019(1-2): 77-83.
- Li JX, Zhang Q, Liang JH. (2004) Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behavioural brain research (Jul), 152(2): 251-7.
- Liang JH, Li JX, Wang XH, Chen B, Lu Y, Zhang P, Han R, Ye XF. (2004) L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta pharmacologica Sinica (May), 25(5): 644-50.
- Zhang Q, Li JX, Zheng JW, Liu RK, Liang JH. (2003) L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice. European journal of pharmacology (Apr), 467(1-3): 145-50.
- Maguire DR, Li JX, France CP. (1900) Impulsivity and drugs of abuse: a juice-reinforced operant procedure for determining within-session delay discounting functions in rhesus monkeys. Journal of pharmacological and toxicological methods (Jan), 66(3): 264-9. doi:10.1016/j.vascn.2012.08.168
Professional Memberships:
- American College on Neuropsychopharmacology; Associate member (2016–present)
- Behavioral Pharmacology Society (2009–present)
- American Society for Pharmacology and Experimental Therapeutics (2007–present)
Service Activities:
- On average, I review 7-8 manuscripts per month.; Ad hoc reviewer for over 30 journals. (2024–2025)
- Pharmacology Research & Perspectives; Senior Editor (2024–2025)
- Metabolic Brain Disease; Senior Editor (2024–2025)
- ; Member, Departmental Executive Committee on Research/Educational Portfolio Planning (2020–2022)
- As a standing member of UB IACUC, I review proposals and attend monthly meetings.; Member of Institutional Animal Care and Use Committee (IACUC) (2018–2025)
- ; Member, Promotion and Tenure Committee (2018–2022)
- ACS Chemical Neuroscience; Editorial Board member (2017–2022)
- Pharmacology & Therapeutics; Associate Editor (2016–2025)
- ; Member, School of Medicine Faculty Council (2014–2022)
- ; Member, Ph.D Program in Biomedical Sciences Admission Committee (2011–2013)
- ; Member, Education Committee Graduate Subcommittee Department of Pharmacology and Toxicology (2011–2022)