My current research program has been focused on the role of obesity and aging in myeloid cell biology as it relates towards oral inflammation in periodontal disease and oral cancer progression.
Education and Training:
Sabbatical, Clinical Research Management, National Institutes of Health (2014)
Fellowship, Department of Pharmacology and Toxicology, University of Buffalo (1999)
PhD, Oral Biology, University of Buffalo (1997)
Certificate, Periodontology, State University of New York at Buffalo (1995)
DDS, Dentistry, West Virginia University (1991)
BA, Chemistry, West Virginia University, Cum Laude (1987)
Employment:
Senior Associate Dean for Research, School of Dental Medicine, University at Buffalo (2022-present)
Adjunct Research Professor of Oncology, Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center (2020-present)
Consulting Scientist, Roswell Park Comprehensive Cancer Center, Department of Head/Neck Surgery (2020-present)
Centennial Endowed Professor, School of Dental Medicine, University at Buffalo (2019-present)
Program Member, Tumor Immunology and Immunotherapy Research Program, Roswell Park Comprehensive Cancer Center (2018-present)
Professor, Oral Biology, University at Buffalo (2017-present)
Interim Chair, Periodontics and Endodontics, University at Buffalo (2021–2022)
Attending Periodontist, Western NY VA Medical Center (2020–2022)
Associate Dean, Innovation and Technology Transfer, University at Buffalo (2019–2021)
Consulting Physician, Oral Oncology, Roswell Park Comprehensive Cancer Center (2018–2020)
Consulting Physician, Roswell Park Comprehensive Cancer Center, Department of Oral Oncology (2018–2020)
Adjunct Professor, Bioengineering, Clemson University (2010–2017)
Adjunct Professor, Microbiology and Immunology, Medical University of South Carolina (2010–2017)
Professor and Chair, Oral Health Sciences, Medical University of South Carolina (2010–2017)
Associate Dean for Research, College of Dental Medicine, Medical University of South Carolina (2008–2017)
Associate Professor, Microbiology and Immunology, Medical University of South Carolina (2008–2010)
Associate Professor and Founding Chair, Oral Health Sciences, Medical University of South Carolina (2008–2010)
Private Practice Limited to Periodontics, Great Expressions Specialty Practice (2006–2008)
Associate Professor, Periodontics and Oral Medicine, University of Michigan School of Dentistry (2007)
Assistant Professor, Periodontics and Oral Medicine, University of Michigan (2004–2007)
Research Assistant Professor, Pharmacology and Toxicology, University of Buffalo (2002–2003)
Assistant Professor, Periodontics And Endodontics, University of Buffalo (2000–2003)
Private Practice Limited to Periodontics, University Dental Associates (2000–2003)
Private Practice Limited to Periodontics, Barzman, Kasimov, and Vieth (1998–2000)
Clinical Assistant Professor, Periodontics, University of Buffalo (1997–2000)
Clinical Assistant Professor, Oral Biology, University of Buffalo (1997–1999)
Post Doctoral Fellow, Pharmacology and Toxicology, University of Buffalo (1997–1999)
Clinical Instructor, Periodontics And Endodontics, University of Buffalo (1995–1997)
Sunstar - AAP Foundation Research Fellowship (2016)
Fellow of the AADR (2016)
Fellow (2016)
IADR/GSK Innovation in Oral Care Award (2014)
IADR Distinguished Scientist Award for Pharmacology/Therapeutics/Toxicology Research (2013)
Elected, Omicron Kappa Upsilon (2011)
Elected, Member-at-Large (2009)
IADR/GSK Innovation in Oral Care Award (2008)
Tarrson Fellowship Career Development Award (2005)
American Dental Association Student Clinician Program (2002)
Young Investigator Award (2002)
Osseointegration Foundation Research Grant Award (2000)
Individual National Research Service Award (F32) (1997)
Mark Diamond Research Award (1996)
Quintessence Research Award for Research Achievement (1991)
Dentist-Scientist Award (K16) (1991)
First Prize (1990)
Cum Laude, Chemistry (1987)
Mary Baab Randolph Cancer Center Student Research Fellowship (1987)
Research Expertise:
Oral Biology: Cytokine gene regulation in bone with identification of novel therapeutics targets and applied nolecular pharmacology targeting signaling mechanisms for therapeutic purposes in inflammatory bone diseases.
Patents:
Auranofin Nanoparticles and Methods of Treatment of Peri-Implantitis and Periodontal Disease (2016)
Professional Memberships:
Erie County Dental Society; Member (2017–present)
Endocrine Society; Member (2012)
Inflammation Research Association; Member (2009–2012)
The American Society of Gene & Cell Therapy; Member (2008–2012)
American Society for Biochemistry and Molecular Biology; Member (2007–2012)
RNA Society; Member (2004–2010)
Michigan Periodontal Society; Member (2004–2007)
Michigan Dental Society; Member (2004–2007)
American Association of Dental Research; Secretary/Treasurer (2002–2005)
Academy of Osseointegration; Member (2000–2002)
New York State Society of Periodontists; Member (1997–2002)
Erie County Dental Society; Member, Program Director (2003) (1995–2003)
New York State Dental Association; Member (1995–2003)
American Association for Bone and Mineral Research; Member (1995–present)
Eight District Dental New York; Member (1995–present)
American Academy of Periodontology; AAP Subcommittee on Research Submissions (2001-2003, 2009-2012) Nominated for AAP Board of Trustees (7th District) (2002) (1991–present)
WVU Student Research Group; President (1990–1991)
WVU Dental Class ’91; Vice President (1988–1990)
American Dental Association; Member (1987–2020)
International Association for Dental Research; Pharmacology/Toxicology/Therapeutic Group: Secretary Treasurer (2002-2005), Vice President (2005), President Elect (2006), President (2007), Immediate Past President (2008); AADR Ethics in Dental Research Committee (2005-2008); IADR/AADR Publications Committee (2009-2011); AADR Hatton Award Committee (2011-2013); IADR Distinguished Scientist Award Committee (2017-present) (1987–present)
"New Mechanistic Insights Engaged in Obesity-associated Periodontitis" International Academy of Periodontology Research Conference (IAPRC), Harvard University (2024)
"The p38/MKP-1 Signaling Axis in Oral Cancer: Opportunities to Target Tumor-associated Macrophages" Boston University (2024)
"Post-Transcriptional Control of Aging-Associated Inflammation and Skeletal Homeostasis" Harvard University (2023)
"Metabolic Reprogramming of Myeloid-derived Suppressor Cells in Periodontitis" 3rd International Conference on Oral Mucosal Immunity and Microbiome (2023)
"Age-related metabolic dysregulation of monocytic MDSCs in osteoclastogenesis" PennPerio Meeting (2023)
"Aging and Oral Cancer" 2023 AADOCR Meeting within a Meeting, Aging and Oral Health Research (2023)
"Tristetraprolin: the fountain of youth for bone homeostasis?" 2023 Mark Wilson Conference (2023)
"Post-Transcriptional Control of Aging-Associated Inflammation and Skeletal Homeostasis" University at Buffalo, School of Engineering (2022)
"Sexual Dimorphism in Oral Inflammatory Diseases" AADOCR Annual Meeting (2022)
"Mechanisms controlling myeloid cell subset mobilization and osteoclast potential" 21st Annual Mark Wilson Conference, 32nd Annual Meeting of the Oral Immunology/Microbiology Research Group (2022)
"The p38/MKP-1 Signaling Axis in Oral Cancer: Impact of Tumor-associated Macrophages" UB Cancer Research Consortium Seminar Series (2021)
"Periodontal disease increases oral-gut transmission of colitogenic Haemophilus parainfluenzae in inflammatory bowel disease patients" 2nd International Conference on Oral Mucosal Immunity and Microbiome (2021)
"Myeloid-derived Suppressor Cells in Obesity-associated Periodontal Disease" University of Pennsylvania (2021)
"The p38/MKP-1 Signaling Axis in Oral Cancer: Impact of Tumor associated Macrophages" University of Arizona (2021)
"Metabolic Reprogramming of Tumor-associated Macrophages in Oral Cancer" Department of Oral Biology, University at Buffalo (2020)
"Metabolic Reprogramming of Tumor-associated Macrophages in Oral Cancer" Upstate NY Virtual Genomics Symposium, Illumina Genomics Symposium (2020)
"p38 MAPK/MKP-1 Signaling Axis in Oral Cancer" UCLA School of Dentistry (2019)
"MDSCs: new players in alveolar bone homeostasis" Rutgers University, School of Dental Medicine (2019)
"Myeloid-derived Suppressor Cells and Alveolar Bone Homeostasis" First Bernhard Gottlieb Conference: Periodontal Homeostasis in Disease and Regeneration; Texas A&M University, College of Dentistry (2019)
"Myeloid-derived Suppressor Cells in Periodontal Osteoimmunology" PennPerio Conference, University of Pennsylvania (2019)
"DUSP1 and Tumor-Associated Macrophage Plasticity in Oral Cancer" Roswell Park Comprehensive Cancer Center, Tumor Immunology Lecture Series (2017)
"Post Transcriptional Regulation of Oral Immunity and the Microbiome" UB’s Community of Excellence in Genome, Environment and Microbiome (GEM) (2017)
"Post Transcriptional Control of Alveolar Bone Homeostasis" New York University (2017)
"Post Transcriptional Control of Alveolar Bone Homeostasis" PennPerio conference; University of Pennsylvania (2017)
"MAPK Signaling and RNA Stability in Osteoimmunology: Therapeutic Targets for Periodontitis Control" The 60th Spring Meeting of the Japanese Society of Periodontology (2017)
"Therapeutic Opportunities to Control Osteoclastogenesis in Periodontitis" Chinese National Oral Biomedical Conference (2016)
"The Quest for Small Molecule Inhibitors of Signal Transduction to Control Osteoclastogenesis in Periodontitis" Oregon Health & Science University School of Dentistry (2016)
"Therapeutic Opportunities to Control Osteoclastogenesis in Periodontitis" University of Louisville School of Dentistry (2016)
"The Quest for Small Molecule Inhibitors of Signal Transduction to Control Osteoclastogenesis in Periodontitis" MUSC College of Dental Medicine Seminar Series (2016)
"Sex-based Differential Regulation of Bacterial-induced Bone Resorption" 15th Annual Mark Wilson Oral Microbiology Immunology Meeting (2016)
"Therapeutic Opportunities to Control Osteoclastogenesis in Periodontitis" Baylor Texas A&M University Baylor College of Dentistry (2016)
"Local Innate Immune Signaling in Osteoclastogenesis" PennPerio Conference (2015)
"Understanding Innate Immune Signaling in Periodontitis" Invited Seminar New York University (2015)
"DUSP1 phosphatase regulates the proinflammatory milieu in oral cancer" 14th Annual Mark Wilson Oral Microbiology Immunology Meeting (2015)
"Lectures “Fostering Collaborative Research and Training the Next Generation of Faculty in US Dental Schools; “Ethics and Professionalism in Dentistry”; and “Development of an Evidence-Based Dentistry Curriculum”" 7th Dental Students’ Scientific Meeting. Qassim University, College of Dentistry (2015)
"p38 MAPK/DUSP1 Axis in Stromal-mediated Tumorigenesis" Life Sciences Baltics MAP Kinases Conference (2014)
"Control of MAPK Signaling in Alveolar Bone Osteoimmunology" IADR Periodontal Research Group; Symposium titled "Molecular Basis of Periodontal Tissue Homeostasis, Destruction and Regeneration" (2014)
"MKP-1 Signaling Nexus in Bone: Dual Roles in Pathology and Homeostasis" MUSC Dept. of Craniofacial Biology Seminar Series (2013)
"Immune Signaling through MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Inflammatory Bone Loss" UPenn Periodontal Conference 2013 (2013)
"Mechanistic Basis for Translational Studies in the Management of Periodontal Diseases" Baylor College of Dentistry, Department of Biological Sciences (2012)
"MAPK Signaling and RNA Stability in Osteoimmunology: Therapeutic Targets in Inflammatory Bone Loss" South Carolina College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences (2011)
"MAPK Signaling Mechanisms in Osteoclast-directed Alveolar Bone Loss" Gordon Research Conference on Periodontal Diseases (2011)
"Defining Novel Therapeutic Targets in Periodontal Diseases" Clemson University (2011)
"Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Inflammatory Bone Loss" University of Alabama at Birmingham (2010)
"Post Transcriptional Control of Periodontal Diseases and Oral Cancer Progression" Virginia Commonwealth University (2010)
"Innate Immune Signaling through p38 MAPK/MKP-1 Pathways in Inflammatory Bone Loss" Kaohsiung Medical University, College of Dental Medicine, Research Day-International Symposium on Oral Cancers, Systemic Diseases, and Bone (2010)
"Potential Role of mRNA Binding Proteins in Oral Cancer Progression" Kaohsiung Medical University, College of Dental Medicine, Research Day-International Symposium on Oral Cancers, Systemic Diseases, and Bone (2010)
"Periodontal Inflammation and mRNA Stability—Implications for Therapeutic Strategies" University of Medicine and Dentistry, New Jersey (2010)
"Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Inflammatory Bone Loss" University of Louisville (2009)
"Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Inflammatory Bone Loss" Harvard School of Dental Medicine (2009)
"Systemic Periodontal Chemotherapy" Medical University of South Carolina (2009)
"Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Oral Cancer" NIDCR Intramural Research Seminar Series (2008)
"Novel Strategies to Harness Periodontal Inflammation" Colgate Palmolive (2008)
"Signaling Mechanisms in Cytokine mRNA Stability: Impact in Inflammatory Bone Loss" University of Western Ontario (2007)
"Therapeutic Strategies to Disrupt Cell Signaling in Periodontal Inflammation" IADR/AADR meeting, Lunch and Learning (2007)
"Signaling Mechanisms Governing Cytokine mRNA Stability: Implications in Inflammatory Bone Loss and Oral Cancer" State University of New York at Buffalo (2007)
"Esthetic Periodontal Plastic Surgery: Present and Future Perspectives" Kuwait Dental Association Annual Meeting (2007)
"MAPK signaling mechanisms governing inflammatory cytokine expression" Gordon Research Conference, Periodontal Diseases (2006)
"Regulation of Gene Expression in Inflammation" State University of Sao Paulo (UNESP) (2006)
"The Role of p38 MAP Kinase in IL-6 Gene Regulation" Roswell Park Cancer Center, Department of Molecular and Cellular Biology (2003)
"Differential Regulation of MMP-13 by Chemical Modified Tetracyclines in Osteoblasts" 8oth Annual Session of the IADR/31th (2002)
"Systemic Medications and Dental Implications" ; University of Rochester (2001)
"Expression Profiling of Genes Regulated by Chemically Modified Tetracycline-8 in Murine Osteoblasts Cellsc Cells" Annual Session of the AADR (2001)
"The Effects of Titanium-Immobilized bioactive Peptides on Osteoblast Differentiation" Osseointegration Academy Meeting (2001)
"Chemically Modified Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" 78th Annual Session of the IADR/29th (2000)
"Inhibition of IL-6 Expression in Osteoblasts by Chemically Modified Tetracyclines" The Ohio State University College of Dentistry (1999)
"Gene Regulation by Chemically Modified Tetracyclines in Murine Osteoblasts" Gordon Research Conference, Non-Antibiotic Properties of Tetracyclines & Other Antibiotics (1999)
"Non-Antimicrobial and Antimicrobial Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" New York Academy of Sciences Meeting (1998)
"OP-1 Induction of the Inositol Trisphosphate Receptor in Human Osteosarcoma Cells" 75th Annual Session of the AADR/25th (1997)
"Inositol Trisphosphate Receptor Subtype Analysis in Human Osteosarcoma Cells" 24th Session of ther AADR (1995)
"IgG Antibodies to A.Actinomycetemconitans 16.6 Kda OMP In Juvenile Periodontitis" 72nd Annual Session of the IADR/23th (1994)
"Selective Expression of Inositol Trisphosphate Rectptor Gene In Human Osteosarcoma Cells" 22nd Annual Session of the AADR (1993)
"Post Transcriptional Control of Alveolar Bone Homeostasis" Tokyo Medical and Dental University
ZDE1 JC (11) Review of NIDCR R03 and DSR Member-Conflict Applications; Acting Chair (2024)
ZDE1 YM (09) Review of NIDCR R03 and DSR Member-Conflict Applications; NIH Study Section Reviewer (2023)
ZDE1-(07) CLINICAL STUDIES; NIH Study Section Reviewer (2022)
ZDE1-(06) NIDCR PREVENTION OF OPIOID DRUG MISUSE AND ABUSE Special Emphasis Panel; NIH Study Section Reviewer (2022)
ZDE1 JFR (11) T32 and T90/R90 Special Emphasis Panel; NIH Study Section Reviewer (2022)
Member of the University Associate Deans for Research Committee; Committee Member (2022–present)
SDM Information Technology Steering Committee [ITSC]; Committee Member (2022–present)
SDM Facilities Management Committee; Member (2022–present)
Member of Oversight Committee, Buffalo Translational Consortium (BTC) Clinical Research Achievement Awards; Oversight Committee Member (2022–present)
Big Mouth Dental Data Repository, Consortium of Oral Health Research and Informatics; Committee Member (2021–present)
KL2 Scholar Mentor for Dr. Hyuk Jae Edward Kwon; Mentor (2020–2022)
School of Dental Medicine; Executive Council (2019–present)
SDM Student Research Review Committee; Committee Member (2018–2020)
School of Dental Medicine search committee for Core Facility Manager for the Dept. of Oral Biology; Search Committee Member (2018)
Clinical Practice Management Plan (CPMP) Governing Board; Basic Sciences Representative (2018–present)
School of Dental Medicine search committee for Core Facility Manager for the Dept. of Oral Biology; Committee Member (2018–present)
AADR Fellows Committee; Committee Member (2018–present)
Member of the UB Clinical and Translational Science Institute (CTSI) Steering Committee; Steering Committee Member (2018–present)
Member of the UB Clinical and Translational Science Institute (CTSI) Workforce Development Steering Committee; Steering Committee Member (2018–present)
World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions (2017)
Served on Thesis Committee Meetings for the following students: PhD Candidates: Jiho Sohn (MD/PhD) (Major Professor: K.L. Kirkwood) Yin Luo (Major Professor: D. Xu) Natalie Anselmi (Major Professor: J. Kay) Armond June (MD/PhD) (Major Professor: P. Diaz) Edwin Ovalle (Major Professor: J. Kay) Dayron M Leyva Rodriguez (Major Professor: M. Visser) Omar Glover (Perio/PhD) (Major Professor: K.L. Kirkwood) Masters Candidates: Yuxiang Pan (Major Professor: K.L. Kirkwood) Cameron Kirkwood (Major Professor: K.L. Kirkwood) Jade Green (Major Professor: K.L. Kirkwood); Committee Member (2017–present)
Oral, Dental and Craniofacial Sciences Study Section; Standing Member (2015–2021)
IADR Distinguished Scientist Awards Committee; Committee Member (2015–present)
ZRG1 MOSS-U (82) Special Emphasis Panel and Chair; NIH Study Section Reviewer (2014)
ZRG1 MOSS-C (02) M Special Emphasis Panel; NIH Study Section Reviewer (2013)
ZDE1 MH 19 1, Special Emphasis Panel and Chair; NIH Study Section Reviewer (2013)
Oral Cancer Screenings for Hollings Cancer Center; Provider (2012–2017)
Hatton Committee, IADR; Committee Member (2012–2015)
MOSS Skeletal Biology Development and Disease Study Section; NIH Study Section Reviewer (2011)
Dental Academic Research Training Program (DART), University of Alabama at Birmingham (UAB) School of Dentistry; External Advisory Board Member (2011–2015)
Training Program for the Next Generation of Oral Health Researchers (NextGen), University of North Carolina at Chapel Hill (UNC) School of Dentistry; External Advisory Board Member (2011)
ZRG1 MOSS-B (02) S Oral Microbiology, Immunology, Cell Biology and Periodontal Diseases; NIH Study Section Reviewer (2010)
MOSS Oral, Dental and Craniofacial Sciences Study Section; NIH Study Section Reviewer (2010)
AADR Hatton Awards Committee; Committee Member (2010–2014)
ZDE1 VH (12) Translational Application of Gene Silencing Strategies to Oral and Craniofacial Disorders for NIDCR; NIH Study Section Reviewer (2009)
RC2 NIDCR Grand Opportunity Grants area: Multidisciplinary Approaches to Craniofacial Regeneration and Preclinical Testing; NIH Study Section Reviewer (2009)
National Research Foundation (NRF) of the United Arab Emirates; NIH Study Section Reviewer (2009)
IADR/AADR Publications Committee; Elected Member-at-Large (2009)
ZDE1 RW 32 Osteoimmunology-Crosstalk between the Immune System and Bone; NIH Study Section Reviewer (2008)
Tarrson Selection Committee, American Academy of Periodontology; Committee Member (2008–2018)
AADR Ethics in Dental Research Committee; Committee Member (2005–2008)
Pharmacology Toxicology Therapeutics Group of the IADR/AADR; Vice President (2005–2006)
AADR Symposium, Cytokine and Signal Transduction Blockers for the Treatment of Inflammatory Periodontal Diseases, Baltimore, MD; Organizer and Chair (2005)
American Association for Dental Research, Baltimore MD; Session Chair (2005)
ZAR1 GHZ-D Review of Small Research Grants-(R03s); NIH Study Section Reviewer (2004)
Served on the Thesis Committee for the following students: PhD Candidates: Matt Ruddy (Major Professor: Sarah Gaffen, Oral Biology, defended 2003) Pedro Li (Major Professor: Stelios Andreadis, Chemical Engineering, defended 2004) Masters Candidates: Lynn Solomon (Major Professor: Mizrda Neiders, defended 2004); Committee Member (2003–2004)
ADA Student Clinical Program, Basic Sciences Category; Judge (2002–2005)
Pharmacology Toxicology Therapeutics Group of the IADR/AADR; Secretary/Treasurer (2002–2005)
Major Professor to the following students: Dr. Troy Thompson (defended May 2002) Dr. Fuwad Al-Sabek (defended May 2003); Major Professor (2002–2003)
Ad Hoc Committee for Accreditation; Chair (2002–2003)
Served as Program Director for the Erie County Dental Society; Program Director (2002–2003)
Served on Preliminary Exam Committee for Xin Liu (Oral Biology); Committee Member (2002)
AAP Subcommittee of Research Submissions; Member (2001–2003)
Served on Curriculum Committee; Committee Member (2001–2003)
Served on Bylaws Committee; Committee Member (2001–2003)
Served on Student Research Committee; Committee Member (2000–2003)
Proceedings of the National Academy of Sciences; Ad Hoc Reviewer
Applied Biochemistry and Biotechnology; Ad Hoc Reviewer
Molecular Therapy; Ad Hoc Reviewer
Journal of Periodontology; Ad Hoc Reviewer
Journal of Biological Chemistry; Ad Hoc Reviewer
Journal of Cellular Biology; Ad Hoc Reviewer
Bone; Ad Hoc Reviewer
Journal of Bone and Mineral Research; Ad Hoc Reviewer
Molecular and Cellular Biology; Ad Hoc Reviewer
American Journal of Pathology; Ad Hoc Reviewer
Journal of Immunology; Ad Hoc Reviewer
Science Translational Medicine; Ad Hoc Reviewer
Cancer Research; Ad Hoc Reviewer
Cancer; Ad Hoc Reviewer
Cancer Immunology; Ad Hoc Reviewer
Journal of Immunology; Ad Hoc Reviewer
Frontiers Journals (Immunology, Cancer, Oral Health, Physiology); Ad Hoc Reviewer
Cell Reports; Ad Hoc Reviewer
Molecular Oral Microbiology; Editorial Board
Current Oral Health Reports; Editorial Board
Journal of Dental Research; Editorial Board
Frontiers in Oral Health (Associate Editor); Editorial Board