John Kolega Ph.D.
John Kolega
Ph.D.
Associate Professor / Graduate Program Director
Department of Pathology and Anatomical Sciences
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cardiovascular Disease; Cytoskeleton and cell motility; Molecular and Cellular Biology; Molecular Basis of Disease
Professional Summary:
My primary research interest is the behavior of endothelial cells, which form the inner lining of blood vessels and are key players in the remodeling events that occur during wound healing, aneurysm formation, tumor growth, and a wide variety of disease conditions. There are two questions about endothelial behavior that drive most of the research in my laboratory:
(1) How does an endothelial cell migrate during wound healing and blood-vessel remodeling? We are particularly interested in the motor protein, myosin II, and how it exerts force within the cytoskeleton to push or pull the cell as it moves. In order to study the organization and movements of cytoskeletal proteins - and not just there biochemical properties - we use a variety of light microscopic methods to examine the dynamics and biochemistry of cytoskeletal proteins in living migrating endothelial cells. We also use conventional biochemical, genetic, and pharmacological manipulations to investigate the regulatory events that control myosin II behavior in situ.
(2) How do endothelial cells sense and respond to their mechanical environment?
Blood vessels remodel to accommodate long-term changes in blood flow. Certain flow environments can cause destructive remodeling that leads to cerebral aneurysms (local “ballooning” of vessels). Working with biomedical engineers in the laboratory of Dr. Hui Meng at the Toshiba Stroke Research Center, we use cell culture and whole animal systems to examine how endothelial cells respond to specific hemodynamic micro-environments in order to understand the mechanism and regulation of flow-induced remodeling, especially as it relates to cerebral aneurysms.
A third interest is understanding the response of cultured endothelial cells to electrical fields, which have been shown to orient endothelial migration in vitro and to suppress edema in vivo by enhancing the endothelial permeability barrier.
Education and Training:
- PhD, Cell Biology, Yale University (1984)
- Biology, Yale University (1981)
- BA, Life Sciences, Massachusetts Institute of Technology (1978)
- BS, Chemistry, Massachusetts Institute of Technology (1978)
Employment:
- Associate Professor, Pathology and Anatomical Sciences, Univeristy of Buffalo, State University of New York Jacobs School of Medicine & Biomedical Sciences (2001-present)
- Post Doctoral Fellow, Laboratory for Developmental Biology and Anomalies, National Institutes of Health National Institute for Dental Research
- Assistant Professor, Pathology and Anatomical Sciences, University of Buffalo, State University of New York Jacobs School of Medicine & Biomedical Sciences (2000–2001)
- Clinical Assistant Professor, Pathology and Anatomical Sciences, University of Buffalo, State University of New York Jacobs School of Medicine & Biomedical Sciences (1998–2000)
- Assistant Professor, Pathology and Anatomical Sciences, University of Buffalo, State University of New York Jacobs School of Medicine & Biomedical Sciences (1993–1998)
- Special Research Faculty, Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University - (1992–1993)
- Post Doctoral Fellow, Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University Faculty of Arts and Letters (1989–1992)
- Post Doctoral Fellow, Dermatology, New York University Medical Center Medicine (1985–1989)
- Technical Collaborator, -, Brookhaven National Laboratory - (1978)
- Technical Collaborator, -, Brookhaven National Laboratory - (1977)
Awards and Honors:
- Didaskalos Award (2011)
Research Expertise:
- Cell Biology: Cytoskeletal regulation and mechanism in cell migration. Endothelial cell biology.
- Cell Biology: Cytoskeleton and Cell Motility
- Gross Anatomy: back and extremeties
- Vascular Biology: endothelial signaling, vessel wall remodeling
Research Centers:
- Toshiba Stroke Research Center
UB 2020 Strategic Strengths:
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- August 2019–July 2021
SBIR Phase II “A Blood-Based Test to Identify Patients with Intracranial Aneurysm”
Neurovascular Diagnostics, Inc.
Role: Principal Investigator
$24,891 - July 2020–June 2021
University at Buffalo’s Center for Advanced Technology in Big Data and Health Sciences Total (UBCAT) “Molecular Markers for Dangerous Intracranial Aneurysms”
Neurovascular Diagnostics, Inc.
Role: Principal Investigator
$17,387 - July 2018–December 2018
Additional work related to SBIR 1746694: A Blood-Based Test to Identify Patients with Intracranial Aneurysm
UB-SBIA
Role: Principal Investigator
$12,983 - January 2018–June 2018
A Blood-Based Test to Identify Patients with Intracranial Aneurysm
Neurovascular Diagnostics, Inc.
Role: Principal Investigator
$67,761 - February 2009–February 2014
Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms
National Institutes of Health/National Institute of Neurological Disorder and Stroke
Role: Co-Investigator
$1,733,595 - October 2006–July 2007
Summer Research Institute in Biomedical Materials Science
National Institutes of Health
Role: Co-Investigator
$641,554 - January 2000–December 2002
Controlling the Direction of Endothelial Migration during Angiogenesis: Cytoskeletal Mechanism and Regulation
American Heart Association
Role: Principal Investigator
$164,923 - February 1995–January 1998
Assembly and Regulation of Myosin II in Endothelial Locomotion
National Science Foundation
Role: Principal Investigator
$237,000 - June 1995–May 1996
Physical Interventions for Controlling Edema
State University of New York at Buffalo Provost's Multidisciplinary Research Pilot Project Program
Role: Co-Investigator
$20,000 - June 1995–December 1995
Multidisciplinary Pilot Project Program:Physical Interventions for Controlling Edema
Multidisciplinary Pilot Project Program
Role: Co-Investigator
$20,000
Journal Articles:
- Ionita CN, Paciorek AM, Dohatcu A, Hoffmann KR, Bednarek DR, Kolega JP, Levy EI, Hopkins LN, Rudin S, Mocco JD. (2009) The asymmetric vascular stent: efficacy in a rabbit aneurysm model. Stroke (Mar), 40(3): 959-965.
- Ionita CN, Paciorek AM, Hoffmann KR, Bednarek DR, Yamamoto J, Kolega JP, Levy EI, Hopkins LN, Rudin S, Mocco J. (2008) Asymmetric vascular stent: feasibility study of a new low-porosity patch-containing stent. Stroke (Jul), 39(7): 2105-2113.
- Tutino, V.M., Rajabzadeh-Oghaz, H., Veeturi, S., Poppenberg, K., Waqas, M., Mandelbaum, M., Liaw, N., Siddiqui, A.H., Meng, H., and Kolega, J. (2021) Endogenous Animal Models of Intracranial Aneurysm Development: A Review. accepted for publication. Neurosurg. Rev. (Jan) doi:10.1007/s10143-021-01481-w
- Tutino, V.M., Yan, A.J., Veeturi, S.S., Patel. T.R., Rajabzadeh-Oghaz, H., Waqas, M., Siddiqui, A.H., Tseng, J., Kolega, J. (2020) Landmark-Based Shape Analysis on Middle Cerebral Intracranial Aneurysms: A Geometric Morphometrics Approach to Infer Natural History. Curr Neurovasc Res (Dec), 17(5): 725-735. doi:10.2174/1567202617999201214230944
- Poppenberg, K.E., Li, L., Waqas, M., Paliwal, N., Jiang, K., Jarvis, J.N., Sun, Y., Snyder, K.V., Levy, E.I., Siddiqui, A.H., Kolega, J., Meng, H., Tutino, V.M. (2020) Whole blood transcriptome biomarkers of unruptured intracranial aneurysm. PloS One (Nov), 6: e0241838. doi:10.1371/journal.pone.0241838. PMID: 33156839
- Poppenberg, K.E., Tutino, V.M., PhD; Li, L, Waqas, M., June, A.,Chaves, L., Jiang, K., Jarvis, J.N., Sun, Y., Snyder, K.V., Levy, L.I., Siddiqui, A.H., Kolega, J., Meng, H. (2020) Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm. J. Transl. Med. (Oct), 18: 392.
- Vaidyanathan, K., Wang, C., Yu, Y., Krajnik, A., Choi, M. Lin, B., Kolega, J., Lee, K., Bae, Y. (2020) Machine Learning approach reveals heterogeneous responses to FAK and Rho GTPases inhibition on smooth muscle spheroid formation. bioRxiv (Jan) doi:10.1101/2020.01.30.927616
- Poppenberg, K.E., Jiang, K., Tso, M.K., Snyder, K.V., Siddiqui, A.H., Kolega, J., Jarvis, J.N., Meng, H., Tutino, V.M. (2019) Epigenetic Landscapes Suggest that Genetic Risk for Intracranial Aneurysm Operates on the Endothelium. BMC Med Genomics (Oct), 12: 149.
- Tutino VM, Poppenberg KE, Li L, Shallwani H, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. (2018) Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms. J Transl Med (Dec), 16(1): 373-373.
- Tutino VM, Rajabzadeh-Oghaz H, Chandra AR, Gutierrez LC, Schweser F, Preda M, Chien A, Vakharia K, Ionita C, Siddiqui A, Kolega J, Ionita CN. (2018) 9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics. Curr Neurovasc Res (Jan), 15(4): 312-325.
- Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H. (2018) Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. PLoS One (Jan), 13(1).
- Tutino VM, Liaw N, Spernyak JA, Ionita CN, Siddiqui AH, Kolega J, Meng H. (2016) Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats. Curr Neurovasc Res (Jan), 13(1): 82-92.
- Tutino VM, Mandelbaum M, Takahashi A, Pope LC, Siddiqui A, Kolega J, Meng H. (2015) Hypertension and Estrogen Deficiency Augment Aneurysmal Remodeling in the Rabbit Circle of Willis in Response to Carotid Ligation. Anat Rec (Hoboken) (Nov), 298(11): 1903-1910.
- Liaw N, Fox JM, Siddiqui AH, Meng H, Kolega J. (2014) Endothelial nitric oxide synthase and superoxide mediate hemodynamic initiation of intracranial aneurysms. PLoS One (Jul), 9(7): 101721-101721.
- Tutino VM, Mandelbaum M, Choi H, Pope LC, Siddiqui A, Kolega J, Meng H. (2014) Aneurysmal remodeling in the circle of Willis after carotid occlusion in an experimental model. J Cereb Blood Flow Metab (Mar), 34(3): 415-424.
- Mandelbaum M, Kolega J, Dolan JM, Siddiqui AH, Meng H, Siddiqui A. (2013) A critical role for proinflammatory behavior of smooth muscle cells in hemodynamic initiation of intracranial aneurysm. PLoS One (Sep), 8(9): 74357-74357.
- Alfano JM, Kolega J, Natarajan SK, Xiang J, Paluch RA, Levy EI, Siddiqui AH, Meng H, Siddiqui A. (2013) Intracranial aneurysms occur more frequently at bifurcation sites that typically experience higher hemodynamic stresses. Neurosurgery (Sep), 73(3): 497-505.
- Dolan JM, Kolega J, Meng H. (2013) High wall shear stress and spatial gradients in vascular pathology: a review. Ann Biomed Eng (Jul), 41(7): 1411-1427.
- Dolan JM, Meng H, Sim FJ, Kolega J. (2013) Differential Gene Expression by Endothelial Cells Under Positive and Negative Streamwise Gradients of High Wall Shear Stress. Am J Physiol Cell Physiol (Jul)C854-C866.
- Xiang J, Tremmel M, Kolega J, Levy EI, Natarajan SK, Meng H. (2012) Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk. J Neurointerv Surg (Sep), 4(5): 351-357.
- Martins GG, Kolega J. (2012) A role for microtubules in endothelial cell protrusion in three-dimensional matrices. Biol Cell (May), 104(5): 271-286.
- Dolan JM, Sim FJ, Meng H, Kolega J. (2012) Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling. Am J Physiol Cell Physiol (Apr), 302(8): 1109-1118.
- Xiang J, Tremmel M, Kolega J, Levy EI, Natarajan SK, Meng H. (2011) Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk. J Neurointerv Surg (Sep).
- Meng H, Metaxa E, Gao L, Liaw N, Natarajan SK, Swartz DD, Siddiqui AH, Kolega J, Mocco J. (2011) Progressive aneurysm development following hemodynamic insult. J Neurosurg (Apr), 114(4): 1095-1103.
- Dolan J, Meng H, Singh S, Paluch R, Kolega J. (2011) High fluid shear stress and spatial shear stress gradients affect endothelial proliferation, survival and alignment. Ann Biomed Res (Jan).
- Tanweer, O., Metaxa, E., Liaw, N., Sternberg, D.S., Siddiqui, A.H., Kolega, J., Meng, H. (2011) Inhibition of Stretch-activated Ion Channels on Endothelial Cells Disrupts Nitric Oxide-mediated Arterial Outward Remodeling. J Biorheology (Jan).
- Meng H, Metaxa E, Gao L, Liaw N, Natarajan SK, Swartz DD, Siddiqui AH, Kolega J, Mocco J, Siddiqui A. (2010) Progressive aneurysm development following hemodynamic insult. J Neurosurg (Oct).
- Tremmel M, Xiang J, Hoi Y, Kolega J, Siddiqui AH, Mocco J, Meng H, Siddiqui A. (2010) Mapping vascular response to in vivo hemodynamics: application to increased flow at the basilar terminus. Biomech Model Mechanobiol (Jan), 9: 421-434.
- Metaxa, E., Tremmel, M., Natarajan, S.K., Xiang, J., Paluch, R., Mandelbaum, M., Siddiqui, A.H., Kolega, J., Mocco, J., Meng, H. (2010) Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model. Stroke (Jan), 41: 1774-1782.
- Wang Z, Kolega J, Hoi Y, Gao L, Swartz DD, Levy EI, Mocco J, Meng H, Kolega JP. (2009) Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation. Neurosurgery (Jul), 65(1): 169-177.
- Gao L, Hoi Y, Swartz DD, Kolega J, Siddiqui A, Meng H, Kolega JP. (2008) Nascent aneurysm formation at the basilar terminus induced by hemodynamics. Stroke (Jul), 39(7): 2085-2090.
- Szymanski MICHAEL, Metaxa E, Meng H, Kolega JP. (2008) Endothelial Cell Layer Subjected to Impinging Flow Mimicking the Apex of an Arterial Bifurcation. Ann Biomed Eng (Jul).
- Metaxa E, Meng H, Kaluvala SR, Szymanski MP, Paluch RA, Kolega JP. (2008) Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow. Am J Physiol Heart Circ Physiol (Jun).
- Meng H, Wang Z, Hoi Y, Gao L, Metaxa E, Swartz DD, Kolega JP. (2007) Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke (Jun), 38(6): 1924-1931.
- Meng H, Swartz DD, Wang Z, Hoi Y, Metaxa EM, Szymanski MP, Yamamoto J, Sauvageau E, Levy EI, Kolega JP. (2006) A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Neurosurgery (Nov), 59(5): 1094-1100.
- Kolega J, Kolega JP. (2006) The role of myosin II motor activity in distributing myosin asymmetrically and coupling protrusive activity to cell translocation. Mol Biol Cell (Oct), 17(10): 4435-4445.
- Martins GG, Kolega J, Kolega JP. (2006) Endothelial cell protrusion and migration in three-dimensional collagen matrices. Cell Motil Cytoskeleton (Feb), 63(2): 101-115.
- Kolega J. (2004) Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun (Jul), 320(3): 1020-1025.
- Kolega J. (2003) Asymmetric distribution of myosin IIB in migrating endothelial cells is regulated by a rho-dependent kinase and contributes to tail retraction. Mol Biol Cell (Dec), 14(12): 4745-4757.
- KOLEGA J Li X. (2002) Effects of direct current electric fields on cell migration and actin filament distribution in bovine vascular endothelial cells. Journal of Vascular Research (Jan), 39: 4745-4757.
- John Kolega. (1999) Turnover rates at regulatory phosphorylation sites on myosin II in endothelial cells. J Cell Biochem (Dec), 75(4): 629-639.
- Kolega J, Kumar S, Kolega JP. (1999) Regulatory light chain phosphorylation and the assembly of myosin II into the cytoskeleton of microcapillary endothelial cells. Cell Motil Cytoskeleton (Jan), 43(3): 255-268.
- Kolega J, Kolega JP. (1998) Cytoplasmic dynamics of myosin IIA and IIB: spatial 'sorting' of isoforms in locomoting cells. J Cell Sci (Aug), 111 (: 2085-2095.
- John Kolega. (1998) Cytoplasmic dynamics of myosin IIA and IIB: spatial ‘sorting‘ of isoforms in locomoting cells. J Cell Sci (Aug), 111 (: 2085-2095.
- John Kolega. (1998) Fluorescent analogues of myosin II for tracking the behavior of different myosin isoforms in living cells. J Cell Biochem (Mar), 68(3): 389-401.
- John Kolega. (1997) Asymmetry in the distribution of free versus cytoskeletal myosin II in locomoting microcapillary endothelial cells. Exp Cell Res (Feb), 231(1): 66-82.
- Taylor DL, DeBiasio R, LaRocca G, Pane D, Post P, John Kolega, Giuliano K, Burton K, Gough B, Dow A. (1994) Potential of machine-vision light microscopy in toxicologic pathology. Toxicol Pathol (Jan), 22(2): 145-159.
- John Kolega, Taylor DL. (1993) Gradients in the concentration and assembly of myosin II in living fibroblasts during locomotion and fiber transport. Mol Biol Cell (Aug), 4(8): 819-836.
- John Kolega, Nederlof, M. A., Taylor, D. L. (1993) Quantitation of cytoskeletal fibers in fluorescence images: stress fiber disassembly accompanies dephosphorylation of the regulatory light chains of myosin II. Bioimaging (Jan), 1: 136-150.
- Giuliano KA, John Kolega, DeBiasio RL, Taylor DL. (1992) Myosin II phosphorylation and the dynamics of stress fibers in serum-deprived and stimulated fibroblasts. Mol Biol Cell (Sep), 3(9): 1037-1048.
- Loomis CA, John Kolega, Manabe M, Sun TT. (1992) Characterization of a keratinocyte-specific extracellular epitope of desmoglein. Implications for desmoglein heterogeneity and function. J Biol Chem (Aug), 267(23): 16676-16684.
- Janson LW, John Kolega, Taylor DL. (1991) Modulation of contraction by gelation/solation in a reconstituted motile model. J Cell Biol (Sep), 114(5): 1005-1015.
- John Kolega, Janson LW, Taylor DL. (1991) The role of solation-contraction coupling in regulating stress fiber dynamics in nonmuscle cells. J Cell Biol (Sep), 114(5): 993-1003.
- John Kolega, Manabe M. (1990) Tissue-specific distribution of a novel component of epithelial basement membranes. Exp Cell Res (Aug), 189(2): 213-221.
- John Kolega, Manabe M, Sun TT. (1989) Basement membrane heterogeneity and variation in corneal epithelial differentiation. Differentiation (Oct), 42(1): 54-63.
- John Kolega. (1986) Effects of mechanical tension on protrusive activity and microfilament and intermediate filament organization in an epidermal epithelium moving in culture. J Cell Biol (Apr), 102(4): 1400-1411.
- John Kolega, Shure MS, Chen WT, Young ND. (1982) Rapid cellular translocation is related to close contacts formed between various cultured cells and their substrata. J Cell Sci (Apr), 54: 23-34.
- John Kolega. (1981) The movement of cell clusters in vitro: morphology and directionality. J Cell Sci (Jun), 49: 15-32.
Books and Book Chapters:
- K. Hahn, John Kolega, J. Montibeller, R. DeBiasio, P. Post, J. Myers, D. L. Taylor. (1999) In: Fluorescent analogs: optical biosensors of the chemical and molecular dynamics of macromolecules in living cells. , 554-566.
- John Kolega, Taylor, D. L. (1991) In: Regulation of actin and myosin II dymamics in living cells. , 187-206.
- John Kolega. (1986) In: The cellular basis of epithelial morphogenesis. , 103-143.
Professional Memberships:
- American Heart Association (2000–present)
- American Heart Association Council (2000–present)
- The American Association for the Advancement of Science (1991–present)
- American Society for Cell Biology (1991–present)
Presentations:
- "Rubbed the Wrong Way: How Hemodynamic Forces Contribute to the Development of Brain Aneurysms" Department of Oral Biology seminar series; UB School of Dental Medicine (2018)
Service Activities:
- Five-year evaluation of Pathology Master's program at University of Vermont School of Medicine; External Reviewer (2021)
- review of promotion dossier for Research Associate Professor candidate for the Dept. of Physiology & Biophysics; ad hoc promotion review (2021)
- Frontiers in Cardiovascular Medicine, Nature Medicine; manuscript review (2020–2021)
- review of biomedical research grants ofr the Florida Department of Health; review panel member (2019–2020)
- Director of Graduate Studies for PhD program in Computational Cell Biology, Anatomy & Pathology; Director of Graduate Studies (2017–present)
- Swiss National Science Foundation; Swiss National Science Foundation: Mobility fellowships;; Ad Hoc Reviewer (2014)
- Academic Calendar Committee, School of Dental Medicine Academic Calendar Committee, School of Dental Medicine; Committee Member (2011–2017)
- Curriculum Committee, School of Dental Medicine Curriculum Committee, School of Dental Medicine; Committee Member (2010–2017)
- First Year Committee, School of Dental Medicine First Year Committee, School of Dental Medicine; Committee Member (2009–2017)
- Phase I Committee, School of Medicine; Committee Member (2009–present)
- National Cancer Institute; Network of Translational Research: Optical Imaging; National Cancer Institute ad hoc study section CA-03-002: Network of Translational Research: Optical Imaging, 2003;; Ad Hoc Reviewer (2003)
- City University of New York; PSC-CUNY Research Award Program; PSC-CUNY Research Award Program (City University of New York;; External Reviewer (2002–2003)
- Executive Committee, Department of Pathology & Anatomical Sciences Executive Committee, Department of Pathology & Anatomical Sciences; Committee Member (2002–present)
- Wellcome Trust; Wellcome Trust grant reviews; Wellcome Trust ad hoc grant reviews;; Ad Hoc Reviewer (2002–2009)
- United States-Israel Binational Science Foundation; United States-Israel Binational Science Foundation; United States-Israel Binational Science Foundation;; Ad Hoc Reviewer (2002)
- Director of Graduate Studies Director for the Pathology and Anatomical Sciences Master's and PhD programs; Director (2001–present)
- U.S. Civilian Research & Development Foundation; NRC COBASE; U.S. Civilian Research & Development Foundation;; Ad Hoc Reviewer (2001)
- journal peer review ad hoc review for the following journals: Nature; Journal of Cell Biology; Molecular Biology of the Cell; FASEB Journal; Biophysical Journal; American Journal of Physiology; Journal of Vascular Research; Arteriosclerosis, Thrombosis and Vascular Biology; Cardiovascular Research; Cell Motility and the Cytoskeleton; Experimental Cell Research; Cell Biochemistry and Biophysics; Journal of Neurobiology; Journal of the Royal Society Interface; Cell and Molecular Life Sciences; Wound Repair and Regeneration; Neurosurgery; Acta Biomaterialia; Peer Reviewer (2000–2018)
- National Science Foundation; NSF Cellular Organization program; National Science Foundation (Cellular Organization program) ad hoc grant reviews;; Ad Hoc Reviewer (1999–2008)