Mikhail V. Pletnikov M.D. Ph.D.
Mikhail V. Pletnikov
M.D. Ph.D.
Professional Summary:
My research focuses the mechanisms of neuron-glia interaction in the pathophysiology of behavioral alterations and cognitive impairment in neuropsychiatric disorders. We are interested in the role of astrocytes and astrocyte bioenergetics in mediating avderse neurodevelopmental effects of environmental factors, including microbial pathogens, cannabis and stress. These mechanisms are studied using mouse genetics, molecular, cellular and systems approaches and in vivo imaging technologies.
Education and Training:
- PhD, P.K. Anokhin Institute of Normal Physiology (1990)
- MD, medicine and Physiology, I.M. Sechenov Moscow Medical Institute, Cum Laude (1986)
Employment:
- Chair, Physiology and Biophysics, Jacobs School of Medicine & Biomedical Sciences (2020-present)
Grants and Sponsored Research:
- Astrocytes Bioenergetics in Brain Development
NIMH
Role: Principal Investigator
$358,982 - Molecular mechanism of astrocytic vulnerability to adolescent cannabis use
NIDA
Role: Principal Investigator
$336,938 - Gene-Environment Interactions for Cortical Development and Schizophrenia
NIMH
Role: Co-Investigator
$1,345,709
Journal Articles:
- Hollander JA, Cory-Slechta DA, Jacka FN, Szabo ST, Guilarte TR, Bilbo SD, Mattingly CJ, Moy SS, Haroon E, Hornig M, Levin ED, Pletnikov MV, Zehr JL, McAllister KA, Dzierlenga AL, Garton AE, Lawler CP, Ladd-Acosta C. (2020) Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. Neuropsychopharmacology (Jun), 45(7): 1086-1096.
- Hurd YL, Manzoni OJ, Pletnikov MV, Lee FS, Bhattacharyya S, Melis M. (2019) Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects. J Neurosci (Oct), 39(42): 8250-8258.
- Jouroukhin Y, Zhu X, Shevelkin AV, Hasegawa Y, Abazyan B, Saito A, Pevsner J, Kamiya A, Pletnikov MV. (2019) Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood. Biol Psychiatry (Jan), 85(11): 891-903.
- Kentner AC, Bilbo SD, Brown AS, Hsiao EY, McAllister AK, Meyer U, Pearce BD, Pletnikov MV, Yolken RH, Bauman MD. (2019) Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model. Neuropsychopharmacology (Jan), 44(2): 245-258.
- Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko AV, Dannals RF, Pletnikov MV, Pomper MG. (2019) PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A (Jan), 116(5): 1686-1691.
- Jouroukhin Y, Kageyama Y, Misheneva V, Shevelkin A, Andrabi S, Prandovszky E, Yolken RH, Dawson VL, Dawson TM, Aja S, Sesaki H, Pletnikov MV. (2018) DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. Transl Psychiatry (Jan), 8(1): 76-76.
- McFarland R, Wang ZT, Jouroukhin Y, Li Y, Mychko O, Coppens I, Xiao J, Jones-Brando L, Yolken RH, Sibley LD, Pletnikov MV. (2018) AAH2 gene is not required for dopamine-dependent neurochemical and behavioral abnormalities produced by Toxoplasma infection in mouse. Behav Brain Res (Jan), 347: 193-200.
- Terrillion CE, Abazyan B, Yang Z, Crawford J, Shevelkin AV, Jouroukhin Y, Yoo KH, Cho CH, Roychaudhuri R, Snyder SH, Jang MH, Pletnikov MV. (2017) DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice. Neuropsychopharmacology (Oct), 42(11): 2242-2251.