My research laboratory studies metalloproteins involved in human health and disease, with focus on proteins from bacterial pathogens to develop new antimicrobial targets. We are actively developing new methods for crystallization of biomolecules, new methods for detection of nanocrystals for electron crystallography, and new methods for in situ X-ray data collection. We are especially interested in developing new methods that combine crystallographic and spectroscopic approaches to answer fundamental questions about protein biochemistry, especially in proteins that contain metals. We are working to develop spectroscopic methods for single crystals (electron paramagnetic resonance, UV-visible microspectrophotometry, and energy dispersive X-ray spectroscopy for elemental analysis) to be used in parallel with crystallography.