Vincent M. Tutino Ph.D

Vincent Tutino

Vincent M. Tutino

Assistant Professor

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Aneurysms – Intracranial; Biomedical Engineering; Biomedical Imaging; Biomedical Imaging; Cardiovascular Disease; Cerebrovascular (Stroke); Gene Expression; Gene Sequencing; Hematology; Hemostasis / Thrombosis; Inflammation; Quantitative Histology; RNA; Stroke; Transcription and Translation; Transcriptomics; Translational Research; Vascular and Interventional Radiology; Vascular Malformations

Professional Summary:

My lab resides in the Canon Stroke and Vascular Research Center (CSVRC), where I direct the Hemodynamics and Vascular Biology Lab, leading a multidisciplinary group of graduate students, post-docs and technicians. There, I am also the Study Director for GLP research, where I interface with corporate entities to execute industry-sponsored research. My research uses a broad array of analytical techniques to study neurovascular disease, namely ischemic stroke and brain aneurysms. The lab implements combinations of histology, medical imaging, optical imaging, computational fluid dynamics, and mechanical testing to characterize progressive, mal-adaptive remodeling of the brain’s arterial system induced during these diseases in small animal models. Other areas of my lab focus on translational science. Here, we are developing clinically-useful biomarkers, software, and simulation tools for brain aneurysms and stroke. State-of-the-art technology, such as next-generation RNA sequencing, spatial sequencing, and machine and deep learning tools are routinely implemented. As part of these endeavors, I have also founded the Stroke and Brain Tumor Biobank at the CTRC, which is becoming a cornerstone for the CSVRC’s human subjects research.

Education and Training:

  • Certificate, Fundamentals & Applications of Clinical and Translational Research, Harvard University (2019)
  • PhD, Biomedical Engineering, University at Buffalo (2018)
  • MS, Biomedical Engineering, University at Buffalo (2014)
  • BS, Chemistry, St. John Fisher University, Magna Cum Laude (2010)


  • Affiliated Assistant Professor, Biomedical Engineering, University at Buffalo
  • Affiliated Assistant Professor, Mechanical and Aerospace Engineering, University at Buffalo
  • Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo
  • President and CEO, Neurovascular Diagnostics, Inc.
  • Research Assistant Professor, Neurosurgery, University at Buffalo
  • Vice-President and CFO, QAS.AI, Inc.

Research Expertise:

  • Animal models of vascular disease: Rat, rabbit and mouse models of brain aneurysm and stroke
  • Biobanking: Biobank of tissue and liquid biopsy for stroke, aneurysms, and brain tumors
  • Gene expression profiling: transcriptomics of vascular diseases towards biomarker development
  • Medical image analysis: CTA, nCCT, MRI, MRA, DSA

Research Centers:

  • Center of Excellence in Bioinformatics and Life Sciences
  • Clinical and Translational Research Center (CTRC)
  • Toshiba Stroke Research Center

Grants and Sponsored Research:

  • Exploring Mechanisms of Intracranial Aneurysm Rupture through Magnetic Vessel Wall Imaging.
    SUNY Research Seed Grant Program
    Role: Principal Investigator
  • A Whole Blood RNA Diagnostic for Unruptured Brain Aneurysm: Risk Assessment Prototype Development and Testing.
    Brain Aneurysm Foundation
    Role: Principal Investigator
  • Molecular Biomarkers of Dangerous Intracranial Aneurysms.
    Role: Principal Investigator
  • Circulating Molecular Markers of High-Risk Brain Aneurysms from Circulating Neutrophil Gene Expression
    Brain Aneurysm Foundation
    Role: Principal Investigator
  • A Blood-Based Test to Identify Patients with Intracranial Aneurysm.
    Role: Principal Investigator
  • Blood-Based Biomarkers Associated with Aneurysm Vessel Wall Enhancement on Post-Contrast MRI.
    Role: Principal Investigator
  • Biomarkers for Ischemic Stroke Origin.
    Clinical and Translational Science Award, Pilot Study
    Role: Co-Principal Investigator
  • An AI-Enhanced Angiographic System to Guide Endovascular Treatment of Intracranial Aneurysms.
    Role: Co-Investigator


  • Biomarkers for intracranial aneurysm Provided are methods for determining a presence of an intracranial aneurysm in a subject suspected of having an intracranial aneurysm or at risk for developing an intracra nial aneurysm, or a subject in need of aneurysm monitoring. The method involves analyzing a biological sample from the subject for expression of a combination of biomarkers that provide a signature of an aneurism. Specification includes a Sequence Listing. (2020)

Journal Articles:

See all (51 more)

Professional Memberships:

  • SB3C Foundation; The Summer Biomechanics Bioengineering and Biotransport Foundation
  • American Heart Association; Stroke Council Council on Genomic and Precision Medicine (GPM)


  • "RNA Sequencing for Identification of Circulating Biomarkers to Detect Unruptured Intracranial Aneurysms" Upstate New York Illumina Next-Generation Sequencing (NGS) Seminar
  • "Developing Molecular Diagnostics of Intracranial Aneurysm: A Collision of Translational Research and Entrepreneurship." Mayo Clinic Neuroscience Grand Rounds
  • "Development of Biological and Imaging Markers for Hemorrhagic and Ischemic Strokes" Geneva University Hospitals, Department of Clinical Neurosciences – Grand Rounds
  • "Translational Stroke Research" The “Circle of Willis” Webinar/Podcast

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