Vincent M. Tutino Ph.D

Vincent Tutino

Vincent M. Tutino
Ph.D

Assistant Professor

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Aneurysms – Intracranial; Biomedical Engineering; Biomedical Imaging; Biomedical Imaging; Cardiovascular Disease; Cerebrovascular (Stroke); Gene Expression; Gene Sequencing; Hematology; Hemostasis / Thrombosis; Inflammation; Quantitative Histology; RNA; Stroke; Transcription and Translation; Transcriptomics; Translational Research; Vascular and Interventional Radiology; Vascular Malformations

Contact Information
955 Main Street
Room 4204
Buffalo, New York 14203
Phone: (716) 829-2265
vincentt@buffalo.edu



Professional Summary:

I am passionate about conducting translational research in the field of neurovascular diseases, with a specific focus on ischemic stroke, intracranial aneurysm, subarachnoid hemorrhage, and reperfusion injury. My research interests lie at the intersection of biomarker development, computational biology, and big data analysis. I strive to leverage cutting-edge technologies such as transcriptomics, systems biology, and experimental models of vascular disease to gain a comprehensive understanding of these complex conditions.

In my research, I also explore the application of advanced imaging techniques, such as CT imaging and digital pathology, to enhance diagnostics and prognostics in neurovascular diseases. I have a keen interest in developing novel methods for image processing and segmentation, leveraging machine learning and deep learning algorithms to extract meaningful information from medical images. By integrating spatial sequencing data and utilizing biobanking resources, I strive to uncover molecular signatures and identify potential therapeutic targets for improved patient outcomes.

Furthermore, I am broadly interested in the field of hematology and the role of the circulating blood, as a tissue, in the pathophysiology of stroke and aneurysm, their endovascular treatment, and their healing. In addition, investigating systems biology, and how the blood can be used as a surrogate biomarker tissue of the disease, I am also interested in blood clotting and its role in aneurysm and stroke. Along with collaborators in the field of mechanical engineering, I use simulation to conduct research on the efficacy of endovascular devices, such as mechanical thrombectomy, in treating ischemic strokes by removing complex blood clots. I am enthusiastic about utilizing numerical simulations to model and optimize these devices' performance, contributing to advancements in the field of neurovascular interventions.

Overall, my research interests span a diverse range of areas, including biomarker development, computational biology, big data analysis, image processing, and machine learning, all with a specific focus on neurovascular diseases. I am committed to making significant contributions to the field through a multidisciplinary approach that integrates clinical insights, experimental models, and advanced technologies.

Education and Training:

  • Other, National Science Foundation, I-Corps Shor Course, QAS.AI, Inc. (2020)
  • Certificate, Fundamentals & Applications of Clinical and Translational Research, Harvard University (2019)
  • PhD, Biomedical Engineering, University at Buffalo (2018)
  • Other, National Science Foundation, I-Corps Short Course, Neurovascular Diagnostics, Inc. (2017)
  • MS, Biomedical Engineering, University at Buffalo (2014)
  • BS, Chemistry, St. John Fisher University, Magna Cum Laude (2010)
  • Internship, Chemical Engineering University of Rochester, University of Rochester (2005)

Employment:

  • Member, Board of Directors, Brain Aneurysm Foundation (2023-present)
  • Member, Board of Directors, QAS.AI, Inc. (2020-present)
  • Vice-President and CFO, QAS.AI, Inc. (2020-present)
  • Affiliated Assistant Professor, Biomedical Engineering, University at Buffalo (2018-present)
  • Affiliated Assistant Professor, Mechanical and Aerospace Engineering, University at Buffalo (2018-present)
  • Member, Board of Directors, Neurovascular Diagnostics, Inc. (2016-present)
  • President and CEO, Neurovascular Diagnostics, Inc. (2016-present)
  • Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo (2022-present)
  • Research Assistant Professor, Neurosurgery, University at Buffalo (2018–2022)

Awards and Honors:

  • National NSF I-Corps Program, Atlanta-Winter Cohort, Industry Mentor (2021)
  • REU program, National Science Foundation (2021)
  • 200K Challenge 2nd Place Winner (2019)
  • Emerging Company (2017)
  • MEDTECH 2017 Invitee (2017)
  • New York Small Business Development Center (NYSBDC) Pilot SBIR/STTR Acceleration Contest (2016)
  • OutputLinks Winner (2013)
  • Transfer Achievement Scholarship (2007)
  • Dean's List (2007)
  • Advanced Placement Scholar Award (2006)

Research Expertise:

  • Animal models of vascular disease: Rat, rabbit and mouse models of brain aneurysm and stroke
  • Biobanking: Biobank of tissue and liquid biopsy for stroke, aneurysms, and brain tumors
  • Gene expression profiling: transcriptomics of vascular diseases towards biomarker development
  • Medical image analysis: CTA, nCCT, MRI, MRA, DSA

Research Centers:

  • Center of Excellence in Bioinformatics and Life Sciences
  • Clinical and Translational Research Center (CTRC)
  • Toshiba Stroke Research Center

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • September 2023–August 2027
    Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
    National Institutes of Health – NHLBI
    Role: Co-Investigator
    $4,000,000
  • October 2023–September 2026
    Liquid and endovascular coil biopsy for understanding sex differences in Intracranial Aneurysms
    CNS – Joint CV Section/CNSF Young Investigator’s Award
    Role: Co-Investigator
    $150,000
  • May 2023–April 2025
    An AI-Enhanced Angiographic System to Guide Endovascular Treatment of Intracranial Aneurysms
    National Science Foundation
    Role: Co-Investigator
    $1,000,000
  • September 2023–August 2024
    Development of a Molecular Diagnostic to Identify Dangerous Intracranial Aneurysms
    National Institutes of Health – NINDS
    Role: Co-Principal Investigator
    $2,900,000
  • July 2022–August 2024
    Hemodynamically-Induced Molecules Regulating the Initiation of Intracranial Aneurysm
    National Institutes of Health – NINDS
    Role: Co-Principal Investigator
    $475,000
  • June 2022–June 2024
    Validation of a Blood-Based Diagnostic Assay for Rupture Risk Assessment of Intracranial Aneurysms
    Center for Advanced Technology (NYSTAR)
    Role: Principal Investigator
    $117,000
  • November 2020–November 2023
    An AI-Enhanced Angiographic System to Guide Endovascular Treatment of Intracranial Aneurysms
    National Science Foundation
    Role: Co-Investigator
    $256,000
  • August 2019–November 2023
    A Blood-Based Test to Identify Patients with Intracranial Aneurysm
    National Science Foundation
    Role: Co-Principal Investigator
    $750,000
  • September 2022–August 2023
    Combination Blood and MRI Biomarkers for Rupture Risk Assessment of Brain Aneurysms
    Brain Aneurysm Foundation
    Role: Co-Investigator
    $50,000
  • August 2020–August 2023
    Exploring Mechanisms of Intracranial Aneurysm Rupture through Magnetic Vessel Wall Imaging
    SUNY Research Seed Grant Program
    Role: Principal Investigator
    $30,000
  • October 2021–August 2022
    Finite Element Analysis for Flow Diverter Simulation
    MEDTRONIC
    Role: Principal Investigator
    $24,000
  • September 2021–August 2022
    Blood-Based Biomarkers Associated with Aneurysm Vessel Wall Enhancement on Post-Contrast MRI
    Brain Aneurysm Foundation
    Role: Principal Investigator
    $30,000
  • July 2021–June 2022
    Validation of AneuScreenTM, a Novel Blood-Based Diagnostic Prototype for Detection of Unruptured Brain Aneurysms
    Center for Advanced Technology (NYSTAR)
    Role: Principal Investigator
    $93,000
  • May 2021–April 2022
    Small RNA Biomarkers for Brain Injury
    UB – Buffalo Blue Sky Grant
    Role: Co-Investigator
    $25,000
  • November 2019–November 2021
    Molecular Biomarkers of Dangerous Intracranial Aneurysms
    National Institutes of Health – NINDS
    Role: Principal Investigator
    $225,000
  • September 2020–August 2021
    A Whole Blood RNA Diagnostic for Unruptured Brain Aneurysm: Risk Assessment Prototype Development and Testing
    Brain Aneurysm Foundation
    Role: Principal Investigator
    $40,000
  • September 2019–August 2020
    Circulating Molecular Markers of High-Risk Brain Aneurysms from Circulating Neutrophil Gene Expression
    Brain Aneurysm Foundation
    Role: Principal Investigator
    $45,000
  • July 2019–June 2020
    Validation of a Blood-Based Diagnostic Prototype for Detection of Unruptured Brain Aneurysms
    Center for Advanced Technology (NYSTAR)
    Role: Principal Investigator
    $26,000
  • September 2018–August 2019
    A Prototype Blood Test for Detecting Unruptured Brain Aneurysms
    Brain Aneurysm Foundation
    Role: Principal Investigator
    $50,000
  • July 2018–June 2019
    Development of Whole Blood RNA Expression-Based Assay for Detecting Unruptured Brain Aneurysms
    Center for Advanced Technology (NYSTAR).
    Role: Principal Investigator
    $43,500
  • May 2018–May 2019
    Biomarkers for Ischemic Stroke Origin
    UB CTSI – Clinical and Translational Science Award: Pilot Study
    Role: Co-Investigator
    $50,000
  • January 2018–January 2019
    A Blood-Based Test to Identify Patients with Intracranial Aneurysm
    National Science Foundation
    Role: Principal Investigator
    $224,000
  • June 2018–December 2018
    Blood Testing for Detecting Brain Aneurysm
    UB – Small Business Innovation Award
    Role: Principal Investigator
    $13,500
  • October 2017–October 2018
    Tissue Bank to Facilitate Translational Research in Stroke Diagnostics
    James H. Cummings Foundation
    Role: Co-Investigator
    $25,000
  • September 2017–August 2018
    Feasibility of Detecting Brain Aneurysm Biomarkers in Whole Blood on a Diagnostic Platform
    Brain Aneurysm Foundation
    Role: Principal Investigator
    $45,000
  • January 2018–June 2018
    Detecting Brain Aneurysm Biomarkers in Whole Blood on a Diagnostic Platform
    Center for Advanced Technology (NYSTAR)
    Role: Principal Investigator
    $23,300
  • September 2015–August 2016
    MicroRNA in Unruptured Intracranial Aneurysm: Fostering a Mechanism of Early Detection
    Brain Aneurysm Foundation
    Role: Co-Investigator
    $25,000
  • January 2019
    BIG Incentive Proposal
    Buffalo Institute of Genomics (NYSTAR)
    Role: Principal Investigator
    $50,000
  • Brain Aneurysm Research in the Tutino Lab
    The Ascanio and Jean Boccuti Family Charitable Fund
    Role: Principal Investigator
    $27,000
See all (19 more)

Patents:

  • Biomarkers for intracranial aneurysm Provided are methods for determining a presence of an intracranial aneurysm in a subject suspected of having an intracranial aneurysm or at risk for developing an intracra nial aneurysm, or a subject in need of aneurysm monitoring. The method involves analyzing a biological sample from the subject for expression of a combination of biomarkers that provide a signature of an aneurism. Specification includes a Sequence Listing. (2020)

Journal Articles:

See all (70 more)

Professional Memberships:

  • Congress of Neurological Surgeons; Associate Member (2023–present)
  • Society of Vascular and Interventional Neurology (2022–present)
  • American Association for Clinical Chemistry (2016–present)
  • Biomedical Engineering Society; University at Buffalo Chapter (2013–2016)
  • Collaborative Learning and Integrated Mentoring in the Biosciences (CLIMB) Program; CLIMB (2011–2016)
  • American Association for the Advancement of Science (2010–2011)
  • American Chemical Society (2007–2010)
  • SB3C Foundation; The Summer Biomechanics Bioengineering and Biotransport Foundation
  • American Heart Association; Stroke Council Council on Genomic and Precision Medicine (GPM)

Presentations:

  • "Vessel Wall Imaging Radiomics as Biomarkers of Aneurysm Rupture Risk" AHA International Stroke Conference (2024)
  • "Acute Ischemic Stroke Clot Analysis at the CSVRC" University College London, British Heart Foundation Lab Invitation Seminar (2023)
  • "Circulating gene expression signatures as molecular markers for intracranial aneurysm detection and risk stratification" 19th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2023)
  • "Molecular and Radiographic Signatures of Ischemic Stroke Etiology and Outcomes in Retrieved Thrombi" 19th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2023)
  • "Aneurysm Biomarkers" 13th Cerebrovascular Complications Conference (3C) (2023)
  • "Circulating Molecular Signatures of Intracranial Aneurysm" 16th International Conference on Subarachnoid Hemorrhage (2023)
  • "Current Perspectives in Brain Aneurysm Research" Brain Aneurysm Foundation Seminar Series (2023)
  • "A History of Brain Aneurysm Research" Brain Aneurysm Foundation Advocacy Day (2023)
  • "Circulating transcriptome profiles reveal expression signatures of intracranial aneurysm rupture risk and potential role of fibronectin" 7th International Conference on Computational and Mathematical Biomedical Engineering (2022)
  • "Development of a Blood-Based Diagnostic for Brain Aneurysms" Clinical and Translational Research Center Seminar Series (2021)
  • "Developing Molecular Diagnostics of Intracranial Aneurysm: A Collision of Translational Research and Entrepreneurship." Mayo Clinic Neuroscience Grand Rounds (2021)
  • "Translational Stroke Research" The “Circle of Willis” Webinar/Podcast (2021)
  • "Development of Biological and Imaging Markers for Hemorrhagic and Ischemic Strokes" Geneva University Hospitals, Department of Clinical Neurosciences – Grand Rounds (2020)
  • "A Blood-Based Diagnostic to Detect Brain Aneurysm: Translational Science Meets Entrepreneurship" Grand Rounds, Department of Pathology and Anatomical Sciences (2019)
  • "Circulating Expression Biomarkers to Detect Unruptured Aneurysms" 16th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2019)
  • "RNA Sequencing for Identification of Circulating Biomarkers to Detect Unruptured Intracranial Aneurysms" Upstate New York Illumina Next-Generation Sequencing (NGS) Seminar - UofR (2019)
  • "Building Biomarkers of Brain Aneurysm" Department of Mechanical and Aerospace Engineering Spring Seminar Series (2019)
  • "Blood Tests for Brain Aneurysms: My Experience in Translational Research" Mechanical and Aerospace Engineering, Department Advisory Board Annual Meeting (2018)
  • "Machine Learning for Classification of Unruptured Intracranial Aneurysms" 15th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2018)
  • "Circulating RNA Profiles of Intracranial Aneurysm as a Potential Diagnostic Biomarker" Lecture, 2nd International Neurovascular Exploratory Workshop (2018)
  • "Epigenetic Landscapes in Regulatory Regions of Genetic Risk for Intracranial Aneurysm" Lecture, 2nd International Neurovascular Exploratory Workshop (2018)
  • "Neurovascular Diagnostics: Better Care through Personalized Medicine" MEDTECH 2017 (2017)
  • "High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis" Lecture, 1st International Neurovascular Exploratory Workshop (2017)
  • "Imprints of Intracranial Aneurysm on Circulating Neutrophils" Lecture, 1st International Neurovascular Exploratory Workshop (2017)
  • "Cerebrovascular Symposium. Complex Role of Hemodynamics in Intracranial Aneurysm Initiation, Growth, and Rupture" Lecture, 13th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium (2016)
  • "Cerebral Aneurysms: How They Form and How We Study Them" SEAS Seminar (2014)
See all (16 more)

Service Activities:

  • Awards Committee; Member (2032–present)
  • NIH, NINDS SBIR Review Panel; Reviewer (2024)
  • International Stroke Conference (AHA), Imaging Biomarkers of Aneurysm Biology. Phoenix, Arizona, USA; Conference Invited Panel Member (2024–present)
  • PPBS Admission Committee; PPBS Admission Committee (2024–present)
  • PAS new faculty; Search committee (2023–present)
  • Detection and Classification of Intracranial Aneurysm. 19th Interdisciplinary Cerebrovascular Symposium. Forum Genève. Geneva, Switzerland.; Session Chair/Moderator (2023–present)
  • JSMBS Faculty Senate – University Shared Governance; Member (2023–2024)
  • Consultant-Speakers Bureau (Honorarium), Canon Medical Systems, USA, Inc.; Consultancy (2023–present)
  • For Special Issue: “Proceedings from the 2023 International Conference on Subarachnoid Hemorrhage”; Guest Editor for Special Issue, Translational Stroke Research (2023–present)
  • Unruptured Aneurysms – 1. 16th International Conference on Subarachnoid Hemorrhage. Duke University. Durham, NC.; Session Chair/Moderator (2023–present)
  • Admission Committee of the Graduate Program; Member (2022–present)
  • Graduate Program Committee; Member (2022–present)
  • R230049, R230054, R230064, R220158, R220259,U2100017, R2100074, R2000011, U2000004, R1900296; Search committee (2019–2024)
  • “Omics” Session. 2nd International Neurovascular Exploratory Workshop. Zurich, Switzerland.; Session Chair/Moderator (2018–present)
  • Advocate to promote brain aneurysm awareness and research-related bills, resolutions, and appropriations language. Washington, D.C.; Brain Aneurysm Foundation (2018–present)
  • Hemodynamics and Vascular Biology Lab, Canon Stroke and Vascular Research Center; Director (2018–present)
  • Destructive Remodeling Session. Inflammatory Aneurysm Wall Remodeling Session. 1st International Neurovascular Exploratory Workshop. Zurich, Switzerland.; Session Chair/Moderator (2017–present)
  • SNF Symposium. 13th International Intracranial Stent Meeting and Interdisciplinary Cerebrovascular Symposium. Kobe, Japan.; Conference Invited Panel Member (2016–present)
  • Helped introduce elementary and middle school aged children to biomedical research of brain disorders, such as aneurysm and stroke. Buffalo, NY; Jacobs Institute Brain Bootcamp (2016–present)
  • Sponsor for the program; Kenmore West High School Career Exploration Internship Program (2015–present)
  • Testing /Modeling and Design Challenges Session. 7th Frontiers in Biomedical Devices, ASME 2014 International Design and Engineering Conference. Buffalo, NY.; Session Chair/Moderator (2014–present)
  • Worked with doctors and nurses from ProHealth, a Nigerian health NGO, to provide free health-care services in Africa. Bundung, Republic of the Gambia; Jammeh Foundation for Peace (2009–present)
  • Brain Aneurysm Foundation at NIH; Academic Ambassador
  • Scientific Reports; Reviewer
  • Circulation Research; Reviewer
  • Stroke and Vascular Neurology; Reviewer
  • Stroke; Reviewer
  • European Journal of Neurology; Reviewer
  • Journal of Thrombosis and Thrombolysis; Reviewer
  • BMC Medical Genomics; Reviewer
  • Neurosurgical Focus; Reviewer
  • Annals of Biomedical Engineering; Reviewer
  • Neuropsychiatric Disease and Treatment; Reviewer
  • American Journal of Neuroradiology; Reviewer
  • EMBO Molecular Medicine; Reviewer
  • Journal of Neurointerventional Surgery; Reviewer
  • Journal of the American Heart Association; Reviewer
  • Stroke: Vascular and Interventional Neurology; Reviewer
  • Acta Neuropathologica; Reviewer
  • Computers in Biology and Medicine; Reviewer
  • Journal of Translational Research; Reviewer
  • Translational Stroke Research; Reviewer
  • Brain Research Bulletin; Reviewer

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Contact Information

955 Main Street
Room 4204
Buffalo, New York 14203
Phone: (716) 829-2265
vincentt@buffalo.edu