Xiuqian Mu MD, PhD

Xiuqian Mu

Xiuqian Mu
MD, PhD

Professor

Department of Ophthalmology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bioinformatics; Cell growth, differentiation and development; Developmental Biology; Epigenetics; Gene Expression; Genomics and proteomics; Models - cell and animal; Molecular and Cellular Biology; Neuroscience; Progenitor Cells; Retina – retinal disease and therapy; RNA; Stem Cells; Transcription - Gene; Transcription and Translation; Transcription Factors; Transcriptomics; Transgenic organisms; Translation - Protein; Vision science

Contact Information
955 Main Street
Rm 4124
Buffalo, New York 14203
Phone: 716-881-7463
Fax: 716-887-2991
xmu@buffalo.edu



Professional Summary:

I am interested in the fundamental mechanisms regulating the shift of cellular states in neuronal differentiation. We address this issue by studying cell fate specification and differentiation in the developing retina. Our efforts are on identifying key regulators, uncovering their roles in individual cell lineages, and understanding how they carry out their functions. One major focus of our research is how transcription factors influence the epigenetic landscape along the developmental trajectory of retinal ganglion cells. We are also investigating how posttranscriptional control of gene expression affects retinal cell differentiation. We conduct our research using a combinatorial approach of genetics, molecular biology, genomics, single-cell technologies, and bioinformatics.

Education and Training:

  • PhD, Biochemistry and Molecular Biology, Peking Union Medical College (1994)
  • MD, Medicine, Qingdao Medical College (1989)

Employment:

  • Professor, Ophthalmology, University at Buffalo School of Medicine and Biological Sciences (2022-present)
  • Associate Professor (with tenure), Ophthalmology, University at Buffalo School of Medicine and Biological Sciences (2015–2022)
  • Assistant Professor, Ophthalmology, University at Buffalo School of Medicine and Biological Sciences (2008–2015)
  • Assistant Professor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (2003–2008)
  • Instructor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (2002–2003)
  • Postdoctoral Associate, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (1999–2001)
  • Visiting Fellow, National Institutes of Health (1994–1999)

Research Expertise:

  • Developmental biology: mouse retinal development, neural development, cell fate specification, cell differentiation
  • Genomics: genomics, transcriptomics, epigenomics, single cell RNA-seq, single cell ATAC-seq
  • Molecular biology: gene regulation, transcription factors, enhancers, epigenetics, post-transcriptional regulation
  • Mouse genetics: genetically modified mice, gene targeting, CRISPR/cas9, genetic labeling

Research Centers:

  • Ira G. Ross Eye Institute Research Center

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • April 2020–March 2024
    Regulation of mRNA decay in retinal development and maintenance
    National Eye Institute
    Role: Principal Investigator
    $2,024,085
  • September 2017–May 2022
    Regulatory mechanisms for retinal ganglion cell genesis
    National Institutes of Health
    Role: Principal Investigator
    $1,960,167
  • June 2016–May 2018
    Generation of retinal ganglion cells by direct reprograming
    BrightFocus Foundation
    Role: Principal Investigator
    $150,000
  • March 2011–February 2016
    Interaction of Isl1 and Pou4f2 in retinal development
    National Institutes of Health
    Role: Principal Investigator
    $1,950,000
  • January 2013–December 2014
    Function of Onecut transcription factors in retinal development and vision
    SUNY Research Foundation
    Role: Principal Investigator
    $100,000
  • January 2010–December 2013
    Molecular mechanism for the formation of retinal ganglion cells
    The Whitehall Foundation
    Role: Principal Investigator
    $225,000
  • January 2009–December 2009
    Math5 target genes in retinal ganglion cell formation
    The Glaucoma Foundation
    Role: Principal Investigator
    $40,000
  • July 2005–June 2007
    Investigating retinal ganglion cell development using purified progenitor cells
    The E. Matilda Ziegler Foundation for the Blind
    Role: Principal Investigator
    $210,000

Journal Articles:

See all (29 more)

Professional Memberships:

  • The Association for Research in Vision and Ophthalmology (ARVO); Member
  • Society for Neuroscience (SFN); Member
  • International Society for Eye Research (ISER); Member

Presentations:

  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard University (2021)
  • "Genetic and Epigenetic Mechanisms Underlying Retinal Ganglion Cell Genesis" Department of Ophthalmology, Columbia University, (2021)
  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Roski Eye Institute, Department of Ophthalmology, University of Southern California (2021)
  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Department of Ophthalmology, SUNY Downstate Health Sciences University (2021)
  • "The shifting epigenetic landscape along the developmental trajectory of retinal ganglion cells" Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, May 2021. Virtual online; Oral presentation. (2021)
  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Cole Eye Institute, Cleveland Clinic Foundation, (2021)
  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Department of Ophthalmology, University of Washington (2021)
  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Stein Eye Institute, UCLA (2021)
  • "Genetic and Epigenetic Control of Retinal Ganglion Cell Genesis" Department of Ophthalmology and Visual Sciences and W. K. Kellogg Eye Center, University of Michigan (2021)

Service Activities:

  • Biology and Development of the Eye (BDE) study section, NIH; Regular Member (2021–2025)
  • • PLOS Biology • Scientific Reports • Developmental Biology • Experimental Eye Research • Frontiers in Cell and Developmental Biology • Frontiers in Neuroscience • IOVS • PlosOne; Reviewer (2021–present)
  • Neurogenomics section, Frontiers in Genetics, Frontiers in Neuroscience, and Frontiers in Neurology; Member (2021–present)
  • ; Applicants interviewer, PhD Program in Biomedical Sciences (PPBS) (2019–2022)
  • Tenure and Promotion Committee; Member (2016–present)
  • Developmental Dynamics; Member (2015–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

955 Main Street
Rm 4124
Buffalo, New York 14203
Phone: 716-881-7463
Fax: 716-887-2991
xmu@buffalo.edu