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Anthony                        Campagnari

Anthony A. Campagnari PhD

Department of Microbiology and Immunology

Professor of Microbiology/Immunology and Medicine

Specialty/Research Focus

Infectious Disease; Microbial Pathogenesis; Microbiology

 
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Professional Summary:

Our research interests focus on microbial pathogenesis, particularly on the identification and characterization of bacterial virulence factors and putative vaccine antigens for the gram-negative human pathogens: Moraxella catarrhalis and Acinetobacter baumannii.

I. One major area of focus involves the gram-negative human pathogen Moraxella catarrhalis. This bacterium predominantly causes middle ear infections and sinusitis in infants and children, and lower respiratory tract infections in adults. This organism is the third leading cause of otitis media and it is estimated that approximately 50% of children will become colonized by this bacterium in the first six months of life.

M. catarrhalis-related projects ongoing in the lab:
A. One prominent bacterial surface component implicated as a potential virulence factor is the lipooligosaccharide (LOS) molecule. Structural studies show that M. catarrhalis LOS is similar to the LOS of other Gram-negative human mucosal pathogens. Currently there is interest in defining the role of LOS in pathogenesis and in determining the assembly and expression of this major surface glycolipid. The focus of this work is to perform a comprehensive analysis of the genetics and biology of M. catarrhalis LOS.

B. We have now demonstrated that M. catarrhalis express peritrichious type-IV pili. Our studies indicate pilus production by this bacterium is essential for DNA uptake by natural transformation and undergoes iron-responsive regulation. Additional studies will focus on elucidating the prevalence and role of type IV pili in the pathogenesis and host response of M. catarrhalis infections. We have also entered into a collaborative study using a Chinchilla colonization model in order to correlate our in vitro studies with a relevant in vivo biologic system.

C. In addition, we are also attempting to identify specific bacterial factors involved in attachment to host tissues. M. catarrhalis often colonizes the mucosal surfaces in the nasopharynx of young children. There is a strong correlation between colonization and subsequent development of otitis media. We have recently identified a two-partner secretion (TPS) locus in M. catarrhalis termed MCH (M. catarrhalis hemagglutinin-like proteins). The MCH locus consists of three open reading frames: mchA1 and mchA2 encode homologues to the filamentous hemagglutinin of Bordetella pertussis, mchB encodes the TPS transporter. We are currently characterizing this region and are investigating the function of the M. catarrhalis TPS locus.


II. Acinetobacter baumannii, a Gram-negative pathogen, causes nosocomial infections in susceptible populations. This organism has the ability to persist for extended periods on abiotic surfaces suggesting that these bacteria form biofilms. Recently, the military has seen an increased prevalence of multi-drug resistant Acinetobacter-infections in wounded soldiers returning from Iraq and Afghanistan increasing interest in studying this under-characterized pathogen.

A. baumannii-related projects ongoing in the lab:
A. The biosynthesis and expression of the lipopolysaccharide (LPS) molecule of A. baumannii is a new research focus of our laboratory. LPS is a common constituent of the outer membrane of Gram-negative bacteria and studies are underway to define the role of LPS in the pathogenesis in A. baumannii infections. Studies of defined mutants that can no longer express full-length LPS molecules will yield important insights into the virulence of this opportunistic pathogen.

B. Nosocomial A. baumannii infections have been linked to the fact that A. baumannii colonizes hospital equipment and the organism is able to resist physical and chemical disinfection by forming biofilms. One of the bacterial factors that have been shown to play a role in abiotic surface attachment, persistence and virulence is the polysaccharide poly-N-acetylated glucosamine (PGA), a large extracellular polysaccharide. We have identified a PGA-encoding locus in A. baumannii that shares homology with the previously described pga locus of E. coli, A. pleuropneumoniae, and A. actinomycetemcomitans and the homologous PNAG/PIA-encoding ica locus in S. aureus and S. epidermidis. We are interested in investigating the functional role of the PGA expressed by A. baumannii.

C. We have identified an approximately 26-kb open reading frame in the A. baumannii chromosome that encodes a large outer membrane protein homologous the biofilm-associated protein (Bap) of Staphylococcus aureus. We have produced monoclonal and polyclonal antibodies to the A. baumannii Bap-homologue and generated a transposon mutant defective in Bap expression. Our analyses indicate this protein is expressed on the bacterial surface and is conserved among clinical isolates. Additional studies will focus on the contribution of this molecule to biofilm formation and adherence of A. baumannii to abiotic surfaces.

Education and Training:
  • PhD, Tumor Immunology, University at Buffalo (1984)
  • MS, Biochemistry, University at Buffalo (1981)
Employment:
  • Senior Associate Dean for Research and Graduate Education, University at Buffalo (2013-present)
  • Microbiology, Immunology and Medicine, University at Buffalo (2001-present)
  • Adjunct Assistant Professor, Medicial Technology, University at Buffalo (1994-present)
  • Associate Professor, University at Buffalo (1999–2001)
  • Associate Professor, University at Buffalo (1996–2001)
  • Research Assistant Professor, University at Buffalo (1987–1999)
  • Adjunct Assistant Professor, University at Buffalo (1992–1996)
  • Instructor, University at Buffalo (1985–1987)
  • Post Doctoral Fellow, Division of Infectious Diseases, University at Buffalo (1983–1985)
Awards and Honors:
  • Elected to the College of CSR Reviewers National Institutes of Health (2010)
  • UB Inventor and Entrepreneur Award (2009)
  • UB Visionary Innovator Award (2008)
  • Sustained Achievement Award (2002)

Research Expertise:
  • Antibody development: Development of monoclonal and polyclonal antibodies to biothreat organisms.
  • Identification of biofilm associated factors.: Characterizing bacterial components involved in biofilm formation and stability.
  • Microbial pathogenesis: Gram-negative microbial pathogenesis. Identification of colonization and virulence factors. Identification and characterization of vaccine antigens.
  • Novel antimicrobial treatments.: Analyzing photo dynamic therapy and electrical stimulation as potential treatments for antibiotic resistant bacteria.
Grants and Sponsored Research:
  • October 2012–September 2014
    Analysis of Novel Acinetobacter baumannii Adhesions
    NIAID
    Role: Principal Investigator
    $435,875
  • April 2013–April 2014
    A Novel Electrical Stimulation Method for the Eradication/Preventions of Orthopedic Biofilms
    Bruce Holm Memorial Catalyst Fund
    Role: Co-Principal Investigator
    $50,000
  • October 2010–October 2013
    Electrical Stimulation of Titanium for the Prevention and/or Eradication of A. baumannii and S. aureus Biofilm Infections on Osseointegrated Prostheses
    Congressionally Directed Medical Research Program-Peer Reviewed Orthopaedic Research Program
    Role: Co-Investigator
    $621,591
  • November 2007–December 2012
    Genetics & Biology of M. catarrhalis LOS in Otitis Media
    NIDCD
    Role: Principal Investigator
    $1,846,053
  • September 2002–September 2007
    Genetics & Biology of M. catarrhalis LOS in Otitis Media
    NIDCD
    Role: Principal Investigator
    $1,725,060
  • November 2002–November 2005
    Comprehensive Analysis of Virulence Factors and Potential Vaccine Antigens of Haemophilus ducreyi.
    The John R. Oishei Foundation
    Role: Principal Investigator
    $300,000
  • August 2001–July 2005
    Analysis of Moraxella catarrhalis LOS: Role in Immunity
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $851,269
  • February 2000–January 2005
    Analysis of M. catarrhalis receptors as Vaccine Antigens
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $906,722
  • June 2002–May 2004
    Capture, Isolation and Identification of Biologic Agents
    New York State Center for Applied Technology
    Role: Principal Investigator
    $428,000
  • June 2001–May 2002
    Development of Monoclonal Antibodies
    University Service Account
    Role: Principal Investigator
    $59,108
  • June 1997–May 2002
    Structure of Haemophilus ducreyi LOS: Role in Adherence/Invasion
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $806,769
See All (11 Total) >
Patents:
  • Tools for Detecting Moraxella catarrhalis (2008)
  • PCR modification USA patent No. 5,871,906 titled; Method for the Detection of Amplified Nucleic Acid Products and Related Diagnostic Assays, 1999. (1999)
  • Moraxella catarrhalis a vaccine antigen. USA patent No. 6,004,562 (1999)
  • Concentrator/Detector USA patent No. 4,859,421 titled; Disposable Antigen Concentrator and Detector and Methods for Using Same. (1989)

Evaluative Studies and Case Reports:
Journal Articles:
  • Russo TA, Luke NR, Beanan JM, Olson R, Sauberan SL, MacDonald U, Schultz LW, Umland TC, Campagnari AA. The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor. Infect Immun. 2010; 78(9).
  • Russo TA, Beanan JM, Olson R, MacDonald U, Luke NR, Gill SR, Campagnari AA. Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology. Infect Immun. 2008; 76(8).
  • Luke-Marshall NR, Mang TS, Hansen LA, Campagnari AA. Moraxella catarrhalis is susceptible to antimicrobial photodynamic therapy with Photofrin. Lasers Surg Med. 2014.
  • Luke-Marshall NR, Edwards KJ, Sauberan S, St Michael F, Vinogradov EV, Cox AD, Campagnari AA. Characterization of a trifunctional glucosyltransferase essential for Moraxella catarrhalis lipooligosaccharide assembly. Glycobiology. 2013; 23(8).
  • Russo TA, Beanan JM, Olson R, MacDonald U, Cox AD, St Michael F, Vinogradov EV, Spellberg B, Luke-Marchall NR, Campagnari AA. The K1 Capsular Polysaccharide from Acinetobacter baumannii Is a Potential Therapeutic Target via Passive Immunization. Infection and Immunity. 2013; 81(3).
  • Brossard KA, Campagnari AA. The Acinetobacter baumannii biofilm-associated protein plays a role in adherence to human epithelial cells. Infect Immun. 2012; 80(1).
  • Brossard KA, Campagnari AA. The Acinetobacter baumannii Biofilm Associated Protein (Bap) Plays a Role in Adherence to Human Epithelial Cells. Infect Immun. 2011.
  • Luke NR, Sauberan SL, Russo TA, Beanan JM, Olson R, Loehfelm TW, Cox AD, St Michael F, Vinogradov EV, Campagnari AA. Identification and characterization of a glycosyltransferase involved in Acinetobacter baumannii lipopolysaccharide core biosynthesis. Infect Immun. 2010; 78(5).
  • Schwingel JM, Edwards KJ, Cox AD, Masoud H, Richards JC, St Michael F, Tekwe CD, Sethi S, Murphy TF, Campagnari AA. Use of Moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies. Infect Immun. 2009; 77(10).
  • Schwingel JM, St Michael F, Cox AD, Masoud H, Richards JC, Campagnari AA. A unique glycosyltransferase involved in the initial assembly of Moraxella catarrhalis lipooligosaccharides. Glycobiology. 2008; 18(6).
  • Loehfelm TW, Luke NR, Campagnari AA. Identification and characterization of an Acinetobacter baumannii biofilm-associated protein. J Bacteriol. 2008; 190(3).
  • Adams MD, Goglin K, Molyneaux N, Hujer KM, Lavender H, Jamison JJ, MacDonald IJ, Martin KM, Russo T, Campagnari AA, Hujer AM, Bonomo RA, Gill SR. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J Bacteriol. 2008; 190(24).
  • Luke NR, Jurcisek JA, Bakaletz LO, Campagnari AA. Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation. Infect Immun. 2007; 75(12).
  • Plamondon P, Luke NR, Campagnari AA. Identification of a novel two-partner secretion locus in Moraxella catarrhalis. Infect Immun. 2007; 75(6).
  • Janowicz D, Luke NR, Fortney KR, Katz BP, Campagnari AA, Spinola SM. Expression of OmpP2A and OmpP2B is not required for pustule formation by Haemophilus ducreyi in human volunteers. Microb Pathog. 2006; 40(3).
  • Edwards KJ, Allen S, Gibson BW, Campagnari AA. Characterization of a cluster of three glycosyltransferase enzymes essential for Moraxella catarrhalis lipooligosaccharide assembly. J Bacteriol. 2005; 187(9).
  • Furano K, Luke NR, Howlett AJ, Campagnari AA. Identification of a conserved Moraxella catarrhalis haemoglobin-utilization protein, MhuA. Microbiology. 2005; 151(Pt 4).
  • Furano K, Campagnari AA. Identification of a hemin utilization protein of Moraxella catarrhalis (HumA). Infect Immun. 2004; 72(11).
  • Prather DT, Bains M, Hancock RE, Filiatrault MJ, Campagnari AA. Differential expression of porins OmpP2A and OmpP2B of Haemophilus ducreyi. Infect Immun. 2004; 72(11).
  • Luke NR, Howlett AJ, Shao J, Campagnari AA. Expression of type IV pili by Moraxella catarrhalis is essential for natural competence and is affected by iron limitation. Infect Immun. 2004; 72(11).
  • Luke NR, Allen S, Gibson BW, Campagnari AA. Identification of a 3-deoxy-D-manno-octulosonic acid biosynthetic operon in Moraxella catarrhalis and analysis of a KdsA-deficient isogenic mutant.. Infect Immun. 2003; 71(11).
  • Furano K, Campagnari AA. Inactivation of the Moraxella catarrhalis 7169 ferric uptake regulator increases susceptibility to the bactericidal activity of normal human sera.. Infect Immun. 2003; 71(4).
  • Schilling B, Gibson BW, Filiatrault M, Campagnari AA. Characterization of lipooligosaccharides from Haemophilus ducreyi containing polylactosamine repeats.. J Am Soc Mass Spectrom. 2002; 13(6).
  • Tullius MV, Phillips NJ, Scheffler NK, Samuels NM, Munson Jr RS, Hansen EJ, Stevens-Riley M, Campagnari AA, Gibson BW. The lbgAB gene cluster of Haemophilus ducreyi encodes a beta-1,4-galactosyltransferase and an alpha-1,6-DD-heptosyltransferase involved in lipooligosaccharide biosynthesis.. Infect Immun. 2002; 70(6).
  • Luke NR, Karalus RJ, Campagnari AA. Inactivation of the Moraxella catarrhalis Superoxide Dismutase SodA Induces Constitutive Expression of Iron-Repressible Outer Membrane Proteins.. Infect Immun. 2002; 70(4).
  • Filiatrault MJ, Munson RS, Anthony Campagnari. Genetic Analysis of a Pyocin-Resistant Lipooligosaccharide (LOS) Mutant of Haemophilus ducreyi: Restoration of Full-Length LOS Restores Pyocin Sensitivity.. J Bacteriol. 2001; 183(19).
  • Young RS, Filiatrault MJ, Fortney KR, Hood AF, Katz BP, Munson RS, Anthony Campagnari, Spinola SM. Haemophilus ducreyi lipooligosaccharide mutant defective in expression of beta-1,4-glucosyltransferase is virulent in humans.. Infect Immun. 2001; 69(6).
  • Zaleski A, Scheffler NK, Densen P, Lee FK, Anthony Campagnari, Gibson BW, Apicella MA. Lipooligosaccharide P(k) (Galalpha1-4Galbeta1-4Glc) epitope of moraxella catarrhalis is a factor in resistance to bactericidal activity mediated by normal human serum.. Infect Immun. 2000; 68(9).
  • Filiatrault MJ, Gibson BW, Schilling B, Sun S, Munson RS, Campagnari AA. Construction and characterization of Haemophilus ducreyi lipooligosaccharide (LOS) mutants defective in expression of heptosyltransferase III and beta1,4-glucosyltransferase: identification of LOS glycoforms containing lactosamine repeats.. Infect Immun. 2000; 68(6).
  • Yu H, Raymonda JW, McMahon TM, Anthony Campagnari. Detection of biological threat agents by immunomagnetic microsphere-based solid phase fluorogenic- and electro-chemiluminescence.. Biosens Bioelectron. 2000; 14(10-11).
  • Young RS, Fortney K, Haley JC, Hood AF, Anthony Campagnari, Wang J, Bozue JA, Munson RS, Spinola SM. Expression of sialylated or paragloboside-like lipooligosaccharides are not required for pustule formation by Haemophilus ducreyi in human volunteers.. Infect Immun. 1999; 67(12).
  • Luke NR, Anthony Campagnari. Construction and characterization of Moraxella catarrhalis mutants defective in expression of transferrin receptors.. Infect Immun. 1999; 67(11).
  • Luke NR, Thomas Russo, Luther N, Anthony Campagnari. Use of an isogenic mutant constructed in Moraxella catarrhalis To identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6.. Infect Immun. 1999; 67(2).
  • Inzana TJ, Hensley J, McQuiston J, Alan Lesse, Anthony Campagnari, Boyle SM, Apicella MA. Phase variation and conservation of lipooligosaccharide epitopes in Haemophilus somnus.. Infect Immun. 1997; 65(11).
  • Gibson BW, Anthony Campagnari, Melaugh W, Phillips NJ, Apicella MA, Grass S, Wang J, Palmer KL, Munson RS. Characterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide biosynthesis.. J Bacteriol. 1997; 179(16).
  • Hiltke TJ, Anthony Campagnari, Spinola SM. Characterization of a novel lipoprotein expressed by Haemophilus ducreyi.. Infect Immun. 1996; 64(12).
  • Anthony Campagnari, Ducey TF, Rebmann CA. Outer membrane protein B1, an iron-repressible protein conserved in the outer membrane of Moraxella (Branhamella) catarrhalis, binds human transferrin.. Infect Immun. 1996; 64(9).
  • Spinola SM, Orazi A, Arno JN, Fortney K, Kotylo P, Chen CY, Anthony Campagnari, Hood AF. Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection.. J Infect Dis. 1996; 173(2).
  • Melaugh W, Anthony Campagnari, Gibson BW. The lipooligosaccharides of Haemophilus ducreyi are highly sialylated.. J Bacteriol. 1996; 178(2).
  • Thomas Russo, Sharma G, Brown CR, Anthony Campagnari. Loss of the O4 antigen moiety from the lipopolysaccharide of an extraintestinal isolate of Escherichia coli has only minor effects on serum sensitivity and virulence in vivo.. Infect Immun. 1995; 63(4).
  • Melaugh W, Phillips NJ, Anthony Campagnari, Tullius MV, Gibson BW. Structure of the major oligosaccharide from the lipooligosaccharide of Haemophilus ducreyi strain 35000 and evidence for additional glycoforms.. Biochemistry. 1994; 33(44).
  • Anthony Campagnari, Shanks KL, Dyer DW. Growth of Moraxella catarrhalis with human transferrin and lactoferrin: expression of iron-repressible proteins without siderophore production.. Infect Immun. 1994; 62(11).
  • Westerink MA, Anthony Campagnari, Giardina P, Apicella MA. Antiidiotype antibodies as surrogates for polysaccharide vaccines.. Ann N Y Acad Sci. 1994; 730.
  • Anthony Campagnari, Karalus R, Apicella M, Melaugh W, Alan Lesse, Gibson BW. Use of pyocin to select a Haemophilus ducreyi variant defective in lipooligosaccharide biosynthesis.. Infect Immun. 1994; 62(6).
  • Spinola SM, Linda Wild, Apicella MA, Gaspari AA, Anthony Campagnari. Experimental human infection with Haemophilus ducreyi.. J Infect Dis. 1994; 169(5).
  • Brentjens RJ, Spinola SM, Anthony Campagnari. Haemophilus ducreyi adheres to human keratinocytes.. Microb Pathog. 1994; 16(3).
  • Gibson BW, Melaugh W, Phillips NJ, Apicella MA, Anthony Campagnari, Griffiss JM. Investigation of the structural heterogeneity of lipooligosaccharides from pathogenic Haemophilus and Neisseria species and of R-type lipopolysaccharides from Salmonella typhimurium by electrospray mass spectrometry.. J Bacteriol. 1993; 175(9).
  • Melaugh W, Phillips NJ, Anthony Campagnari, Karalus R, Gibson BW. Partial characterization of the major lipooligosaccharide from a strain of Haemophilus ducreyi, the causative agent of chancroid, a genital ulcer disease.. J Biol Chem. 1992; 267(19).
  • Sarwar J, Anthony Campagnari, Kirkham C, Murphy TF. Characterization of an antigenically conserved heat-modifiable major outer membrane protein of Branhamella catarrhalis.. Infect Immun. 1992; 60(3).
  • Anthony Campagnari, Linda Wild, Griffiths GE, Karalus RJ, Wirth MA, Spinola SM. Role of lipooligosaccharides in experimental dermal lesions caused by Haemophilus ducreyi.. Infect Immun. 1991; 59(8).
  • Haase EM, Anthony Campagnari, Sarwar J, Shero M, Wirth M, Cumming CU, Murphy TF. Strain-specific and immunodominant surface epitopes of the P2 porin protein of nontypeable Haemophilus influenzae.. Infect Immun. 1991; 59(4).
  • Westerink MA, Giardina PC, Anthony Campagnari, Apicella MA. The thymus-dependent nature of the murine antibody response to a monoclonal anti-idiotypic antibody to the Neisseria meningitidis serogroup C capsular polysaccharide.. Microb Pathog. 1990; 8(6).
  • Spinola SM, Kwaik YA, Alan Lesse, Anthony Campagnari, Apicella MA. Cloning and expression in Escherichia coli of a Haemophilus influenzae type b lipooligosaccharide synthesis gene(s) that encodes a 2-keto-3-deoxyoctulosonic acid epitope.. Infect Immun. 1990; 58(6).
  • Anthony Campagnari, Spinola SM, Alan Lesse, Kwaik YA, Mandrell RE, Apicella MA. Lipooligosaccharide epitopes shared among gram-negative non-enteric mucosal pathogens.. Microb Pathog. 1990; 8(5).
  • Alan Lesse, Anthony Campagnari, Bittner WE, Apicella MA. Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis.. J Immunol Methods. 1990; 126(1).
  • Fukatsu A, Yuzawa Y, Olson L, Miller J, Milgrom M, Zamlauski-Tucker MJ, Van Liew JB, Anthony Campagnari, Niesen N, Patel J. Interaction of antibodies with human glomerular epithelial cells.. Lab Invest. 1989; 61(4).
  • Murphy TF, Anthony Campagnari, Nelson MB, Apicella MA. Somatic antigens of Haemophilus influenzae as vaccine components.. Pediatr Infect Dis J. 1989; 8(1 Sup).
  • Westerink MA, Anthony Campagnari, Nelson MB, Murphy TF, Apicella MA. New concepts in vaccines for mucosal non-enteric human bacterial pathogens.. Adv Exp Med Biol. 1989; 251.
  • Westerink MA, Anthony Campagnari, Wirth MA, Apicella MA. Development and characterization of an anti-idiotype antibody to the capsular polysaccharide of Neisseria meningitidis serogroup C.. Infect Immun. 1988; 56(5).
  • Murphy TF, Bernstein JM, Dryja DM, Anthony Campagnari, Apicella MA. Outer membrane protein and lipooligosaccharide analysis of paired nasopharyngeal and middle ear isolates in otitis media due to nontypable Haemophilus influenzae: pathogenetic and epidemiological observations.. J Infect Dis. 1987; 156(5).
  • Campagnari AA, Gupta MR, Dudas KC, Murphy TF, Apicella MA. Antigenic diversity of lipooligosaccharides of nontypable Haemophilus influenzae.. Infect Immun. 1987; 55(4).
  • Murphy TF, Bartos LC, Anthony Campagnari, Nelson MB, Apicella MA. Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae.. Infect Immun. 1986; 54(3).
  • Harvey, S., Douglass, H.O., Holyoke, E.D. and Goldrosen, M.H.. Localization of an acidic protein isolated from the effusion fluid of patients with pancreatic cancer.. Tumor Diagnostik and Therapie.. 1986; 7.
  • Apicella MA, Dudas KC, Anthony Campagnari, Rice P, Joseph Mylotte, Murphy TF. Antigenic heterogeneity of lipid A of Haemophilus influenzae.. Infect Immun. 1985; 50(1).
  • Harvey, S., Douglass, H.O., Holyoke, E.D. and Goldrosen, M.H.. Detection, isolation and biochemical characterization of an acidic protein from the effusion fluid of patients with pancreatic cancer.. Tumor Diagnostik and Therapie.. 1985; 6.
  • Goldrosen MH, Anthony Campagnari, Howell JH, Harvey S, Jenkins D, Berjian R, Harold Douglass. Immunodiagnosis of pancreatic cancer.. Prog Clin Biol Res. 1983; 133.
See All (66 Total) >

Professional Memberships:
  • American Association for the Advancement of Science (2010)
  • New York Academy of Sciences (1997)
  • Western New York Branch of ASM (1987)
  • American Society for Microbiology (1986)
Presentations:
  • "Identification and Characterization of an Acinetobacter baumannii Surface Component Involved in Biofilm Formation and Stability" Conversations in Global Health., SUNY Upstate Medical University (2013)
  • "Potential Vaccine Antigens Versus Moraxella catarrhalis" 10th International Symposium on Recent Advances in Otitis Media. (2011)
  • "Biofilm factors of Acinetobacter baumannii" Departmental Seminar, University of Nebraska Medical Center (2011)
  • "The Role of Surface Carbohydrates in Acinetobacter baumannii Pathogenesis" Departmental Seminar, Emory University (2010)
  • "Identification and Characterization of Acinetobacter baumannii Surface Components Involved in Biofilm Formation and Stability" Departmental Seminar, University of Texas, Southwest Medical Center (2009)
  • "Identification and Characterization of an Acinetobacter baumannii Biofilm-Associated Protein" USAMRMC MIDRP W Wound Conference, WRAIR/NMRC facility (2009)
  • "Expression of a large Surface Protein on Acinetobacter baumannii Correlates with Biofilm Formation and Stability" Departmental Seminar, University of Oklahoma Health Sciences Center (2008)
  • "A Novel Two-Partner Secretion Pathway of Moraxella catarrhalis" Departmental Seminar, SUNY at Buffalo/Oral Biology (2006)
  • "Type IV Pilus Expression by Moraxella catarrhalis" Departmental Seminar, Wake Forest University School of Medicine (2006)
  • "Is Type IV Pilus Expression by Moraxella catarrhalis Essential for Pathogenesis?" Departmental Seminar, Medical College of Ohio (2005)
  • "Virulence Factors for Moraxella catarrhalis" Departmental Seminar, Allegheny-Singer Research Institute, Center for Genomic Sciences, Allegheny General Hospital (2004)
  • "Potential Vaccine Antigens for the Prevention of Moraxella catarrhalis Induced Otitis Media." Otitis Media: New Approaches for Analysis, Treatment and Prevention, NIH, NICDCD (2000)
  • "Moraxella catarrhalis Lipooligosaccharides; Unique Glycolipids" Departmental Seminar, Ohio State University, Department of Molecular Microbiology, Immunology and Bacteriology (2000)
  • "Iron-regulated Proteins of Moraxella catarrhalis" Departmental Seminar, SUNY@Buffalo, Oral Biology (1999)
  • "Iron-regulated Protein Expression by Moraxella catarrhalis may be Important for Sensitivity to Human Complement." Research Exchange Series, SUNY@Buffalo, Center for Advanced Molecular Biology and Immunology (1997)
  • "Potential Cell Surface Receptors for Haemophilus ducreyi LOS Expressed on Human Keratinocytes" Departmental Seminar, University of California at San Francisco, Pharmaceutical Chemistry (1997)
  • "Iron-repressible proteins expressed during infections caused by Moraxella (Branhamella) catarrhalis" Fall Conference Microbial Pathogenesis, SUNY@Buffalo, Microbial Pathogenesis Graduate Group (1996)
  • "The immune response to Iron-regulated proteins expressed during otitis media caused by Moraxella catarrhalis" Departmental Seminar, Children’s Hospital of Buffalo, Department of Pediatric Infectious Diseases (1996)
  • "The major lipooligosaccharide (LOS) structure conserved on the surface of different Haemophilus ducreyi strains, binds to proteins expressed by human keratinocytes in vitro." American Society for Microbiology, 95th general meeting., American Society for Microbiology, Microbial Pathogenesis (1995)
  • "The role of the Lipooligosaccharides in Haemophilus ducreyi adherence and invasion of human cells" Departmental Seminar, SUNY at Buffalo, Department of Microbiology (1995)
  • "Iron-regulated proteins of Moraxella catarrhalis" Infectious Diseases Research Conference, SUNY at Buffalo, Department of Medicine (1994)
  • "A Tn916 Lipooligosaccharide (LOS) Mutant of Haemophilus ducreyi Shows a Decreased Ability to Adhere to and Invade Human Keratinocytes." 94th General Meeting, American Society for Microbiology, Microbial Pathogenesis (1994)
  • "Development and Current Uses for Monoclonal Antibodies." Current Trends in Clinical Laboratory Medicine, SUNY at Buffalo, Department of Medical Technology (1994)
  • "The Role of the Lipooligosaccharides in the Pathogenesis of Haemophilus ducreyi" Western New York Branch of the American Society for Microbiology, WNY ASM (1993)
  • "Advancements in the Development of Bacterial Vaccines; Anti-idiotypic Antibodies" City Wide Grand Rounds, SUNY at Buffalo, Department of Medicine (1992)
  • "The Role of LOS in Experimental Dermal Lesions Caused by Haemophilus ducreyi" The Molecular Immunology of Sexually Transmitted Diseases, NIH, Rocky Mountain Laboratories, NIAID, National Vaccine Program, CDC, FDA and the Department of Defense (1991)
  • "Monoclonal Antibodies and Recombinant DNA Technology" Advances in Immunology, New State Council of Hospital Pharmacists (1989)
See All (27 Total) >
Service Activities:
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences Graduate Affairs; Director (2000–2002)
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences Graduate Affairs; Member (1998–2000)
  • Journal of Endotoxin Research.; Ad hoc reviewer for the Journal of Endotoxin Research.; Ad Hoc Reviewer (2001)
  • Microbial Pathogenesis Graduate Group.; Director of the Microbial Pathogenesis Graduate Group.; Director (2000–2002)
  • Infection and Immunity.; Editorial board of Infection and Immunity.; Editorial Board Member (2000)
  • Director of Admissions and Recruiting MSTP.; Director of Admissions and Recruiting Medical Scientist Training Program.; Director (2000–2001)
  • Director of Graduate Studies.; Director of the graduate program, Department of Microbiology.; Director (2000–2002)
  • Faculty Search Committee.; Member of the Immunology Faculty Search Committee, Department of Microbiology.; Member (2000)
  • Preliminary Examination.; Chairman of the Preliminary Examination Committee Department of Microbiology.; Ad Hoc Reviewer (2000)
  • Masters Program.; Director of the masters program, Department of Microbiology.; Director (1999–2000)
  • Director of Recruiting IGPBS; Director of Recruiting Interdisciplinary Graduate Program in the Biomedical Sciences.; Director (1999–2000)
  • Curriculum review.; Member of a special ad hoc subcommittee reviewing BMS 501/502 for the Interdisciplinary Graduate Program.; Department Representative (1998–1999)
  • Institutional Animal Care and Use Committee; Associate Chair of the Institutional Animal Care and Use Committee (IACUC).; Ad Hoc Reviewer (1997–1999)
  • Lecture on HIV and AIDS.; Guest speaker at Our Lady of the Sacred Heart School. Presentation to the eighth grade class, topic “HIV and AIDS”.; Guest Lecturer (1997)
  • Push-Excel Career Awareness Day; Guest speaker for Push-Excel Career Awareness Day at the Academic Challenge Center, Buffalo, New York.; Guest Lecturer (1993)
  • Monoclonal Center; Director of the Monoclonal Antibody Center.; Director (1992)
  • Career Day; Guest speaker at Career Day, Attica Middle School, Attica, New York..; Guest Lecturer (1992)
  • Microbial Pathogenesis; Adhoc reviewer Microbial Pathogenesis.; Ad Hoc Reviewer (1992)
  • HIV in the community.; Lecture on Viral infections and the Human Immunodeficiency Virus to the Senior Biology Class at Frontier High School, Hamburg, N.Y.; Guest Lecturer (1989)
  • AIDS risks.; Informational lecture on AIDS to Western New York Association of Hospital Security Guards.; Guest Lecturer (1988)
  • Glycobiology; Ad Hoc Reviewer
  • Journal of Bacteriology; Ad Hoc Reviewer
  • Journal of Infectious Diseases; Ad Hoc Reviewer
  • Journal of Microbiology; Ad Hoc Reviewer
  • Microbiology; Ad Hoc Reviewer
  • Molecular Microbiology; Ad Hoc Reviewer
  • PLOS One; Ad Hoc Reviewer
  • PLOS Pathogens; Ad Hoc Reviewer
  • Vaccine; Ad Hoc Reviewer

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

3435 Main Street
143 Biomedical Research Building
Buffalo, NY 14214
Phone: (716) 829-2673
Fax: 716-829-3889
Email: aac@buffalo.edu


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