Amy Jacobs PhD

Amy Jacobs

Amy Jacobs
PhD

Research Associate Professor

Department of Microbiology and Immunology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Virology

Contact Information
109 Biomedical Research Building
Buffalo, NY 14214
Phone: (716) 829-2085
ajacobs2@buffalo.edu



Professional Summary:

The human immunodeficiency virus (HIV) is now considered a chronic disease in the developed world. In underdeveloped areas where access to antiretroviral therapy is limited, however, it remains a devastating disease contributing to grave socioeconomic problems.

The goal of my research is to expand our knowledge of pathogen interactions with cellular membranes by developing a detailed understanding of the mechanism of HIV entry and by studying co-infection of HIV with the pathogenic fungus Cryptococcus neoformans in human macrophages.

The first step of HIV infection is HIV entry when the envelope protein complex on the surface of the virus comes into contact with the cellular receptors, glycoprotein CD4 and coreceptor, and mediates merging of the viral and cellular membranes leading to delivery of the viral genetic material. Mechanistic studies help to inform the development of inhibitors to HIV entry that will be beneficial on both therapeutic and prophylactic levels. The envelope protein complex is the machinery that gets the virus into the cell; as such, it is also a prime target for the development of vaccines.

HIV/AIDS often kills by priming the host for opportunistic infections. Cryptococcal meningitis is one of the leading killers of AIDS patients. The human macrophage is the cell type tasked with ingesting and clearing microbes. In my lab, we are working to define the role of the human macrophage in the copathogenesis of the opportunistic fungus Cryptococcus neoformans and HIV during AIDS progression. The mechanisms of host-microbe interactions also serve as templates for the design of novel drug regimens, including immunotherapy.

We have recently utilized our extensive experience in the study of how HIV enters the cell to begin studies in Ebolavirus entry which has a similar mechanism. We are developing inhibitors to the process of Ebolavirus entry and using developments in inhibition to study the mechanism of attachment and membrane fusion into multiple cell types.

It is my objective throughout my career to provide vital basic research in virology and cell biology in order to advance medical treatment and prevention. As an academic researcher, I put a strong emphasis on the training and mentoring of young scientists in my lab, and I participate in the T35 training grant from the National Institutes of Health that UB and Roswell Park Cancer Institute jointly secured. I train master’s and PhD students as well as postdoctoral fellows in the departments of Microbiology and Immunology and Biochemistry. I also mentor undergraduates in research projects; these students may come to me independently or through UB’s Center for Undergraduate Research and Creative Activities (CURCA) in which I am active. I direct undergraduate studies for my department, and I am the course director for Biomedical Microbiology, my department’s large undergraduate basic science course.

Education and Training:

  • PhD, Biochemistry and Molecular Biology, University of Illinois at Chicago (2000)
  • BA, Comparative Literature and Italian, University of Iowa (1992)

Employment:

  • Assistant Professor, Microbiology and Immunology, State University of New York at Buffalo (2008-present)
  • Post Doctoral Fellow, Center for Cancer Research Nanobiology Program, National Cancer Institute, National Institutes of Health (2004–2008)

Awards and Honors:

  • H. Brody/Medical Emeritus Society Award for Clinical/Translational Research (2010)
  • National Cancer Institute Director's Intramural Innovation Award (2007)
  • Award for Excellence in Research, Sigma Xi Scientific Research Society (2002)
  • Provost's Award for Graduate Research, Univ. of Il at Chicago (2001)
  • National Science Foundation (2001)
  • National Study Abroad Scholarship, Italian Government (1990)
  • Eva M. Byerly Scholarship (1989)

Research Expertise:

  • Microbial pathogenesis
  • Molecular virology: molecular and cellular biology of HIV entry, development of inhibitors of HIV entry, biophysics of viral membrane fusion
  • Viral pathogenesis: secondary opportunistic infections, co-pathogenesis of HIV and C. neoformans, viral mimicry

Journal Articles:

See all (13 more)

Professional Memberships:

  • American Chemical Society (2010–present)
  • American Society for Nanomedicine (2009–present)
  • Biophysical Society (2006–present)
  • Sigma Xi Scientific Research Society (2002–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

109 Biomedical Research Building
Buffalo, NY 14214
Phone: (716) 829-2085
ajacobs2@buffalo.edu