Brian R. Weil PhD

Brian Weil

Brian R. Weil
PhD

Assistant Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cardiology; Cardiovascular Disease; Stem Cells

Contact Information
Clinical and Translational Research Center
Suite 7030
875 Ellicott Street
Buffalo, NY 14203
Phone: 716-829-3599
Fax: 716-854-1840
bweil@buffalo.edu



Professional Summary:

My research program is focused on the investigation of mechanisms underlying functional and structural cardiac remodeling in heart disease, as well as novel therapeutic interventions to prevent or reverse left ventricular dysfunction caused by acute and chronic myocardial injury. These studies generally utilize non-invasive cardiovascular imaging techniques and invasive hemodynamic assessment to assess cardiac performance in vivo, along with ex vivo analysis of myocardial tissue to examine cellular and molecular mechanisms underlying observed changes in physiological function. Using this approach, our primary objective is to conduct impactful translational research with direct relevance to the pathophysiology and treatment of human heart disease.

Education and Training:

  • PhD, Integrative Physiology, University of Colorado - Boulder (2011)
  • MS, Exercise Science, Syracuse University (2007)
  • BS, Clinical Exercise Science, Ithaca College (2005)

Employment:

  • Assistant Professor, Physiology and Biophysics, University at Buffalo (2019-present)
  • Research Assistant Professor, Physiology and Biophysics, University at Buffalo (2016–2019)
  • Post Doctoral Fellow, Medicine, University at Buffalo (2011–2016)

Research Centers:

  • Center for Research in Cardiovascular Medicine

Grants and Sponsored Research:

  • July 2018–June 2020
    T3np in Cardiac Resuscitation – Pivotal Pre-Clinical Trial
    UB Center for Advanced Biomedical and Bioengineering Technology
    Role: Principal Investigator
  • July 2017–June 2020
    Pathophysiology of Myocardial Remodeling in Heart Failure With Preserved Ejection Fraction
    American Heart Association
    Role: Principal Investigator
  • December 2018–November 2019
    Preclinical Evaluation of Systemic Cellular Postconditioning as a Novel Cardioprotective and Neuroprotective Therapy Following Cardiac Arrest
    The ZOLL Foundation
    Role: Principal Investigator
  • November 2018–October 2019
    Novel Biomarkers of Extracellular Matrix Expansion and Interstitial Fibrosis in Heart Failure
    The Community Foundation for Greater Buffalo
    Role: Principal Investigator
  • June 2018–May 2019
    Quantitative Proteomics and Phosphoproteomics of Stretch-induced Myocardial Stunning and Adaptive Left Ventricular Stiffening in Swine
    Proteomics and Bioanalysis Core Seed Fund
    Role: Principal Investigator
  • April 2018–March 2019
    Pre-Clinical Evaluation of a Novel Antibody-Based Therapy to Improve Cardiac Repair After Acute Myocardial Infarction
    UB CTSI Translational Pilot Studies Program
    Role: Principal Investigator

Journal Articles:

See all (27 more)

Abstracts:

  • Weil BR, Allen, S, Barbaccia, B, Young, R, Palka, B, Canty J. A Blinded, Randomized, Vehicle-Controlled Preclinical Trial of Novel Nanoparticle Formulations of Triiodothyronine in Cardiac Arrest. American Heart Association - Resuscitation Science Symposium 2019. 2019; 08(651).

Professional Memberships:

  • American Physiological Society (2017–present)
  • American Heart Association (2011–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Clinical and Translational Research Center
Suite 7030
875 Ellicott Street
Buffalo, NY 14203
Phone: 716-829-3599
Fax: 716-854-1840
bweil@buffalo.edu