Dr. Canty is a physician-scientist whose career has focused on translational cardiovascular research and noninvasive cardiology. He received his BS in Biomedical Engineering from Rensselaer Polytechnic Institute and MD from the University at Buffalo. After completing residency at the University of Rochester he returned to join the Division of Cardiology at UB where he has risen to become Chief of Cardiovascular Medicine. He has focused his research career on translational studies that employ acute and chronic large animal models of ischemic heart disease. Although his initial research focused on coronary circulatory control, his more recent studies have advanced our understanding of chronic hibernating myocardium. Ongoing areas of investigation include application of proteomic approaches to identify intrinsic adaptive responses of the heart to ischemia, imaging inhomogeneity of myocardial sympathetic innervation with positron emission tomography to predict the risk of sudden cardiac arrest and employing large animal models of ischemic heart disease to examine the ability of intracoronary stem cell infusions to stimulate endogenous cardiomyocyte proliferation. Dr. Canty currently serves on several editorial boards, NIH DSMBs and peer review panels. He is recipient of a Chancellors Award from New York State and is the Albert and Elizabeth Rekate Chair in Cardiovascular Diseases. In addition to being a Fellow of the American College of Cardiology, American College of Physicians and American Heart Association, he has been elected to the Association of University Cardiologists and is President of the Association of Professors of Cardiology (2013).
Education and Training:
MD, Medicine, University of New York at Buffalo, Thesis Honors (1979)
BS, Biomedical Engineering, Rensselaer Polytechnic Institute, Cum Laude (1975)
Employment:
Professor of Biomedical Engineering, Department of Biomedical Engineering, University at Buffalo (2010-present)
Chief, Division of Cardiovascular Medicine, University at Buffalo (2006-present)
Albert and Elizabeth Rekate Professor of Medicine, University at Buffalo (2001-present)
Physiology & Biophysics; Chairman with Dr. Harold Strauss, University at Buffalo (1996-present)
Department of Physiology, University at Buffalo (1975-present)
Vice-Chair for Research, Department of Medicine, University at Buffalo (2006–2011)
Professor of Medicine, University at Buffalo (1995–2001)
Assistant Professor of Physiology, University at Buffalo (1986–1996)
Associate Professor of Medicine, University at Buffalo (1989–1995)
Assistant Professor of Medicine, University at Buffalo (1983–1989)
Cardiology Fellow and Instructor of Medicine, University at Buffalo (1981–1983)
Chief of Service, University of Rochester (1980–1981)
Medical Intern, University of Rochester, Strong Memorial Hospital (1979–1980)
Division of Cardiology, University at Buffalo (1976–1979)
American Heart Association Louis N. Katz Award Finalist
Sinsheimer Scholar
University at Buffalo Sustained Achievement Award
Clinical Investigator Award NHLBI
Association of University Cardiologists
Stockton Kimball Award
Distinguished Alumnus Award
SUNY Chancellor‘s Award for Excellence in Scholarship & Creative Activities
Grants and Sponsored Research:
August 1996–November 2014 Chronic Adaptations to Myocardial Ischemia NIH Role: Principal Investigator $1,850,918
May 2010–April 2012 PET/CT for Multidimensional Translational Cardiovascular Research NIH Role: Co-Investigator $2,000,000
May 2006–April 2012 Metabolic Adaptation and Functional Recovery of Hibernating Myocardium NIH Role: Co-Investigator $2,459,933
January 2006–January 2012 NIH National Heart Lung and Blood Institute:Mesenchymal Stem Cell Therapeutics in Hibernating Myocardium NIH National Heart Lung and Blood Institute Role: Co-Investigator $1,923,795
July 2007–June 2011 Department of Veterans Affairs. Statins and Growth Factors for Chronic Ischemic Heart Failure Role: Principal Investigator $712,500
Fernandez SF, V Ovchinnikov, JM Canty Jr, JA Fallavollita. Hibernating Myocardium Results in Partial Sympathetic Denervation and Nerve Sprouting. Am J. Physiol Heart Circ Physiol. 2013; 304.
Cary MG, Al-Zaiti SS, Canty JM, Jr and Fallavollita JA. High-risk electrocardiographic parameters are ubiquitous in patients with ischemic cardiomyopathy. Annals of Noninvasive Electrocardiology. 2012; 17.
Gangasani, A.
Sidhu, S.
Fallavollita, J.A.
Korotchkina, L. G.
Suzuki, G.
Patel, M.S.
Canty, J.M., Jr.. Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy.. Circulation. 2005; 112(II).
Thijssen VL, Borgers M, Lenders MH, Ramaekers FC, Suzuki G, Palka B, Fallavollita JA, Thomas SA, Canty JM Jr. Temporal and Spatial Variations in Structural Protein Expression During the Progression From Stunned to Hibernating Myocardium. Circulation. 2004; 110(21).
Farhi ER, Canty JM, Klocke FJ. Dissociation of diastolic pressure-segment length and pressure-wall thickness relations during vasodilation in the conscious dog.. J Am Coll Cardiol. 1991; 18(3).
Mates RE, Klocke FJ, Canty JM. Coronary capacitance. Prog Cardiovasc Dis. 1988; 31(1).
Canty JM, Klocke FJ. Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure.. Circ Res. 1987; 61(5 Pt).
Klocke FJ, Ellis AK, Canty JM. Interpretation of changes in coronary flow that accompany pharmacologic interventions.. Circulation. 1987; 75(6 Pt).
Canty JM, Klocke FJ, Mates RE. Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters.. Circ Res. 1987; 60(2).
Klocke FJ, Canty JM, Arani DT, Krawczyk JA. Adjustments in regional coronary perfusion accompanying reductions in regional coronary arterial pressure.. Can J Cardiol. 1986; Suppl.
Klocke FJ, Weinstein IR, Klocke JF, Ellis AK, Kraus DR, Mates RE, Canty JM, Anbar RD, Romanowski RR, Wallmeyer KW, Echt MP. Zero-flow pressures and pressure-flow relationships during single long diastoles in the canine coronary bed before and during maximum vasodilation. Limited influence of capacitive effects.. J Clin Invest. 1981; 68(4).
Fallavollita J, BM Heavey, S Baldwa, TL Mashtare Jr, AD Hutsob, M Sajjad, RA deKemp, AB Curtis, ME Cain and JM Canty Jr.. Volume of denervated myocardium is a novel predictor of VT/VF: Prediction of arrhythmic events with positron emission tomography (PAREPET) study. Heart Rhythm Journal. 2012.
Suzuki G, BA Palka and JM Canty, Jr.. Pravastatin stimulates proliferation of endogenous cardiac progenitor cells in the heart. FASEB J. 2012.
Pietrasik G, JM Canty, Jr and JA Fallavollita. Deceleration capacity, not heart rate turbulence, predicts sudden cardiac death in high-risk patients with ischemic cardiomyopathy. Heart Rhythm Journal. 2012.
Iyer VS
Canty,J.M.,Jr.. Regional reductions in b-adrenergic receptor mediated cAMP prpoduction and reciprocal alterations in Ga protein expression in swine with hibernating myocardium. FASEB J. 2003; 17(4).
Iyer VS
Young,R.F.
Lee,T.C.
Nowak,N.
Canty,J.M.,Jr.. Microarray analysis of differential gene expression in hibernating myocardium is consistent with regional remodeling and local neurohumoral activation. FASEB J. 2003; 17(4).
Grant BJB and JM Canty, Jr.. Pulmonary arterial pressure-diameter relations in awake dogs. Circulation. 1987; 76(IV).
Professional Memberships:
Diplomat, National Board of Medical Examiners, 1980
Associate, American College of Physicians, 1981 – 1985
Affiliate, American College of Cardiology, 1982 – 1985
Member, American Heart Association, 1983
Member, American Heart Association Council on Basic Science
Member, American Society for the Advancement of Science, 1984 – 1986
Member, American Federation for Clinical Research, 1984 – 1998
Diplomat, American Board of Internal Medicine, 1984
Subspecialty Certification in Cardiovascular Diseases, 1985
Member, American College of Physicians, 1985 – 1994
Member, American Physiological Society, 1985 – present
Fellow, American Heart Association Council on Circulation, 1985 – 2001
Fellow, American College of Cardiology, 1985 – present
Fellow, American College of Physicians, 1995 – present
Member, American Heart Association Council on Clinical Cardiology, 1993 – present
Fellow of the American Heart Association, 2001 – present
President, Association of Professors of Cardiology, 2012-2013
Member, International Society for Heart Research, 2011 - present
Presentations:
""Viable Chronically Dysfunctional Myocardium - A New Paradigm to Predict Vulnerability to Sudden Cardiac Death in Ischemic Heart Disease"" , Medtronic Inc. (2004)
"Myocardial Flow-function Relationship. Intrinsic Adaptive Mechanisms During Ischemia and Reperfusion." , European Society of Cardiology (2004)
"Metabolic Control of Myocardial Perfusion in Hibernating Myocardium, Experimental Biology 2003" (2003)
"Chronic Adaptions to Myocardial Ischemia. Rolling with the Punches: How Cells, Tissues, Organs, Animals and People Adapt to Hyposia." 31st Critical Care Congress, Society for Critical Care Medicine (2002)
"Chronic adaptive responses of the heart to repetitive reversible ischemia: The hibernating myocardium." , University of Maastricht, Division of Cardiology (2002)
"Hibernating and Chronically Stunned Myocardium: A continuum of Chronic Adaptions to Myocardial Ischemia. Cardiology Grand Rounds" , Massachusetts General Hospital (2001)
"Hibernating Myocardium and Chronic Stunning: Apoptosis in Viable Dysfunctional Myocardium. Cardiology Grand Rounds" , University of Virginia (2001)
"Chronic Effects of Ischemia on Myocardial Function, Cardiac Adaptation to Myocardial Ischemia, Cardiovascular Seminar" 73rd Annual AHA Scientific Sessions (2000)
"The pathophysiology of stunning and hibernation, XXII Congress of the European Society of Cardiology" (2000)
"Apoptosis and Myocyte Remodeling in Viable, Chronically Dysfunctional Myocardium: Death Without a Trace" , Feinberg Cardiovascular Institute, Northwestern University (1999)
"Apoptosis in hibernating myocardium - "Death without a trace," Department of Physiology" , Texas A & M University (1999)
"Chronic downregulation of myocardial function: the hibernating myocardium Experimental Biology 99" (1999)
"Ischemia-induced gene expression in vivo, International Society for Heart Research, XXII Scientific Sessions" (1999)
"Viable, chronically dysfunctional myocardium: Transition from chronic stunning to hibernation, Cardiology Grand Rounds" , University of Louisville (1999)
"A porcine model of hibernating Myocardium, Scientific Conference on Fascular and Myocardial Aspects of Ischemic Heart Disease." (1998)
"Physiological and molecular adaptions to ischemia in viable chronically dysfunctional myocardium, Division of Cardiology" , Medical College of Wisconsin (1998)
"Regulation of Myocardial Perfusion by Nitric Oxide: Workshop on Coronary Physiology and Cardiac Metabolism, XXXIII International Congress of Physiological Sciences." (1997)
"Adaptions to Myocardial Ischemia: Repetitive Stunning vs. Hibernation. 69th Scientific Sessions of the American Heart Association." (1996)
"Physiological and Molecular Adaptions to Ischemia in Hibernating Myocardium." , Deborah Heart and Lung Center (1996)
"Control of Coronary Flow Through Shear Stress-Induced Release of NO. Symposium on Nitric Oxide: Role in Pathophysiology." University at Buffalo (1994)
"Endothelium-Dependent Regulation of Myocardial Perfusion. Feinberg Cardiovascular Research Institute." , Northwestern University (1993)
"Endothelium-Dependent Control of Coronary Tone. Department of Physiology, New York Medical College" (1993)
"Regulation of Coronary Tone by Nitric Oxide. Department of Physiology, New York Medical College" (1993)
"Myocardial Function Under Conditions of Chronic Hypoperfusion: Physiological Responses of" (1993)
"Nitric Oxide and Coronary Flow. Symposium on Cardiovascular Reactivity. State University of New York at Buffalo" (1992)
"Evaluation of Relative Myocardial Perfusion with Ultrafast CT. Advances in Ultrafast CT: 1991, An International Symposium, The University of Iowa, College of Medicine, Burlingame, CA" (1991)
"Quantitation of CAD. Meet the Experts, American College of Cardiology, 40th Annual Scientific Session, Atlanta, Georgia, Georgia World Congress Center." (1991)
"Measurement of Myocardial Perfusion with Fast CT. Northwestern University, Division of Cardiology," (1991)
"Cine CT: Application in the assessment of transmural coronary blood flow. New Frontiers in Cardiac Imaging, Symposium. American Heart Association" (1990)
"Comparison of subendocardial versus transmural flow reserve in assessing stenosis severity using ultrafast computed tomography. American Heart Association Council on Circulation Meeting." (1990)
"Regional myocardial flow using fast CT. Fourth Annual Computer Simulation Summer Workshop: Tracer Exchange Kinetics in Organs. University of Washington, August , 1990" (1990)
"Cine CT measurement of myocardial perfusion. Rhode Island Hospital, Brown University, Cardiovascular Grand Rounds" (1990)
"The use of pressure - function relations to study subendocardial autoregulation" , International Society for Heart Research (1989)
"Endocardial Autoregulation as Examined Through the Coronary Pressure-Function Relation in Conscious Animals, 5th Henry Goldberg Workshop, Analysis and Simulation of the Cardiac System: Inhomogeneity and Imaging" (1988)
"Endocardial autoregulation examined using coronary pressure-function relations." , University of Rochester (1988)
"Myocardial Flow - Function Relations in Conscious Dogs With Chronically Reduced Regional Coronary Pressure - "The Idling Myocardium", Scientific Conference on Myocardial Ischemia and Reperfusion, American Heart Association Council on Circulation" (1987)
"Modeling Coronary Pressure - Flow Relations, Joint Scientific Sessions of the Councils on Circulation and Basic Science, American Heart Association" (1984)
"Limitations of Coronary Autoregulatory Responses in The Presence of Coronary Stenosis, Fourth International Workshop on Regional Myocardial Blood Flow" (1983)
"In Vivo Coronary Input Impedance, Capacitance and Conductance; Influences on Diastolic Pressure - Flow Relationships, Louis N. Katz award Competition, 55th Scientific Sessions of the American Heart Association," (1982)
"Fast CT Detection of Coronary Calcification in the Diagnosis of Coronary Disease, Cardiology for the Practitioner." , American College of Cardiology
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