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John                           Canty, Jr.

John M. Canty, Jr. MD

Department of Medicine

SUNY Distinguished Professor, Albert and Elizabeth Rekate Professor and Chief, Division of Cardiovascular Medicine

Specialty/Research Focus

Apoptosis and cell death; Cardiac pharmacology; Cardiology; Cardiovascular Disease; Gene therapy; Genomics and proteomics; Molecular Basis of Disease; Stem Cells

 
Professional Summary:

As chief of the Division of Cardiovascular Medicine at UB, I am responsible for the clinical, teaching and research programs related to adult patients with heart disease. I care for patients at the UBMD Internal Medicine practice group in Amherst, the Gates Vascular Institute (GVI) of Buffalo General Medical Center (BGMC) and the Buffalo VA Medical Center (VAMC). My clinical areas of expertise are in diagnosing and caring for patients with coronary artery disease and heart failure.

My research group conducts translational studies directed at advancing our mechanistic understanding of cardiac pathophysiology as well as developing new diagnostic and therapeutic approaches for the management of patients with chronic ischemic heart disease. Our ongoing areas of preclinical investigation apply proteomic approaches to identify intrinsic adaptive responses of the heart to ischemia and studies examining the ability of intracoronary stem cell therapies to stimulate endogenous cardiomyocyte proliferation and improve heart function. We also conduct basic and patient-oriented research to understand how reversible ischemia modifies the cellular composition and sympathetic innervation of the heart to help develop new approaches to identify patients at risk of sudden cardiac arrest from ventricular fibrillation.
In addition to my laboratory investigation, I serve as the deputy director of the UB Clinical and Translational Research Center (CTRC) and the director of the UB Translational Imaging Center. The Translational Imaging Center offers researchers opportunities to perform multimodality research imaging using PET molecular imaging, high-field magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Our overall goal is to use advanced cardiac imaging to translate new applications between the bench and bedside in order to identify new imaging biomarkers of pathophysiological processes such as chronic myocardial ischemia and cardiac arrhythmogenesis.

I am engaged in the cardiology profession at national and international levels, including as former president of the Association of Professors of Cardiology.

Education and Training:
  • Fellowship, cardiovascular disease, University at Buffalo, University at Buffalo (1983)
  • Internship/Residency, University at Rochester, University at Rochester (1981)
  • MD, Medicine, University at Buffalo, Thesis Honors (1979)
  • BS, Biomedical Engineering, Rensselaer Polytechnic Institute, Cum Laude (1975)
Employment:
  • Professor of Biomedical Engineering, Department of Biomedical Engineering, University at Buffalo (2010-present)
  • Chief, Division of Cardiovascular Medicine, University at Buffalo (2006-present)
  • Albert and Elizabeth Rekate Professor of Medicine, University at Buffalo (2001-present)
  • Professor of Physiology & Biophysics, University at Buffalo (1996-present)
  • Vice-Chair for Research, Department of Medicine, University at Buffalo (2006–2011)
  • Professor of Medicine, University at Buffalo (1995–2001)
  • Associate Professor of Medicine, University at Buffalo (1989–1995)
  • Assistant Professor of Medicine, University at Buffalo (1983–1989)
Awards and Honors:
  • SUNY Distinguished Professor (2015)
  • Robert J. Bache Award (2012)
  • SUNY Chancellor‘s Award for Excellence in Scholarship & Creative Activities (2010)
  • Distinguished Alumnus Award (2008)
  • Stockton Kimball Award (2005)
  • Association of University Cardiologists (2003)
  • University at Buffalo Sustained Achievement Award (2003)
  • Clinical Investigator Award NHLBI (1988)
  • Sinsheimer Scholar (1983)
  • American Heart Association Louis N. Katz Award Finalist (1982)
  • John C. Sable Memorial Heart Fund Award (1982)
  • Upjohn Research Award in Medicine (1979)
  • John Watson Award in Medicine (1979)
  • Buswell Student Research Award (1978)
  • Alpha Omega Alpha
  • James A. Gibson Anatomical Society
  • Tau Beta Pi Engineering Honorary Society

Research Centers:
  • Center for Research in Cardiovascular Medicine
Grants and Sponsored Research:
  • November 2014–October 2018
    Mechanisms of cKit+ Cardiac Stem Cell-Mediated Repair in Ischemic Cardiomyopathy
    National Heart Lung and Blood Institute
    Role: Principal Investigator
    $2,056,476
  • July 2015–June 2017
    Self-replicating RNA-nanoplexes for Programming Monocytes to Regenerate the Heart
    National Heart Lung and Blood Institute
    Role: Co-Investigator
    $432,013
  • January 2011–December 2015
    Biomarker Release after Reversible Ischemia
    American Heart Association
    Role: Co-Investigator
    $385,000
  • August 1996–November 2015
    Chronic Adaptations to Myocardial Ischemia
    NIH
    Role: Principal Investigator
    $1,850,918
  • July 2013–June 2015
    T3np for Cardiac Resuscitation - Pivotal Pre-Clinical Trial
    UB CAT/Pro-Al Medico Technologies
    Role: Co-Investigator
  • May 2010–April 2012
    PET/CT for Multidimensional Translational Cardiovascular Research
    NIH
    Role: Co-Investigator
    $2,000,000
  • January 2006–January 2012
    NIH National Heart Lung and Blood Institute:Mesenchymal Stem Cell Therapeutics in Hibernating Myocardium
    NIH National Heart Lung and Blood Institute
    Role: Co-Investigator
    $1,923,795
  • July 2007–June 2011
    Department of Veterans Affairs. Statins and Growth Factors for Chronic Ischemic Heart Failure
    Role: Principal Investigator
    $712,500
  • July 2007–June 2011
    Department of Veterans Affairs Statins and Growth Factors for Chronic Ischemic Heart Failure
    Veterans Administration
    Role: Principal Investigator
  • July 2007–June 2008
    New York State Stem Cell Science Institutional Support Pilot Project Award
    NYSTEM
    Role: Principal Investigator
See All (10 Total) >

Journal Articles:
See All (97 Total) >
Abstracts:
  • Iyer VS, Canty Jr, JM. Regional reductions in b-adrenergic receptor mediated cAMP prpoduction and reciprocal alterations in Ga protein expression in swine with hibernating myocardium. FASEB J. 2003; 17(4).
  • Iyer VS Young,R.F. Lee,T.C. Nowak,N. Canty,J.M.,Jr.. Microarray analysis of differential gene expression in hibernating myocardium is consistent with regional remodeling and local neurohumoral activation. FASEB J. 2003; 17(4).
  • Kositprapa C, Zhang B, Berger S, Canty JM Jr. & Lee TC. Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes. Mol. Cell. Biochem.. 2000; 214.
Books and Book Chapters:
  • Canty Jr JM, and DJGM Duncker. Coronary blood flow and myocardial ischemia (10th Ed). 2014.
  • Canty, Jr. JM and B Weil. Coronary Blood Flow and Myocardial Ischemia. 2013.
  • Mates, R. E., F. J. Klocke and J. M. Canty, Jr. JM. Impedance to coronary flow. In: Activation, Metabolism and Perfusion of the Heart.. Martinus Nijhoff Publishers, Dordrecht (Netherlands). 1987.
  • Mates, R. E., T. Burns, J. M. Canty, R. Greenberg and J. Neeson. JM. Modeling diastolic impedance to coronary blood flow. 1983.

Professional Memberships:
  • Member, AAMC Council of Faculty and Academic Societies (CFAS) (2013)
  • Member, American Heart Association (1983)
  • Diplomat, National Board of Medical Examiners, 1980
  • Associate, American College of Physicians, 1981 – 1985
  • Affiliate, American College of Cardiology, 1982 – 1985
  • Member, American Heart Association, 1983
  • Member, American Heart Association Council on Basic Science
  • Member, American Society for the Advancement of Science, 1984 – 1986
  • Member, American Federation for Clinical Research, 1984 – 1998
  • Diplomat, American Board of Internal Medicine, 1984
  • Subspecialty Certification in Cardiovascular Diseases, 1985
  • Member, American College of Physicians, 1985 – 1994
  • Member, American Physiological Society, 1985 – present
  • Fellow, American Heart Association Council on Circulation, 1985 – 2001
  • Fellow, American College of Cardiology, 1985 – present
  • Fellow, American College of Physicians, 1995 – present
  • Member, American Heart Association Council on Clinical Cardiology, 1993 – present
  • Fellow of the American Heart Association, 2001 – present
  • President, Association of Professors of Cardiology, 2012-2013
  • Member, International Society for Heart Research, 2011 - present
Presentations:
  • "Viable Chronically Dysfunctional Myocardium - A New Paradigm to Predict Vulnerability to Sudden Cardiac Death in Ischemic Heart Disease" , Medtronic Inc. (2004)
  • "Myocardial Flow-function Relationship. Intrinsic Adaptive Mechanisms During Ischemia and Reperfusion." , European Society of Cardiology (2004)
  • "Metabolic Control of Myocardial Perfusion in Hibernating Myocardium, Experimental Biology 2003" (2003)
  • "Chronic Adaptions to Myocardial Ischemia. Rolling with the Punches: How Cells, Tissues, Organs, Animals and People Adapt to Hyposia." 31st Critical Care Congress, Society for Critical Care Medicine (2002)
  • "Chronic adaptive responses of the heart to repetitive reversible ischemia: The hibernating myocardium." , University of Maastricht, Division of Cardiology (2002)
  • "Hibernating and Chronically Stunned Myocardium: A continuum of Chronic Adaptions to Myocardial Ischemia. Cardiology Grand Rounds" , Massachusetts General Hospital (2001)
  • "Hibernating Myocardium and Chronic Stunning: Apoptosis in Viable Dysfunctional Myocardium. Cardiology Grand Rounds" , University of Virginia (2001)
  • "Chronic Effects of Ischemia on Myocardial Function, Cardiac Adaptation to Myocardial Ischemia, Cardiovascular Seminar" 73rd Annual AHA Scientific Sessions (2000)
  • "The pathophysiology of stunning and hibernation, XXII Congress of the European Society of Cardiology" (2000)
  • "Apoptosis and Myocyte Remodeling in Viable, Chronically Dysfunctional Myocardium: Death Without a Trace" , Feinberg Cardiovascular Institute, Northwestern University (1999)
  • "Apoptosis in hibernating myocardium - Death without a trace, Department of Physiology" , Texas A & M University (1999)
  • "Chronic downregulation of myocardial function: the hibernating myocardium Experimental Biology 99" (1999)
  • "Ischemia-induced gene expression in vivo, International Society for Heart Research, XXII Scientific Sessions" (1999)
  • "Viable, chronically dysfunctional myocardium: Transition from chronic stunning to hibernation, Cardiology Grand Rounds" , University of Louisville (1999)
  • "A porcine model of hibernating Myocardium, Scientific Conference on Fascular and Myocardial Aspects of Ischemic Heart Disease." (1998)
  • "Physiological and molecular adaptions to ischemia in viable chronically dysfunctional myocardium, Division of Cardiology" , Medical College of Wisconsin (1998)
  • "Regulation of Myocardial Perfusion by Nitric Oxide: Workshop on Coronary Physiology and Cardiac Metabolism, XXXIII International Congress of Physiological Sciences." (1997)
  • "Adaptions to Myocardial Ischemia: Repetitive Stunning vs. Hibernation. 69th Scientific Sessions of the American Heart Association." (1996)
  • "Physiological and Molecular Adaptions to Ischemia in Hibernating Myocardium." , Deborah Heart and Lung Center (1996)
  • "Control of Coronary Flow Through Shear Stress-Induced Release of NO. Symposium on Nitric Oxide: Role in Pathophysiology." University at Buffalo (1994)
  • "Endothelium-Dependent Regulation of Myocardial Perfusion. Feinberg Cardiovascular Research Institute." , Northwestern University (1993)
  • "Endothelium-Dependent Control of Coronary Tone. Department of Physiology, New York Medical College" (1993)
  • "Regulation of Coronary Tone by Nitric Oxide. Department of Physiology, New York Medical College" (1993)
  • "Myocardial Function Under Conditions of Chronic Hypoperfusion: Physiological Responses of" (1993)
  • "Nitric Oxide and Coronary Flow. Symposium on Cardiovascular Reactivity. State University of New York at Buffalo" (1992)
  • "Evaluation of Relative Myocardial Perfusion with Ultrafast CT. Advances in Ultrafast CT: 1991, An International Symposium, The University of Iowa, College of Medicine, Burlingame, CA" (1991)
  • "Quantitation of CAD. Meet the Experts, American College of Cardiology, 40th Annual Scientific Session, Atlanta, Georgia, Georgia World Congress Center." (1991)
  • "Measurement of Myocardial Perfusion with Fast CT. Northwestern University, Division of Cardiology," (1991)
  • "Cine CT: Application in the assessment of transmural coronary blood flow. New Frontiers in Cardiac Imaging, Symposium. American Heart Association" (1990)
  • "Comparison of subendocardial versus transmural flow reserve in assessing stenosis severity using ultrafast computed tomography. American Heart Association Council on Circulation Meeting." (1990)
  • "Regional myocardial flow using fast CT. Fourth Annual Computer Simulation Summer Workshop: Tracer Exchange Kinetics in Organs. University of Washington, August , 1990" (1990)
  • "Cine CT measurement of myocardial perfusion. Rhode Island Hospital, Brown University, Cardiovascular Grand Rounds" (1990)
  • "The use of pressure - function relations to study subendocardial autoregulation" , International Society for Heart Research (1989)
  • "Endocardial Autoregulation as Examined Through the Coronary Pressure-Function Relation in Conscious Animals, 5th Henry Goldberg Workshop, Analysis and Simulation of the Cardiac System: Inhomogeneity and Imaging" (1988)
  • "Endocardial autoregulation examined using coronary pressure-function relations." , University of Rochester (1988)
  • "Myocardial Flow - Function Relations in Conscious Dogs With Chronically Reduced Regional Coronary Pressure - The Idling Myocardium, Scientific Conference on Myocardial Ischemia and Reperfusion, American Heart Association Council on Circulation" (1987)
  • "Modeling Coronary Pressure - Flow Relations, Joint Scientific Sessions of the Councils on Circulation and Basic Science, American Heart Association" (1984)
  • "Limitations of Coronary Autoregulatory Responses in The Presence of Coronary Stenosis, Fourth International Workshop on Regional Myocardial Blood Flow" (1983)
  • "In Vivo Coronary Input Impedance, Capacitance and Conductance; Influences on Diastolic Pressure - Flow Relationships, Louis N. Katz award Competition, 55th Scientific Sessions of the American Heart Association," (1982)
  • "Fast CT Detection of Coronary Calcification in the Diagnosis of Coronary Disease, Cardiology for the Practitioner." , American College of Cardiology
See All (40 Total) >

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: 829-2663
Fax: 854-1840
Email: canty@buffalo.edu

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