John M. Canty, Jr. MD

John M. Canty, Jr.
MD

SUNY Distinguished and Albert and Elizabeth Rekate Professor of Medicine

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Apoptosis and cell death; Biomedical Engineering; Biomedical Imaging; Cardiac pharmacology; Cardiology; Cardiopulmonary physiology; Cardiovascular Disease; Gene Therapy; Genomics and proteomics; Imaging In Vivo; Implementation Science; Models - cell and animal; Molecular Basis of Disease; Molecular Imaging Techniques; Pathophysiology; Preclinical MRI; Proteomics; Quantitative Histology; Stem Cells; Team Science; Translational imaging; Translational Research; Translational Research

Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, New York 14203
Phone: 716-829-2666
Fax: 716-854-1840
canty@buffalo.edu

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Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Overview Research Publications Activities Latest News

Professional Summary:

As a SUNY Distinguished Professor, I am involved in the clinical, teaching and research programs is the Division of Cardiovascular Medicine at the University at Buffalo. I care for patients at the Gates Vascular Institute (GVI) of Buffalo General Medical Center (BGMC) and the Buffalo VA Medical Center (VAMC). My clinical areas of expertise are in diagnosing and caring for patients with coronary artery disease and heart failure.

My research group conducts bench to bedside translational studies directed at advancing our mechanistic understanding of cardiac pathophysiology as well as developing new diagnostic and therapeutic approaches for the management of patients with chronic ischemic heart disease. Our ongoing areas of preclinical investigation apply proteomic approaches to identify intrinsic adaptive responses of the heart to ischemia and studies examining the ability of intracoronary stem cell therapies to stimulate endogenous cardiomyocyte proliferation and improve heart function. We are particularly interested in understanding how elevations in heart filling pressures and reversible ischemia lead to cardiomyocyte cell death and fibrosis. We have demonstrated that the interstitial fibrosis arising from repetitive preload elevation leads to a cardiac phenotype reproducing some of the physiological features of heart failure with a preserved ejection fraction or HFpEF. We are currently examining therapeutic interventions to reverse interstitial fibrosis to improve the reduced left ventricular diastolic distensibility in this model.

Our group also conducts basic and patient-oriented research to understand how chronic ischemia modifies the cellular composition and sympathetic innervation of the heart to help develop new approaches to identify patients at risk of sudden cardiac arrest (SCA) from ventricular fibrillation. The Prediction of Arrhythmic Events with Positron Emission Tomography (PAREPET) study found that two imaging variables, myocardial sympathetic denervation and left ventricular volume predicted the risk of having an appropriate ICD discharge for SCA. We are currently extending this in the ongoing PAREPET II study using an F-18 labeled norepinephrine analog with potentially broader implementation than the C-11 analog studied in PAREPET.

In addition to my laboratory investigation, I am engaged in the cardiology profession at national and international levels, including study sections of the National Heart Lung and Blood Institute, professional guidelines committees and served as former president of the Association of Professors of Cardiology.

Education and Training:

Fellowship, Cardiovascular Diseases, University at Buffalo (1983)
Residency, Internal Medicine, University at Rochester (1981)
MD, Medicine, University at Buffalo (1979)
BS, Biomedical Engineering, Rensselaer Polytechnic Institute, Cum Laude (1975)

Employment:

Medical Staff, Kaleida Health (2008-present)
Director, Center for Research in Cardiovascular Medicine, University at Buffalo (2002-present)
Staff Cardiologist, Cardiology, WNY Veterans Affairs Medical Center (1988-present)
Board of Directors,Central Radiation Services (CRS) (2015-present)
SUNY Distinguished Professor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2015-present)
Professor of Biomedical Engineering, Department of Biomedical Engineering, University at Buffalo (2010-present)
Director, Center for Research in Cardiovascular Medicine, University at Buffalo, Cardiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2002-present)
Albert and Elizabeth Rekate Professor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001-present)
Professor of Physiology & Biophysics, Physiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996-present)
Staff Cardiologist, Western New York Department of Veterans Affairs Medical Center (1987-present)
Director of Cardiology Research Programs, Division of Cardiology (1992–2022)
Deputy Director, UB Clinical and Translational Science Institution, Cardiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2013–2020)
Deputy Director,UB Clinical and Translational Science Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (2013–2020)
Chief, Division of Cardiovascular Medicine, Medicine, University at Buffalo (2006–2019)
Director, UB CTRC Translational Imaging Facility, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2012–2018)
Director UB CTRC Translational Imaging Facility, UB Clinical and Translational Research Institute (2012–2017)
Attending Cardiologist, Erie County Medical Center (1983–2013)
Medical Staff, Erie County Medical Center (1983–2013)
Vice-Chair for Research, Department of Medicine, Medicine, University at Buffalo (2006–2011)
Associate Chief of Cardiology, Division of Cardiology, University at Buffalo (1998–2006)
Interim Director, Division of Cardiology, Coronary Care Unit, Erie County Medical Center (2001–2002)
Director of Cardiology Research Program, Cardiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–2002)
Professor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1995–2001)
Assistant Professor of Physiology, Physiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1986–1996)
Associate Professor of Medicine, University at Buffalo (1989–1995)
Cardiologist, Erie County Medical Center (1983–1994)
Assistant Professor of Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1983–1989)
Cardiology Fellow, University at Buffalo (1981–1983)
Cardiology Fellow and Instructor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1981–1983)
Medical Resident, Strong Memorial Hospital (1980–1981)
Medical Intern, Strong Memorial Hospital (1979–1980)

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Awards and Honors:

Senior Clinician Scientist Award, Department of Veterans Affairs (2020)
Wiggers Award (2020)
Outstanding Mentorship in Research Award (2018)
SUNY Distinguished Professor (2015)
Robert J. Bache Award (2012)
SUNY Chancellor‘s Award for Excellence in Scholarship & Creative Activities (2010)
Distinguished Alumnus Award (2008)
Stockton Kimball Award (2005)
University at Buffalo Sustained Achievement Award (2003)
Association of University Cardiologists (2003)
Clinical Investigator Award NHLBI (1988)
Sinsheimer Scholar (1983)
American Heart Association Louis N. Katz Award Finalist (1982)
John C. Sable Memorial Heart Fund Award (1982)
John Watson Award in Medicine (1979)
Upjohn Research Award in Medicine (1979)
Alpha Omega Alpha (1979)
Buswell Student Research Award (1978)
James A. Gibson Anatomical Society (1976)
Tau Beta Pi Engineering Honorary Society (1975)
Castle Connolly Top Doctor
Best Doctors in America

Research Expertise:

Cardiovascular stem cell therapy
Chronic adaptations to myocardial ischemia
Heart Failure with a Preserved Ejection Fraction
Sudden cardiac death

Research Centers:

Center for Research in Cardiovascular Medicine
Clinical and Translational Research Center (CTRC)

Grants and Sponsored Research:

July 2020–June 2028
VA Merit Review, 2IO1BX002659, Preventing and Reversing Interstitial Fibrosis in HFpEF
Department of Veterans Affairs
Role: Principal Investigator
$709,984
November 2016–December 2024
Prediction of Arrhythmic Events with Positron Emission Tomography - II (PAREPET II)
National Heart Lung and Blood Institute - NHLBI
Role: Co-Principal Investigator
$3,726,616
September 2017–August 2023
K12 HL138052 National Heart Lung and Blood Institute, UB Clinical Scholar Program in implementation science to achieve triple aims
UB Clinical Scholar Program in Implementation Science to Achieve Triple Aims
Role: Co-Principal Investigator
$1,022,277
January 2016–December 2019
VA Merit Review, Dynamic remodeling from reversible ischemia and sudden cardiac arrest
VA
Role: Co-Investigator
$649,600
January 2016–January 2019
Clinical Translational Science Award (CTSA)
National Institutes of Health
Role: Co-Principal Investigator
$16,000,000
January 2013–December 2018
T3-Nanformulation Evaluation in Preparation for Clinical Trials
UB Cat
Role: Principal Investigator
November 2014–October 2018
Mechanisms of cKit+ Cardiac Stem Cell-Mediated Repair in Ischemic Cardiomyopathy
National Heart Lung and Blood Institute
Role: Principal Investigator
$2,056,476
July 2015–June 2017
Self-replicating RNA-nanoplexes for Programming Monocytes to Regenerate the Heart
National Heart Lung and Blood Institute
Role: Co-Investigator
$432,013
January 2011–December 2015
Biomarker Release after Reversible Ischemia
American Heart Association
Role: Co-Investigator
$385,000
August 1996–November 2015
Chronic Adaptations to Myocardial Ischemia
NIH
Role: Principal Investigator
$1,850,918
July 2013–June 2015
T3np for Cardiac Resuscitation - Pivotal Pre-Clinical Trial
UB CAT/Pro-Al Medico Technologies
Role: Co-Investigator
December 2013–December 2014
UB CAT: T3 Nanformulation Evaluation in Preparation for Clinical Trials
Pro Al Medico Technologies Inc.
Role: Co-Investigator
$200,000
May 2010–April 2012
PET/CT for Multidimensional Translational Cardiovascular Research
NIH
Role: Co-Investigator
$2,000,000
January 2006–January 2012
NIH National Heart Lung and Blood Institute:Mesenchymal Stem Cell Therapeutics in Hibernating Myocardium
NIH National Heart Lung and Blood Institute
Role: Co-Investigator
$1,923,795
July 2007–June 2011
Department of Veterans Affairs. Statins and Growth Factors for Chronic Ischemic Heart Failure
Role: Principal Investigator
$712,500
July 2007–June 2008
New York State Stem Cell Science Institutional Support Pilot Project Award
NYSTEM
Role: Principal Investigator
March 2019
National Center for Advancing Translational Sciences
NIH
Role: Contributor

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Journal Articles:

Techiryan G, Weil BR, Young RF, Canty JM. (2022) Widespread Intracoronary Allogeneic Cardiosphere-Derived Cell Therapy With and Without Cyclosporine in Reperfused Myocardial Infarction. American journal of physiology. Heart and circulatory physiology (Sep).
Canty JM. (2022) Myocardial injury, troponin release, and cardiomyocyte death in brief ischemia, failure, and ventricular remodeling. American journal of physiology. Heart and circulatory physiology (Jul), 323(1): H1-H15. doi:10.1152/ajpheart.00093.2022
Messé SR, Overbey JR, Thourani VH, Moskowitz AJ, Gelijns AC, Groh MA, Mack MJ, Ailawadi G, Furie KL, Southerland AM, James ML, Moy CS, Gupta L, Voisine P, Perrault LP, Bowdish ME, Gillinov AM, O'Gara PT, Ouzounian M, Whitson BA, Mullen JC, Miller MA, Gammie JS, Pan S, Erus G, Browndyke JN, . (2022) The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement. The Journal of thoracic and cardiovascular surgery (Mar).
Gammie JS, Chu MWA, Falk V, Overbey JR, Moskowitz AJ, Gillinov M, Mack MJ, Voisine P, Krane M, Yerokun B, Bowdish ME, Conradi L, Bolling SF, Miller MA, Taddei-Peters WC, Jeffries NO, Parides MK, Weisel R, Jessup M, Rose EA, Mullen JC, Raymond S, Moquete EG, O'Sullivan K, Marks ME, Iribarne A, Beyersdorf F, Borger MA, Geirsson A, Bagiella E, Hung J, Gelijns AC, O. (2022) Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation. The New England journal of medicine (Jan), 386(4): 327-339. doi:10.1056/NEJMoa2115961
Momeni A, Eagler L, Lo CY, Weil BR, Canty JM, Lang JK, Neelamegham S. (2021) Neutrophils aid cellular therapeutics by enhancing glycoengineered stem cell recruitment and retention at sites of inflammation. Biomaterials (Sep), 276: 121048.
Wang JZ, Zelt JGE, Kaps N, Lavallee A, Renaud JM, Rotstein B, Beanlands RSB, Fallavollita JA, Canty JM, deKemp RA. (2021) Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (Aug).
Zelt JGE, Wang JZ, Mielniczuk LM, Beanlands RSB, Fallavollita JA, Canty JM, deKemp RA. (2021) Positron Emission Tomography Imaging of Regional Versus Global Myocardial Sympathetic Activity to Improve Risk Stratification in Patients With Ischemic Cardiomyopathy. Circulation. Cardiovascular imaging (Jun), 14(6): e012549. doi:10.1161/CIRCIMAGING.121.012549
Januzzi JL, Canty JM, Das S, DeFilippi CR, Gintant GA, Gutstein DE, Jaffe A, Kaushik EP, Leptak C, Mehta C, Pina I, Povsic TJ, Rambaran C, Rhyne RF, Salas M, Shi VC, Udell JA, Unger EF, Zabka TS, Seltzer JH. (2021) Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week. Journal of the American College of Cardiology (Apr), 77(15): 1922-1933.
Bebu I, Keshavarzi S, Gao X, Braffett BH, Canty AJ, Herman WH, Orchard TJ, Dagogo-Jack S, Nathan DM, Lachin JM, Paterson AD, . (2021) Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes care (Apr). doi:10.2337/dc20-2388
Clemency BM, Innes JC, Waldrop M, White LJ, Dievendorf E, Orlowski R, Wang K, Lindstrom HA, Canty JM, Hostler D. (2021) Changes in Field Termination of Resuscitation and Survival Rates After an Educational Intervention to Promote on Scene Resuscitation for Out-of-Hospital Cardiac Arrest. The Journal of emergency medicine (Mar), 60(3): 349-354.
Wang J, Lee CJ, Deci MB, Jasiewicz N, Verma A, Canty JM, Nguyen J. (2020) MiR-101a loaded extracellular nanovesicles as bioactive carriers for cardiac repair. Nanomedicine : nanotechnology, biology, and medicine (Jul), 27: 102201. doi:10.1016/j.nano.2020.102201
Wang X, Shen X, Weil BR, Young RF, Canty JM, Qu J. (2020) Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine. American journal of physiology. Heart and circulatory physiology (May), 318(5): H1256-H1271. doi:10.1152/ajpheart.00713.2019
Wang JZ, Moody JB, Kaps N, Britt D, Lavallee A, Renaud JM, Zelt JGE, Wu KY, Beanlands RS, Fallavollita JA, Canty JM, deKemp RA. (2020) Reproducible Quantification of Regional Sympathetic Denervation with [11C]meta-Hydroxyephedrine PET Imaging. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (Apr). doi:10.1007/s12350-020-02114-3
Weil BR, Suzuki G, Canty JM. (2020) Transmural variation in microvascular remodeling following percutaneous revascularization of a chronic coronary stenosis in swine. American journal of physiology. Heart and circulatory physiology (Mar), 318(3): H696-H705. doi:10.1152/ajpheart.00502.2019
Padro T, Manfrini O, Bugiardini R, Canty J, Cenko E, De Luca G, Duncker DJ, Eringa EC, Koller A, Tousoulis D, Trifunovic D, Vavlukis M, de Wit C, Badimon L. (2020) ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on . Cardiovascular research (Mar), 116(4): 741-755. doi:10.1093/cvr/cvaa003
Malhotra S, Canty JM. (2019) Structural and Physiological Imaging to Predict the Risk of Lethal Ventricular Arrhythmias and Sudden Death. JACC. Cardiovascular imaging (Oct), 12(10): 2049-2064. doi:10.1016/j.jcmg.2019.05.034
Weil BR, Techiryan G, Suzuki G, Konecny F, Canty JM. (2019) Adaptive Reductions in Left Ventricular Diastolic Compliance Protect the Heart From Stretch-Induced Stunning. JACC. Basic to translational science (Aug), 4(4): 527-541. doi:10.1016/j.jacbts.2019.04.002
Suzuki G, Weil BR, Young RF, Fallavollita JA, Canty JM. (2019) Nonocclusive multivessel intracoronary infusion of allogeneic cardiosphere-derived cells early after reperfusion prevents remote zone myocyte loss and improves global left ventricular function in swine with myocardial infarction. American journal of physiology. Heart and circulatory physiology (Aug), 317(2): H345-H356. doi:10.1152/ajpheart.00124.2019
Suzuki G, Weil BR, Young, Rebeccah, Fallavollita JA, Canty J. (2019) Nonocclusive Multivessel Intracoronary Infusion of Allogeneic Cardiosphere-derived Cells Early After Reperfusion Prevents Remote Zone Myocyte Loss and Improves Global Left Ventricular Function in Swine with Myocardial Infarction. Am J Physiol Heart Circ Physiol (Aug), 317(2): H345-H356.
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, Mickley H, Crea F, Van de Werf F, Bucciarelli-Ducci C, Katus HA, Pinto FJ, Antman EM, Hamm CW, De Caterina R, Januzzi JL, Apple FS, Alonso Garcia MA, Underwood SR, Canty JM, Lyon AR, Devereaux PJ, Zamorano JL, Lindahl B, Weintraub WS, Newby LK, Virmani R, Vranckx P, Cutlip D, Gibbons RJ, Smith SC, Atar D, Luepker RV, Robertson RM, Bonow RO, Steg PG, O. (2019) Fourth universal definition of myocardial infarction (2018). European Heart Journal 2019;40:237-269 (Jan), 40(January): 237-269.
Wang J, Seo MJ, Deci MB, Weil BR, Canty JM, Nguyen J. (2018) Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction. Int J Nanomedicine (Oct), 13: 6441-6451.
Techiryan G, Weil BR, Palka BA, Canty JM. (2018) Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine. Circ Res (Sep), 123(8): 986-995.
Thygesen, K, Alpert, J, Jaffe, A, Chaitman, B, Bax, J, Morrow, D, White, H, Executive Group on behalf of the JESC, Canty J. (2018) Fourth Universal Definition of Myocardial Infarction (2018) Expert Consensus Document. Circulation (Aug)
Weil BR, Suzuki G, Young RF, Iyer V, Canty JM. (2018) Troponin Release and Reversible Left Ventricular Dysfunction After Transient Pressure Overload. Journal of the American College of Cardiology (Jun), 71(25): 2906-2916. doi:10.1016/j.jacc.2018.04.029
Zhang M, An B, Qu Y, Shen S, Fu W, Chen YJ, Wang X, Young R, Canty JM, Balthasar JP, Murphy K, Bhattacharyya D, Josephs J, Ferrari L, Zhou S, Bansal S, Vazvaei F, Qu J. (2018) Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics. Analytical chemistry (Feb), 90(3): 1870-1880. doi:10.1021/acs.analchem.7b03949
Ferguson SW, Wang, J, Lee, CJ, Liu, M, Neelamegham S, Canty J, Nguyen, J. (2018) The microRNA regulatory landscape of mesenchymal stem cell-derived exosomes: a systems view. Sci Rep. (Jan), 8(1): 1419-1419.
Lindsey, ML, Boli, R, Canty J, Du, S-J, Frangogiannis, NG, Frantz, S, Gourdie, RG, Homes, JW, Jones, SP, Kloner, RA, Lefer, D, Liao, R, Murphy, E, Ping, P, Przyklenk, K, Recchia, FA, Schwartz-Longacre L, Ripplinger, CM, Van Eyk, JE, Heusch, G, None. (2018) Guidelines for Experimental Models of Myocardial Ischemia and Infarction. Am J. Physiol. Heart and Circulatory (Jan), 214(4): H812-H838.
Fallavollita JA, Dare, JD, Carter, RL, Baldwa S, Canty J. (2017) Denervated myocardium preferentially predicts sudden cardiac arrest in ischemic cardiomyopathy: A competing risk analysis of cause-specific mortality. Circulation: Cardiovascular Imaging (Aug), 10(8).
Weil BR, Young RF, Shen X, Suzuki G, Qu J, Malhotra S, Canty JM. (2017) Reply: Apoptosis, A Double-Edge Sword!. JACC. Basic to translational science (Aug), 2(4): 499. doi:10.1016/j.jacbts.2017.07.009
Weil BR, Young RF, Shen X, Suzuki G, Qu J, Malhotra S, Canty JM. (2017) Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine. JACC. Basic to translational science (Apr), 2(2): 105-114. doi:10.1016/j.jacbts.2017.01.006
Weil BR, Young, Rebeccah, Shen, Xiaomeng, Suzuki G, Qu J, Malhotra S, Canty J. (2017) Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine. J Am Coll Cardiol Basic Trans Science (Apr), 2(2): 114-105.
Malhorta S and Canty, Jr. JM. (2017) American Perspective: Comparing the AHA/ACC and ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Journal of Nuclear Cardiology (Jan).
Weil BR, RF Young, X Shen, G Suzuki, JK Qu, S Malhotra and JM Canty, Jr. (2017) Brief myocardial ischemia produces cardiac troponin I release and focal myocyte apoptosis in the absence of pathological infarction in swine. J Am Coll Cardiol Basic Trans Sci (Jan), 2(2): 105-114.
Canty, Jr. JM and BR Weil. (2017) Cortical Bone Stem Cells Administered at Reperfusion Attenuate Adverse Post-Infarction Left Ventricular Remodeling and Prevent Myocyte Loss at a Distance. Circulation Research (Jan), 121: 1210-1213.
Fallavollita JA, JD Dare, RL Carter, S Baldwa and JM Canty Jr. (2017) Denervated myocardium is preferentially associated with sudden cardiac arrest in ischemic cardiomyopathy. A pilot competing risks analysis of cause-specific mortality. Circ Cardiovascular Imaging (Jan), 10: e0064.
Canty, Jr. JM. (2017) Is it still important to evaluate patients with ischemic cardiomyopathy for viable dysfunctional myocardium prior to myocardial revascularization?. Trends in Cardiovascular Medicine (Jan), 17.
Malhotra, S and Canty, Jr. JM. (2017) Vasodilator stress and left ventricular asynchrony. Journal of Nuclear Cardiology (Jan), 24(1): 53-56.
Weil BR, Konecny F, Suzuki G, Iyer V, Canty JM. (2016) Comparative Hemodynamic Effects of Contemporary Percutaneous Mechanical Circulatory Support Devices in a Porcine Model of Acute Myocardial Infarction. JACC Cardiovasc Interv (Nov), 9(22): 2292-2303.
Canty J, Weil BR, Suzuki G. (2016) Widespread Intracoronary Cardiopoietic Cell Infusion: Treating at the Time of Myocardial Reperfusion to Prevent Rather Than Reverse Established Left Ventricular Dysfunction Moves Us Closer to Practical Clinical Translation. Circ Res (Apr), 118(7): 1045-1048.
Malhotra S, Canty JM. (2016) Life-Threatening Ventricular Arrhythmias: Current Role of Imaging in Diagnosis and Risk Assessment. J Nucl Cardiol (Jan).
Zlotnick DM and Canty JM Jr. (2016) Striking a balance: Individualizing antithrombotic therapy after myocardial infarction. Trends in Cardiovascular Medicine (Jan), 74: 19-30.
Lang JK, Young RF, Ashraf H, Canty JM. (2016) Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro. PloS one (Jan), 11(11): e0165926. doi:10.1371/journal.pone.0165926
Lo CY, Weil BR, Palka BA, Momeni A, Canty JM, Neelamegham S. (2016) Cell surface glycoengineering improves selectin-mediated adhesion of mesenchymal stem cells (MSCs) and cardiosphere-derived cells (CDCs): Pilot validation in porcine ischemia-reperfusion model. Biomaterials (Jan), 74: 19-30. doi:10.1016/j.biomaterials.2015.09.026
Weil BR, Suzuki G, Leiker MM, Fallavollita JA, Canty, Jr. JM. (2015) Comparative efficacy of intracoronary allogeneic mesenchymal stem cells and cardiosphere derived cells in swine with hibernating myocardium. Circulation Research (Sep), 117: 634-644.
Weil BR, Suzuki G, Leiker MM, Fallavollita JA, Canty, Jr., JM. (2015) Comparative Efficacy of Intracoronary Allogeneic Mesenchymal Stem Cells and Cardiosphere-Derived Cells in Swine with Hibernating Myocardium. Circ Res (Sep), 117(7): 634-644.
Al-Zaiti SS, Fallavollita JA, Canty, Jr. JM, Carey MG. (2015) The prognostic value of discordant T waves in lead aVR: A simple risk marker of sudden cardiac arrest in ischemic cardiomyopathy. J Electrocardiol (Sep), 17(8): 887-892.
Malhotra S, Fernandez SF, Fallavollita JA, Canty Jr JM. (2015) Prognostic significance of imaging myocardial sympathetic innnervation. Curr Cardiol Rep (Aug), 17(8): 62.
Malhotra S, Fernandez SF, Fallavollita JA, Canty JM. (2015) Prognostic Significance of Imaging Myocardial Sympathetic Innervation. Current cardiology reports (Aug), 17(8): 62. doi:10.1007/s11886-015-0613-9
Page BJ, Banas MD, Suzuki G, Weil BR, Young RF, Fallavollita JA, Palka BA, Canty JM. (2015) Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. Journal of the American College of Cardiology (Feb), 65(7): 684-97. doi:10.1016/j.jacc.2014.11.040
Gillinov AM, Canty J. (2015) Surgical Ablation of Atrial Fibrillation During Mitral-valve Surgery. N Engl J Med (Jan), 372: 1399-1409.
Canty JM Jr, Duncker DJ, Koller D, and Merkus D. (2015) Regulation of coronary blood flow in health and ischemic heart disease. Prog Cardiovasc Dis (Jan), 57: 409-422.
Page BJ, Banas MD, Suzuki G, Weil BR, Young RF, Fallavollita JA, Palka BA and Canty JM Jr. (2015) Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. J Am College Card (Jan), 65(7): 684-697.
Wong AS, Mortin-Toth S, Sung M, Canty AJ, Gulban O, Greaves DR, Danska JS. (2014) Polymorphism in the innate immune receptor SIRPa controls CD47 binding and autoimmunity in the nonobese diabetic mouse. Journal of immunology (Baltimore, Md. : 1950) (Nov), 193(10): 4833-44.
Suzuki G, Weil B, Leiker MM, Ribbeck AE, Young RF, Canty JM. (2014) Global intracoronary infusion of allogeneic cardiosphere-derived cells (CDCs) immediately after reperfusion stimulates myocyte regeneration in remote viable myocardium in swine with acute myocardial infarction. PLOS ONE (Nov), 9(11).
Haji DL, Ali MM, Royse A, Canty DJ, Clarke S, Royse CF. (2014) Interatrial septum motion but not Doppler assessment predicts elevated pulmonary capillary wedge pressure in patients undergoing cardiac surgery. Anesthesiology (Oct), 121(4): 719-29.
Shen X, Young R, Canty JM, Qu J. (2014) Quantitative proteomics in cardiovascular research: global and targeted strategies. Proteomics. Clinical applications (Aug), 8(7-8): 488-505. doi:10.1002/prca.201400014
Qu J, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM. (2014) Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models. Journal of proteome research (May), 13(5): 2571-84. doi:10.1021/pr5000472
Goldberger JJ, Basu A, Boineau R, Buxton AE, Cain ME, Canty JM, Chen PS, Chugh SS, Costantini O, Exner DV, Kadish AH, Lee B, Lloyd-Jones D, Moss AJ, Myerburg RJ, Olgin JE, Passman R, Stevenson WG, Tomaselli GF, Zareba W, Zipes DP, Zoloth L. (2014) Risk stratification for sudden cardiac death: a plan for the future. Circulation (Jan), 129(4): 516-26.
Fallavollita JA, Heavey BM, Luisi AJ, Michalek SM, Baldwa S, Mashtare TL, Hutson AD, Dekemp RA, Haka MS, Sajjad M, Cimato TR, Curtis AB, Cain ME, Canty JM. (2014) Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. Journal of the American College of Cardiology (Jan), 63(2): 141-9. doi:10.1016/j.jacc.2013.07.096
Qu J, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM Jr. (2014) A reproducible ion current-based approach for 24-plex comparison of the tissue proteomes of hibernating vs normal myocardium in swine models. J Proteome Research (Jan), 13(5): 2571-2584.
Weil BR and Canty, Jr. JM. (2014) Ceramide signaling in the coronary microcirculation: A double-edged sword?. Circulation Research (Jan), 115: 475-477.
Al-Zaiti SS, Fallavollita JA, Canty JM Jr and Carey MG. (2014) Electrocardiographic predictors of sudden and non-sudden cardiac death in patients with ischemic cardiomyopathy. Heart Lung: Journal of Acute and Critical Care (Jan), 43: 527-533.
Sharma UC and Canty JM Jr. (2014) Myocardial repair around-the-clock. Circ Res (Jan), 114(11): 1675-1677.
Goldberger JJ, Basu A, Boineau R, Buxton AE, Cain ME, Canty JM Jr, Chen PS, Chugh SS, Costantini O, Exner DV, Kadish AH, Lee B, Lloyd-Jones D, Moss A, Myerburg R, Olgin J, Passman R, Stevenson W, Tomaselli G, Zareba W, Zipes DP and Zoloth L. (2014) Risk stratification for sudden cardiac death: A plan for the future. Circulation (Jan), 129: 516-526.
Fallavollita JA, Heavey BM, Luisi AJ Jr, Michalek SM, Baldwa S, Mashtare TL, Hutson AD, deKemp RA, Haka MS, Sajjad M, Cimato TR, Curtis AB, Cain ME and Canty JM Jr. (2014) Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol (Jan), 63: 141-149.
Shen X, Young R, Canty Jr, JM and Qu J. (2014) Quantitative proteomics in cardiovascular research: global and targeted strategies. Proteom Clin Apps (Jan), 8: 488-505.
Suzuki G, Weil BR, Leiker MM, Ribbeck AE, Young RF, Cimato TR, Canty JM. (2014) Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventricular function and stimulates endogenous myocyte regeneration throughout the heart in swine with hibernating myocardium. PloS one (Jan), 9(11): e113009. doi:10.1371/journal.pone.0113009
Weil BR, Canty JM. (2013) Stem cell stimulation of endogenous myocyte regeneration. Clinical science (London, England : 1979) (Aug), 125(3): 109-19. doi:10.1042/CS20120641
Page BJ, Young RF, Suzuki G, Fallavollita JA, Canty JM. (2013) The physiological significance of a coronary stenosis differentially affects contractility and mitochondrial function in viable chronically dysfunctional myocardium. Basic research in cardiology (Jul), 108(4): 354. doi:10.1007/s00395-013-0354-0
Pizzuto MF, Suzuki G, Banas MD, Heavey B, Fallavollita JA, Canty JM. (2013) Dissociation of hemodynamic and electrocardiographic indexes of myocardial ischemia in pigs with hibernating myocardium and sudden cardiac death. American journal of physiology. Heart and circulatory physiology (Jun), 304(12): H1697-707. doi:10.1152/ajpheart.00166.2013
Fernandez SF, Ovchinnikov V, Canty JM Jr, Fallavollita JA. (2013) Hibernating Myocardium Results in Partial Sympathetic Denervation and Nerve Sprouting. Am J. Physiol Heart Circ Physiol (Jan), 304: H318-H327.
Canty, Jr. JM. (2013) "The role of short QT interval and elevated LV end-diastolic pressure in the genesis of ventricular tachycardia and fibrillation.". Am. J. Physiol. Heart Circ. Physiol. (Jan).
Pizzuto MF, Suzuki G, Banas MD,Heavey B, Fallavolita JA and Canty JM Jr. (2013) Dissociaton of hemodynamic and electrocardiographic indices of myocardial ischemia in pigs with hibernating myocardium and sudden cardiac death. Am J Physiol Heart Circ Physiol (Jan), 304: H1697-H1707.
Pizzuto MF, Suzuki G, Banas MD, Heavey B, Fallavollita JA and Canty JM. (2013) Dissociation of hemodynamic and electrocardiographic indices of myocardial ischemia in pigs with hibernating myocardium and sudden cardiac death. Am. J. Physiol. Heart Circ. Physiol. (Jan), 304: 1697-1707.
Page BJ, Young RF, Suzuki G, Fallavollita JA and Canty JM Jr. (2013) The Physiological Significance of a Coronary Stenosis Differentially Affects Contractility and Mitochondrial Function in Viable Chronically Dysfunctional Myocardium. Basic Research in Cardiology (Jan), 108: 354.
Fernandez SF, Ovchinnikov V, Canty JM, Fallavollita JA. (2013) Hibernating myocardium results in partial sympathetic denervation and nerve sprouting. American journal of physiology. Heart and circulatory physiology (Jan), 304(2): H318-27. doi:10.1152/ajpheart.00810.2011
Weil BR, Canty JM Jr. (2013) Stem cell stimulation of endogenous myocyte regeneration. Clinical Science (London) (Jan), 125: 109-119.
Carey MG, Al-Zaiti SS, Canty JM, Fallavollita JA. (2012) High-risk electrocardiographic parameters are ubiquitous in patients with ischemic cardiomyopathy. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (Jul), 17(3): 241-51. doi:10.1111/j.1542-474X.2012.00506.x
Canty JM, Suzuki G. (2012) Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease. Journal of molecular and cellular cardiology (Apr), 52(4): 822-31. doi:10.1016/j.yjmcc.2011.08.019
Cary MG, Al-Zaiti SS, Canty JM Jr and Fallavollita JA. (2012) High-risk electrocardiographic parameters are ubiquitous in patients with ischemic cardiomyopathy. Annals of Noninvasive Electrocardiology (Jan), 17: 245-251.
Canty Jr, JM and Suzuki G. (2012) Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease. J Mol Cell Cardiol (Jan), 52: 822-831.
Suzuki G, Iyer V, Lee TC, Canty, JM Jr. (2011) Autologous mesenchymal stem cells mobilize cKit positive and CD133 positive bone marrow progenitor cells and improve regional function in hibernating myocardium. Circulation Research (Oct), 109(9): 1044-1054.
Suzuki G, Iyer V, Lee TC, Canty JM. (2011) Autologous mesenchymal stem cells mobilize cKit+ and CD133+ bone marrow progenitor cells and improve regional function in hibernating myocardium. Circulation research (Oct), 109(9): 1044-54.
Tu C, Li J, Young R, Page BJ, Engler F, Halfon MS, Canty JM, Qu J. (2011) Combinatorial peptide ligand library treatment followed by a dual-enzyme, dual-activation approach on a nanoflow liquid chromatography/orbitrap/electron transfer dissociation system for comprehensive analysis of swine plasma proteome. Analytical chemistry (Jun), 83(12): 4802-13. doi:10.1021/ac200376m
Fernandez SF, Basra M and Canty, Jr. JM. (2011) Takotsubo cardiomyopathy following initial chemotherapy presenting with syncope and cardiogenic shock - a case report and literature review. J Clinic Experiment Cardiology (Jan), 17: 1107-1115.
Tu C, J Li, R Young, BJ page, F. Engler, MS Halfon, JM Canty Jr. and J Qu. (2011) Combinatorial peptide ligand library treatment followed by a dual-enzyme, dual-activation approach on a nanoflow liquid chromatography/orbitrap/electron transfer dissocation system for comprehensive analysis of swine plasma proteome. Anal. Chem. (Jan), 2(2): 4802-4813.
Wang W, Lang JK, Suzuki G, Canty JM, Cimato T. (2011) Statins enhance clonal growth of late outgrowth endothelial progenitors and increase myocardial capillary density in the chronically ischemic heart. PloS one (Jan), 6(9): e24868. doi:10.1371/journal.pone.0024868
Fallavollita JA, Canty JM. (2010) Dysinnervated but viable myocardium in ischemic heart disease. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (Dec), 17(6): 1107-15. doi:10.1007/s12350-010-9292-5
Fallavollita JA, Luisi AJ, Yun E, deKemp RA, Canty JM. (2010) An abbreviated hyperinsulinemic-euglycemic clamp results in similar myocardial glucose utilization in both diabetic and non-diabetic patients with ischemic cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (Aug), 17(4): 637-45. doi:10.1007/s12350-010-9228-0
Cary MG, AJ Luisi Jr,, S Baldwa, MJ Veneziano, S Al-Zaiti, RA deKemp, JM Canty Jr and JA Fallavollita. (2010) The Selvester QRS Score is More Accurate than Q Waves and Fragmented QRS Complexes using the Mason-Likar Configuration in Estimating infarct Volume in Patients with Ischemic Cardiomyopathy. J Electrocardiology (Jan), 43: 318-325.
Fallavollita JA, Luisi AJ Jr, Yun E, deKemp RA and Canty JM Jr. (2010) An abbreviated hyperinsulinemic-euglycemic clamp results in similar myocardial glucose utilization in both diabetic and non-diabetic patients with ischemic cardiomyopathy. Journal of Nuclear Cardiology (Jan), 17: 637-645.
Fallavollita JA, Banas MD, Suzuki G, deKemp RA, Sajjad M, Canty JM. (2010) 11C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium. J Nucl Cardiol (Jan), 17(1): 85-96.
Hu Q, Suzuki G, Young RF, Page BJ, Fallavollita JA, Canty JM. (2009) Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol (Jul), 297(1): 223-232.
Duan X, Young R, Straubinger RM, Page B, Cao J, Wang H, Yu H, Canty JM, Qu J. (2009) A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome. J Proteome Res (Jun), 8(6): 2838-2850.
Suzuki G, Iyer V, Cimato T, Canty JM. (2009) Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle. Circ Res (Jan), 104(2): 255-264.
Jing D, Parikh A, Canty JM, Tzanakakis ES. (2008) Stem cells for heart cell therapies. Tissue Eng Part B Rev (Dec), 14(4): 393-406.
Baldwa S, Rana M, Canty JM, Fallavollita JA. (2008) Comparison of thallium deposition with segmental perfusion in pigs with chronic hibernating myocardium. Am J Physiol Heart Circ Physiol (Dec), 295(6): 2522-2529.
Sidhu S, Gangasani A, Korotchkina LG, Suzuki G, Fallavollita JA, Canty JM, Patel MS. (2008) Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. American journal of physiology. Heart and circulatory physiology (Sep), 295(3): H946-H952. doi:10.1152/ajpheart.00363.2008
Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM, Lee T. (2008) Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. J Cell Physiol (Aug), 216(2): 458-468.
Leiker M, G Suzuki, VS Iyer, JM Canty Jr., and TC Lee. (2008) Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplantation (Jan)911-922.
Page B, Young R, Iyer V, Suzuki G, Lis M, Korotchkina L, Patel MS, Blumenthal KM, Fallavollita JA, Canty JM Jr. (2008) Persistent Regional Downregulation in Mitochondrial Enzymes and Upregulation of Stress Proteins in Swine with Chronic Hibernating Myocardium. Circulation Research (Jan), 102: 103-112.
Sidhu S, A Gangasani, LB Korotchkina, G Suzuki, JA Fallavollita, JM Canty and MS Patel. (2008) Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. Am. J. Physiol. Heart Circ. Physiol. (Jan), 295: 946-952.
Canty JM, Iyer VS. (2007) Hydrogen peroxide and metabolic coronary flow regulation. J Am Coll Cardiol (Sep), 50(13): 1279-1281.
Banas MD, Baldwa S, Suzuki G, Canty JM, Fallavollita JA. (2007) Determinants of contractile reserve in viable, chronically dysfunctional myocardium. American journal of physiology. Heart and circulatory physiology (Jun), 292(6): H2791-7.
Lynch P, Lee TC, Fallavollita JA, Canty JM Jr, Suzuki G. (2007) Intracoronary administration of AdvFGF-5 (Fibroblast Growth Factor-5) ameliorates left ventricular dysfunction and prevents myocyte loss in swine with developing collaterals and ischemic cardiomyopathy. Circulation. (Jan), 116: 71-76.
Carey MG, Luisi AJ, Baldwa S, Thomas JM, Canty JM, Fallavollita, JA. (2007) The presence of Q Waves, QRS Fragmerntation or QRS Duration does not correlate with scar volume in patients with ischemic cardiomyopathy circulation. Circulation (Jan), 116.
Pizzuto MF, Valverde AM, Heavey BM, Banas MD, Michelakis N, Suzuki G, Fallavollita JA, Canty JM. (2006) Brief sympathetic activation precedes the development of ventricular tachycardia and ventricular fibrillation in hibernating myocardium. Journal of electrocardiology (Oct), 39(4 Suppl): S140-5.
Fallavollita JA, Luisi AJ, Michalek SM, Valverde AM, deKemp RA, Haka MS, Hutson AD, Canty JM. (2006) Prediction of arrhythmic events with positron emission tomography: PAREPET study design and methods. Contemp Clin Trials (Aug), 27(4): 374-388.
Banas, M.D. Young, H. Fallavollita, J.A. Canty, J.M., Jr. (2006) Persistent reductions in flow and function after revascularization of swine with hibernating myocardium. Journal of the American College of Cardiology (Jan).
Canty, Jr. JM. (2006) Brief sympathetic activation precedes the development of VT/VF in hibernating myocardium. J. Electrocardiol (Jan), 39: 140-145.
Fallavollita JA, Riegel BJ, Suzuki G, Valeti U, Canty JM. (2005) Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy. American journal of physiology. Heart and circulatory physiology (Dec), 289(6): H2688-96.
Ovchinnikov V, Suzuki G, Canty JM, Fallavollita JA. (2005) Blunted functional responses to pre- and postjunctional sympathetic stimulation in hibernating myocardium. Am J Physiol Heart Circ Physiol (Oct), 289(4): 1719-1728.
Iyer VS, Canty JM. (2005) Regional desensitization of beta-adrenergic receptor signaling in swine with chronic hibernating myocardium. Circ Res (Oct), 97(8): 789-795.
Luisi AJ, Suzuki G, Dekemp R, Haka MS, Toorongian SA, Canty JM, Fallavollita JA. (2005) Regional 11C-hydroxyephedrine retention in hibernating myocardium: chronic inhomogeneity of sympathetic innervation in the absence of infarction. J Nucl Med (Aug), 46(8): 1368-1374.
Suzuki G, Lee TC, Fallavollita JA, Canty JM. (2005) Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle. Circulation research (Apr), 96(7): 767-75.
Suzuki, G Lee, TC Fallavollita, JA Canty, JM, Jr. (2005) Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle. Circulation Research (Jan), 96: 767-775.
Gangasani, A. Sidhu, S. Fallavollita, J.A. Korotchkina, L. G. Suzuki, G. Patel, M.S. Canty, J.M., Jr. (2005) Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy. Circulation (Jan), 112(II): II-21-II-22.
Canty, J. M. Fallavollita, J. A. (2005) Hibernating myocardium. J Nucl Cardiol (Jan), 12(1): 104-119.
Canty JM, Fallavollita JA. (2005) Hibernating myocardium. J Nucl Cardiol (Jan), 12(1): 104-119.
Vacanti V, Kong E, Suzuki G, Sato K, Canty JM Jr, Lee TC. (2005) Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture. Journal of Cellular Physiology (Jan), 205: 194-201.
Fallavollita, J.A. Riegel, B.J. Suzuki, G. Valeti, U. Canty, J.M., Jr. (2005) Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy. American Journal of Physiology - Heart & Circulatory Physiology (Jan), 289: H2688-H2696.
Luisi AJ Canty, J.M., Jr. deKemp, R.A. Haka, M.S. Toorongian, S.A. Fallavollita, J.A. (2005) Patients with ischemic cardiomyopathy eligible for ICD therapy demonstrate extensive sympathetic denervation out of proportion to previous infarction. Circulation (Jan), 112: 472-472.
Luisi AJ Fallavollita, J.A. Luisi, A.J. Valverde, A.M. Michalek, S.M. Heavey, B.M. Canty, J.M. (2005) Electrocardiographic risk stratification of sudden cardiac death. J Electrocardiol (Jan), 35(4S): 140-140.
Thijssen VL, Borgers M, Lenders MH, Ramaekers FC, Suzuki G, Palka B, Fallavollita JA, Thomas SA, Canty JM. (2004) Temporal and spatial variations in structural protein expression during the progression from stunned to hibernating myocardium. Circulation (Nov), 110(21): 3313-21.
Fallavollita JA, Valeti U, Oza S, Canty JM. (2004) Spatial heterogeneity of endocardial voltage amplitude in viable, chronically dysfunctional myocardium. Basic Res Cardiol (May), 99(3): 212-222.
Canty JM, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA. (2004) Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death. Circ Res (Apr), 94(8): 1142-1149.
Canty JM, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA. (2004) Hibernating Myocardium. Chronically Adapted to Ischemia but Vulnerable to Sudden Death. Circ Res (Mar).
Thijssen VL, Borgers M, Lenders MH, Ramaekers FC, Suzuki G, Palka B, Fallavollita JA, Thomas SA, Canty JM Jr. (2004) Temporal and Spatial Variations in Structural Protein Expression During the Progression From Stunned to Hibernating Myocardium. Circulation (Jan), 110(21): 2213-2221.
Canty JM, Fallavollita JA. (2003) Sympathetic nerves and myocyte necrosis: more than meets the eye. Circ Res (Oct), 93(9): 796-798.
Fallavollita JA, Malm BJ, Canty JM. (2003) Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circ Res (Jan), 92(1): 48-55.
Fallavollita JA, Malm BJ, Canty JM. (2003) Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circulation research (Jan), 92(1): 48-55.
Malm BJ, Suzuki G, Canty JM, Fallavollita JA. (2002) Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation. Cardiovascular research (Dec), 56(3): 422-32.
Malm BJ, Suzuki G, Canty JM, Fallavollita JA. (2002) Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation. Cardiovasc Res (Dec), 56(3): 422-432.
Thomas SA, Fallavollita JA, Suzuki G, Borgers M, Canty JM. (2002) Dissociation of regional adaptations to ischemia and global myolysis in an accelerated Swine model of chronic hibernating myocardium. Circulation research (Nov), 91(10): 970-7.
Thomas SA, Fallavollita JA, Suzuki G, Borgers M, Canty JM. (2002) Dissociation of regional adaptations to ischemia and global myolysis in an accelerated Swine model of chronic hibernating myocardium. Circ Res (Nov), 91(10): 970-977.
Luisi AJ, Fallavollita JA, Suzuki G, Canty JM. (2002) Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium. Circulation (Aug), 106(7): 779-81.
Fallavollita JA, Logue M, Canty JM. (2002) Coronary patency and its relation to contractile reserve in hibernating myocardium. Cardiovascular research (Jul), 55(1): 131-40.
Fallavollita JA, Logue M, Canty JM. (2002) Coronary patency and its relation to contractile reserve in hibernating myocardium. Cardiovasc Res (Jul), 55(1): 131-140.
Canty JM, Lee TC. (2002) Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don‘t. J Mol Cell Cardiol (Apr), 34(4): 375-377.
Fallavollita JA, Canty JM. (2002) Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium. Am J Physiol Heart Circ Physiol (Apr), 282(4): 1370-1379.
Fallavollita JA, Canty JM. (2002) Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium. American journal of physiology. Heart and circulatory physiology (Apr), 282(4): H1370-9.
Luisi AJ, Fallavollita JA, Suzuki G, Canty JM. (2002) Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium. Circulation (Jan), 106(7): 779-781.
Canty, Jr. JM, T-C Lee. (2002) Troponin I proteolysis and mocardial stunning: Now you see it - now you don't. J. Mol. Cell. Cardiol. (Jan), 34: 375-377.
Canty JM Jr, Suzuki G. (2002) Heterogeneity of apoptosis and myolysis in coronary microembolization: A competition between programmed cell death and programmed cell survival. European Heart Journal (Jan), 23(11): 838-840.
Fallavollita JA, Lim H, Canty JM. (2001) Myocyte apoptosis and reduced SR gene expression precede the transition from chronically stunned to hibernating myocardium. J Mol Cell Cardiol (Nov), 33(11): 1937-1944.
Fallavollita JA, Lim H, Canty JM. (2001) Myocyte apoptosis and reduced SR gene expression precede the transition from chronically stunned to hibernating myocardium. Journal of molecular and cellular cardiology (Nov), 33(11): 1937-44.
Canty JM, Fallavollita JA. (2001) Lessons from experimental models of hibernating myocardium. Coronary artery disease (Aug), 12(5): 371-80.
Canty JM, Fallavollita JA. (2001) Lessons from experimental models of hibernating myocardium. Coron Artery Dis (Aug), 12(5): 371-380.
Dube S, Canty JM. (2001) Shear stress-induced vasodilation in porcine coronary conduit arteries is independent of nitric oxide release. American journal of physiology. Heart and circulatory physiology (Jun), 280(6): H2581-90.
Fallavollita JA, Logue M, Canty JM. (2001) Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. J Am Coll Cardiol (Jun), 37(7): 1989-1995.
Dube S, Canty JM. (2001) Shear stress-induced vasodilation in porcine coronary conduit arteries is independent of nitric oxide release. Am J Physiol Heart Circ Physiol (Jun), 280(6): 2581-2590.
Fallavollita JA, Logue M, Canty JM. (2001) Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. Journal of the American College of Cardiology (Jun), 37(7): 1989-95.
Feng J, Schaus BJ, Fallavollita JA, Lee TC, Canty JM. (2001) Preload induces troponin I degradation independently of myocardial ischemia. Circulation (Apr), 103(16): 2035-7.
Feng J, Schaus BJ, Fallavollita JA, Lee T, Canty, Jr. JM. (2001) Preload induces troponin I degradation independently of myocardial ischemia. Circulation (Apr), 103(16): 2035-2037.
Pizzuto MF, AM Valverde, BM Heavey, MD Basnas, N Michelakis, G Suzuki, JA Fallavollita and JM Canty Jr. (2001) Brief sympathetic activation precedes the development of VT/VF in reductions in flow, function and coronary flow reserve. J. Am. .Coll. Cardiol (Jan), 37: 1989-1995.
Fallavollita JA, Logue M, Canty JM. (2001) Stability of hibernating myocardium in pigs with chronic LAD stenosis: Absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. J Am Coll Cardiol, (Jan), 37: 1989-1995.
Kositprapa C, Zhang B, Berger S, Canty JM, Lee TC. (2000) Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes. Mol Cell Biochem (Nov), 214(1-2): 47-55.
Kositprapa C, Zhang B, Berger S, Canty JM, Lee TC. (2000) Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes. Molecular and cellular biochemistry (Nov), 214(1-2): 47-55.
Fallavollita JA, Trojan C, Canty JM. (2000) Transmural distribution of FDG uptake in stunned myocardium. American journal of physiology. Heart and circulatory physiology (Jul), 279(1): H102-9.
Fallavollita JA, Trojan C, Canty JM. (2000) Transmural distribution of FDG uptake in stunned myocardium. Am J Physiol Heart Circ Physiol (Jul), 279(1): 102-109.
Canty JM, Fallavollita JA. (2000) Chronic hibernation and chronic stunning: a continuum. J Nucl Cardiol (Jan), 7(5): 509-527.
Canty, Jr. JM. (2000) Nitric oxide and short-term hibernation. Friend or foe?. Circ. Res. (Jan), 87: 85-87.
Lim H, Fallavollita JA, Hard R, Kerr CW, Canty JM. (1999) Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium. Circulation (Dec), 100(23): 2380-6.
Lim H, Fallavollita JA, Hard R, Kerr CW, Canty JM. (1999) Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium. Circulation (Dec), 100(23): 2380-2386.
Morgan EN, Boyle EM, Yun W, Kovacich JC, Canty TG, Chi E, Pohlman TH, Verrier ED. (1999) Platelet-activating factor acetylhydrolase prevents myocardial ischemia-reperfusion injury. Circulation (Nov), 100(19 Suppl): II365-8.
Boyle EM, Canty TG, Morgan EN, Yun W, Pohlman TH, Verrier ED. (1999) Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription. The Annals of thoracic surgery (Nov), 68(5): 1949-53.
Fallavollita JA, Jacob S, Young RF, Canty JM. (1999) Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium. Am J Physiol (Oct), 277(4 Pt): 1418-1428.
Fallavollita JA, Jacob S, Young RF, Canty JM. (1999) Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium. The American journal of physiology (Oct), 277(4): H1418-28.
Thomas SA, Fallavollita JA, Lee T, Feng J, Canty, Jr. JM. (1999) Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine. Circ Res (Sep), 85(5): 446-456.
Thomas SA, Fallavollita JA, Lee TC, Feng J, Canty JM. (1999) Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine. Circulation research (Sep), 85(5): 446-56.
Morgan EN, Boyle EM, Yun W, Griscavage-Ennis JM, Farr AL, Canty TG, Pohlman TH, Verrier ED. (1999) An essential role for NF-kappaB in the cardioadaptive response to ischemia. The Annals of thoracic surgery (Aug), 68(2): 377-82.
Boyle EM, Morgan EN, Kovacich JC, Canty TG, Verrier ED. (1999) Microvascular responses to cardiopulmonary bypass. Journal of cardiothoracic and vascular anesthesia (Aug), 13(4 Suppl 1): 30-5; discussion 36-7.
Canty JM, Fallavollita JA. (1999) Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology. Am J Physiol (Jul), 277(1 Pt): 417-422.
Kovacich JC, Boyle EM, Morgan EN, Canty TG, Farr AL, Caps MT, Frank N, Pohlman TH, Verrier ED. (1999) Inhibition of the transcriptional activator protein nuclear factor kappaB prevents hemodynamic instability associated with the whole-body inflammatory response syndrome. The Journal of thoracic and cardiovascular surgery (Jul), 118(1): 154-62.
Canty JM, Fallavollita JA. (1999) Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology. The American journal of physiology (Jul), 277(1): H417-22.
Fallavollita JA, Canty JM. (1999) Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs. Circulation (Jun), 99(21): 2798-805.
Fallavollita JA, Canty JM. (1999) Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs. Circulation (Jun), 99(21): 2798-2805.
Boyle EM, Kovacich JC, Canty TG, Morgan EN, Chi E, Verrier ED, Pohlman TH. (1998) Inhibition of nuclear factor-kappa B nuclear localization reduces human E-selectin expression and the systemic inflammatory response. Circulation (Nov), 98(19 Suppl): II282-8.
Boyle EM, Kovacich JC, Hèbert CA, Canty TG, Chi E, Morgan EN, Pohlman TH, Verrier ED. (1998) Inhibition of interleukin-8 blocks myocardial ischemia-reperfusion injury. The Journal of thoracic and cardiovascular surgery (Jul), 116(1): 114-21.
Canty TG, Mainwaring R, Vecchione T, Lamberti J, Collins D, Lynch F, Mathewson J. (1998) Separation of omphalopagus twins: unique reconstruction using syngeneic cryopreserved tissue. Journal of pediatric surgery (May), 33(5): 750-3.
Canty TG, Boyle EM, Linden B, Healey PJ, Tapper D, Hall DG, Sawin RS, Foker JE. (1997) Aortic arch anomalies associated with long gap esophageal atresia and tracheoesophageal fistula. Journal of pediatric surgery (Nov), 32(11): 1587-91.
Mehta NK, Carroll M, Sykes DE, Tan Z, Bergsland J, Canty J, Bhayana JN, Hoover EL, Salerno TA. (1997) Heat shock protein 70 expression in native and heterotopically transplanted rat hearts. The Journal of surgical research (Jul), 70(2): 151-5.
Fallavollita JA, Perry BJ, Canty JM. (1997) 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium. Circulation (Apr), 95(7): 1900-9.
Fallavollita JA, Perry BJ, Canty JM. (1997) 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium. Circulation (Apr), 95(7): 1900-1909.
Mehta NK, M Caroll, DE Sykes, Z Tan, J Bergsland, JM Canty, JN Bhayana, EL Hoover and TA Salerno. (1997) Heat shock protein 70 expression in native and heterotopically transplanted rat hearts. J. Surg (Jan), 70: 151-155.
Fallavollita JA, BJ Perry and JM Canty Jr. (1997) F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: Evidence for transmural variations in chronic hibernating myocardium. Circulation (Jan), 95: 1900-1909.
Fallavollita JA, Kumar K, Brody AS, Bunnell IL, Canty JM. (1996) Detection of coronary artery calcium to differentiate patients with early coronary atherosclerosis from luminally normal arteries. Am J Cardiol (Dec), 78(11): 1281-1284.
Fallavollita JA, Kumar K, Brody AS, Bunnell IL, Canty JM. (1996) Detection of coronary artery calcium to differentiate patients with early coronary atherosclerosis from luminally normal arteries. The American journal of cardiology (Dec), 78(11): 1281-4.
Canty JM, Smith TP. (1995) Modulation of coronary autoregulatory responses by endothelium-derived nitric oxide. International journal of cardiology (Jul), 50(3): 207-15.
Canty JM, Smith TP. (1995) Modulation of coronary autoregulatory responses by endothelium-derived nitric oxide. Int J Cardiol (Jul), 50(3): 207-215.
Canty JM, Smith TP. (1995) Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state. Circ Res (Jun), 76(6): 1079-1087.
Canty JM, Smith TP. (1995) Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state. Circulation research (Jun), 76(6): 1079-87.
Rajagopalan S, Dube S, Canty JM. (1995) Regulation of coronary diameter by myogenic mechanisms in arterial microvessels greater than 100 microns in diameter. The American journal of physiology (Feb), 268(2 Pt 2): H788-93.
Rajagopalan S, Dube S, Canty JM. (1995) Regulation of coronary diameter by myogenic mechanisms in arterial microvessels greater than 100 microns in diameter. Am J Physiol (Feb), 268(2 Pt): 788-793.
Canty JM, Fallavollita JA. (1995) Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis. Basic Res Cardiol (Jan), 90(1): 5-8.
Fallavollita JA, Brody AS, Bunnell IL, Kumar K, Canty JM. (1994) Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old. Circulation (Jan), 89(1): 285-90.
Canty JM, Schwartz JS. (1994) Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs. Circulation (Jan), 89(1): 375-384.
Fallavollita JA, Brody AS, Bunnell IL, Kumar K, Canty JM. (1994) Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old. Circulation (Jan), 89(1): 285-290.
Canty JM, Schwartz JS. (1994) Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs. Circulation (Jan), 89(1): 375-84.
Canty JM. (1993) Measurement of myocardial perfusion by fast computed tomography. Am J Card Imaging (Dec), 7(4): 309-316.
Canty JM. (1993) Measurement of myocardial perfusion by fast computed tomography. American journal of cardiac imaging (Dec), 7(4): 309-16.
Canty JM. (1993) Methods of assessing coronary blood flow and flow reserve. Am J Card Imaging (Sep), 7(3): 222-232.
Canty JM. (1993) Methods of assessing coronary blood flow and flow reserve. American journal of cardiac imaging (Sep), 7(3): 222-32.
Satoh S, Klocke FJ, Canty JM. (1993) Tone-dependent coronary arterial-venous pressure differences at the cessation of venous outflow during long diastoles. Circulation (Sep), 88(3): 1238-44.
Satoh S, Klocke FJ, Canty JM. (1993) Tone-dependent coronary arterial-venous pressure differences at the cessation of venous outflow during long diastoles. Circulation (Sep), 88(3): 1238-1244.
Smith TP, Canty JM. (1993) Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs. Circulation research (Aug), 73(2): 232-40.
Smith TP, Canty JM. (1993) Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs. Circ Res (Aug), 73(2): 232-240.
Grant BJ, Canty JM, Srinivasan G, Brody AS. (1993) Pulmonary arterial elasticity in awake dogs. J Appl Physiol (Aug), 75(2): 840-848.
Canty, Jr. JM. (1993) Measurement of Myocardial Perfusion by fast X-ray computed Tomography. Am. J. Cardiac Imag. (Jan), 7: 309-316.
Canty JM, Judd RM, Brody AS, Klocke FJ. (1991) First-pass entry of nonionic contrast agent into the myocardial extravascular space. Effects on radiographic estimates of transit time and blood volume. Circulation (Nov), 84(5): 2071-2078.
Canty JM, Judd RM, Brody AS, Klocke FJ. (1991) First-pass entry of nonionic contrast agent into the myocardial extravascular space. Effects on radiographic estimates of transit time and blood volume. Circulation (Nov), 84(5): 2071-8.
Farhi ER, Canty JM, Klocke FJ. (1991) Dissociation of diastolic pressure-segment length and pressure-wall thickness relations during vasodilation in the conscious dog. Journal of the American College of Cardiology (Sep), 18(3): 850-7.
Farhi ER, Canty JM, Klocke FJ. (1991) Dissociation of diastolic pressure-segment length and pressure-wall thickness relations during vasodilation in the conscious dog. J Am Coll Cardiol (Sep), 18(3): 850-857.
Farhi ER, Klocke FJ, Mates RE, Kumar K, Judd RM, Canty JM, Satoh S, Sekovski B. (1991) Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts. Circ Res (Feb), 68(2): 392-401.
Farhi ER, Klocke FJ, Mates RE, Kumar K, Judd RM, Canty JM, Satoh S, Sekovski B. (1991) Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts. Circulation research (Feb), 68(2): 392-401.
Canty JM, Giglia J, Kandath D. (1990) Effect of tachycardia on regional function and transmural myocardial perfusion during graded coronary pressure reduction in conscious dogs. Circulation (Nov), 82(5): 1815-25.
Canty JM, Giglia J, Kandath D. (1990) Effect of tachycardia on regional function and transmural myocardial perfusion during graded coronary pressure reduction in conscious dogs. Circulation (Nov), 82(5): 1815-1825.
Canty JM, Brooks A. (1990) Phasic volumetric coronary venous outflow patterns in conscious dogs. Am J Physiol (May), 258(5 Pt): 1457-1463.
Canty JM, Brooks A. (1990) Phasic volumetric coronary venous outflow patterns in conscious dogs. The American journal of physiology (May), 258(5 Pt 2): H1457-63.
Thorp D, Canty A, Whiting J, Dart G, Lloyd JV, Duncan E, Gallus A. (1990) Plasma exchange and heparin-induced thrombocytopenia. Progress in clinical and biological research (Jan), 337: 521-2.
Farhi ER, Canty JM, Klocke FJ. (1989) Effects of graded reductions in coronary perfusion pressure on the diastolic pressure-segment length relation and the rate of isovolumic relaxation in the resting conscious dog. Circulation (Nov), 80(5): 1458-1468.
Farhi ER, Canty JM, Klocke FJ. (1989) Effects of graded reductions in coronary perfusion pressure on the diastolic pressure-segment length relation and the rate of isovolumic relaxation in the resting conscious dog. Circulation (Nov), 80(5): 1458-68.
Grant BJ, Canty JM. (1989) Effect of cardiac output on pulmonary hemodynamics. Respir Physiol (Jun), 76(3): 303-317.
Canty JM. (1988) Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog. Circ Res (Oct), 63(4): 821-836.
Canty JM. (1988) Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog. Circulation research (Oct), 63(4): 821-36.
Mates RE, Klocke FJ, Canty JM. (1988) Coronary capacitance. Prog Cardiovasc Dis (Jul), 31(1): 1-15.
Canty JM, Klocke FJ. (1987) Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure. Circulation research (Nov), 61(5 Pt 2): II107-16.
Canty JM, Klocke FJ. (1987) Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure. Circ Res (Nov), 61(5 Pt): 107-116.
Klocke FJ, Ellis AK, Canty JM. (1987) Interpretation of changes in coronary flow that accompany pharmacologic interventions. Circulation (Jun), 75(6 Pt 2): V34-8.
Klocke FJ, Ellis AK, Canty JM. (1987) Interpretation of changes in coronary flow that accompany pharmacologic interventions. Circulation (Jun), 75(6 Pt): 34-38.
Canty AA, Driedzic WR. (1987) Evidence that myoglobin does not support heart performance at maximal levels of oxygen demand. The Journal of experimental biology (Mar), 128: 469-73.
Canty JM, Klocke FJ, Mates RE. (1987) Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters. Circulation research (Feb), 60(2): 273-82.
Canty JM, Klocke FJ, Mates RE. (1987) Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters. Circ Res (Feb), 60(2): 273-282.
Klocke FJ, Canty JM, Arani DT, Krawczyk JA. (1986) Adjustments in regional coronary perfusion accompanying reductions in regional coronary arterial pressure. Can J Cardiol (Jul), Suppl: 200-204.
Klocke FJ, Canty JM, Arani DT, Krawczyk JA. (1986) Adjustments in regional coronary perfusion accompanying reductions in regional coronary arterial pressure. The Canadian journal of cardiology (Jul), Suppl A: 200A-204A.
Canty JM, Klocke FJ, Mates RE. (1985) Pressure and tone dependence of coronary diastolic input impedance and capacitance. The American journal of physiology (May), 248(5 Pt 2): H700-11.
Canty JM, Klocke FJ, Mates RE. (1985) Pressure and tone dependence of coronary diastolic input impedance and capacitance. Am J Physiol (May), 248(5 Pt): 700-711.
Klocke FJ, Mates RE, Canty JM, Ellis AK. (1985) Coronary pressure-flow relationships. Controversial issues and probable implications. Circ Res (Mar), 56(3): 310-323.
Klocke FJ, Mates RE, Canty JM, Ellis AK. (1985) Coronary pressure-flow relationships. Controversial issues and probable implications. Circulation research (Mar), 56(3): 310-23.
Canty JM, Klocke FJ. (1985) Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve. Circulation (Feb), 71(2): 370-7.
Canty JM, Klocke FJ. (1985) Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve. Circulation (Feb), 71(2): 370-377.
Aversano T, Klocke FJ, Mates RE, Canty JM. (1984) Preload-induced alterations in capacitance-free diastolic pressure-flow relationship. The American journal of physiology (Mar), 246(3 Pt 2): H410-7.
Aversano T, Klocke FJ, Mates RE, Canty JM. (1984) Preload-induced alterations in capacitance-free diastolic pressure-flow relationship. Am J Physiol (Mar), 246(3 Pt): 410-417.
Canty JM, Mates RE. (1982) A programmable pressure control system for coronary flow studies. Am J Physiol (Nov), 243(5): 796-802.
Canty JM, Mates RE. (1982) A programmable pressure control system for coronary flow studies. The American journal of physiology (Nov), 243(5): H796-802.
Klocke FJ, Weinstein IR, Klocke JF, Ellis AK, Kraus DR, Mates RE, Canty JM, Anbar RD, Romanowski RR, Wallmeyer KW, Echt MP. (1981) Zero-flow pressures and pressure-flow relationships during single long diastoles in the canine coronary bed before and during maximum vasodilation. Limited influence of capacitive effects. J Clin Invest (Oct), 68(4): 970-980.
Klocke FJ, Weinstein IR, Klocke JF, Ellis AK, Kraus DR, Mates RE, Canty JM, Anbar RD, Romanowski RR, Wallmeyer KW, Echt MP. (1981) Zero-flow pressures and pressure-flow relationships during single long diastoles in the canine coronary bed before and during maximum vasodilation. Limited influence of capacitive effects. The Journal of clinical investigation (Oct), 68(4): 970-80. doi:10.1172/JCI110351
Duncker DJ, Koller A, Merkus D, Canty JM. (1900) Regulation of coronary blood flow in health and ischemic heart disease. Progress in cardiovascular diseases (Jan), 57(5): 409-22. doi:10.1016/j.pcad.2014.12.002
Canty JM, Fallavollita JA. (1900) Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis. Basic research in cardiology (Jan), 90(1): 5-8.
Al-Zaiti SS, Pietrasik G, Carey MG, Alhamaydeh M, Canty JM, Fallavollita JA. (1900) The role of heart rate variability, heart rate turbulence, and deceleration capacity in predicting cause-specific mortality in chronic heart failure. Journal of electrocardiology (Jan), 52: 70-74. doi:10.1016/j.jelectrocard.2018.11.006
Al-Zaiti SS, Fallavollita JA, Canty JM, Carey MG. (1900) Electrocardiographic predictors of sudden and non-sudden cardiac death in patients with ischemic cardiomyopathy. Heart & lung : the journal of critical care (Jan), 43(6): 527-33. doi:10.1016/j.hrtlng.2014.05.008
Al-Zaiti SS, Fallavollita JA, Canty JM, Carey MG. (1900) The prognostic value of discordant T waves in lead aVR: A simple risk marker of sudden cardiac arrest in ischemic cardiomyopathy. Journal of electrocardiology (Jan), 48(5): 887-92. doi:10.1016/j.jelectrocard.2015.06.013
Canty JM, Fallavollita JA. (1900) Chronic hibernation and chronic stunning: a continuum. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (Jan), 7(5): 509-27.
Carey MG, Luisi AJ, Baldwa S, Al-Zaiti S, Veneziano MJ, deKemp RA, Canty JM, Fallavollita JA. (1900) The Selvester QRS Score is more accurate than Q waves and fragmented QRS complexes using the Mason-Likar configuration in estimating infarct volume in patients with ischemic cardiomyopathy. Journal of electrocardiology (Jan), 43(4): 318-25. doi:10.1016/j.jelectrocard.2010.02.011

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Books and Book Chapters:

Duncker DJGM and Canty JM Jr. (2021) Coronary Blood Flow and Myocardial Ischemia. In: Braunwald's Heart Disease. Elsevier, 609-635.
Fernandez SF, Canty JM, Fallavollita J. (2017) Atlas of Cardiac Innervation. In: PET imaging and quantitation of cardiac innervation. Spring International Publishing, 71-82.
Canty Jr JM, and DJGM Duncker. (2014) Braunwald‘s Heart Disease. In: Coronary blood flow and myocardial ischemia (10th Ed). Elsevier, 1029-1056.
Canty, Jr. JM and B Weil. (2013) Coronary Blood Flow and Myocardial Ischemia. Humana Press.
Canty, Jr. JM. (2012) Braunwald‘s Heart Disease, 9th Edition. In: Coronary blood flow and myocardial ischemia. Elsevier, 1049-1075.
Canty, Jr.; Fallavollita J. (2010) In: Pathophysiological basis of hibernating myocardium. , 577-593.
Canty, Jr. JM. (2007) Braunwald's Heart Disease, 8th Edition. In: Coronary blood flow and myocardial ischemia. Elsevier, 1167-1194.
Canty, Jr. JM. (1997) Stunning, Hibernation and Preconditioning: Clinical Pathophysiology of Myocardial Ischemia. In: Myocardial perfusion-contraction matching. Vatner and Wijns, 49-68.
Mates RE, JM Canty Jr, E Farhi, R Judd and FJ Klocke. (1991) Imaging, Measurement and Analysis of the Heart. In: Clinical importance of coronary pressure-flow relationships. Hemisphere, 199-211.
Canty JM, Jr., J Giglia and FJ Klocke. (1990) Inhomogeneity and Imaging. In: Prediction of endocardial ischemia with indices of coronary driving pressure and endocardial function in conscious dogs. Freund, 315-334.
Canty, Jr. JM and FJ Klocke. (1987) Activation, Metabolism and Perfusion of the Heart. In: Modulation of coronary autoregulatory responses. Martinus Nijhoff, 519-530.
Mates, R. E., F. J. Klocke and J. M. Canty, Jr. JM. (1987) In: Impedance to coronary flow. In: Activation, Metabolism and Perfusion of the Heart. , 409-418.
Klocke, F. J., R. E. Mates, J. M. Canty, Jr. and A. K. Ellis. (1987) Simulation and Control of the Cardiac System. In: Current controversies concerning coronary pressure-flow relationships. CRC Press, 169-180.
Klocke, F. J., J. M. Canty, Jr., and R. E. Mates. JM. (1984) Functional Aspects of the Normal, Hypertrophied and Failing Heart. F. L. Abel and W.H. Newman, editors. In: Evolving concepts of coronary pressure-flow relationships. Martinus Nijhoff Publishing, 40-56.
Mates, R. E., T. Burns, J. M. Canty, R. Greenberg and J. Neeson. JM. (1983) Mechanics of the Coronary Circulation. In: Modeling diastolic impedance to coronary blood flow. American Society of Mechanical Engineers, 41-44.

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Abstracts:

Allen, S, Ang, S, Smith, C, Techiryan, G, Canty J, Weil BR. (2019) Deterioration of Hemodynamic Support During Prolonged Mechanical CPR in a Porcine Model of Cardiac Arrest. AHA Resuscitation Symposium 2019, (Nov) 2049-2064
Weil BR, Allen, S, Barbaccia, B, Young, R, Palka, B, Canty J. (2019) A Blinded, Randomized, Vehicle-Controlled Preclinical Trial of Novel Nanoparticle Formulations of Triiodothyronine in Cardiac Arrest. American Heart Association - Resuscitation Science Symposium 2019, (Nov)
Wang, JZ, Kaps, N, Lavallee, A, Renaud, J, Zelt, J, Beanlands, R, Fallavollita JA, Canty J, deKemp, R. (2019) Quantitative imaging biomarkers of cardiac sympathetic innervation and perfusion using C-11-metahydroxyephedrine and N-13-ammonia PET in ischemic cardiomyopathy. International Congress of Nuclear Cardiology and Cardiac CT, (May)
Wang, JZ, Kaps, N, Lavallee, A, Renaud, J, Zelt, J, Beanlands, R, Fallavollita JA, Canty J, deKemp, R. (2019) Comparison of C-11-meta-hydroxyephedrine and N-13-ammonia PET imaging biomarkers of cardiac sympathetic innervation and perfusion in ischemic cardiomyopathy. Journal Nucelar Medicine, (Jan)
Singh V, Malhotra S, Canty J, Fallavollita JA. (2018) The volume of denervated myocardium predicts sudden cardiac death (SCD) and ICD therapies for VF but not ICD therapies for slower ventricular tachyarrhythmia (VT): An analysis of the prediction of arrhythmic events with positron emission tomography (PARE. Journal of the American College of Cardiology, (May)

Professional Memberships:

European Society of Cardiology; Member (2014–present)
Member, AAMC Council of Faculty and Academic Societies (CFAS) (2013–2016)
President, Association of Professors of Cardiology, 2012-2013 (2012–2013)
Member, International Society for Heart Research, 2011 - present (2011–present)
Fellow, American Physiological Society Cardiovascular Section (2005–present)
Fellow of the American Heart Association, Council on Basic Cardiovascular Sciences (2001–present)
Fellow, American College of Physicians, 1995 – present (1995–present)
Member, American Heart Association Council on Clinical Cardiology, 1993 – present (1993–2002)
Fellow, American Heart Association Council on Circulation, 1985 – 2001 (1985–2001)
Member, American College of Physicians, 1985 – 1994 (1985–1994)
Subspecialty Certification in Cardiovascular Diseases, 1985 (1985)
Member, American Physiological Society, 1985 – present (1985–present)
Fellow, American College of Cardiology, 1985 – present (1985–present)
Member, American Federation for Clinical Research, 1984 – 1998 (1984–1998)
Member, American Society for the Advancement of Science, 1984 – 1986 (1984–1986)
Diplomat, American Board of Internal Medicine, 1984 (1984)
Member, American Heart Association, 1983 (1983)
Affiliate, American College of Cardiology, 1982 – 1985 (1982–1985)
Associate, American College of Physicians, 1981 – 1985 (1981–1985)
Diplomat, National Board of Medical Examiners, 1980 (1980)
Member, American Heart Association Council on Basic Science

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Service Activities:

Search Committee, Chair, Department of Medicine (2023–present)
DSMB NHLBI PIVATAL Study; Member (2022–present)
Presidents Review Board (2021–2024)
Search Committee Dean Jacobs School of Medicine and Vice President of Health Sciences (2021)
University at Buffalo Presidential Advisory Group; Member (2021–present)
European Society of CArdiology Working Group on Coronary Pathophysiology and MIcrocirculation; Member (2019–present)
Member; Trends in Cardiovascular Medicine (2018–present)
University at Buffalo Distinguished ranks/Chancellor's Awards Selection Committee (2017–2020)
Journal of the American College of Cardiology Basic to Translational Science; Member (2016–present)
UB Clinical and Translational Science Award Executive Committee; Member (2015–2019)
Member, NHLBI Program Project Review Committee (PPG Parent); Chaired or co-chaored 6-8 PPG review panels per year (2014–2018)
European Society of Cardiology Task Force for the Fourth Universal Definition of Myocardial Infarction; Member (2014–2018)
Stockton Kimball Awards Selection Committee; Member (2014–present)
Member, American College of Cardiology Awards Committee, 2014 - 2016 Member, American College of Cardiology Awards Committee, 2014 - 2016; Member (2014–2016)
Member, AAMC Council of Faculty and Academic Societies (CFAS); UB Representative (2013–2016)
American Heart Association, Member, Council on Basic Cardiovascular Sciences Writing Committee American Heart Association, Member, Council on Basic Cardiovascular Sciences Writing Committee; Member (2013)
American Heart Association, Member, Council on Basic Cardiovascular Sciences Writing Committee, Scientific Writing Committee "Preclinical Models of Myocardial Ischemia/Reperfusion Injury."; Member (2013)
NHLBI DSMB for the Cardiothoracic Surgical Network (CTSN); Data Safety Monitoring Board (2012–present)
Member, American College of Cardiology Academic Cardiology Council Executive Committee Member, American College of Cardiology Academic Cardiology Council Executive Committee; Member (2012–2015)
University at Buffalo Faculty Senate Budget Priorities Committee; Member (2011–2012)
National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; Kirk Hammond, MD, University of California at San Diego, 2011.; Member (2011)
NHLBI Protocol Review and Monitoring Committee forthe Preclinical Consortium to Facilitate Translation and Cardioprotective Therapies (CAESAR); Chairman (2010–2016)
National Institutes of Health - NHLBI; Ad hoc Member National Institutes of Health - NHLBI; Ad hoc Member; S10 Special Emphasis Panel, 2010; Member (2010)
National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel. National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; Jun Sadoshima, Ph.D., UMDNJ, 2009.; Member (2009)
National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel. National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; Roger Hajjar, M.D., Mount Sinai Medical School, 2009; Member (2009)
UB Clinical and Translational Science Award Steering Committee; Member (2008–2015)
Member, American College of Cardiology Research Awards Committee (ACCF) Member, American College of Cardiology Research Awards Committee (ACCF); Member (2008–2014)
American Heart Association; Member, Melvin L. Marcus Award Selection Committee American Heart Association; Member, Melvin L. Marcus Award Selection Committee.; Member (2008–2010)
American Heart Association; Member, AHA Scientific Publication Committee American Heart Association; Member, AHA Scientific Publication Committee; Member (2008–2009)
University Standing Committee for Facilities Planning and Budget; Member (2008–2009)
National Institutes of Health - NHLBI: Member, R24 Special Emphasis Panel National Institutes of Health - NHLBI: Member, R24 Special Emphasis Panel; Roberto, Bolli, MD, University of Louisville, 2008.; Member (2008)
American Heart Association, Member, Circulation Research Editor Selection Committee American Heart Association, Member, Circulation Research Editor Selection Committee.; Member (2008)
Association of Professors of Cardiology; President 2012-2013 , Council (2011-2014) (2007–2019)
American Heart Association; Member, AHA Interdisciplinary Committee on the Prevention of the Epidemiology and Prevention Council of the American Heart American Heart Association; Member, AHA Interdisciplinary Committee on the Prevention of the Epidemiology and Prevention Council of the American Heart Association; Member (2007–2010)
UBMD Internal Medicine (AMS), Member, Board of Directors; Member (2007–2010)
UBMD Project Team; Member (2007–2008)
National Institutes of Health - NHLBI: Member, Program Project Special Emphasis Panel National Institutes of Health - NHLBI: Member, Program Project Special Emphasis Panel, Kirk Hammond, M.D.; University of California at San Diego, 2006 and 2007.; Member (2006–2007)
National Institutes of Health - NHLBI: Ad hoc Member, Mentored Patient Oriented Research Career Development Award Study Section National Institutes of Health - NHLBI: Ad hoc Member, Mentored Patient Oriented Research Career Development Award Study Section, 2006.; Member (2006)
American Society of Nuclear Cardiology; Member, ASNC Task force on Cardiac Neural Imaging, 2006 American Society of Nuclear Cardiology; Member, ASNC Task force on Cardiac Neural Imaging, 2006; Member (2006)
National Institutes of health - NHLBI, Regular Member National Institutes of health - NHLBI, Regular Member; Myocardial Ischemia and Metabolism Study Section (MIMS), 2005-2009; Member (2005–2009)
National Institutes of Health - NHLBI: Temporary Member, Myocardial Ischemia and Metabolism Study Section National Institutes of Health - NHLBI: Temporary Member, Myocardial Ischemia and Metabolism Study Section; 2004-2005.; Member (2004–2005)
National Institutes of Health - NHLBI: Ad hoc Member, Gene and Drug Delivery Systems Study Section National Institutes of Health - NHLBI: Ad hoc Member, Gene and Drug Delivery Systems Study Section; 2004; Member (2004)
National Institutes of Health - NHLBI; Ad hoc Member, Clinical Cardiovascular Sciences Special Emphasis Panel National Institutes of Health - NHLBI; Ad hoc Member, Clinical Cardiovascular Sciences Special Emphasis Panel, 2003-2004; Member (2003–2004)
University at Buffalo Faculty Senate; Delegate (2002–2004)
National Institutes of Health - NHLBI; Member, Evaluation Committee for the Specialized Centers of Research (SCOR) in Ischemic Heart Disease, Heart Fa National Institutes of Health - NHLBI; Member, Evaluation Committee for the Specialized Centers of Research (SCOR) in Ischemic Heart Disease, Heart Failure and Sudden Cardiac Death, 2002.; Member (2002)
National Institutes of Health - NHLBI: Ad hoc Member, Cardiovascular A special Emphasis panel 2002 National Institutes of Health - NHLBI: Ad hoc Member, Cardiovascular A special Emphasis panel 2002.; Member (2002)
Journal of Cardiovascular Pharmacology; Member (1999–2019)
Regular Member, Cardiovascular Renal Study Section (CVB), 1999-2001 Regular Member, Cardiovascular Renal Study Section (CVB); Member (1999–2001)
University at Buffalo Faculty Research Advisory Council; Member (1999–2000)
Vice President’s Ad Hoc Committee on VA Research; Member (1999–2000)
National Institutes of Health - NHLBI, Member, SPIR/STTR National Institutes of Health - NHLBI, Member, SPIR/STTR; Cardiovascular Sciences Initial Review Group.; Member (1999)
Circulation Research; Member (1998–2019)
National Institutes of health - Ad hoc Reviewer, Cardiovascular Renal Study Section (CVB) National Institutes of health - Ad hoc Reviewer, Cardiovascular Renal Study Section (CVB).; Ad Hoc Reviewer (1998–1999)
American Heart Association; Editor, Council on Circulation Newsletter American Heart Association; Editor, Council on Circulation Newsletter; Editor (1995–1997)
American Heart Association; Council on Circulation Representative, AHA Public Affairs Committee American Heart Association; Council on Circulation Representative, AHA Public Affairs Committee; Councilor (1995–1996)
American Heart Association, Member, Long Range Planning Committee; Council on Circulation Member, Long Range Planning Committee, Council on Circulation; Member (1995–1996)
American College of Cardiology; Chapter Councilor, New York State Chapter American College of Cardiology; Chapter Councilor, New York State Chapter.; Councilor (1994–1996)
American Heart Association; Associate Editor, Council on Circulation Newsletter American Heart Association; Associate Editor, Council on Circulation Newsletter.; Associate Editor (1994–1995)
National Institutes of Health - NHLBI, Member, SCOR Site Visit National Institutes of Health - NHLBI, Member, SCOR Site Visit; Thomas Smith, Harvard Medical School.; Member (1994)
Basic Research in Cardiology; Member (1993–2015)
American Journal of Physiology, Heart Circulatory Physiology; Member (1993–present)
National Institutes of health - NHLBI, Regular Member National Institutes of health - NHLBI, Regular Member; Cardiovascular Renal Study Section (CVB).; Member (1993–1997)
American Heart Association; Ad hoc Reviewer - Melvin L. Marcus Award, 1993 American Heart Association; Ad hoc Reviewer - Melvin L. Marcus Award, 1993; Ad Hoc Reviewer (1993)
American College of Cardiology, Chairman, Computer Applications Committee Program, 1993 ACC Scientific Sessions American College of Cardiology, Chairman, Computer Applications Committee Program, 1993 ACC Scientific Sessions; Chair (1993)
National Institutes of Health - NHLBI, Member, Special Emphasis Panel; National Institutes of Health - NHLBI, Member, Special Emphasis Panel on Effects of Sex Hormones on Coronary Artery Reactivity.; Member (1993)
Member, Executive Committee, Council on Circulation, AHA National Center Member, Executive Committee, Council on Circulation, AHA National Center; Member (1992–1997)
American Heart Association, Member, Budget Committee, Council on Circulation Member, Budget Committee, Council on Circulation; AHA National Center; Member (1992–1995)
University Public Relations Task Force on Animal Research; Member (1992–1994)
National Institutes of Health - NHLBI, Member, Program Project Site Visit National Institutes of Health - NHLBI, Member, Program Project Site Visit; Julien I.E. Hoffman, University of California at San Francisco.; Member (1992)
National Institutes of Health - NHLBI, Member, SCOR Site Visit National Institutes of Health - NHLBI, Member, SCOR Site Visit; D. Skorton, University of Iowa.; Member (1991)
American College of Cardiology, Member, Computer Applications Committee American College of Cardiology, Member, Computer Applications Committee.; Member (1990–1995)
National Institutes of Health - NHLBI, Member, SCOR Site Visit National Institutes of Health - NHLBI, Member, SCOR Site Visit; M. Marcus, University of Iowa.; Member (1989)
American Heart Association; Member, Program Committee of the Council on Circulation American Heart Association; Member, Program Committee of the Council on Circulation; Member (1985–1990)

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Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, New York 14203
Phone: 716-829-2666
Fax: 716-854-1840
canty@buffalo.edu

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This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

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Jacobs School of Medicine
and Biomedical Sciences

John M. Canty, Jr. MD

John M. Canty, Jr.
MD

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Jacobs School of Medicine and Biomedical Sciences

Jacobs School of Medicineand Biomedical Sciences

John M. Canty, Jr. MD

John M. Canty, Jr. MD

Specialty/Research Focus

Professional Summary:

Education and Training:

Employment:

Awards and Honors:

Research Expertise:

Research Centers:

Grants and Sponsored Research:

Journal Articles:

Books and Book Chapters:

Abstracts:

Professional Memberships:

Service Activities:

School News:

In the Media:

Clinical Specialties:

Clinical Offices:

Insurance Accepted:

Contact Information

Jacobs School of Medicine and Biomedical Sciences

Join the School

Get Involved

Find People

UB Academic Health Center

Connect with Us

About The School

Centers and Affiliations

Education and Training

Research Facilities and Services

Health Care

Resources by Audience

Alumni and Friends

Governance

Learning Resources

Support Services

Site Tools

Jacobs School of Medicine and Biomedical Sciences

Jacobs School of Medicine
and Biomedical Sciences

John M. Canty, Jr.
MD