John M. Canty, Jr. MD

John Canty, Jr.

John M. Canty, Jr.
MD

SUNY Distinguished Professor, Albert and Elizabeth Rekate Professor and Chief, Division of Cardiovascular Medicine

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Apoptosis and cell death; Cardiac pharmacology; Cardiology; Cardiovascular Disease; Gene therapy; Genomics and proteomics; Molecular Basis of Disease; Stem Cells

Contact Information
Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: 829-2663
Fax: 854-1840
canty@buffalo.edu


Patient Care

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Professional Summary:

As chief of the Division of Cardiovascular Medicine at UB, I am responsible for the clinical, teaching and research programs related to adult patients with heart disease. I care for patients at the UBMD Internal Medicine practice group in Amherst, the Gates Vascular Institute (GVI) of Buffalo General Medical Center (BGMC) and the Buffalo VA Medical Center (VAMC). My clinical areas of expertise are in diagnosing and caring for patients with coronary artery disease and heart failure.

My research group conducts translational studies directed at advancing our mechanistic understanding of cardiac pathophysiology as well as developing new diagnostic and therapeutic approaches for the management of patients with chronic ischemic heart disease. Our ongoing areas of preclinical investigation apply proteomic approaches to identify intrinsic adaptive responses of the heart to ischemia and studies examining the ability of intracoronary stem cell therapies to stimulate endogenous cardiomyocyte proliferation and improve heart function. We also conduct basic and patient-oriented research to understand how reversible ischemia modifies the cellular composition and sympathetic innervation of the heart to help develop new approaches to identify patients at risk of sudden cardiac arrest from ventricular fibrillation.

In addition to my laboratory investigation, I serve as the deputy director of the UB Clinical and Translational Research Center (CTRC) and the director of the UB Translational Imaging Center. The Translational Imaging Center offers researchers opportunities to perform multimodality research imaging using PET molecular imaging, high-field magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Our overall goal is to use advanced cardiac imaging to translate new applications between the bench and bedside in order to identify new imaging biomarkers of pathophysiological processes such as chronic myocardial ischemia and cardiac arrhythmogenesis.

I am engaged in the cardiology profession at national and international levels, including as former president of the Association of Professors of Cardiology.

Education and Training:

  • Fellowship, cardiovascular disease, University at Buffalo, University at Buffalo (1983)
  • Internship/Residency, University at Rochester, University at Rochester (1981)
  • MD, Medicine, University at Buffalo, Thesis Honors (1979)
  • BS, Biomedical Engineering, Rensselaer Polytechnic Institute, Cum Laude (1975)

Employment:

  • Professor of Pharmacology and Toxicology, University at Buffalo (2015-present)
  • SUNY Distinguished Professor of Medicine, Medicine, University at Buffalo (2015-present)
  • Deputy Director, UB Clinical and Translational Science Institution, Cardiology, University at Buffalo (2013-present)
  • Professor of Biomedical Engineering, Department of Biomedical Engineering, University at Buffalo (2010-present)
  • Chief, Division of Cardiovascular Medicine, University at Buffalo (2006-present)
  • Director, Center for Research in Cardiovascular Medicine, University at Buffalo, Cardiology, University at Buffalo (2002-present)
  • Albert and Elizabeth Rekate Professor of Medicine, Medicine, University at Buffalo (2001-present)
  • Professor of Physiology & Biophysics, Physiology, University at Buffalo (1996-present)
  • Director of Cardiology Research Program, Cardiology, University at Buffalo (1992-present)
  • Director, UB CTRC Translational Imaging Facility, Medicine, University at Buffalo (2012–2017)
  • Vice-Chair for Research, Department of Medicine, University at Buffalo (2006–2011)
  • Professor of Medicine, Medicine, University at Buffalo (1995–2001)
  • Assistant Professor of Physiology, Physiology, University at Buffalo (1986–1996)
  • Associate Professor of Medicine, University at Buffalo (1989–1995)
  • Assistant Professor of Medicine, University at Buffalo (1983–1989)
  • Cardiology Fellow and Instructor of Medicine, Medicine, University at Buffalo (1981–1983)
  • Medical Resident, Medicine, Strong Memorial Hospital (1980–1981)
  • Medical Intern, Medicine, Strong Memorial Hospital (1979–1980)
See all (8 more)

Awards and Honors:

  • SUNY Distinguished Professor (2015)
  • Robert J. Bache Award (2012)
  • SUNY Chancellor‘s Award for Excellence in Scholarship & Creative Activities (2010)
  • Distinguished Alumnus Award (2008)
  • Stockton Kimball Award (2005)
  • Association of University Cardiologists (2003)
  • University at Buffalo Sustained Achievement Award (2003)
  • Best Doctors in America (1998)
  • Clinical Investigator Award NHLBI (1988)
  • Sinsheimer Scholar (1983)
  • American Heart Association Louis N. Katz Award Finalist (1982)
  • John C. Sable Memorial Heart Fund Award (1982)
  • Upjohn Research Award in Medicine (1979)
  • John Watson Award in Medicine (1979)
  • Buswell Student Research Award (1978)
  • Alpha Omega Alpha
  • James A. Gibson Anatomical Society
  • Tau Beta Pi Engineering Honorary Society

Research Expertise:

  • Cardiovascular stem cell therapy
  • Chronic adaptations to myocardial ischemia
  • Sudden cardiac death

Research Centers:

  • Center for Research in Cardiovascular Medicine

Grants and Sponsored Research:

  • September 2017–August 2022
    National Heart Lung and Blood Institute, UB Clinical Scholar Program in implementation science to achieve triple aims
    National Heart Lung and Blood Institute
    Role: Co-Principal Investigator
  • November 2016–December 2021
    Prediction of Arrhythmic Events with Positron Emission Tomography - II (PAREPET II)
    National Heart Lung and Blood Institute - NHLBI
    Role: Co-Principal Investigator
    $3,726,616
  • January 2016–December 2021
    Prediction ARrhythmic Events with Positron Emission Tomography - II (PAREPET-II)
    NIH - NHLBI
    Role: Co-Principal Investigator
  • September 2015–June 2020
    National Center for Advancing Translational Sciences
    NIH
    Role: Contributor
  • January 2016–December 2019
    VA Merit Review, Dynamic remodeling from reversible ischemia and sudden cardiac arrest
    VA
    Role: Co-Investigator
    $649,600
  • January 2016–January 2019
    Clinical Translational Science Award (CTSA)
    National Institutes of Health
    Role: Co-Principal Investigator
    $16,000,000
  • January 2013–December 2018
    T3-Nanformulation Evaluation in Preparation for Clinical Trials
    UB Cat
    Role: Principal Investigator
  • November 2014–October 2018
    Mechanisms of cKit+ Cardiac Stem Cell-Mediated Repair in Ischemic Cardiomyopathy
    National Heart Lung and Blood Institute
    Role: Principal Investigator
    $2,056,476
  • July 2015–June 2017
    Self-replicating RNA-nanoplexes for Programming Monocytes to Regenerate the Heart
    National Heart Lung and Blood Institute
    Role: Co-Investigator
    $432,013
  • January 2011–December 2015
    Biomarker Release after Reversible Ischemia
    American Heart Association
    Role: Co-Investigator
    $385,000
  • August 1996–November 2015
    Chronic Adaptations to Myocardial Ischemia
    NIH
    Role: Principal Investigator
    $1,850,918
  • July 2013–June 2015
    T3np for Cardiac Resuscitation - Pivotal Pre-Clinical Trial
    UB CAT/Pro-Al Medico Technologies
    Role: Co-Investigator
  • May 2010–April 2012
    PET/CT for Multidimensional Translational Cardiovascular Research
    NIH
    Role: Co-Investigator
    $2,000,000
  • January 2006–January 2012
    NIH National Heart Lung and Blood Institute:Mesenchymal Stem Cell Therapeutics in Hibernating Myocardium
    NIH National Heart Lung and Blood Institute
    Role: Co-Investigator
    $1,923,795
  • July 2007–June 2011
    Department of Veterans Affairs. Statins and Growth Factors for Chronic Ischemic Heart Failure
    Role: Principal Investigator
    $712,500
  • July 2007–June 2008
    New York State Stem Cell Science Institutional Support Pilot Project Award
    NYSTEM
    Role: Principal Investigator
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Journal Articles:

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Books and Book Chapters:

  • Fernandez SF, Canty JM, Fallavollita J. PET imaging and quantitation of cardiac innervation. Atlas of Cardiac Innervation. 2017.
  • Canty Jr JM, and DJGM Duncker. Coronary blood flow and myocardial ischemia (10th Ed). Braunwald‘s Heart Disease. 2014.
  • Canty, Jr. JM and B Weil. Coronary Blood Flow and Myocardial Ischemia. Essential Cardiology. 2013.
  • Canty, Jr. JM. Coronary blood flow and myocardial ischemia.. Braunwald‘s Heart Disease, 9th Edition. 2012; 52.
  • Canty, Jr.; Fallavollita J.. Pathophysiological basis of hibernating myocardium.. Clinical Nuclear Cardiology: State of the Art and Future Direction 4th Edition. 2010.
  • Canty, Jr. JM. Coronary blood flow and myocardial ischemia. Braunwald's Heart Disease, 8th Edition. 2007.
  • Canty, Jr. JM. Myocardial perfusion-contraction matching.. Stunning, Hibernation and Preconditioning: Clinical Pathophysiology of Myocardial Ischemia. 1997; 4.
  • Mates RE, JM Canty Jr, E Farhi, R Judd and FJ Klocke.. Clinical importance of coronary pressure-flow relationships.. Imaging, Measurement and Analysis of the Heart. 1991.
  • Canty JM, Jr., J Giglia and FJ Klocke.. Prediction of endocardial ischemia with indices of coronary driving pressure and endocardial function in conscious dogs.. Inhomogeneity and Imaging. 1990.
  • Canty, Jr. JM and FJ Klocke. Modulation of coronary autoregulatory responses.. Activation, Metabolism and Perfusion of the Heart. 1987.
  • Klocke, F. J., R. E. Mates, J. M. Canty, Jr. and A. K. Ellis.. Current controversies concerning coronary pressure-flow relationships. Simulation and Control of the Cardiac System.. 1987.
  • Mates, R. E., F. J. Klocke and J. M. Canty, Jr. JM. Impedance to coronary flow. In: Activation, Metabolism and Perfusion of the Heart. Martinus Nijhoff Publishers, Dordrecht (Netherlands). 1987.
  • Klocke, F. J., J. M. Canty, Jr., and R. E. Mates. JM. Evolving concepts of coronary pressure-flow relationships. Martinus Nijhoff Publishing. 1984.
  • Mates, R. E., T. Burns, J. M. Canty, R. Greenberg and J. Neeson. JM. Modeling diastolic impedance to coronary blood flow. Mechanics of the Coronary Circulation. 1983.
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Abstracts:

  • Singh V, Malhotra S, Canty J, Fallavollita JA. The volume of denervated myocardium predicts sudden cardiac death (SCD) and ICD therapies for VF but not ICD therapies for slower ventricular tachyarrhythmia (VT): An analysis of the prediction of arrhythmic events with positron emission tomography (PARE. Journal of the American College of Cardiology. 2018.

Professional Memberships:

  • Member, AAMC Council of Faculty and Academic Societies (CFAS) (2013–2016)
  • President, Association of Professors of Cardiology, 2012-2013 (2012–2013)
  • Member, International Society for Heart Research, 2011 - present (2011–present)
  • Fellow, American Physiological Society Cardiovascular Section (2005–present)
  • Fellow of the American Heart Association, Council on Basic Cardiovascular Sciences (2001–present)
  • Fellow of the American Heart Association, 2001 – present (2001–present)
  • Fellow, American College of Physicians, 1995 – present (1995–present)
  • Member, American Heart Association Council on Clinical Cardiology, 1993 – present (1993–2002)
  • Fellow, American Heart Association Council on Circulation, 1985 – 2001 (1985–2001)
  • Member, American College of Physicians, 1985 – 1994 (1985–1994)
  • Subspecialty Certification in Cardiovascular Diseases, 1985 (1985)
  • Member, American Physiological Society, 1985 – present (1985–present)
  • Fellow, American College of Cardiology, 1985 – present (1985–present)
  • Member, American Federation for Clinical Research, 1984 – 1998 (1984–1998)
  • Member, American Society for the Advancement of Science, 1984 – 1986 (1984–1986)
  • Diplomat, American Board of Internal Medicine, 1984 (1984)
  • Member, American Heart Association, 1983 (1983)
  • Member, American Heart Association (1983–present)
  • Affiliate, American College of Cardiology, 1982 – 1985 (1982–1985)
  • Associate, American College of Physicians, 1981 – 1985 (1981–1985)
  • Diplomat, National Board of Medical Examiners, 1980 (1980)
  • Member, American Heart Association Council on Basic Science
See all (12 more)

Service Activities:

  • Member, American College of Cardiology Awards Committee, 2014 - 2016; Member, American College of Cardiology Awards Committee, 2014 - 2016; Member (2014–2016)
  • Veteran's Hospital; Member, Research and Development Committee; Member, Research and Development Committee; VA Hospital; Buffalo, NY; Member (2014–2016)
  • American Heart Association, Member, Council on Basic Cardiovascular Sciences Writing Committee; American Heart Association, Member, Council on Basic Cardiovascular Sciences Writing Committee; Member (2013)
  • American Heart Association, Member, Council on Basic Cardiovascular Sciences Writing Committee, Scientific Writing Committee; "Preclinical Models of Myocardial Ischemia/Reperfusion Injury."; Member (2013)
  • Member, American College of Cardiology Academic Cardiology Council Executive Committee; Member, American College of Cardiology Academic Cardiology Council Executive Committee; Member (2012–2015)
  • National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; Kirk Hammond, MD, University of California at San Diego, 2011.; Member (2011)
  • National Institutes of Health - NHLBI; Ad hoc Member; National Institutes of Health - NHLBI; Ad hoc Member; S10 Special Emphasis Panel, 2010; Member (2010)
  • National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel.; National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; Jun Sadoshima, Ph.D., UMDNJ, 2009.; Member (2009)
  • National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel.; National Institutes of Health - NHLBI: Ad hoc Member, PPG Special Emphasis Panel; Roger Hajjar, M.D., Mount Sinai Medical School, 2009; Member (2009)
  • Member, American College of Cardiology Research Awards Committee (ACCF); Member, American College of Cardiology Research Awards Committee (ACCF); Member (2008–2014)
  • American Heart Association; Member, Melvin L. Marcus Award Selection Committee; American Heart Association; Member, Melvin L. Marcus Award Selection Committee.; Member (2008–2010)
  • American Heart Association; Member, AHA Scientific Publication Committee; American Heart Association; Member, AHA Scientific Publication Committee; Member (2008–2009)
  • American Heart Association, Member, Circulation Research Editor Selection Committee; American Heart Association, Member, Circulation Research Editor Selection Committee.; Member (2008)
  • National Institutes of Health - NHLBI: Member, R24 Special Emphasis Panel; National Institutes of Health - NHLBI: Member, R24 Special Emphasis Panel; Roberto, Bolli, MD, University of Louisville, 2008.; Member (2008)
  • American Heart Association; Member, AHA Interdisciplinary Committee on the Prevention of the Epidemiology and Prevention Council of the American Heart; American Heart Association; Member, AHA Interdisciplinary Committee on the Prevention of the Epidemiology and Prevention Council of the American Heart Association; Member (2007–2010)
  • National Institutes of Health - NHLBI: Member, Program Project Special Emphasis Panel; National Institutes of Health - NHLBI: Member, Program Project Special Emphasis Panel, Kirk Hammond, M.D.; University of California at San Diego, 2006 and 2007.; Member (2006–2007)
  • American Society of Nuclear Cardiology; Member, ASNC Task force on Cardiac Neural Imaging, 2006; American Society of Nuclear Cardiology; Member, ASNC Task force on Cardiac Neural Imaging, 2006; Member (2006)
  • National Institutes of Health - NHLBI: Ad hoc Member, Mentored Patient Oriented Research Career Development Award Study Section; National Institutes of Health - NHLBI: Ad hoc Member, Mentored Patient Oriented Research Career Development Award Study Section, 2006.; Member (2006)
  • National Institutes of health - NHLBI, Regular Member; National Institutes of health - NHLBI, Regular Member; Myocardial Ischemia and Metabolism Study Section (MIMS), 2005-2009; Member (2005–2009)
  • National Institutes of Health - NHLBI: Temporary Member, Myocardial Ischemia and Metabolism Study Section; National Institutes of Health - NHLBI: Temporary Member, Myocardial Ischemia and Metabolism Study Section; 2004-2005.; Member (2004–2005)
  • National Institutes of Health - NHLBI: Ad hoc Member, Gene and Drug Delivery Systems Study Section; National Institutes of Health - NHLBI: Ad hoc Member, Gene and Drug Delivery Systems Study Section; 2004; Member (2004)
  • National Institutes of Health - NHLBI; Ad hoc Member, Clinical Cardiovascular Sciences Special Emphasis Panel; National Institutes of Health - NHLBI; Ad hoc Member, Clinical Cardiovascular Sciences Special Emphasis Panel, 2003-2004; Member (2003–2004)
  • National Institutes of Health - NHLBI: Ad hoc Member, Cardiovascular A special Emphasis panel 2002; National Institutes of Health - NHLBI: Ad hoc Member, Cardiovascular A special Emphasis panel 2002.; Member (2002)
  • National Institutes of Health - NHLBI; Member, Evaluation Committee for the Specialized Centers of Research (SCOR) in Ischemic Heart Disease, Heart Fa; National Institutes of Health - NHLBI; Member, Evaluation Committee for the Specialized Centers of Research (SCOR) in Ischemic Heart Disease, Heart Failure and Sudden Cardiac Death, 2002.; Member (2002)
  • Regular Member, Cardiovascular Renal Study Section (CVB), 1999-2001; Regular Member, Cardiovascular Renal Study Section (CVB); Member (1999–2001)
  • National Institutes of Health - NHLBI, Member, SPIR/STTR; National Institutes of Health - NHLBI, Member, SPIR/STTR; Cardiovascular Sciences Initial Review Group.; Member (1999)
  • National Institutes of health - Ad hoc Reviewer, Cardiovascular Renal Study Section (CVB); National Institutes of health - Ad hoc Reviewer, Cardiovascular Renal Study Section (CVB).; Ad Hoc Reviewer (1998–1999)
  • American Heart Association; Editor, Council on Circulation Newsletter; American Heart Association; Editor, Council on Circulation Newsletter; Editor (1995–1997)
  • American Heart Association, Member, Long Range Planning Committee; Council on Circulation; Member, Long Range Planning Committee, Council on Circulation; Member (1995–1996)
  • American Heart Association; Council on Circulation Representative, AHA Public Affairs Committee; American Heart Association; Council on Circulation Representative, AHA Public Affairs Committee; Councilor (1995–1996)
  • Veteran's Hospital, Buffalo, NY Member, Research and Development Product Support Group; Member, Research and Development Product Support Group; Member (1995–1996)
  • American College of Cardiology; Chapter Councilor, New York State Chapter; American College of Cardiology; Chapter Councilor, New York State Chapter.; Councilor (1994–1996)
  • American Heart Association; Associate Editor, Council on Circulation Newsletter; American Heart Association; Associate Editor, Council on Circulation Newsletter.; Associate Editor (1994–1995)
  • National Institutes of Health - NHLBI, Member, SCOR Site Visit; National Institutes of Health - NHLBI, Member, SCOR Site Visit; Thomas Smith, Harvard Medical School.; Member (1994)
  • National Institutes of health - NHLBI, Regular Member; National Institutes of health - NHLBI, Regular Member; Cardiovascular Renal Study Section (CVB).; Member (1993–1997)
  • VA Hospital, Buffalo, NY - Animal Study Subcommittee; Member, Animal Study Subcommittee; Member (1993–1997)
  • American College of Cardiology, Chairman, Computer Applications Committee Program, 1993 ACC Scientific Sessions; American College of Cardiology, Chairman, Computer Applications Committee Program, 1993 ACC Scientific Sessions; Chair (1993)
  • American Heart Association; Ad hoc Reviewer - Melvin L. Marcus Award, 1993; American Heart Association; Ad hoc Reviewer - Melvin L. Marcus Award, 1993; Ad Hoc Reviewer (1993)
  • National Institutes of Health - NHLBI, Member, Special Emphasis Panel;; National Institutes of Health - NHLBI, Member, Special Emphasis Panel on Effects of Sex Hormones on Coronary Artery Reactivity.; Member (1993)
  • Member, Executive Committee, Council on Circulation, AHA National Center; Member, Executive Committee, Council on Circulation, AHA National Center; Member (1992–1997)
  • American Heart Association, Member, Budget Committee, Council on Circulation; Member, Budget Committee, Council on Circulation; AHA National Center; Member (1992–1995)
  • National Institutes of Health - NHLBI, Member, Program Project Site Visit; National Institutes of Health - NHLBI, Member, Program Project Site Visit; Julien I.E. Hoffman, University of California at San Francisco.; Member (1992)
  • National Institutes of Health - NHLBI, Member, SCOR Site Visit; National Institutes of Health - NHLBI, Member, SCOR Site Visit; D. Skorton, University of Iowa.; Member (1991)
  • American College of Cardiology, Member, Computer Applications Committee; American College of Cardiology, Member, Computer Applications Committee.; Member (1990–1995)
  • National Institutes of Health - NHLBI, Member, SCOR Site Visit; National Institutes of Health - NHLBI, Member, SCOR Site Visit; M. Marcus, University of Iowa.; Member (1989)
  • American Heart Association; Member, Program Committee of the Council on Circulation; American Heart Association; Member, Program Committee of the Council on Circulation; Member (1985–1990)

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Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: 829-2663
Fax: 854-1840
canty@buffalo.edu

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD