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Christine                      Schaner Tooley

Christine E. Schaner Tooley PhD

Department of Biochemistry

Assistant Professor

Specialty/Research Focus

Cell growth, differentiation and development; DNA Replication, Recombination and Repair; Gene Expression; Molecular and Cellular Biology; Proteins and metalloenzymes; Signal Transduction; Transcription and Translation

 
Professional Summary:

The main goal of my research group is to understand the role of N-terminal methylation on human development and disease. I identified the first eukaryotic N-terminal methyltransferases, NRMT1 and NRMT2, and am now working to identify how these enzymes and this new type of methylation affect cancer development and ageing. Our laboratory has shown that NRMT1 functions as a tumor suppressor in mammary glands, and its loss sensitizes breast cancer cells to DNA damaging chemotherapeutics. We have also created the first NRMT1 knockout mouse and shown it to have developmental defects, as well as, exhibit phenotypes of premature ageing. Currently, we are working to understand the exact biochemical pathways that lead from loss of N-terminal methylation to these phenotypes. We are also studying how post-translational modifications on the N-terminus of proteins may interact and dictate protein function, similar to the post-translational modifications found on histone tails.

Education and Training:
  • Postdoctoral Fellow, Biochemistry, University of Virginia (2011)
  • PhD, Biochemistry, Cell, & Developmental Biology, Emory University (2005)
  • BS, Biochemistry, University of Rochester, Magna Cum Laude (2000)
Employment:
  • Assistant Professor, Biochemistry, University at Buffalo (2016-present)
  • Assistant Professor, Biochemistry & Molecular Genetics, University of Louisville (2011–2016)

Grants and Sponsored Research:
  • September 2015–June 2020
    Deciphering the Code of N-terminal Post-translational Modification
    NIGMS
    Role: Principal Investigator
    $1,504,140
  • September 2013–August 2015
    The Role of the First Mammalian N-terminal Methyltransferase, NRMT1, in tumorigenesis
    NCI
    Role: Principal Investigator
    $454,074
  • September 2011–August 2013
    The Role of the First Mammalian N-term. Methyltransferase, NRMT, in tumorigenesis
    NCI
    Role: Principal Investigator
    $176,934
  • September 2006–December 2008
    Regulation of RCC1 through N-terminal serine methylation
    NIGMS
    Role: Principal Investigator

Journal Articles:
See all (4 more)


School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:


Contact Information

University at Buffalo
3435 Main St.
312 Farber Hall
Buffalo, NY 14214
Phone: (716) 829-2978
Fax: (716) 829-2725
Email: ceschane@buffalo.edu


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